Papers by Akintayo Ogundajo
Records of Natural Products, 2009
The steam distilled volatile oil obtained from dried Lippia multiflora Moldenke was examined by g... more The steam distilled volatile oil obtained from dried Lippia multiflora Moldenke was examined by gas chromatography-mass spectrometry (GC-MS). The major components were 1,8-cineole (60.5%), sabinene (16.9%), α-terpineol (14.1%) and α-pinene (4.4%). The oil displayed no antibacterial activity against either gram positive Bacillus cereus or Staphylococcus aureus or gram negative Escherichia coli, (MIC = 1250 µg/mL). A cluster analysis was performed for comparison and characterization of L. multiflora essential oil from Nigeria with other oils reported in the literature from different locations across central Africa, and reveals much chemical variation in this species with at least 13 different chemotypes.
Journal of Essential Oil and Plant Composition
Phytochemical analysis of T. monadelpha bark revealed the presence of an array of plant constitue... more Phytochemical analysis of T. monadelpha bark revealed the presence of an array of plant constituents, such as saponins, tannins, alkaloids, cardiac glycosides,
Journal of essential oil & plant composition, 2024
Vitex agnus-castus L. (Lamiaceae) is a perennial shrub tree commonly grown in tropical and subtro... more Vitex agnus-castus L. (Lamiaceae) is a perennial shrub tree commonly grown in tropical and subtropical regions. V. agnus-castus is used traditionally for the treatment of menstrual disorders, premenstrual dysphoric disorder, and menopausal problems. The chemical compositions of the essential oil, hydrodistilled from three different parts of the plants, were analyzed by gas chromatography and mass spectrometry as well as chiral gas chromatography. Also, hierarchical cluster analysis was performed on the essential oil compositions samples from northern Nigeria as well as samples from other geographical locations. The essential oil samples were dominated by 1,8-cineole (31.6 -20.6%), followed by terpinen-4-ol (8.9-2.6%), sabinene (9.4-5.8%), (E)-βfarnesene (8.1-5.5%), α-pinene (8.1-4.6%), α-terpinyl acetate (7.7-3.0%), α-terpineol (7.4-2.4%) and manoyl oxide (6.3-0.4%). The dextrorotatory enantiomers were the major stereoisomers for α-pinene (88.5-83.4%), α-phellandrene (95.2-88.9%), and β-phellandrene (86.7-81.4%), while the levorotary enantiomers were predominated by α-thujene (100%), sabinene (88.3-86.1%), limonene (60.4-58.6%), terpinen-4-ol (86.8-68.9%), and α-terpineol (90.6-82.9%). The cluster analysis revealed three major chemotypes: one dominated by 1,8-cineole/sabinene/(E)-βcaryophyllene and other two uncommon chemotypes but rich in α-pinene and 1,8cineole/sabinene/α-pinene respectively. The essential oils demonstrated antibacterial activities against seven microorganisms with minimum inhibitory concentrations (MIC) ranging from 312.5 to 1250 µg/mL; active against Staphylococcus aureus and Escherichia coli (312.5 µg/mL); moderately active against Streptococcus faecalis and Pseudomonas aeruginosa (625 µg/mL), weakly active against Bacillus subtilis,Proteus vulgaris and Salmonella typhi (1250 µg/mL). The antibacterial activity of V. agnus-castus essential oil can be attributed to the major components 1,8-cineole, αpinene, terpinen-4-ol, and α-terpineol. The study shows that the essential oils of V. agnus-castus possess potential bacterial activities for pharmaceutical usage.
Clinical and Experimental Pharmacology, Apr 4, 2017
Research Journal of Phytochemistry, 2011
Annals of Science and Technology
Moringa oleifera (Moringa) is a highly valued plant and various parts of this plant are employed ... more Moringa oleifera (Moringa) is a highly valued plant and various parts of this plant are employed for the therapeutic purposes in the indigenous system of medicine. This study was undertaken to compare the phytochemical, mineral, proximate and antioxidant constituents of the aqueous, ethanol and coconut oil extracts of M. oleifera leaf, seed and pod. Pulverized samples of the leaves, seeds and pods were extracted separately with distilled water, ethanol and coconut oil. The proximate analysis was carried out using standard AOAC protocols while the mineral contents were analyzed through atomic absorption spectrometry. The phytochemicals and antioxidants constituents of the extracts were analysed using standard protocols. The phytochemical screening of M. oleifera revealed the presence of alkaloids in each extract of the leaf, seed and pod in varying concentrations with the absence of phlobatannins in all sampled parts. Proximate composition of M. oleifera revealed higher percentage of...
