Papers by Herve Vespignani
Clinical Neurophysiology, 2016
Revue d'Épidémiologie et de Santé Publique, 2009
Revue d'Épidémiologie et de Santé Publique, 2009
Annals of Neurology, 2020
In March 2020, we treated a cohort of 26 critically ill hospitalized SARS-CoV-2-infected patients... more In March 2020, we treated a cohort of 26 critically ill hospitalized SARS-CoV-2-infected patients who underwent electroencephalography to assess unexplained altered mental status, loss of consciousness, or poor arousal and responsiveness. Of the 26 patients studied, 5 patients had electroencephalograms that showed periodic discharges consisting of high-amplitude frontal monomorphic delta waves with absence of epileptic activity. These findings may suggest central nervous system injury potentially related to COVID-19 in these patients.
NANCY1-SCD Medecine (545472101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
NeuroImage, 2010
Addendum to “Automated cortical projection of EEG sensors: Anatomical correlation via the interna... more Addendum to “Automated cortical projection of EEG sensors: Anatomical correlation via the international 10–10 system” [NeuroImage 46 (2009) 64–72] L. Koessler , L. Maillard , A. Benhadid , J.P. Vignal , J. Felblinger , H. Vespignani , M. Braun a,c,d,⁎ a INSERM U947, Nancy University, France b Neurology Department, University Hospital, Nancy, France c Neuroradiology Department, University Hospital, Nancy, France d Anatomy Department, Nancy University, France
Annals of Biomedical Engineering, 2010
This paper deals with the co-registration of an MRI scan with EEG sensors. We set out to evaluate... more This paper deals with the co-registration of an MRI scan with EEG sensors. We set out to evaluate the effectiveness of a 3D handheld laser scanner, a device that is not widely used for co-registration, applying a semi-automatic procedure that also labels EEG sensors. The scanner acquired the sensors' positions and the face shape, and the scalp mesh was obtained from the MRI scan. A pre-alignment step, using the position of three fiducial landmarks, provided an initial value for co-registration, and the sensors were automatically labeled. Co-registration was then performed using an iterative closest point algorithm applied to the face shape. The procedure was conducted on five subjects with two scans of EEG sensors and one MRI scan each. The mean time for the digitization of the 64 sensors and three landmarks was 53 s. The average scanning time for the face shape was 2 min 6 s for an average number of 5,263 points. The mean residual error of the sensors co-registration was 2.11 mm. These results suggest that the laser scanner associated with an efficient co-registration and sensor labeling algorithm is sufficiently accurate, fast and user-friendly for longitudinal and retrospective brain sources imaging studies.
Journal of Neurology, Neurosurgery & Psychiatry, 2010
Objective: To observe the effect of voluntary hyperventilation on electroencephalographic activit... more Objective: To observe the effect of voluntary hyperventilation on electroencephalographic activity during routine EEG recording on patients referred to a tertiary care hospital.
Data Revues 00380814 00520720 24, Oct 4, 2008
![Research paper thumbnail of [Impact of group therapeutic education in the management of adult sleep disorders. Prospective study conducted from September 2007 to March 2008 by a group of general practitioners]](https://a.academia-assets.com/images/blank-paper.jpg)
La Revue Du Praticien, Jun 20, 2010
The prescription of hypnotic drugs in the management of adult insomnia is a public health issue. ... more The prescription of hypnotic drugs in the management of adult insomnia is a public health issue. The implementation of a non-pharmacological, therapeutic approach is a daily problem for primary physicians. This study aimed at assessing the impact of a group therapeutic education approach in the non-medical management of adult insomnia by general practitioners. Prospective study conducted from September 2007 to March 2008. Two conferences were held in a two-month period by 5 general practitioners from Laxou, Meurthe-et-Moselle (France). Volunteers were recruited by general practitioners, through local press, posters displayed in pharmacies, leaflet distribution and local radio announcements. A questionnaire was provided at the beginning and the end of the conferences. A phone interview was conducted 1 month and 3 months after the conferences were held, to assess their impact. Seventy-six participants completed the questionnaire during both conferences, and 55 adults were followed-up at 1 and 3 months; 58% (n = 43) were aged over 60, and women represented 65% (n = 48) of the participants; 63% (n = 46) reported insomnia, out of which 89% complained of chronic insomnia (26%, 40% and 34% reported mild insomnia, moderate insomnia and severe insomnia, respectively). At 3 months, 20% of the participants had completed the sleep diary and specifically seen their general practitioner; 56% of the participants taking hypnotic drugs had initiated a dose reduction or a discontinuation of their treatment; 84% of the participants who followed recommendations and initiated cognitive behavioral therapies noted a partial or complete improvement in their sleep disorder. Group therapeutic education in the form of cognitive behavioral therapy performed during a conference results in a change in behaviors and a mid-term improvement in sleep quality in participants.
La Revue Du Praticien, Mar 1, 2005
As regards road safety, the doctors have the duty to inform their patients on the affections inco... more As regards road safety, the doctors have the duty to inform their patients on the affections incompatible, transitorily or in a final way, with control of a vehicle. In the majority of the countries, the very large majority of the epileptics is not in rule with respect to this legislation with regard to the private cars. Moreover, the legislation is too restrictive for the drivers of group 2. After having begun again the conditions for application of the French and European current legislation, the authors specifie the later upgrading capabilities relating to the epilepsy.
