Papers by Adriana Bastidas
Desde los mismos origenes del diseno como profesion y paralelo a su desarrollo al servicio de la ... more Desde los mismos origenes del diseno como profesion y paralelo a su desarrollo al servicio de la industria y el mercado, se han expresado visiones en torno al diseno como modo de accion centrado la resolucion de problemas y necesidades de las personas y la sociedad. Este articulo busca aportar a la definicion de las diferentes variantes y perspectivas de accion del diseno social, la evolucion y transformacion historica de este enfoque y las formas de pensamiento y accion que lo fundamentan teorica y metodologicamente. Se realiza una revision historica de los conceptos asociados a la disciplina y se resenan autores y publicaciones que han abierto el debate frente al papel del diseno en el progreso de la sociedad, desde los aspectos economicos, tecnologicos, culturales y sociales.
El proyecto se propone hacer una valoracion de los aspectos esteticos, graficos y tipograficos de... more El proyecto se propone hacer una valoracion de los aspectos esteticos, graficos y tipograficos de la imprenta de Pasto del Siglo XIX y principios del siglo XX al tenor de tres personajes que caracterizan el periodo: Pastor Enriquez, quien en 1837 construye la primera imprenta de la ciudad conocida como: Imprenta de Palo; Alejandro Santander (Pasto, 1849 - 1905), quien edita funda varios periodicos y escribe textos como Biografia de Aldana y Corografia de Pasto (1896), en donde hace un recuento de la imprenta en Pasto en el siglo XIX; y Leopoldo Lopez Alvarez (Pasto, 1891, 1940), reconocido humanista, escritor y traductor, que en 1938 funda la Tipografia Atenas, donde utiliza la imprenta para editar obras bilingues griego-castellano. Los tres personajes senalados representan tres momentos relevantes en la historia de la imprenta en Pasto: Un primer periodo de surgimiento de la imprenta, retrasado con respecto al resto del pais, pero de gran influencia cultural y politica; una segunda...
Contraception, 2021
OBJECTIVE To evaluate the effects of estetrol 15 mg/drospirenone 3 mg on ovarian function. STUDY ... more OBJECTIVE To evaluate the effects of estetrol 15 mg/drospirenone 3 mg on ovarian function. STUDY DESIGN Single-center, randomized, open-label, parallel study in healthy young women with proven ovulatory cycles. Participants received either estetrol 15 mg/drospirenone 3 mg (E4/DRSP) (n=41) or ethinylestradiol 20 µg/drospirenone 3 mg (EE/DRSP) (n=41) in a 24/4-day regimen for 3 consecutive cycles. Follicular size and endometrial thickness were measured by transvaginal ultrasound every three days in cycles 1 and 3. Blood was sampled for hormone analysis. Ovarian function expressed as Hoogland score was based on follicular size, serum estradiol (E2) and progesterone (P) concentrations. Ovulation was defined as a ruptured follicle-like structure >13 mm with serum E2 concentrations >100 pmol/L and serum P concentrations >5 nmol/L. We assessed return of ovulation after treatment cessation, and safety throughout the study. RESULTS None of the participants ovulated with E4/DRSP use, while one participant ovulated once and one participant ovulated twice during EE/DRSP treatment. Most participants had a Hoogland score of 1 (no ovarian activity) in cycle 1 (85.0% and 82.9% of participants on E4/DRSP and EE/DRSP, respectively) and in cycle 3 (65.8% and 83.8%, respectively). E4/DRSP suppressed follicle-stimulating hormone and luteinizing hormone to a lesser extent than E4/DRSP, whereas both treatments comparably suppressed E2 and P and endometrial thickness. Return of ovulation occurred, on average, 15.5 days after E4/DRSP treatment discontinuation. E4/DRSP was safe and well-tolerated. CONCLUSIONS E4 15 mg/ DRSP 3 mg results in adequate ovulation inhibition and ovarian function suppression, comparable to a marketed combined oral contraceptive containing EE/DRSP. IMPLICATIONS STATEMENT Treatment with E4 15 mg/DRSP 3 mg showed complete ovulation inhibition, despite less suppression of follicle-stimulating hormone and luteinizing hormone compared to EE/DRSP. If it becomes commercially available, E4/DRSP, containing a naturally occurring estrogen, should be as effective as EE/DRSP.
Human vaccines & immunotherapeutics, Jun 20, 2018
In adults aged ≥60 years, two doses of the herpes zoster subunit vaccine (HZ/su; 50µg varicella-z... more In adults aged ≥60 years, two doses of the herpes zoster subunit vaccine (HZ/su; 50µg varicella-zoster virus glycoprotein E [gE] and AS01Adjuvant System) elicited humoral and cell-mediated immune responses persisting for at least six years. We assessed immunogenicity nine years post-initial vaccination. This open extension study (NCT02735915) followed 70 participants who received two HZ/su doses in the initial trial (NCT00434577). Blood samples to assess the cellular (intracellular cytokine staining) and humoral (ELISA) immunity were taken at year nine post-initial vaccination. Participants' mean age at dose 1 was 72.3 years. The fold increases over pre-vaccination in the mean frequency of gE-specific CD4+ T-cells expressing ≥2 activation markers plateaued from year four post-dose 1 until year nine. Anti-gE antibody geometric mean concentrations plateaued and remained above pre-vaccination levels from year four onwards. Immunogenicity at year nine was similar across age strata (...
