Papers by Antonella Paccone
The COVID-19 pandemic has had a significant impact on Italian new graduates in the health profess... more The COVID-19 pandemic has had a significant impact on Italian new graduates in the health professions. This study investigated the impact of the pandemic on graduates' experiences with anxiety, depression, clinical placements, and employment readiness. Methods: An anonymous online survey was conducted with 200 new graduates in the health professions. The survey collected data on graduates' experiences with anxiety, depression, clinical placements, and employment readiness. The survey results showed that there were significant disruptions in practical training for new graduates. Graduates also reported changes in their attitudes to patient care, and a significant number had difficulty finding work that matched their gained abilities. The study findings suggest that universities and healthcare institutions need to adapt their training programs and support structures to accommodate the particular challenges that students in the health professions face during a pandemic. To assist effective transitions into the workforce, practical training opportunities should be maximized, mental health support services should be improved, and career counselling should be offered. The findings of this study have implications for the practice of teaching and supporting new graduates in the health professions. Universities and healthcare institutions need to be aware of the challenges that these graduates face, and they need to take steps to mitigate these challenges. By providing comprehensive support to new graduates, universities and healthcare institutions can help to ensure that these graduates are well-prepared to enter the workforce and to provide high-quality care to patients.
Journal of radiological review, Nov 30, 2023
Conclusions Many conditions, very common in the elderly, may restrict ChEIs use and/or effi cacy ... more Conclusions Many conditions, very common in the elderly, may restrict ChEIs use and/or effi cacy in Alzheimer's disease patients. Memantine has a good profi le of efficacy and tolerability with a better safety in pulmonary, cardiovascular and central nervous system comorbidities compared to Cholinesterase inhibitors. Memantine's drug interactions are more favourable since they concern mostly drugs of uncommon use in the elderly. Moreover, having some effects in behavioral symptoms and language disturbances, Memantine is probably useful in AD subtypes overlapping with Frontotemporal Lobar Degeneration. References
Alzheimers & Dementia, Jul 1, 2011
butyrylcholinesterase specific imaging agents. Methods: A series of benzoate oxyand thioesters we... more butyrylcholinesterase specific imaging agents. Methods: A series of benzoate oxyand thioesters were synthesized containing the N-methylpiperidinyl moiety. The benzoate oxyesters were measured for hydrolysis using changes in UV absorption for the benzoate reactants and products and comparable thioesters were analyzed using the Ellman method. In addition, thioesters of several acetyl-, propionyland butyryl-containing oxyester cholinesterase imaging agents were synthesized and their kinetic parameters evaluated using the Ellman method. Several of the thioester compounds were used for histochemical staining of post-mortem human tissue to assess their distribution and specificity towards acetylcholinesterase or butyrylcholinesterase. Results:Nmethylpiperidinyl oxyand thioesters (Figure 1) were synthesized in analogous reaction procedures. Enzyme kinetic analyses indicated comparable interactions of oxyand thioesters with acetylcholinesterase and butyrylcholinesterase. Histochemical studies indicate a unique distribution of each thioester, dependent upon their specificity towards the cholinesterases. Conclusions: We have established a strategy for the development of cholinesterase ligands based on thioesters of N-methyl piperidinol. Molecules derived from this moiety can be rapidly evaluated in vitro for their potential as imaging agents. Imaging agents developed using this approach have the potential to detect cholinesterase levels associated with disease pathology, thus providing an approach for early diagnosis and treatment monitoring of AD. P4-066 RESTING STATE CONNECTIVITY IN POSTERIOR CINGULATE AND HYPPOCAMPUS IN MILD ALZHEIMER’S DISEASE AND MILD COGNITIVE IMPAIRMENT Patrizia Montella, Fabrizio Esposito, Manuela de Stefano, Daniela Buonanno, Angiola Maria Fasanaro, Mario Cirillo, Antonella Paccone, Gioacchino Tedeschi, Second University of Naples, Naples, Italy; University of Naples Federico II, Naples, Italy; Second University of Naples, Naples, Italy; Second University of Naples, Naples, Italy; Neurological Institute for Diagnosis and Care “Hermitage Capodimonte”, Naples, Italy.
Symposia Joint ENS-PNS Symposium-Familial amyloid polyneuropathy 46-49 Presidential Symposium Tre... more Symposia Joint ENS-PNS Symposium-Familial amyloid polyneuropathy 46-49 Presidential Symposium Treatment of muscle diseases: The future is already here 91-94 Symposium Molecular and cellular mechanisms of ischaemic stroke 96-99 Psychiatric aspects of neurological disorders 101-103 Metals and movement disorders 134-136 Biomarkers for diagnosis, prognosis and response to treatment in MS __________________________________ Symposium Molecular and cellular mechanisms of ischaemic stroke 96 Novel molecular targets for acute stroke treatment G. Stoll Julius-Maximilians-University (Wu ¨rzburg, DE) In acute thrombo-embolic stroke the principal treatment goal is to rapidly achieve recanalization of occluded vessels. Patients may, S5
Journal of Radiological Review
Neurological Sciences, 2021
Sleep is a fundamental physiological process necessary for efficient cognitive functioning especi... more Sleep is a fundamental physiological process necessary for efficient cognitive functioning especially in relation to memory consolidation and executive functions, such as attentional and switching abilities. The lack of sleep strongly alters the connectivity of some resting-state networks, such as default mode network and attentional network. In this study, by means of magnetoencephalography (MEG) and specific cognitive tasks, we investigated how brain topology and cognitive functioning are affected by 24 h of sleep deprivation (SD). Thirty-two young men underwent resting-state MEG recording and evaluated in letter cancellation task (LCT) and task switching (TS) before and after SD. Results showed a worsening in the accuracy and speed of execution in the LCT and a reduction of reaction times in the TS, evidencing thus a worsening of attentional but not of switching abilities. Moreover, we observed that 24 h of SD induced large-scale rearrangements in the functional network. These fi...
The topology of brain networks changes according to environmental demands and can be described wi... more The topology of brain networks changes according to environmental demands and can be described within the framework of graph theory. We hypothesized that 24-hours long sleep deprivation (SD) causes functional rearrangements of the brain topology so as to impair optimal communication, and that such rearrangements relate to the performance in specific cognitive tasks, namely the ones specifically requiring attention. Thirty-two young men underwent resting-state MEG recording and assessments of attention and switching abilities before and after SD. We found loss of integration of brain network and a worsening of attention but not of switching abilities. These results show that brain network changes due to SD affect switching abilities, worsened attention and induce large-scale rearrangements in the functional networks.
La radiologia medica, 2013
Neurobiology of Aging, 2012
Journal of Neurology, 2012
Alzheimer's & Dementia, 2011
Uploads
Papers by Antonella Paccone