Papers by Abdullah S Mahmutoğlu
Egy stroke-ot utánzó ritka állapot: diabetikus uraemiás encephalopathia
Ideggyógyászati szemle, 2018
Uremic encephalopathy (UE) is a metabolic disorder associated with acute or chronic renal failure... more Uremic encephalopathy (UE) is a metabolic disorder associated with acute or chronic renal failure. It is characterized by the acute or subacute onset of reversible neurological symptoms and specific imaging findings. It is uncommon for uremic encephalopathy to be associated with acute bilateral lesions of the basal ganglia in diabetic uremic patients, and this can be seen most often in Asian patients. Here, we report a patient with diabetic uremic encephalopathy and bilateral basal ganglia lesions who developed acute onset dysarthria. The clinical and magnetic resonance brain imaging findings resolved after hemodialysis treatment.
İstanbul medical journal, Feb 8, 2022
Introduction: Vertebral artery hypoplasia (VAH) is a common variation; however, its role in poste... more Introduction: Vertebral artery hypoplasia (VAH) is a common variation; however, its role in posterior circulation stroke (PCS) has not been fully elucidated. Thus, this study aimed to evaluate the relationship between VAH and PCS with clinical and laboratory parameters. Methods: Between January 2016 and June 2020, 178 patients with PCS who were hospitalized in the neurology department were included. The demographic characteristics, vascular risk factors, stroke patterns, and the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores of patients were recorded. Patients with VA diameter of ≤2.0 mm or 1:1.7 ratio difference in computed tomography angiography were included in the VAH group. Results: This study included 115 females and 63 males. The mean age of patients was 65.8±12 years. VAH was determined in 74 (41.6%) patients, whereas none in 104 patients (58.4%). No significant difference was determined in terms of gender and age in patients with and without VAH (p=0.310 and p=0.676, respectively). No statistically significant difference was found between the two groups in terms of vascular risk factors (p>0.05). Lacunar stroke pattern was less frequently found in patients with VAH (p=0.045). Other stroke patterns were similar in both groups (p>0.05). The NIHSS (p=0.01) and mRS (p=0.018) scores were significantly higher in patients with VAH than those without. Conclusion: The presence of VAH in PCS may adversely affect the clinical severity.
İstanbul medical journal, May 31, 2023
Introduction: Incomplete partition (IP) type and accompanying cochlear nerve (CN) anomalies affec... more Introduction: Incomplete partition (IP) type and accompanying cochlear nerve (CN) anomalies affect the patient's management. We revealed the cochlear nerve area (CNA), cochlear nerve canal width (CNCW), and inner auditory canal width (IACW) of IP types. Methods: We retrospectively scanned patients with IP. There were 88 IP ears (26 IP type 1, 54 IP type 2, 8 IP type 3) and 54 controls. The CNCW and IACW were measured in axial temporal computed tomography sections. The CNA and facial nerve area (FNA) were measured in the distal IAC on the sagittal-oblique plane of 3D constructive interference steady-state T2-weighted magnetic resonance images. Results: CNA and CNA/FNA values for each IP type differed significantly compared with the control group. However, the CNCW and IACW values did not differ significantly. The CNA was the least in IP 1 cases. Five CN aplasia were detected, and all were associated with IP type 1 anomaly (3.5% of all, 5.6% of IP types, and 19.2% of IP type 1 cases). CN hypoplasia was observed in 10 IP type 1 (38.5% of IP 1), 6 IP type 2 (6.8% of IP type 2), and 1 IP type 3 (12.5% of IP type 3) ears. None of the CN hypoplasia had a CNC hypoplasia. Conclusion: CN aplasia and hypoplasia most frequently accompanied with IP type 1 in our study. Therefore, they need an extra interest in CN evaluation. CNCW and IACW are not very useful in predicting CN dysplasia in IP cases.
Olfactory bulb volume in cochlear implant candidates as compared to age-matched control subjects: A potential marker of cognitive function for auditory information processing
International Journal of Pediatric Otorhinolaryngology, May 1, 2023
Türk otolarengoloji arşivi, Aug 31, 2022
Objective: To reveal the correlation between implantation age, the internal acoustic canal (IAC) ... more Objective: To reveal the correlation between implantation age, the internal acoustic canal (IAC) width, bony cochlear nerve canal (BCNC) width, and auditory performance in primary school children with bilateral cochlear implantation (CI). Methods: Preoperative IAC and BCNC widths of 57 pre-lingually deaf children aged 7-11 years who had previously undergone bilateral CI in our institution were reviewed and cutoff values were calculated. Twenty-four patients who had additional problems and could not attend school and those who refused to participate in the study were excluded. The remaining 33 were invited to the hospital, and their speech perception tests, and language development scores were analyzed (16 of 33 patients had been operated on before the age of 24 months). Results: The cutoff values calculated from the 114 ears of 57 patients were 3.86 mm for IAC width and 1.56 mm for BCNC width. The auditory performances of the 33 patients after CI were not significantly different in the narrow and normal width groups. However, speech perception test results, and language development scores of patients implanted before the age of 24 months were significantly higher. Conclusion: There are some studies showing that children with bilateral sensorineural hearing loss have narrower IAC and BCNC widths. However, we concluded that the widths of the IAC and the bone cochlear nerve canal did not affect auditory performance. We found that implantation age is the single most important determinant of speech-language development after CI.
