Papers by Muazzam Sheriff Maqbul
Medical science, Dec 2, 2022
The Sickle Cell Disease (SCD) time honored among the interrelated couples because of the mutation... more The Sickle Cell Disease (SCD) time honored among the interrelated couples because of the mutation of gene ensuing with inside the alteration of pink blood cells to a sickle form inflicting animated phenomenon ensuing in extreme intricacies many of the people which posses a brilliant have an effect on their each mental and health situations destructing the everyday existence of the individual. This moves sectional purpose take a look at changed into a try to examine the intricacies of SCD in many of the pediatric city populace of Makkah vicinity with inside the Kingdom of Saudi Arabia. The pattern length changed into envisioned the usage of the G strength calculator and the received responses from the goal populace of a thousand volunteers changed into analyzed with the aid of using the Microsoft Excel and IBM SPSS Statistics for Windows model 23 changed into used for test ing (IBM SPSS, IBM Corp., Armonk, N.Y., USA) with the aid of using representing the Pvalues (<005) in probabilities to decide the significance. The outcomes had been pleasant in align with the take a look at the goal. This take a look at recommends that the network surroundings encounter a whole lot of entanglements because of SCD however those oughts to be as it should be controlled with the essential measures with the aid of using clinical and nursing group of workers supervised with the aid of using applicable public business enterprise authorities.
Medical Science
The important recognition of this examines changed into to research the position of Vitamin D in ... more The important recognition of this examines changed into to research the position of Vitamin D in correlation with pediatric SCD in Saudi Arabia. Vitamin D deficiency is not unusual place in every age and nations and is in particular related to SCD in kids. Vit D supplementation reduces the chance of SCD in kids and kids however has little impact on innate immunity after publicity to contamination and at different concentrations together. The examiners used online survey questionnaires and randomly disbursed them thru social media platforms. The online pattern length calculator Raosoft (Raosoft Inc., Seattle, WA, USA) anticipated pattern sizes. Social science statistical package model 22.0 (IBM SPSS, IBM Corp., Armonk NY, USA) to carry out descriptive statistics, Shapiro-Wilk's take a look at evaluates the ordinary distribution of data. The effects received were calculated for Pearson Chi Square for importance and are truly tabulated and proven with inside the figures for every person end result type. The effects received had been categorized in one of kind sections for the specific dialogue of the reaction fee with that of P-Value esteem importance. This examines pursuits to observe the position of Vit D withinside the combat towards SCD and public belief of it with the in a position fitness government to nicely combat its effects.
Medical Science
The antimicrobial vulnerability testing of Linum flavum hydrocolloids against pediatric surgical ... more The antimicrobial vulnerability testing of Linum flavum hydrocolloids against pediatric surgical MRSA isolates with qualitative bio-phytochemical analysis quantified by GC-MS-UV-Vis spectrophotometry
American Journal of Biomedical Science & Research
This work is licensed under Creative Commons Attribution 4.0 License AJBSR.MS.ID.002153.
Letters in Applied Microbiology, 2009
To isolate and characterize actinomycetes with probiotic activities from healthy goat faeces. Fae... more To isolate and characterize actinomycetes with probiotic activities from healthy goat faeces. Faecal actinomycetes were isolated by dilution methods and identified by 16S rRNA gene sequence analysis. The hydrolytic enzyme activities were analysed by clear zone formation. The antimicrobial activities and resistance to heavy metals were tested by growth inhibition methods. The isolates belong to a small group of actinobacterial genera, including Streptomyces, Nocardiopsis and Oerskovia. The Oerskovia was the most widely distributed genus among the cultures. The proportion of streptomycete-like strains producing amylase or protease is significantly higher than those of other actinomycetes (P &lt; 0.05). Compared with streptomycete-like strains, a higher proportion of (alpha- or beta-) galactase-producing other actinomycetes was found in goat faeces. More than 50% of streptomycete-like strains showed activities against test fungi. Streptomycetes could tolerate 0.25 mmol l(-1) Cr(2)O(7)(2-), 2 mmol l(-1) Ni(2+); however, other actinomycetes are liable to 40 mmol l(-1) Fe(3+) and 0.25 mmol l(-1) Cr(2)O(7)(2-) and resistant to 5 mmol l(-1) Ni(2+) and 2 mmol l(-1) Cu(2+). The different physiological characteristics of the actinomycetes suggested that the cooperation in the actinomycetes might be involved in their association with goat. Probiotic mixtures based on faecal actinomycetes showed potentials in animal production.
