Alberto MUNOZ

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Raul Alonso-calvo

Universidad Politécnica de Madrid

Fernando Martin-Sanchez

University of Melbourne

Pietro Guccione

Politecnico di Bari

Diana de la Iglesia

Universidad Politécnica de Madrid

Isabel Hermosilla

Ferran Sanz

Pompeu Fabra University

Josipa Kern

University of medicine Zagreb

Casimir A Kulikowski

Rutgers, The State University of New Jersey

Holger Billhardt

Universidad Rey Juan Carlos

Cristian Robert Munteanu

Universidade da Coruña

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Papers by Alberto MUNOZ

Cloud Computing Service for Managing Large Medical Image Data-Sets Using Balanced Collaborative Agents

Advances in Intelligent and Soft Computing, 2011

Managing large medical image coltections is an increasingiy demanding important issue in many hos... more Managing large medical image coltections is an increasingiy demanding important issue in many hospitals and other medica) settings. A huge amount of this informaüon is daily generated, which requires robust and agüe systems. In this paper we present a distributed multi-agent system capable of managing very large medical image dataseis. In this approach, agents extract low-Ievel informaüon from ímages and store them in a data structure impiemented in a relational datábase. The data structure can also store semantic información related to images and particular regions. A distinctive aspect of our work is that a single image can be divided so that the resultant sub-images can be stored and managed separately by different agents to improve performance in data accessing and processing. The system also offers the possibüity of applying some region-based operations and filters on images, facilitating image classification. These operations can be performed directly on data structures in the datábase.

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Detecting the Number of Clusters Using a Support Vector Machine Approach

Lecture Notes in Computer Science, 2002

In this work we introduce a new methodology to determine the number of clusters in a data set. We... more

Extending the SOM Algorithm to Non-Euclidean Distances via the Kernel Trick

Lecture Notes in Computer Science, 2004

The Self Organizing Map is a nonlinear projection technique that allows to visualize the underlyi... more The Self Organizing Map is a nonlinear projection technique that allows to visualize the underlying structure of high dimensional data. However, the original algorithm relies on the use of Euclidean distances which often becomes a serious drawback for a number of real problems. In this paper, we present a new kernel version of the SOM algorithm that incorporates non-Euclidean dissimilarities

Extending the SOM Algorithm to Visualize Word Relationships

Lecture Notes in Computer Science, 2005

Self Organizing Maps (SOM) are useful tools to discover the underlying structure of high dimensio... more Self Organizing Maps (SOM) are useful tools to discover the underlying structure of high dimensional data. However the algorithms proposed in the literature rely on the use of symmetric measures such as the Euclidean. Therefore when asymmetry arises they fail to reflect accurately the object proximities and the resulting maps become often meaningless. This is a serious drawback for several

Specializations of the Cortical Microstructure of Humans

Evolution of Nervous Systems, 2007

... by J DeFelipe, L Alonso-Nanclares, J Arellano, I Ballesteros-Yáñez, R Benavides-Piccione, AMu... more

Kernel Procrustes

18th International Conference on Pattern Recognition (ICPR'06), 2006

In this work we introduce a new methodology to build a kernel matrix from a collection of kernels... more In this work we introduce a new methodology to build a kernel matrix from a collection of kernels. The key idea is to build a unique kernel that eliminates spurious differences between kernels. We propose a method based on the Procrustes problems that uses the alternating projections method to minimize a certain error measure. The resulting kernel will be used

From Indefinite to Positive Semi-Definite Matrices

Lecture Notes in Computer Science, 2006

Similarity based classification methods use positive semidefinite (PSD) similarity matrices. When... more Similarity based classification methods use positive semidefinite (PSD) similarity matrices. When several data representations (or metrics) are available, they should be combined to build a single similarity matrix. Often the resulting combination is an indefinite matrix and can not be used to train the classifier. In this paper we introduce new methods to build a PSD matrix from an indefinite matrix. The obtained matrices are used as input kernels to train Support Vector Machines (SVMs) for classification tasks. Experimental results on artificial and real data sets are reported.

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Snail1 Expression Is Required for Sarcomagenesis

Neoplasia, 2014

Snail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but i... more Snail1 transcriptional repressor is a major inducer of epithelial-to mesenchymal transition but is very limitedly expressed in adult animals. We have previously demonstrated that Snail1 is required for the maintenance of mesenchymal stem cells (MSCs), preventing their premature differentiation. Now, we show that Snail1 controls the tumorigenic properties of mesenchymal cells. Increased Snail1 expression provides tumorigenic capabilities to fibroblastic cells; on the contrary, Snail1 depletion decreases tumor growth. Genetic depletion of Snail1 in MSCs that are deficient in p53 tumor suppressor downregulates MSC markers and prevents the capability of these cells to originate sarcomas in immunodeficient SCID mice. Notably, an analysis of human sarcomas shows that, contrarily to epithelial tumors, these neoplasms display high Snail1 expression. This is particularly clear for undifferentiated tumors, which are associated with poor outcome. Together, our results indicate a role for Snail1 in the generation of sarcomas.

