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64-M-B Maria ilyas

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Eastern Mediterranean University

Sam Koohi-Kamali

University of Malaya, Malaysia

IOANNIS LIRITZIS

Northwestern Polytechnical University

Muhammad Gulraiz Ahmed

Politeknik Negeri Ujung Pandang

Hazlee Azil Illias

University of Malaya, Malaysia

Muharrem Keskin

Mustafa Kemal University

Lehigh University

University of East London

Gwen Robbins Schug

University of North Carolina at Greensboro

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Papers by 64-M-B Maria ilyas

Structural insights into emerging pediatric pathogens human bocaparvoviruses

Journal of virology, Jun 22, 2017

Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) c... more Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) causes severe respiratory infections and HBoV2-4 gastrointestinal infections in young children. Recent reports of life threatening cases, lack of direct treatment or vaccination, and a limited understanding of their disease mechanisms demand the need to study these pathogens on a molecular and structural level for the development of therapeutics. Towards this end, the capsid structures of HBoV1, HBoV3, and HBoV4 were determined to 2.8 - 3.0 Å resolution using cryo-electron microscopy and 3D image reconstruction. The bocaparvovirus capsids, that display different tissue tropisms, share common features with other parvoviruses, such as depressions at the icosahedral 2-fold and surrounding the 5-fold symmetry axes, protrusions surrounding the 3-fold, and a channel at the 5-fold axis. However, unlike other parvoviruses densities extending the 5-fold channel into the capsid interior are conserv...

Structural insights into emerging pediatric pathogens human bocaparvoviruses

Journal of virology, Jun 22, 2017

Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) c... more Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) causes severe respiratory infections and HBoV2-4 gastrointestinal infections in young children. Recent reports of life threatening cases, lack of direct treatment or vaccination, and a limited understanding of their disease mechanisms demand the need to study these pathogens on a molecular and structural level for the development of therapeutics. Towards this end, the capsid structures of HBoV1, HBoV3, and HBoV4 were determined to 2.8 - 3.0 Å resolution using cryo-electron microscopy and 3D image reconstruction. The bocaparvovirus capsids, that display different tissue tropisms, share common features with other parvoviruses, such as depressions at the icosahedral 2-fold and surrounding the 5-fold symmetry axes, protrusions surrounding the 3-fold, and a channel at the 5-fold axis. However, unlike other parvoviruses densities extending the 5-fold channel into the capsid interior are conserv...

Structural insights into emerging pediatric pathogens human bocaparvoviruses

Journal of virology, Jun 22, 2017

Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) c... more Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) causes severe respiratory infections and HBoV2-4 gastrointestinal infections in young children. Recent reports of life threatening cases, lack of direct treatment or vaccination, and a limited understanding of their disease mechanisms demand the need to study these pathogens on a molecular and structural level for the development of therapeutics. Towards this end, the capsid structures of HBoV1, HBoV3, and HBoV4 were determined to 2.8 - 3.0 Å resolution using cryo-electron microscopy and 3D image reconstruction. The bocaparvovirus capsids, that display different tissue tropisms, share common features with other parvoviruses, such as depressions at the icosahedral 2-fold and surrounding the 5-fold symmetry axes, protrusions surrounding the 3-fold, and a channel at the 5-fold axis. However, unlike other parvoviruses densities extending the 5-fold channel into the capsid interior are conserv...

Structural insights into emerging pediatric pathogens human bocaparvoviruses

Journal of virology, Jun 22, 2017

Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) c... more Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) causes severe respiratory infections and HBoV2-4 gastrointestinal infections in young children. Recent reports of life threatening cases, lack of direct treatment or vaccination, and a limited understanding of their disease mechanisms demand the need to study these pathogens on a molecular and structural level for the development of therapeutics. Towards this end, the capsid structures of HBoV1, HBoV3, and HBoV4 were determined to 2.8 - 3.0 Å resolution using cryo-electron microscopy and 3D image reconstruction. The bocaparvovirus capsids, that display different tissue tropisms, share common features with other parvoviruses, such as depressions at the icosahedral 2-fold and surrounding the 5-fold symmetry axes, protrusions surrounding the 3-fold, and a channel at the 5-fold axis. However, unlike other parvoviruses densities extending the 5-fold channel into the capsid interior are conserv...