COVID-19'da Radyolojik Görüntüleme
Türkiye Klinikleri COVID - 19, 2020
İstanbul medical journal, Nov 22, 2022
Introduction: In this retrospective study, our purpose was to research the usefulness of apparent... more Introduction: In this retrospective study, our purpose was to research the usefulness of apparent diffusion coefficient (ADC) histogram graphics for the preoperative diagnosis of parotis tumors with heterogeneous signal distribution. Methods: Our patient group included 50 patients with total 52 parotid gland masses who had diffusion-weighted imaging and ADC maps before operation or biopsy, which were archived in our instutional Picture Archiving and Communications System. Freehand region of interest-based ADC histogram parameters were minimum (ADC min), maximum (ADC max), mean (ADC mean) and standard deviation (SD) (ADC SD). Statistical analyses were performed with the SPSS 17.0 using Kruskal-Wallis, Mann-Whitney U tests, Spearmans' rho correlation and receiver operating characteristic (ROC) curve. Results: ADC min, ADC max and especially the ADC mean were statistically significant in differentiating pleomorphic adenoma (PA) from Warthin tumor (WT). ADC min and ADC max values were also significant in differentiating PA from malignant tumor (MT) (p<0.05). In PA-WT differentiation ADC mean value with 1465.50 cutoff level, sensitivity was 94.1% and specificity was 88.6%. For PA-MT differentiation, ADC min value with 962.00 cutoff level, sensitivity was 82.4% and specificity was 94.3%. Whereas, ADC histogram values for WT-MT differentiation were statistically insignificant (p>0.05). Conclusion: Our results support the assumption that ADC histogram parameters can help discriminate PA from WT and PA from MTs preoperatively. However, they are unhelpful in the differential diagnosis of malignant masses from WT.
The assessment of cognitive functions in patients with isolated cerebellar infarctions: A follow-up study
Neuroscience Letters, Nov 1, 2021
The role of the cerebellum on cognitive functions have been well-defined; however, the informatio... more The role of the cerebellum on cognitive functions have been well-defined; however, the information related to the progress in time process is limited. In this study, we aimed to evaluate the cognitive function of patients with isolated cerebellar infarction in both the acute stage and the follow-up period. Twenty-three patients with isolated cerebellar infarction and 22 healthy control were examined through an extensive neuropsychological assessment battery. The patients were evaluated in the acute stage and at least six months after the stroke in the follow-up period. There were no significant differences between the patients and the controls regarding age (52.2 ± 7.0 and 54.9±6.6, p=0.184) and gender (Female/Male: 6/17 and 7/15, p=0.672). There was no statistically significant difference between patients with right cerebellar infarction and left cerebellar infarction in terms of cognitive functions. Verbal fluency, attention, and verbal and non-verbal episodic memory scores were significantly lower in patient group in the acute stage when compared to the control group. When the follow-up evaluation was compared to acute stage, it was revealed that patients had recovered in all areas; however, less improvement was seen in word reading time. Our results support that lesions of the cerebellum affect cognitive functions in the acute stage. However, the improvement was demonstrated in all cognitive functions in the follow-up period.
Comprehension of Cochlear Duct Length for Incomplete Partition Types
Journal of Computer Assisted Tomography
Ethmoid roof morphometric measurements of a pediatric population using computed tomography
Surgical and Radiologic Anatomy
Archives of Neuropsychiatry, 2018
Wernicke ensefalopatisi (WE), tiamin eksikliği sonucu oluşan, klasik olarak bilinç değişikliği, a... more Wernicke ensefalopatisi (WE), tiamin eksikliği sonucu oluşan, klasik olarak bilinç değişikliği, ataksi ve oftalmoparezi ile karakterize bir nörolojik hastalıktır. Sıklıkla kronik alkol kullanımı ile ilişkilidir; ancak, tiamin eksikliği yapan, gastrik cerrahi, hiperemezis, parenteral beslenme, malnutrisyon gibi birçok durum da bu tabloya neden olabilir. WE, erken tanı konulması ve hızlıca intravenöz tiamin tedavisine başlanması gereken, hayatı tehdit eden bir durumdur. Hastalarda karakteristik muayene bulguları her zaman görülmeyebilir; bu açıdan görüntüleme yöntemleri büyük önem taşır. Bu yazıda, tipik ve atipik görüntüleme bulguları olan üç WE olgusunu, benzer ve farklı yönlerini vurgulayarak sunmayı amaçladık.
