Papers by Atsuhito Toyomaki
Frontiers in Psychiatry, Jul 20, 2023
Real-world data from wearable devices has the potential to understand mental health status in eve... more Real-world data from wearable devices has the potential to understand mental health status in everyday life. We aimed to investigate the feasibility of estimating mental health status using a wrist-worn wearable device (Fitbit Sense) that measures movement using a 3D accelerometer and optical pulse photoplethysmography (PPG). Methods: Participants were 110 patients with mental illnesses from different diagnostic groups. The study was undertaken between 1 October 2020 and 31 March 2021. Participants wore a Fitbit Sense on their wrist and also completed the State-Trait Anxiety Inventory (STAI), Positive and Negative Affect Schedule (PANAS), and EuroQol 5 dimensions 5-level (EQ-5D-5L) during the study period. To determine heart rate (HR) variability (HRV), we calculated the sdnn (standard deviation of the normal-to-normal interval), coefficient of variation of R-R intervals, and mean HR separately for each sleep stage and the daytime. The association between mental health status and HR and HRV was analyzed. Results: The following significant correlations were found in the wake after sleep onset stage within 3 days of mental health status assessment: sdnn, HR and STAI scores, HR and PANAS scores, HR and EQ-5D-5L scores. The association between mental health status and HR and HRV was stronger the closer the temporal distance between mental health status assessment and HR measurement. Conclusion: A wrist-worn wearable device that measures PPG signals was feasible for use with patients with mental illness. Resting state HR and HRV could be used as an objective assessment of mental health status within a few days of measurement.
Psychiatry Research-neuroimaging, Aug 1, 2020
Cognitive functions are often affected during the euthymic state of bipolar disorder (BD). In 14 ... more Cognitive functions are often affected during the euthymic state of bipolar disorder (BD). In 14 this study, we investigated the associations among cognitive complaints, objective cognitive 15 functions, and the mean amplitudes of the P300 event-related potential (ERP) wave in 16 individuals with BD. The study population comprised 33 individuals with BD who were in remission and was conducted at Hokkaido University Hospital, Sapporo, Japan. Cognitive complaints were assessed using the Japanese version of the tool named "cognitive complaints in bipolar disorder rating assessment (COBRA)", whereas objective cognitive functions were measured by neuropsychological tests. P300 mean amplitudes were investigated during twoand three-stimulus oddball tasks and showed significant correlations with neuropsychological test scores at all electrode locations, confirming that ERPs and objective cognitive tests that assessed attention and memory function tend to coincide; however, neither P300 amplitudes nor neuropsychological test scores were correlated with COBRA scores. ERPs most likely represent the neurophysiological basis for objective rather than subjective cognitive function in euthymic individuals. Thus, our results suggest that objective cognitive function is related more to P300 mean amplitude scores than subjective cognitive function in individuals with BD.
Journal of Magnetic Resonance Imaging, 2007
To clarify whether a strong static magnetic field affects brain activity such as arousal level. W... more To clarify whether a strong static magnetic field affects brain activity such as arousal level. We compared the electroencephalography (EEG) inside an MRI scanner in the presence/absence of the static magnetic field in two different arousal levels of task and rest conditions. Cardiac-related pulsations of head and blood flow induce an electric voltage at each EEG electrode in a static magnetic field. This induced voltage overlaps with the intrinsic EEG signal and becomes a large confounding factor. To extract the information of the intrinsic EEG from the contaminated EEG data measured in a static magnetic field, we developed a new analysis method. No significant difference was observed in the intrinsic EEG in the absence of a magnetic field, whereas in the presence of the static magnetic field, the theta frequency band of the intrinsic EEG increased, especially during the task condition, but other frequency bands did not change. Our results demonstrate that a static magnetic field affects brain activity.
