Alastair Goss

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Eiji Tanaka

The University of Tokushima

Carlos Baraldi

Universidade Federal do Rio Grande do Sul

Laurent Ameye

Andrea Michelotti

Rebekah Cosden Decker

Novartis

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Papers by Alastair Goss

Repeated Live Imaging in the Temporomandibular Joint of an Anterior Crossbite Mouse Model Using a 7T Magnetic Resonance Device

In Vivo

Background/Aim: Few studies have performed magnetic resonance (MR) imaging on live animals. The a... more Background/Aim: Few studies have performed magnetic resonance (MR) imaging on live animals. The aim of this study was to perform 7T MR microimaging of the temporomandibular joint (TMJ) multiple times in the same living mice with malocclusion, and to compare between MR imaging and histopathological findings. Materials and Methods: Mice were examined by MR imaging at 3-4, 6 and 12 weeks following the attachment of a metal tube on the left mandibular incisor. Histopathological examination was done at 3, 6 and 12 weeks. Results: The detailed structure of the TMJ was evident from MR microimaging. The histopathological examination showed some changes in the cartilage, but no changes in the bone structure of these mice. Conclusion: We successfully performed multiple 7T MR imaging in living mice. Even if the TMJ showed no obvious changes on MR images, minute changes may be present in the cartilage.

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MicroRNA-204 regulates osteogenic induction in dental follicle cells

Journal of Dental Sciences

Relationship Between Intracapsular Fracture Patterns and Arthroscopic Findings

Journal of Oral and Maxillofacial Surgery

Comparing antibiotic adjuncts in periodontitis

Australian Dental Journal

The financial burden of acute odontogenic infections: The South Australian experience

Australian Dental Journal

Mandibular Advancement Splints for Obstructive Sleep Apnoea – A Cautionary Tale

Australian Dental Journal

Synovial fluid glycosaminoglycans of the osteoarthrotic temporomandibular joint in sheep

International Journal of Oral and Maxillofacial Surgery

are deposited in the fibrous connective tissue matrix and may be partially phagocytized. As cellu... more are deposited in the fibrous connective tissue matrix and may be partially phagocytized. As cellular degradation of the silastic material is impossible, the inflammatory process will most likely continue. After exposure of the dacron fibres, the foreign body reaction wil further progress leading to painful restriction of joint function. 7. Effects of NK433 (lanperisone hydrochloride) in the Rat Model of Masseter Muscle Ischemia

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The variable position of the inferior alveolar nerve (IAN) in the mandibular ramus: a computed tomography (CT) study

Surgical and radiologic anatomy : SRA, Jan 20, 2018

This study was designed to quantify the important anatomical landmarks and the path of the inferi... more This study was designed to quantify the important anatomical landmarks and the path of the inferior alveolar nerve (IAN) within the human mandibular body and ramus, in particular with reference to the bilateral sagittal split osteotomy (BSSO). Four hundred and eleven CT scans were studied, 299 of these were involved in determining the position of lingula; and 230 were involved in determining the course of IAN in the mandibular molar region, namely from the mesial of the mandibular first molar to the distal of the mandibular second molar; 118 were involved with both measurements. On average, the lingula was located 17.0 ± 2.2 mm from the external oblique ridge; 11.6 ± 2.0 mm from the internal oblique ridge; 17.2 ± 2.7 mm from the sigmoid notch; and 15.6 ± 1.9 mm from the posterior border of the mandible. The course of the IAN in the mandibular molar region was found to descend vertically from the distal of the mandibular second molar (7) to reach its lowest point between the first an...

Melanoma Metastatic to the Mandible: Symptoms Precede Imaging Findings

Journal of Maxillofacial and Oral Surgery

Malignant melanoma is an aggressive and unpredictable cancer with the propensity for widespread m... more Malignant melanoma is an aggressive and unpredictable cancer with the propensity for widespread metastasis. Whilst metastatic spread to the axial skeleton is relatively common, metastasis to the jaws is rarely reported and the optimal approach to investigation and management is yet to be defined. A 58-year-old woman presented with dental pain, swelling and mental neuropathy on a background of an excised cutaneous melanoma. Early radiological investigations showed non-specific osteolysis despite strong clinical findings. It was not until later that magnetic resonance imaging showed changes consistent with metastatic disease. Dental extraction and biopsy confirmed the diagnosis of metastatic melanoma to the mandible. Metastatic melanoma to the mandible is a rare phenomenon which may arise many years following treatment of the cutaneous primary. This case demonstrates the difficulties in early diagnosis as symptoms preceded radiographic findings using high-resolution modalities. Earlier use of magnetic resonance imaging with or without the use of bone scintigraphy may provide the sensitivity required for early identification of metastatic disease in the mandible.