7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds

Bioorganic & medicinal chemistry letters, Jan 15, 2014

7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic bu... more 7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between γ-hydroxybutenolides and aromatic aldehydes. The following outlines our findings that these spirocycles are potently cytotoxic and have a dramatic structure-function profile that provides excellent insight into the structural features required for this potency.

Combining Kernel Information for Support Vector Classification

Lecture Notes in Computer Science, 2004

Support Vector Machines (SVMs) have proven to be a successful tool for the solution of a wide ran... more

Vitamin D and Wnt/β-Catenin Signaling

Vitamin D, 2011

672 Dissecting the protective role of vitamin D3 on colon cancer: new targets from the protein degradation machinery

European Journal of Cancer Supplements, 2010

Sox2. However, very little is known about Sox2 regulators. It is well-established that mir-21 has... more Sox2. However, very little is known about Sox2 regulators. It is well-established that mir-21 has an anti-apoptotic effect in various cancer cells. Conclusions: The Sox2 suppressing effect of mir-21 suggests a hitherto unknown novel pathway. These findings could be implicated in anti-glioma therapy. Targeting mir-21 would not only lead to increased apoptosis, as has previously been demonstrated by several investigators, but also to decreased expression of a transcription factor which is required for the maintenance of stemness.

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Interaction of vitamin D with membrane-based signaling pathways

Frontiers in Physiology, 2014

Many studies in different biological systems have revealed that 1α,25-dihydroxyvitamin D 3 (1α,25... more Many studies in different biological systems have revealed that 1α,25-dihydroxyvitamin D 3 (1α,25(OH) 2 D 3 ) modulates signaling pathways triggered at the plasma membrane by agents such as Wnt, transforming growth factor (TGF)-β, epidermal growth factor (EGF), and others. In addition, 1α,25(OH) 2 D 3 may affect gene expression by paracrine mechanisms that involve the regulation of cytokine or growth factor secretion by neighboring cells. Moreover, post-transcriptional and post-translational effects of 1α,25(OH) 2 D 3 add to or overlap with its classical modulation of gene transcription rate. Together, these findings show that vitamin D receptor (VDR) cannot be considered only as a nuclear-acting, ligand-modulated transcription factor that binds to and controls the transcription of target genes. Instead, available data support the view that much of the complex biological activity of 1α,25(OH) 2 D 3 resides in its capacity to interact with membrane-based signaling pathways and to modulate the expression and secretion of paracrine factors. Therefore, we propose that future research in the vitamin D field should focus on the interplay between 1α,25(OH) 2 D 3 and agents that act at the plasma membrane, and on the analysis of intercellular communication. Global analyses such as RNA-Seq, transcriptomic arrays, and genome-wide ChIP are expected to dissect the interactions at the gene and molecular levels.

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Facilities Planning Using Coupled Surface and Reservoir Simulation Models

SPE/DGS Saudi Arabia Section Technical Symposium and Exhibition, 2011

Abstract We will discuss issues in developing a production-injection surface facility model to op... more

A Study of Coupling Surface Network to Reservoir Simulation Model in a Large Middle East Field

North Africa Technical Conference and Exhibition, 2010

Abstract This study investigated the feasibility of coupling a subsurface numerical reservoir sim... more

Applications of Time-series Analysis to Antibiotic Resistance and Consumption Data

Antibiotic Policies, 2005

José-María López-Lozano1, Dominique L. Monnet2, Pilar Campillos Alonso1, Alberto Cabrera Quintero... more

Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells

Cancers, 2013

The Wnt/-catenin signaling pathway is abnormally activated in most colorectal cancers and in a p... more The Wnt/-catenin signaling pathway is abnormally activated in most colorectal cancers and in a proportion of other neoplasias. This activation initiates or contributes to carcinogenesis by regulating the expression of a large number of genes in tumor cells. The active vitamin D metabolite 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) inhibits Wnt/-catenin signaling by several mechanisms at different points along the pathway. Additionally, paracrine actions of 1,25(OH) 2 D 3 on stromal cells may also repress this pathway in neighbouring tumor cells. Here we review the molecular basis for the various mechanisms by which 1,25(OH) 2 D 3 antagonizes Wnt/-catenin signaling, preferentially in human colon carcinoma cells, and the consequences of this inhibition for the phenotype and proliferation rate. The effect of the vitamin D system on Wnt/-catenin signaling and tumor growth in animal models will also be commented in detail. Finally, we revise existing data on the relation between vitamin D receptor expression and vitamin D status and the expression of Wnt/-catenin pathway genes and targets in cancer patients.