Nihon Shinri Gakkai Taikai happyo ronbunshu, Sep 19, 2013
Frontiers in Behavioral Neuroscience, Nov 22, 2021
Due to the fact that existing pharmacological treatments for depression are not ideal, effort has... more Due to the fact that existing pharmacological treatments for depression are not ideal, effort has been devoted to the development of complementary, alternative therapies such as physical exercise. The antidepressant effect of exercise is well documented. However, current recommendations and prescriptions of exercise may be too demanding for depressed patients, as some complain about the design of exercise programs and depression is associated with reduced motivation and capacity to exercise. Therefore, appropriately designed, patient-friendly exercise programs may prove critical for the long-term maintenance and therapeutic effects of exercise. In this pilot study, we developed an exercise program based on patients' individual level of ventilatory threshold (VT), a submaximal index of aerobic capacity measured by Cardiopulmonary Exercise Testing (CPX). Compared to traditional measures, CPX provides more trustable indices of aerobic capacity and more homogenous exercise prescriptions. The main episode of the program consisted of 15-25 min of cycling twice a week at an intensity that approached but never went higher than subjects' VT (considered low to moderate in intensity). We found that in patients diagnosed with major depressive disorder or persistent depressive disorder (n = 8), the program resulted in a significant reduction in depressive symptoms at week 8, which was maintained at week 16. Meanwhile, patients' social functioning, quality of life, and cognitive functions improved. Although we used a single arm, non-randomized design, our results suggest that even a brief, low to moderate intensity exercise program may exert therapeutic effects for depression and CPX may be a useful tool for exercise prescriptions.
Asian Journal of Psychiatry, Dec 1, 2020
Journal of Affective Disorders, 2023
Clinical Neurophysiology, Aug 1, 2013
Case: The case was 4th grade boy who was born without abnormal birth history. His spasticity appe... more Case: The case was 4th grade boy who was born without abnormal birth history. His spasticity appeared in his infancy. From one to two years old, seizures with impairment of consciousness were found. EEG revealed left frontal spikes. Later, seizure disappeared spontaneously without medication. In comparison with typical children with same school age as him, he had severe difficulty with reading and writing. His score of full-IQ, verbal-IQ and Performance-IQ were 63, 62 and 71 respectively with WISC-III. Reading assessment test showed over +20SD reading time in all tasks. Methods: His brain functional assessment was executed. He was told to read aloud 2–5 mora words and name pictures. While reading, magnetoencephalography (MEG) data were recorded using a 204-channel, whole-head gradiometer. In 107 trials of each task, words and picture presentation times were 6 s and inter-stimulus intervals were 1 s. MEG data were averaged by each task and analyzed with dynamic statistical parametric mapping (dSPM). Results: In all three tasks, averaged data and dSPM revealed obvious decrease of activities at left temporal and frontal lobule compared to right 200–400 ms after from word/picture presentation. Conclusion: Magnetological deviancy at left temporal and frontal lobule predicts reading difficulty.
Neuroscience Research, 2006
Neuropsychiatrie De L'enfance Et De L'adolescence, Jul 1, 2012
Conclusion.-Atypical face processing in autism could be explained by a lower visual exploration o... more Conclusion.-Atypical face processing in autism could be explained by a lower visual exploration of face, underpinned by specific dimensions of autism.
Neuropsychopharmacology Reports
AimSchizophrenia is characterized by an abnormality in electroencephalography (EEG), which can be... more AimSchizophrenia is characterized by an abnormality in electroencephalography (EEG), which can be affected by antipsychotic drugs. Recently, the mechanism underlying these EEG alterations in schizophrenia patients was reframed from the perspective of redox abnormalities. The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) can be calculated using a computational method and may be useful for evaluating the antioxidant/prooxidant effect of antipsychotic drugs. Thus, we examined the association between the effects of antipsychotic monotherapy on quantitative EEG and HOMO/LUMO energy.MethodsWe used medical report data including EEG results of psychiatric patients admitted to Hokkaido University Hospital. We extracted the EEG records of patients diagnosed with a schizophrenia spectrum disorder undergoing antipsychotic monotherapy during the natural course of treatment (n = 37). We evaluated the HOMO/LUMO energy of all antipsychotic drugs using comp...