Tranexamic acid mouthwash — A prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions

International Journal of Oral and Maxillofacial Surgery

Tranexamic acid mouthwash-A prospective randomized study of a 2-day regimen vs 5-day regimen to p... more

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Endoscopically Assisted Intraoral Removal of an Ectopic Third Molar in the Mandibular Subcondylar Region

The Journal of craniofacial surgery, Jan 16, 2017

The ectopic placement of mandibular third molars in the subcondylar region is an uncommon phenome... more The ectopic placement of mandibular third molars in the subcondylar region is an uncommon phenomenon. Most patients are asymptomatic but can present with acute infection or associated pathology necessitating surgical intervention. Surgical approaches have been described utilizing both extraoral and intraoral approaches to the region.This paper presents a clinical report of a patient presenting with acute fascial space infection arising from an ectopic third molar in the mandibular subcondylar region, managed with surgical removal via an endoscopically assisted intraoral approach.

Medicinal Mishap: Bisphosphonates and osteonecrosis of the jaws

Australian Prescriber, 2007

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An animal model for TMJ arthroscopy

J Oral Maxillofac Surg, 1989

Bisphosphonates and orthodontics

Australian Orthodontic Journal, May 1, 2008

Human palatal development, in vitro

Plast Reconstr Surg, 1977

The effect of an intra‐articular bone fragment in the genesis of temporomandibular joint ankylosis

International Journal of Oral and Maxillofacial Surgery, Aug 1, 2000

The aim of this study was to examine the effect of an intra-articular bone fragment on the genesi... more The aim of this study was to examine the effect of an intra-articular bone fragment on the genesis of temporomandibular joint (TMJ) ankylosis. Twenty-two adult sheep had a unilateral operation of removal of the temporal and condylar articular surfaces, plus discectomy with or without insertion of an intra-articular bone fragment. Functionally, radiologically, macroscopically and histologically, in the group with the intra-articular bone fragment, the joints showed more advanced ankylosis both at one and three months after the operation, as compared to the group with no intra-articular bone. This study Key words: ankylosis; damage; bone shows that the bone fragment increases the extent of ankylosis in the sheep fragment; temporomandibular joint. model. The clinical significance of the various experimental findings of this study and others in the same series is presented.

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$Research paper thumbnail of A comparative study of the etiology of adult mandibular fractures in the Sultanate of Oman and South Australia$

A comparative study of the etiology of adult mandibular fractures in the Sultanate of Oman and South Australia

Saudi Medical Journal, 2009

Postoperative Bleeding Following Dental Extractions in Patients Anticoagulated With Warfarin

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Jan 22, 2016

The practicing dentist must frequently advise on the risks involved with dental extractions in th... more The practicing dentist must frequently advise on the risks involved with dental extractions in the patient taking an anticoagulant. This study assessed the risk of bleeding in a large heterogeneous cohort of patients on warfarin treated by practitioners in training (dental students and junior staff in a teaching hospital). This was a retrospective case-and-control study of 439 patients on warfarin (1,022 extractions) and 439 matched controls (1,049 extractions). Patients with an international normalized ratio (INR) lower than 2.2 had no specific measures, those with an INR 2.2 to 4 received suturing and tranexamic acid mouthwash, and those with an INR higher than 4 did not undergo extraction. Bayesian methods were used to estimate posterior probabilities of bleeding. Of cases, 63% were men, 25% were older than 80 years, 40% had an INR lower than 2.2, and 9% had an INR higher than 3. Nine cases bled 0 to 10 days postoperatively, with 1 requiring admission and transfusion. Significant...

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Medicinal mishaps: Mismanagement of dental infection

Australian Prescriber, 2011

VoLUMe 34 | NUMBeR 2 | APRIL 2011 www.australianprescriber.com patients in their clinic populatio... more VoLUMe 34 | NUMBeR 2 | APRIL 2011 www.australianprescriber.com patients in their clinic population. In contrast, mainstream general practice may experience problems in identifying eligible Aboriginal and Torres Strait Islander people. General practitioners and practice staff should ask all patients whether they identify as being of Aboriginal and Torres Strait Islander origin by asking the National Standard Identification question 'Are you of Aboriginal or Torres Strait Islander origin?'. 14,15 once indigenous people are correctly identified and registered with Medicare Australia they are then eligible to access the co-payment assistance. Pharmacists will be reimbursed for the co-payment the patient no longer pays. General practices will be funded through the Practice Incentives Program Indigenous Health Incentive. 12

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Osteonecrosis of the jaw

Australian Prescriber, 2013

Repeated Live Imaging in the Temporomandibular Joint of an Anterior Crossbite Mouse Model Using a 7T Magnetic Resonance Device

In Vivo

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MicroRNA-204 regulates osteogenic induction in dental follicle cells

Journal of Dental Sciences

Relationship Between Intracapsular Fracture Patterns and Arthroscopic Findings

Journal of Oral and Maxillofacial Surgery

Comparing antibiotic adjuncts in periodontitis

Australian Dental Journal