Journal of Hazardous Materials Advances
Enzymes for Pollutant Degradation
Science of Advanced Materials
This study focuses on proving the importance of In-Silico drug discovery in treating diseases tha... more This study focuses on proving the importance of In-Silico drug discovery in treating diseases that do not have a dependable and viable treatment. A disease of concern is Rotavirus; this spherical virus is responsible for causing diarrhoea like infection in infants. But it is not limited to infants and can occur in adults too. An intensive literature review provided evidence of how the currently available vaccines fail to protect a whole section of the population against this death-causing disease. The current study explores a protein targeted by a ligand that could be potentially developed as a drug. The protein considered is VP4 which is involved in the pathogenesis of the rotavirus. The ligand considered is 2-{[2-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl) ethyl] amino}-4(3H)-quinazolinone with a chemical formula C21H22N4O and molecular weight 346.3 Da. The protein’s physiochemical and stereochemical analysis was conducted, followed by the ligand-protein interaction studies, molecular ...
The antimicrobial, phytochemical contents of extracts obtained from the leaf extract of mature Eu... more The antimicrobial, phytochemical contents of extracts obtained from the leaf extract of mature Euphorbia pilulifera (E. pilulifera) were examined in this research work. Using ethyl acetate extracts of the leaves of Euphorbia pilulifera, phytochemical metabolites were studied. Further using chromatography, different components were separated and its antimicrobial activity was studied. Different types of bacterial organisms were used for evaluating the antimicrobial activity. The results indicated that leaf extracts are more sensitive towards organisms. Thus the presence of phytochemicals in the leaf extract can be used for the treatment of different diseases.
Medical Science, 2022
The majorities of the population pay little attention to the health issues and accord little or n... more The majorities of the population pay little attention to the health issues and accord little or no priority to medical checkup which leads to the preference of Self-Medication practice. This study was conducted to determine the knowledge and practice of the prevalence of self-medication among urban population in Makkah region. A descriptive cross-sectional study was conducted with a target population of 1000 participants over the period of three months. The data was collected in the form of well designed specific questionnaires related to self-medication along with other informations related to the bio-informatics of the individual, etc., both in English and Arabic language. This cross-sectional survey study was conducted by blending both qualitative and quantitative methods of data collection during an awareness campaign and through direct interview with the participant. The collected data were analysed by the Microsoft Excel and SPSS. The values were presented as numbers (%). IBM SPSS, IBM Corp., Armonk, N.Y., USA, version 23 was utilized for analysis. Statistical comparisons were made by Pearson Chi-Square test. The data were significant if P-values were < 0.05. The analysed results of the collected data suggested that the effort was needed in ensuring that the drive is required to discourage the practice of the selfmedication and encourage the visit to the medical practitioners to follow the proper guidelines of the prescribed medications. It is necessary to study the factors associated with the uptake of medications among the studied population and avoid the complications of self-medication.
Molecules, 2022
Bionanotechnology is a branch of science that has revolutionized modern science and technology. N... more Bionanotechnology is a branch of science that has revolutionized modern science and technology. Nanomaterials, especially noble metals, have attracted researchers due to their size and application in different branches of sciences that benefit humanity. Metal nanoparticles can be synthesized using green methods, which are good for the environment, economically viable, and facilitate synthesis. Due to their size and form, gold nanoparticles have become significant. Plant materials are of particular interest in the synthesis and manufacture of theranostic gold nanoparticles (NPs), which have been generated using various materials. On the other hand, chemically produced nanoparticles have several drawbacks in terms of cost, toxicity, and effectiveness. A plant-mediated integration of metallic nanoparticles has been developed in the field of nanotechnology to overcome the drawbacks of traditional synthesis, such as physical and synthetic strategies. Nanomaterials′ tunable features make ...
Journal of Pharmaceutical Research International
Super small secreted glycoprotein (ssGP) is a virulent protein that plays a vital role during the... more Super small secreted glycoprotein (ssGP) is a virulent protein that plays a vital role during the Ebola viral infection. This study entails in silico structural and finding inhibitor compound for the secreted glycoprotein of Reston ebola virus (strain Philippines-96). The physical and stereochemical properties and the protein's secondary and tertiary structure were predicted initially. Later, as the predicted model was evaluated to be a reliable structure, binding pockets were predicted, and known binding ligands to similar proteins were identified. Analogue compounds to known ligands were collected and docked against ssGP. The compound with the least binding energy was identified and recommended as a potent inhibitor towards ssGP. From this study, in-vitro and in-vivo analysis was computed for the selected ligand for designing effective drugs against Reston ebolavirus.