Japanese Journal of Radiology, 2017
Conclusion Although relatively uncommon, appendiceal diverticulitis should be included in the dif... more Conclusion Although relatively uncommon, appendiceal diverticulitis should be included in the differential diagnosis of acute appendicitis. It differs from typical acute appendicitis by the presence of an inflamed diverticulum, seen on CT. These patients are also more likely to have peri-appendiceal extra-luminal loculated fluid, peri-appendiceal fat stranding, and a larger diameter of the appendix. The latter finding is likely due to the increased intraluminal pressure.
Paraganglioma of the larynx diagnosed with maneuvered three-phase contrast-enhanced computed tomography
PubMed, Jun 1, 2018
The standard diagnostic tool for laryngeal paraganglioma is generally accepted to be magnetic res... more The standard diagnostic tool for laryngeal paraganglioma is generally accepted to be magnetic resonance imaging. However, the role of other imaging modalities has not been evaluated extensively. We describe the case of a 38-year-old man who had a history of voice distortion for several years. A hypervascular submucosal lesion was detected on maneuvered three-phase contrast-enhanced computed tomography (CT). The CT showed intense contrast enhancement in the first arterial phase (inspiration), a peak level in the second phase (Valsalva), and washing out in the final phase (phonation). This pattern of contrast enhancement suggested the presence of a hypervascular lesion, such as a hemangioma, paraganglioma, or vascular malformation of the larynx. We conclude that maneuvered three-phase contrast-enhanced CT may be useful for the diagnosis of paraganglioma of the larynx.
Focal Hepatic Infections
Elsevier eBooks, 2015
Clinical Imaging, Mar 1, 2013
Assessment of tumor response to chemotherapy is essential in managing malignant pediatric bone tu... more Assessment of tumor response to chemotherapy is essential in managing malignant pediatric bone tumors prior to resection. Subjects and methods: Pre-chemotherapy and post-chemotherapy osteosarcoma and Ewing sarcoma cases (n = 18) were analyzed with apparent diffusion coefficient (ADC) values measured by two readers. Results: Treated tumors demonstrated significantly greater ADC values compared to untreated tumors (p b 0.001). Intraclass correlation coefficients ranged between 0.858 and 0.935. No significant tumor volume differences were observed. Regression analysis demonstrated average ADC as the best predictor of treatment. Conclusions: Our study suggests that ADC values may be useful for evaluating chemotherapeutic response of malignant pediatric bone tumors.
Journal of International Advanced Otology, Jan 21, 2019
INTRODUCTION A cholesteatoma is a benign but clinically destructive lesion histologically describ... more INTRODUCTION A cholesteatoma is a benign but clinically destructive lesion histologically described as a well-demarcated cystic mass formed from the keratinizing stratified squamous epithelium [1-3]. Surgical resection is the only treatment option for removing cholesteatomas from the middle ear [3-8]. The diagnosis of cholesteatoma is based on the clinical signs and symptoms, primarily discharge and conductive hearing loss due to the mechanical compression and/or erosion of adjacent structures by the lesion and hyperproliferative cells [9, 10]. The clinical diagnosis of cholesteatomas is supported by computed tomography (CT) scans showing bone erosion or destruction, which differentiates cholesteatoma from granulation tissue or fluid retention due to chronic otitis media. The typical CT findings of cholesteatomas are a soft-tissue mass in the middle ear cavity with varying levels of destruction [2, 3, 7, 11]. However, in clinical practice, CT may sometimes show a spontaneously evacuated, nonopacified spontaneously drained auto-evacuated secondary acquired cholesteatoma (SAC) associated with an extensive osseous wall destruction of the middle ear, which has been discussed in literature [12-16]. A drained, nonopacified SAC that is associated with marked destruction of the ossicles or bony structures, indicates a mural cholesteatoma, also known as automastoidectomy or nature's mastoidectomy. In contrast, the term auto-atticotomy or nature's atticotomy, which is less extensive and destructive than automastoidectomy, is used to describe a smaller defect where only the scutum and lower lateral attic wall are affected [1, 16] .