![Research paper thumbnail of [Specificity of epileptic seizures in the elderly: A proposed electro-clinical scale]](https://attachments.academia-assets.com/53996391/thumbnails/1.jpg)
Revue neurologique, 2009
Diagnosis of epileptic seizure may be difficult in older patients because seizure manifestations ... more Diagnosis of epileptic seizure may be difficult in older patients because seizure manifestations are often unusual: confusion, paresis... and because there are multiple differential diagnoses (syncope, transient ischemic attack, transient global amnesia...). To promote and facilitate the diagnosis of seizures in the elderly, neurologists and gerontologists must work together and focus their strategy on two points: firstly, the knowledge of the specific presentation of seizures in elderly patients, and secondly, the adoption of a reasoning based on seizures and not epileptic syndromes. A multidisciplinary group worked on epilepsy of the elderly to elaborate an electro-clinical score which aims to help establish the diagnosis of epilepsy in elderly patients in different clinical settings. This electro-clinical score is based on a systematic review of scientific literature and the recommendations are explicitly linked to supporting evidence. Further, clinical validation of the electro-...
Human Brain Mapping, 2013
Electrical brain stimulation can provide important information about the functional organization ... more Electrical brain stimulation can provide important information about the functional organization of the human visual cortex. Here we report the visual phenomena evoked by a large number (562) of intra-cerebral electrical stimulations performed at low-intensity with depth electrodes implanted in the occipito-parieto-temporal cortex of 22 epileptic patients.
Epilepsia, 2010
Idiopathic partial reading epilepsy (RE) is a rare syndrome. We report the clinical and electroen... more Idiopathic partial reading epilepsy (RE) is a rare syndrome. We report the clinical and electroencephalographic characteristics of two right-handed patients with the following: reading-induced independent bilateral temporal lobe seizures, accompanied by alexia in left (dominant) sided seizures recorded on video-EEG (electroencephalography); subclinical activation over left posterior temporal and occipital electrodes during reading; no spontaneous seizure and no other trigger than reading; onset in adolescence; and history of varying resistance to treatment. Bilateral independent temporal lobe reflex seizures are part of the clinical spectrum of RE. It may result from hyperexcitability of bilateral cortical networks involved in the early steps of the reading process.
Epilepsia, 2010
Establishing an early diagnosis of Lafora disease (LD) is often challenging. We describe two case... more Establishing an early diagnosis of Lafora disease (LD) is often challenging. We describe two cases of LD presenting as myoclonus and tonic-clonic seizures, initially suggesting idiopathic generalized epilepsy. The subsequent course of the disease was characterized by drug-resistant myoclonic epilepsy, cognitive decline, and visual symptoms, which oriented the diagnosis toward progressive myoclonic epilepsy and, more specifically, LD. Early in the evolution in the first case, and before histopathologic and genetic confirmation of LD in both cases, [18]Fluorodeoxyglucose positron emission tomography (FDG-PET) revealed posterior hypometabolism, consistent with the well-known posterior impairment in this disease. This suggests that FDG-PET could help to differentiate LD in early stages from other progressive myoclonic epilepsies, but confirmation is required by a longitudinal study of FDG-PET in progressive myoclonic epilepsy.
Journal of Neurology, 2004
Epilepsia, 2004
Autoscopy is a pathologic perception of one's body or one&amp... more Autoscopy is a pathologic perception of one's body or one's face image within space, either from an internal ("as in a mirror") or from an external ("out-of-body experience") point of view. Among various psychiatric and neurologic disorders, partial epilepsy is the main etiology. However, the significance of this rare ictal symptom remains controversial. We report this phenomenon in three epilepsy patients and discuss its semiologic value and neuropsychological significance. Interictal EEG and/or video-EEG monitoring was performed, as well as neuropsychological examination and cerebral magnetic resonance imaging (MRI). The three patients had a lesion involving, or limited to, the right parietal region on cerebral MRI. All three patients experienced autoscopy associated with other ictal signs supporting a right parietal lobe origin of seizures. In one patient, seizure origin was documented with video and surface EEG ictal recordings. Autoscopy was shown to have an ictal mechanism and was associated with seizures arising from the nondominant parietal region. We hypothesize that ictal autoscopy may result from disruption of the normal integration of body representation.
Epilepsia, 2005
To evaluate the safety and efficacy of zonisamide (ZNS) as adjunctive treatment in patients with ... more To evaluate the safety and efficacy of zonisamide (ZNS) as adjunctive treatment in patients with refractory localization-related epilepsy. This was a double-blind, placebo-controlled study of adjunctive ZNS in 351 patients with refractory partial seizures receiving a stable regimen of one to three antiepileptic drugs (AEDs). Patients were randomized to placebo or ZNS, 100 mg, 300 mg, or 500 mg/day (2:1:1:2) after a 12-week baseline. Dose titration was undertaken over a 6-week titration phase, which was followed by an 18-week fixed-dose assessment phase. Primary efficacy parameters were the differences between ZNS, 500 mg/day, and placebo in the change from baseline in frequency of complex partial (CP) seizures during the fixed-dose assessment phase and in the proportion of CP responders (> or =50% decrease from baseline in seizure frequency). Safety and tolerability also were assessed. Compared with placebo, the highest dose of ZNS (500 mg/day) resulted in a significantly greater decrease in CP seizure frequency from baseline (51.2% vs. 16.3%; p < 0.0001) and a significantly higher proportion of CP responders (52.3% vs. 21.3%; p < 0.001). Both ZNS, 500 mg/day, and 300 mg/day were statistically superior to placebo in reducing the frequency of "all seizures" and simple partial (SP) + CP seizures. For all seizures, a significant dose-response relation was observed (p < 0.0001). The most common adverse events were somnolence, headache, dizziness, and nausea during the titration phase and headache and pharyngitis during the fixed-dose assessment phase. ZNS provides dose-dependent, effective, and generally well-tolerated adjunctive therapy in patients with partial seizures.
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Papers by Herve Vespignani