Transplantation Proceedings, 2016
BACKGROUND Failure of compliance with medical regimen is one of the major risk factors associated... more BACKGROUND Failure of compliance with medical regimen is one of the major risk factors associated with morbidity and mortality in heart transplant (HT) recipients. Nevertheless, to date, there is no specific, gold-standard, comprehensive set of tools for assessing compliance in these patients. OBJECTIVE The objective of the present study was to develop a specific instrument for the assessment of noncompliance with medical recommendations in HT recipients. METHODS This prospective observational study used a nonprobability sampling method, which was performed from January 2006 to December 2012. All of the patients met clinical criteria for being included on the waiting list for a HT. We designed a scale for measuring the compliance degree at 12 months after heart transplantation. This scale included the most important aspects of the medical regimen, using nine discrete quantitative variables. The total score was described as the patient's Noncompliance Factor (NCF). The results were analysed by mean, ranks, and percentages. RESULTS The sample was constituted of 61 participants who underwent surgical HT intervention and completed the 12-month follow-up assessment. The overall incidence of noncompliance was around 30% and only 43.1% of the recipients had an acceptable degree of compliance. CONCLUSIONS The overall incidence of noncompliance in HT recipients is high and this can generate worse clinical outcomes. Evaluation by specific screening instruments like the one proposed in the present study can be useful for a systematic detection of this phenomenon.
Journal of Minimally Invasive Gynecology, 2009
These experiments were designed to examine the effect of manipulation during surgery as a cofacto... more These experiments were designed to examine the effect of manipulation during surgery as a cofactor in adhesion formation at trauma sites. Design: Randomized, controlled trial. Canadian Task Force Classification-class 1. Setting: University laboratory research center. Subjects: A standardized laparoscopic mouse model (Balb\c mice 9-10 weeks old) for adhesion formation after opposing bipolar lesions and 60 minutes of carbon-dioxide pneumoperitoneum. In this model adhesions are known to decrease after the addition of 3% of oxygen, dexamethasone, or both. In addition, adhesions decrease with experience (i.e., with a decreasing amount of manipulation during the learning curve). Interventions: A factorial design was used to evaluate the effects of dexamethasone and of adding 3% of oxygen on manipulation-enhanced adhesion formation during a learning curve. Blocks of 4 animals were thus randomized as controls (carbondioxide pneumoperitoneum only) or received an additional 3% of oxygen, dexamethasone, or both. In a second experiment, the effects of manipulation on adhesion formation were quantified. In a third experiment we evaluated whether dexamethasone had a specific effect on manipulation-enhanced adhesion formation. Measurements and Main Results: Qualitative and quantitative adhesion scoring 7 days after the intervention. The first experiment confirmed that adhesion formation decreased during the learning curve (p ,.0001) and after the addition of dexamethasone whether assessed as the total adhesion score (p ,.0001 and p 5.0009, respectively) or a quantitative score (p ,.0001 and p ,.0001, respectively). The second experiment showed that adhesion formation increased by standardized touching and grasping of omentum and bowels (proportion score p 5.0059 and p 5.0003, respectively) and this effect increased with duration of touching (p 5.0301). In the third experiment, dexamethasone was confirmed to decreased adhesion formation (p 5.0001) but this effect was not specific for manipulation-enhanced adhesion formation. Conclusion: Manipulation of intraperitoneal organs in the upper abdomen enhances adhesion formation at trauma sites, confirming that the peritoneal cavity is a cofactor in adhesion formation. Dexamethasone decreases adhesion formation but the effect is not specific for manipulation-enhanced adhesion formation.
International Journal of Cancer, 2005
Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors in which beta-ca... more Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors in which beta-catenin/TCF3 mediated Wnt signaling is activated. More than 80% of desmoid tumors contain activating mutations in beta-catenin. It has been shown that the Wnt signaling pathway interacts with Wilms' tumor gene 1 (WT1) in normal kidney development and plays a role in the genesis of some Wilms' tumors. About 15% of Wilms' tumors contain WT1 mutations and of these, about 50% contain beta-catenin mutations. This overlap in mutation pattern of WT1 and beta-catenin in Wilms' tumor suggests that these 2 genes may collaborate in the genesis of a subset of Wilms' tumors. To investigate whether this hypothesis could be extended to other Wnt-dependent tumor types, we searched for WT1 mutations and studied WT1 expression in beta-catenin mutant desmoid tumors. We investigated the expression of WT1 mRNA and protein in desmoid tumors. Medium to high abundant levels of WT1 mRNA were detected by TaqMan quantitative PCR in all tested desmoid cells, whereas adjacent normal fibroblasts showed less expression of WT1. Western blot analysis and immunohistochemistry confirmed this overexpression at the protein level. A mutational screen of the WT1 zinc-finger region by sequence analysis did not identify any mutations. Finally, we investigated a possible role of beta-catenin on WT1 regulation and vice versa. Overexpression of different beta-catenin mutants in the HEK293T cell line did not modulate WT1 promoter activity and WT1 did not affect beta-catenin /TCF transcriptional activity in this cell line. These results show that the wild-type WT1 gene is strongly overexpressed in beta-catenin mutant desmoid tumors and may play a role in tumorigenesis of desmoid tumors, similar to what has been suggested in some epithelial malignancies.
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Papers by Adriana Bastidas