Marmara Medical Journal, May 31, 2020
Objective: To evaluate the role of magnetic resonance (MR) diffusion tensor imaging (DTI) in the ... more Objective: To evaluate the role of magnetic resonance (MR) diffusion tensor imaging (DTI) in the assessment of liver fibrosis and inflammation in chronic viral hepatitis by measuring apparent diffusion coefficient (ADC) and fractional anisotropy (Fa) values. Material and Methods: Twenty-seven patients (5 women and 22 men;mean age39.8±11.3) with hepatic fibrosis were included in our study. The relationship between ADC, Fa values and histological activity index (HAI) score were evaluated using Spearman's correlation coefficient. Patients were subgrouped as group A (fibrosis score 1) and group B (fibrosis score 3). The mean ADC and Fa values of groups A and B were compared using Student's t-test. To evaluate the use of ADC and Fa values in distinguishing group A from group B, ROC analysis was applied; sensitivities and specificities were calculated. Results: Fa values correlated with HAI scores significantly (r=0.397, p<0.05) The difference was significant between the mean ADC values (group A:1.46± 0.191x103mm2/s; group B:1.105± 0.141x10-3 mm2/s; p<0.001) and Fa values (group A: 0.473±0.091; group B: 0.643± 0.007; p<0.001) between the groups. For distinguishing group A from group B, ADC had a sensitivity of 81.8% and a specificity of 93.8%. The sensitivity and specificity of Fa were 90.9% and 100%, respectively. Conclusion: Diffusion tensor imaging may play a role in the evaluation of fibrosis and HAI scores in patients with liver fibrosis.
Iranian Journal of Radiology, Oct 31, 2017
Objectives: The aim of the study was to evaluate magnetic resonance imaging (MRI) findings of ili... more Objectives: The aim of the study was to evaluate magnetic resonance imaging (MRI) findings of iliotibial band friction syndrome (ITBFS) and its association with patellar height and facet shape variations. Patients and Methods: Forty-one knees of 32 patients (14 female, 18 male) referred from the orthopedic surgery outpatient clinics with the MRI diagnosis of ITBFS composed the study group. Thirty two knees of 29 patients (13 female, 16 male) with MRI records without any radiologic findings of knee pathology were chosen as the control group. All of the patients were evaluated by MRI, including the assessments of patellar length ratios according to Insall-Salvati method and patellar facet variations according to Wiberg's classification. Results: According to Wiberg's classification, nine knees (21.9%) had type I, 20 (48.8%) had type II, and 12 (29.3%) had type III shape of patella in the study group. Wiberg type I and type III patella ratio in the IBFS group was higher than the control group (P < 0.001, and P = 0.003, respectively). Wiberg type II patella ratio in the IBFS group was lower than the control group (P = 0.006). Ten knees (24.3%) had patella alta and the remaining 31 had patella norma (75.7%) in the study group. The frequency of patella alta was significantly higher in the study group in comparison with the controls (P = 0.002). Conclusion: ITBFS can easily be diagnosed by MRI and it is more likely associated with patella alta and type I and III patella according to Wiberg's classification.
Marmara Medical Journal, 2017
The role of magnetic resonance diffusion tensor imaging in differentiation of benign from maligna... more The role of magnetic resonance diffusion tensor imaging in differentiation of benign from malignant focal renal lesions Fokal renal lezyonlarının benign ve malign ayırımında manyetik rezonans difüzyon tensör görüntülemenin rolü The sensitivity-specificity of ADC and Fa were 100%-83.3%, and 100%-77.8%, respectively. Conclusion: There are statistically significant differences between ADC and Fa values of malignant and benign focal renal lesions. Malignant renal lesions have low ADCs and high Fa values, whereas benign renal lesions have high ADCs and low Fa values.
Early results of real-time qualitative sonoelastography in the evaluation of parotid gland masses: A study with histopathological correlation
Acta Radiologica, 2013
Background Sonoelastography has been used to differentiate malignant from benign lesions in numer... more Background Sonoelastography has been used to differentiate malignant from benign lesions in numerous types of tissues including breast, prostate, liver, blood vessels, thyroid, musculoskeletal structures, and salivary glands. Purpose To evaluate the efficacy and application of real-time qualitative sonoelastography in the differentiation of benign and malignant focal parotid gland lesions. Material and Methods A total of 75 patients (36 boys/men, 39 girls/women; age range, 10–83 years) with 81 lesions were evaluated prospectively by sonoelastography performed and interpreted by two expert radiologists. The results of these experts classification and scoring of lesions according to relative stiffness of the mass were compared with each other and with histopathological findings. The interpretation of sonoelastography scores of 1–4 were as follows: 1, soft; 2, mostly soft; 3, mostly stiff; and 4, stiff. Results The kappa statistic of 0.508 (P <, 0.001) indicated moderate agreement b...
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Papers by Abdullah S Mahmutoğlu