Papers by Aloys HITABATUMA
Food Chemistry, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Foods, 2022
Food contains a variety of poisonous and harmful substances that have an impact on human health. ... more Food contains a variety of poisonous and harmful substances that have an impact on human health. Therefore, food safety is a worldwide public concern. Food detection approaches must ensure the safety of food at every step of the food supply chain by monitoring and evaluating all hazards from every single step of food production. Therefore, early detection and determination of trace-level contaminants in food are one of the most crucial measures for ensuring food safety and safeguarding consumers’ health. In recent years, various methods have been introduced for food safety analysis, including classical methods and biomolecules-based sensing methods. However, most of these methods are laboratory-dependent, time-consuming, costly, and require well-trained technicians. To overcome such problems, developing rapid, simple, accurate, low-cost, and portable food sensing techniques is essential. Metal-organic frameworks (MOFs), a type of porous materials that present high porosity, abundant...
Food Science and Nutrition, 2017
Mycotoxin are secondary metabolite of molds which can cause acute or chronic toxicological effect... more Mycotoxin are secondary metabolite of molds which can cause acute or chronic toxicological effects. One type of mold can produce different types of mycotoxin and its production is affected by various factors. Molds are easily to grow on food product like cereals, coffee, beans, nuts, vegetables and fruits. Also, mycotoxins are founded in commercialized processed product like bread, wine, milk, other milk product, beer, chocolate products and even in meet and meet product because during food processing mycotoxin cannot be eliminated. The best way to protect consumers against mycotoxin effect is early food detection. This review focus on toxicological effect of mycotoxin, practical prevention methods of molds contamination at community level, classical and recent detection methods. Recent biosensors based devices have a great potential for accurate and high-throughput detection on mycotoxins in agricultural and food products. The program of good agriculture practices, storage techniqu...
Mycotoxin are secondary metabolite of molds which can cause acute or chronic toxicological effect... more Mycotoxin are secondary metabolite of molds which can cause acute or chronic toxicological effects. One type of mold can produce different types of mycotoxin and its production is affected by various factors. Molds are easily to grow on food product like cereals, coffee, beans, nuts, vegetables and fruits. Also, mycotoxins are founded in commercialized processed product like bread, wine, milk, other milk product, beer, chocolate products and even in meet and meet product because during food processing mycotoxin cannot be eliminated. Especially, OTA is the most mycotoxin with the nephrotoxic, immunotoxic, teratogenic and carcinogenic effects. The International Agency for Research on Cancer (IARC) has classified OTA in 2B Group (possibly carcinogenic agent) The best way to protect consumers against mycotoxin effect is early food detection. In recent years, various methods have been introduced for detection of OTA. However, they are usually time-consuming, labor-intensive and expensive...
Science of The Total Environment, 2022
Bisphenol A and its substitutions are commonly used to manufacture epoxy resins, plastic material... more Bisphenol A and its substitutions are commonly used to manufacture epoxy resins, plastic materials and different kinds of daily necessities. In this process, a large number of bisphenol analogues (BPs) are continuously released directly/indirectly into the environment. Through the chain of environment-feed-farmed-animals-livestock and poultry products, BPs present the low concentration but chronic exposure for surroundings and environment. In addition, BPs have been revealed by extensive studies as emerging endocrine disruptors, whose effects on androgens/glucocorticoids have rarely been mentioned in previous reports. The (anta-) agonist/antagonist properties of 18 classic BPs were investigated in vitro: We assessed the cytotoxicity and examined the luciferase induction values of BPs in MDA-kb2 cells, incubated single or co-incubated with dihydrotestosterone (DHT), dexamethasone, flutamide and RU486 for 24 h. From the concentration of 10-10 to 10-5 M, BPs had negligible cytotoxicity for MDA-kb2 cells, except for 4,4'-(9-Fluorenylidene)diphenol with the IC50 1.32 μM. All 18 BPs had the response to androgen/glucocorticoid receptors (AR/GR). BPs at nanomolar and trace concentrations are agonists, while BPs at micromolar and higher concentrations are antagonists. Molecular docking showed that BPs interact with AR/GR through hydrophobic bonds, hydrogen bonds, T-type π-stacking and water-bridge. These experimental data demonstrate the universality of the endocrine-disrupting effects of BPs and suggest the urgency of paying attention to the usages of BPs.
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Papers by Aloys HITABATUMA