Transactions of the Royal Society of South Africa
Journal of Essential Oil-Bearing Plants (JEOBP), Jan 2, 2016
Abstract The essential oil obtained from the hydrodistillation of the leaf of Clerodendrum polyce... more Abstract The essential oil obtained from the hydrodistillation of the leaf of Clerodendrum polycephalum Baker collected from Badagary, Nigeria was analyzed by gas chromatography-flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Forty compounds, representing 97.2 % of the total oil contents were identified in the essential oil. Sesquiterpene hydrocarbons (74.1 %) and oxygenated sesquiterpene (11.9 %) are main classes of compounds present in the oil. Monoterpene compounds totalling 10.6 % of the oil contents were also identified in the oil. The main constituents of the oil were β-caryophyllene (28.9 %), α-muurolene (9.0 %) and β-pinene (8.6 %). There were significant amounts of 1,5,9,9-tetramethyl-Z,Z,Z,Z-cycloundecatriene (7.4 %), 9-epi-(E)-caryophyllene (5.6 %) and (E)-nerolidol (5.5 %). The present study represents the first report on the chemical constituents of the volatile oil of Clerodendrum polycephalum.
Journal of Essential Oil Bearing Plants, 2020
Leaves of Afraegle paniculata were collected from southwestern Nigeria and hydrodistilled to give... more Leaves of Afraegle paniculata were collected from southwestern Nigeria and hydrodistilled to give an essential oil in 0.56 % yield. The essential oil was analyzed by gas chromatography-mass spectrometry and was dominated by sesquiterpenoids. The major components in the leaf essential oil were α-copaene (20.1 %), (E)-caryophyllene (15.8 %), δ-cadinene (17.7 %) and caryophyllene oxide (18.4 %). The essential oil was screened for antimicrobial effects but showed only marginal activity (MIC ≥ 156 μg/mL).
Asian Journal of Applied Sciences, 2015
This paper report the chemical constituents identified in the essential oil obtained from the lea... more This paper report the chemical constituents identified in the essential oil obtained from the leaves of Physalis angulata L., grown in Nigeria. The essential oil was obtained by hydrodistillation in an all glass Clevenger-type oil apparatus in the Laboratory, Department of Chemistry, Lagos State University, Ojo, Nigeria. The oil was analysed for its constituents by means of gas chromatography-flame ionization detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC-MS). The main chemical classes identified in the oil were diterpenes (31.7%), fatty acids (22.8%), oxygenated sesquiterpenes (22.3%) and aromatic compounds (13.6%). Monoterpene compounds occurred in trace amounts. The major constituents of the essential oil were phytol (31.7%) and hexahydrofarnesyl acetone or 6,10,14-trimethy-2-pentadecanone (18.8%), with significant amounts of n-nonadecane (8.6%) and n-hexadecanoic acid (5.0%).
The aim of this study was to invest igate the inhibito ry effect of B. sapida leaf extract on the... more The aim of this study was to invest igate the inhibito ry effect of B. sapida leaf extract on the key enzymes linked to diabetes ( α -amylase and α -glucosidase). The inhibitory effect of the leaf extracts on α -amylase and α -glucosidase activities as well as de termination of mode of inhibition was performed. The results revealed that the aqueous extract of B. sapida was the most potent inhibitor of α -amylase (with IC 50 5.80 mg/ml) while ethanolic extract inhibited α -glucosidase (with IC 50 4.57 mg/ml) most effectively. The curve of Lineweaver-Burke plot revealed that aqueous extract of B. sapida exhibited mixed non-competitive inhibition of α -amylase while ethanolic extract displayed an uncompetitive inhibition of α -glucosidase activities. It can be inferred from this study that the α -amylase and α -glucosidase inhibitory potential of B. sapida may be due to the presence of phytochemicals such as saponins and flavonoids. However, further study is required to isolate the enz...
E-Journal of Chemistry, 2010
Water samples, sediments, tilapia and cat fishes from each of Epe and Badagry lagoons in Lagos St... more Water samples, sediments, tilapia and cat fishes from each of Epe and Badagry lagoons in Lagos State, Nigeria were analyzed quantitatively for the presence of zinc, nickel and iron using Perking Elmer atomic absorption spectrophotometer. The sediment contains higher concentration of Fe with a value of 13.30 µg/g against 8.400 µg/g in fishes and 7.30 mg/L in water. Studies on the different parts of the fish revealed higher concentrations of 4.00 µg/g Ni on the head of tilapia fish followed by 2.40 µg/g Ni in the intestine of cat fish. The highest concentration of 1.95 µg/g Zn was detected on the head of the cat fish while the lowest concentration with a value of 0.16 µg/g was recorded in tilapia head. The concentration of Zn in the water is within the limits permitted by the Lagos State Environmental Protection Agency (LASEPA) of 1.0 mg/L Zn set for water. None of the trace metals investigated was above the maximum permissible level set by world health organization ( WHO).