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Mitochondrial Encephalomyopathies in Children. Part I: Conventional MR Imaging Findings

Current Medical Imaging Reviews, 2009

... Alberto Muñoz1,*, Fernando Mateos 2 , Rogelio Simón 2 , Elena Martín-Hernández 3 , Ana Camach... more

Vitamin D

Vitamin D, 2011

Recurrent meningitis and persistence of craniopharyngeal canal: case report

Neurocirugía, 2009

Craniopharyngeal Canal is a rare malformation of the sphenoid bone described in up to 0.42% of th... more Craniopharyngeal Canal is a rare malformation of the sphenoid bone described in up to 0.42% of the asymptomatic population. It&#39;s been related to the development of the Rathke&#39;s pouch during embrionary period although some authors think it&#39;s a vestige of a former vascular channel. This report details a case of a four and a half years old child that developed recurrent meningitis associated with this anomaly. Its origin, clinical manifestations and treatment options are discussed. Due to its low incidence and diagnostic difficulties, a high suspicion index is required while studying a case of recurrent meningitis or CSF leakage. Surgical approach is still controversial.

Cloud Computing Service for Managing Large Medical Image Data-Sets Using Balanced Collaborative Agents

Advances in Intelligent and Soft Computing, 2011

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Detecting the Number of Clusters Using a Support Vector Machine Approach

Lecture Notes in Computer Science, 2002

In this work we introduce a new methodology to determine the number of clusters in a data set. We... more

Extending the SOM Algorithm to Non-Euclidean Distances via the Kernel Trick

Lecture Notes in Computer Science, 2004

Extending the SOM Algorithm to Visualize Word Relationships

Lecture Notes in Computer Science, 2005

Specializations of the Cortical Microstructure of Humans

Evolution of Nervous Systems, 2007

... by J DeFelipe, L Alonso-Nanclares, J Arellano, I Ballesteros-Yáñez, R Benavides-Piccione, AMu... more

Kernel Procrustes

18th International Conference on Pattern Recognition (ICPR'06), 2006

From Indefinite to Positive Semi-Definite Matrices

Lecture Notes in Computer Science, 2006

Download

Snail1 Expression Is Required for Sarcomagenesis

Neoplasia, 2014

7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds

Bioorganic & medicinal chemistry letters, Jan 15, 2014

Combining Kernel Information for Support Vector Classification

Lecture Notes in Computer Science, 2004

Support Vector Machines (SVMs) have proven to be a successful tool for the solution of a wide ran... more

Vitamin D and Wnt/β-Catenin Signaling

Vitamin D, 2011

672 Dissecting the protective role of vitamin D3 on colon cancer: new targets from the protein degradation machinery

European Journal of Cancer Supplements, 2010

Download

Interaction of vitamin D with membrane-based signaling pathways

Frontiers in Physiology, 2014

Download

Facilities Planning Using Coupled Surface and Reservoir Simulation Models

SPE/DGS Saudi Arabia Section Technical Symposium and Exhibition, 2011

Abstract We will discuss issues in developing a production-injection surface facility model to op... more

A Study of Coupling Surface Network to Reservoir Simulation Model in a Large Middle East Field

North Africa Technical Conference and Exhibition, 2010

Abstract This study investigated the feasibility of coupling a subsurface numerical reservoir sim... more

Applications of Time-series Analysis to Antibiotic Resistance and Consumption Data

Antibiotic Policies, 2005

José-María López-Lozano1, Dominique L. Monnet2, Pilar Campillos Alonso1, Alberto Cabrera Quintero... more

Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells

Cancers, 2013

Download

Mitochondrial Encephalomyopathies in Children. Part I: Conventional MR Imaging Findings

Current Medical Imaging Reviews, 2009

... Alberto Muñoz1,*, Fernando Mateos 2 , Rogelio Simón 2 , Elena Martín-Hernández 3 , Ana Camach... more

Vitamin D

Vitamin D, 2011

Recurrent meningitis and persistence of craniopharyngeal canal: case report

Neurocirugía, 2009

Alberto MUNOZ

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