Several contributing factors have been implicated in evolutionary rate heterogeneity among protei... more Several contributing factors have been implicated in evolutionary rate heterogeneity among proteins, but their evolutionary mechanisms remain poorly characterized. The recently sequenced 12 Drosophila genomes provide a unique opportunity to shed light on these unresolved issues. Here, we focus on the role of natural selection in shaping evolutionary rates. We use the Drosophila genomic data to distinguish between factors that increase the strength of purifying selection on proteins and factors that affect the amount of positive selection experienced by proteins. We confirm the importance of translational selection in shaping protein evolution in Drosophila and show that factors such as tissue bias in expression, gene essentiality, intron number, and recombination rate also contribute to evolutionary rate variation among proteins.
In this paper, an electrocardiographic (ECG) signal processing IC, which is used for portable bio... more In this paper, an electrocardiographic (ECG) signal processing IC, which is used for portable biomedical application, was designed using continuous-time technique. The circuit consists of an instrumentation amplifier (INA) with driven-right-leg circuit (DRL), a 5th order Gm -C low pass filter (Gm-C LPF) operating in sub-threshold mode, and amplifiers. DRL circuit is used to detect small amplitude signal in the presence of large common-mode voltage from the human body. The CMRR of the INA is 78 dB and the Gm-C LPF has a cutoff frequency of 18 Hz. As a result of using the DRL, a small signal can be detected in the presence of large common-mode differential. The circuit consumes 1.23 mW when operating from with a supply voltage of plusmn1.5-V and occupies a core area of 0.94 mm2. The circuit was designed in a 0.35mum CMOS process and simulation results have successfully demonstrated the functionalities
IEEE Transactions on Circuits and Systems I-regular Papers, 2005
A near-infrared heart-rate measurement IC that processes the photoplethysmographic signal was des... more A near-infrared heart-rate measurement IC that processes the photoplethysmographic signal was designed using a 0.35-μm CMOS technology. The IC consists of a current-to-voltage (I-V) converter, a buffer, a sample-and-hold circuit, a second-order continuous-time low-pass filter (CT-LPF), a comparator, and a timing circuit that is used to pulse the external light-emitting diode with a very low duty cycle to reduce its
Several contributing factors have been implicated in evolutionary rate heterogeneity among protei... more Several contributing factors have been implicated in evolutionary rate heterogeneity among proteins, but their evolutionary mechanisms remain poorly characterized. The recently sequenced 12 Drosophila genomes provide a unique opportunity to shed light on these unresolved issues. Here, we focus on the role of natural selection in shaping evolutionary rates. We use the Drosophila genomic data to distinguish between factors that increase the strength of purifying selection on proteins and factors that affect the amount of positive selection experienced by proteins. We confirm the importance of translational selection in shaping protein evolution in Drosophila and show that factors such as tissue bias in expression, gene essentiality, intron number, and recombination rate also contribute to evolutionary rate variation among proteins.
In this paper, an electrocardiographic (ECG) signal processing IC, which is used for portable bio... more In this paper, an electrocardiographic (ECG) signal processing IC, which is used for portable biomedical application, was designed using continuous-time technique. The circuit consists of an instrumentation amplifier (INA) with driven-right-leg circuit (DRL), a 5th order Gm -C low pass filter (Gm-C LPF) operating in sub-threshold mode, and amplifiers. DRL circuit is used to detect small amplitude signal in the presence of large common-mode voltage from the human body. The CMRR of the INA is 78 dB and the Gm-C LPF has a cutoff frequency of 18 Hz. As a result of using the DRL, a small signal can be detected in the presence of large common-mode differential. The circuit consumes 1.23 mW when operating from with a supply voltage of plusmn1.5-V and occupies a core area of 0.94 mm2. The circuit was designed in a 0.35mum CMOS process and simulation results have successfully demonstrated the functionalities
IEEE Transactions on Circuits and Systems I-regular Papers, 2005
A near-infrared heart-rate measurement IC that processes the photoplethysmographic signal was des... more A near-infrared heart-rate measurement IC that processes the photoplethysmographic signal was designed using a 0.35-μm CMOS technology. The IC consists of a current-to-voltage (I-V) converter, a buffer, a sample-and-hold circuit, a second-order continuous-time low-pass filter (CT-LPF), a comparator, and a timing circuit that is used to pulse the external light-emitting diode with a very low duty cycle to reduce its
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Papers by Alex Wong