Journal of Essential Oil Research, 2013
ABSTRACT
South African Journal of Botany, 2020
Hermannia geniculata roots are commonly used in the treatment of several diseases in Sotho tradit... more Hermannia geniculata roots are commonly used in the treatment of several diseases in Sotho traditional medicine. A new xanthene derivative, Hermannol (9-(7-methyloctyl)-9H- xanthene-2,3-diol) was isolated from the roots of Hermannia geniculata. The structure was elucidated by analyses of their 1Dimensional and 2Dimensional Nuclear Magnetic Resonance, Mass Spectrometry and Infrared Spectroscopic data. In-vitro antioxidant, antidiabetic and antinflammatory evaluation of the compound using standard procedure showed that the compound has good radical scavenging capabilities against DPPH radicals with an IC50 value of 0.29 ± 0.011 mg/mL which is similar to the IC50 value 0.24 ± 0.020 mg/mL of the standard. Also, the metal-chelating properties of the compound is similar to the reference compound with their respective IC50 values (0.28 ± 0.074 and 0.029 ± 0.091) mg/mL. Inhibitory properties of hermannol against carbohydrate catabolizing enzymes, showed a lower inhibition of α-amylase with ...
Cymbopogon citratus (DC. ex Nees) Stapf. (Poaceae) represents one of the most sourced plants in t... more Cymbopogon citratus (DC. ex Nees) Stapf. (Poaceae) represents one of the most sourced plants in the world because of its distribution and application. Different extracts of C. citratus have shown diverse pharmacological properties. The antimicrobial, antiinflammatory, antidiabetic, and anticancer amongst others are well reported. C. citratus can be used alone or function in synergy with other plant constituents. As a consequence of several ethno-pharmacological applications of C. citratus, many studies have been carried out aimed at the characterization of volatile and nonvolatile chemical compositions. These studies have revealed that the chemical composition of the essential oil and extracts of C. citratus varies according to the geographical origin, age, and nature of the plant. The isolated compounds of C. citratus are of diverse chemical classes including tannins, sterols, terpenoids, phenols, ketone, flavonoids, and sugars.
The chemical composition of the leaf essential oil of Croton zambesicus Mull.-Arg., collected fro... more The chemical composition of the leaf essential oil of Croton zambesicus Mull.-Arg., collected from Agbara-Lagos, Nigeria, was analysed by means of Gas chromatography
Essential oil obtained by hydrodistillation from the air-dried leaves of Hyssopus officinalis L. ... more Essential oil obtained by hydrodistillation from the air-dried leaves of Hyssopus officinalis L. (Lamiaceae) collected in Ajangbadi area, West of Lagos, Nigeria, was analyzed comprehensively for its constituents by means of gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The monoterpene hydrocarbons, a-pinene (70.9%) and â-pinene (10.9%) are the dominant constituents of the oil of H. officinalis. A cluster analysis was performed for comparison and characterization of H. officinalis essential oil from Nigeria with other oils reported in the literature from different locations across the world, and reveals chemical variation in this species with at least 8 different chemotypes. The compositional pattern of Nigerian oil sample was being reported for the first time and represents another chemotype of the oil of H. officinalis.
Objectives To investigate antimicrobial and cytotoxic potentials as well as chemical constituents... more Objectives To investigate antimicrobial and cytotoxic potentials as well as chemical constituents of extracts from Macaranga barteri (M. barteri). Methods Antimicrobial activity was carried out using micro-dilution, cell culture and GC–MS methods were employed to determine the cytotoxicity and chemical constituents of the extracts respectively. Results Marked activity was observed in methanol (ME) fraction [MIC50: (0.097 7–6.250 0) mg/mL] compared to hexane and ethyl acetate fractions. Aeromonas hydrophila (environmental strain) and Shigella sonnei (ATCC 29930) were the most susceptible pathogens to ME and ciprofloxacin (Cl) at MIC50 value of 0.097 7 and Conclusions Methanol fraction of M. barteri is a potent and safe antimicrobial and antifungal alternative which can be useful in the search for new antimicrobial drugs. The study also confirmed the orthodox usage of M. barteri in combating infectious diseases.
The leaf essential oil of Annona muricata, collected from Badagary, Nigeria, was obtained by hydr... more The leaf essential oil of Annona muricata, collected from Badagary, Nigeria, was obtained by hydrodistillation and analyzed by gas chromatography – mass spectrometry. The leaf oil was dominated by (E)-caryophyllene (38.9%) and eugenol (30.2%), with lesser amounts of α-humulene (4.3%), δ-cadinene (6.0%), and caryophyllene oxide (5.0%). A. muricata leaf oil showed notable invitro cytotoxic activity on MCF-7 cells (99.2% kill at 100 μg/mL), which can be attributed to the major components.
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Papers by Akintayo Ogundajo