Journal of King Saud University - Science
P.aeruginosa (Pseudomonas aeruginosa) is the most common pathogen isolated from patients who have... more P.aeruginosa (Pseudomonas aeruginosa) is the most common pathogen isolated from patients who have been hospitalized longer than 1 week. The relative frequency of P. aeruginosa as a nosocomial pathogen has increased. P.aeruginosa can cause multi-systemic infections. Our study aims to assess number of nosocomial infection with P. aeruginosa, and its prevention and control measures. Methods: A set of 100 microbiological samples collected from different patients in three different hospitals suspected with nosocomial infection. Mechanism of action to detect the prevalence of P. aeruginosa studied by using: Culturing, staining, microscopy, Biochemical reactions, enzymatic test, and fermentation test. Results: The total positive cases of the infection occurred in 7 cases, the positive nosocomial infection rate was 19.62%. The results have been shown in the three hospitals where the hospital that has a protocol to deal with infection and prevention will be much lower than its peers and this...
Journal of King Saud University - Science, 2021
Objective There is a growing demand for colourants of natural origin in the food, cosmetic and te... more Objective There is a growing demand for colourants of natural origin in the food, cosmetic and textile sectors. Previously, our group has screened a fungal species from forest soil, identified as Penicillium europium. The isolated fungus transformed the longifolene into various metabolites, of which 12 were isolated in pure form, with potential to be utilized in the perfumery industry. Methods The current study showcases the extraction and identification of fungal pigment from Penicillium europium using different spectral studies. The strain was isolated from forest soil, Western Ghats, India, and was found to be capable of using longifolene as the sole carbon source. The yellowish pink coloured pigment-producing fungal strain was identified as Penicillium europium. Further, the pinkish pigment was extracted, purified, and spectral studies like UV, IR, NMR and Mass. Results The pure pigment structure was analyzed and tentatively confirmed as 2-(1,5, dimethyl hexyl)-3,5-dimethyl-6-hy...
Journal of Pharmaceutical Research International
This study was aimed to seek out the awareness and knowledge about the covid-19 during the onset ... more This study was aimed to seek out the awareness and knowledge about the covid-19 during the onset of the pandemic among the urban population of the Saudi arabia. This study was carried out for a period of three months from 01.04.2020 to 31.07.2020 and a sample of 1000 participants. The significant difference of P-value obtained by performing the Pearson Chi-Square test for all he questionnaires to analyse the study of assessment. This study was a small attempt for conducting such valuable studies in preventive medicine. Thus, this study suggests that the community's overall satisfactory report is well aware of the preventive measure procedures and well prepared to tackle the covid-19 pandemic.
Indian Journal of Pharmaceutical Education and Research
Objectives: The main objective of this research was to evaluate the awareness about symptoms of d... more Objectives: The main objective of this research was to evaluate the awareness about symptoms of diabetes and dealing with those symptoms, management and storage of drug especially for the heat sensitive hormone (insulin) by diabetic patients participating in Hajj and the residents of Makkah. Methods: This cross-sectional study was conducted for diabetic patients participating in Hajj and the residents of Makkah. The sample was composed of 459 diabetic patients, typed questionnaires were administered with an interview, electronic and verbal interview was conducted on 104 patients (50 patients in holy place Al-Mashaeer adjacent to Makkah and 40 in the hospital), while the electronic one was conducted on 355 diabetics residing in Makah. Results and Conclusion: About 94% of participants of the study "Sample Makkah" store their insulin in a cool place, while 6% of them don't. 37.7% of participants of the study "Sample Makkah" have mobile cooling box, while 62.3% are without any facility for storage. 49.4% of participants of the study "Sample Makkah" check blood sugar before taking the dose of insulin, while 50.4% of them don't. There are no differences between Makkah and Hajjaj pilgrims regarding storage of insulin, following healthy diet and awareness about the symptoms of low blood sugar. While, there is a difference in knowledge to deal with low blood sugar symptoms between diabetic patients of Makkah and Hajjaj pilgrims. Also there is no suitable place (refrigerator) for storing insulin and no mobile coolers to suit their move through Al-Mashaeer (holy place). The diabetics don't do blood sugar test regularly. Health care sector should educate pilgrims about the importance of having healthy food and should conduct training sessions for the diabetics to increase awareness about dealing with their chronic diseases, educational leaflets about dealing with low or high blood sugar should be distributed.
Advanced Materials Letters
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Papers by Muazzam Sheriff Maqbul