Journal of Affective Disorders
Frontiers in Psychology
BackgroundDifficulty in distinguishing between self-generated actions and those generated by othe... more BackgroundDifficulty in distinguishing between self-generated actions and those generated by others is a core feature of schizophrenia. This is thought to be underpinned by the failure of corollary discharge. However, few studies have investigated these events using somatosensory evoked potentials (SEPs) and somatosensory evoked magnetic fields (SEFs).MethodsThe study included 15 right-handed patients with schizophrenia and 16 healthy controls. SEP and SEF were elicited by electrical stimuli to the left median nerve at intervals of 1–3 s. In the external condition, stimuli were externally induced by a machine. In the self-condition, stimuli were induced by tapping the participants’ own right index finger. Peak amplitude at C4’ in SEP and root mean square in 10 channels on the right primary somatosensory area in SEF were analyzed.ResultsAlthough there was a significant main effect of condition at N20m, and a significant main effect of condition and group at P30m, no significant inter...
Asian Journal of Psychiatry
Frontiers in Human Neuroscience, 2008
Schizophrenia Research, 2018
Please cite this article as: Nishida, K., et al., Social cognition and metacognition contribute t... more Please cite this article as: Nishida, K., et al., Social cognition and metacognition contribute to accuracy for self-evaluation of real-world functioning in patients with schizophrenia, Schizophr. Res.
International Journal of Neuropsychopharmacology, 2016
Introduction: Patients with schizophrenia show deficits symptoms as anhedonia. This study was des... more Introduction: Patients with schizophrenia show deficits symptoms as anhedonia. This study was designed to find neural correlates of anhedonia during shopping behavior and compared the results between healthy controls and patients with schizophrenia. We hypothesized that anhedonia would influence the shopping behavior as negative way in schizophrenia. Methods: 20 patients with schizophrenia and 20 healthy controls participated in the study. Participants were engaged in a 'shopping task' during functional magnetic resonance imaging (fMRI) scanning. Patients were administered Intrinsic Motivation and Extrinsic Motivation scale (IM & EM) and anhedonia scale. Pearson correlations of regional activities with behavioral responses such as score preference and clinical scales. Results: Patients preferred their own appearance wearing the cloth and that made them finally purchase the product. However, decreased activity of right posterior cingulate cortex (PCC) was found in the 'self-appearance wearing the product' condition in patients. Increment in activation of the lingual gyrus was correlated with lower score of the anhedonia scale. Conclusions: This study investigated neural correlates of shopping behavior affected by anhedonia in controls and patients with schizophrenia. Interestingly, patients preferred more their new look appearance than controls and purchased the products. This shopping behavior was also negatively correlated with severity of anhedonia. As we hypothesized, patients with schizophrenia showed careless shopping behavior and it was related to anhedonia.
International Journal of Neuropsychopharmacology, 2016
genome-wide association studies (GWAS) revealed alterations in immune-related genes and/or immune... more genome-wide association studies (GWAS) revealed alterations in immune-related genes and/or immune responses in patients with schizophrenia. However, the structural and functional consequences of the derived results remain to be discovered. Hence, we review selected aspects of this literature, discussing the involvement of major histocompatibility complex (MHC) and cytokines.
Revista de Nutrição, 2010
Contexto: A Qualidade de Vida (QV) constitui valiosa forma de avaliação do impacto de doenças na ... more Contexto: A Qualidade de Vida (QV) constitui valiosa forma de avaliação do impacto de doenças na vida diária e favorece intervenções mais efetivas sob uma perspectiva biopsicossocial. Objetivos: Este artigo procura analisar criticamente os dados disponíveis sobre as relações entre QV e cognição na esquizofrenia. Métodos: Foi realizada uma pesquisa na base de dados PubMed e Lilacs com os descritores de assunto "schizophrenia" e "cognition disorder" ou "cognition" e "quality of life" ou "outcome assessment". Resultados: Dos 27 artigos selecionados que estudavam a relação entre cognição e QV medida por meio de escalas, 20 mostraram associações. Essas foram mais importantes nos estudos que utilizaram escalas de QV administrada por pesquisador, em comparação com escalas de autoavaliação. Conclusão: A associação entre cognição e QV é mais evidente nos estudos que utilizaram medidas de QV feitas por pesquisadores do que naqueles que utilizaram autoavaliações. A avaliação cognitiva é importante não somente como parâmetro determinante de QV dos pacientes, mas também auxilia na interpretação das escalas de QV, sendo as autoavaliações mais adequadas em pacientes com menor prejuízo cognitivo.
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Papers by Atsuhito Toyomaki