Multiple sclerose

Multiple sclerose
	instantia de: designated intractable/rare disease[], type de maladias[], symptom or sign[*]
	subclasse de: maladia demyelinisante[], demyelinating disease of central nervous system[], autoimmune disease of central nervous system[*]
	;
	Commons: Multiple sclerosis

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Multiple sclerose (MS) es un autoimmun maladia neurodegenerative affectante le copertura del cellulas nervose del cerebro e medulla spinal.

Signos e symptomas

(...)

Causas

MS non es considerate como un maladia hereditari ma plure genetic variationes augmenta le risco de disveloppar lo.^[1]

Genes ligate con MS include human leukocyte antigen (HLA) systema — un gruppo de genes sul chromosoma 6 qui servi como major histocompatibilitate complexo (MHC).^[2] Le cambios in HLA region pote alsi esser implicate in the disveloppamento de altere disordines autoimmun, como diabete de typo I o lupo erythematose systemic.^[3] Le association le plus consistente concerna allelos DR15 e DQ6 del MHC.^[2] Foras HLA locos, al minus 200 variantes pote augmentar un pauc le probabilitate de MS.^[4]

Un genetic variante locate inter genes DYSF e ZNF638 permitterea un progression plus rapide del maladia.^[5]^[6]

Referentias

↑ “Genetics of multiple sclerosis” (1 de februario 2004). The Lancet. Neurology 3 (2): 104–10. doi:10.1016/S1474-4422(03)00663-X. PMID: 14747002.
1 2 “Multiple sclerosis” (1 de octobre 2008). Lancet 372 (9648): 1502–1517. doi:10.1016/S0140-6736(08)61620-7. PMID: 18970977.
↑ “Revealing the genetic basis of multiple sclerosis: are we there yet?” (1 de junio 2011). Current Opinion in Genetics & Development 21 (3): 317–24. doi:10.1016/j.gde.2010.12.006. PMID: 21247752.
↑ International Multiple Sclerosis Genetics Consortium (2019). “Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.”. Science 365 (6460). doi:10.1126/science.aav7188. PMID: 31604244.
↑ https://neurosciencenews.com/genetics-progressive-ms-23546/
↑ doi:10.1038/s41586-023-06250-x

[pmid14747002-1] “Genetics of multiple sclerosis” (1 de februario 2004). The Lancet. Neurology 3 (2): 104–10. doi:10.1016/S1474-4422(03)00663-X. PMID: 14747002.

[pmid18970977-2] 1 2 “Multiple sclerosis” (1 de octobre 2008). Lancet 372 (9648): 1502–1517. doi:10.1016/S0140-6736(08)61620-7. PMID: 18970977.

[pmid21247752-3] “Revealing the genetic basis of multiple sclerosis: are we there yet?” (1 de junio 2011). Current Opinion in Genetics & Development 21 (3): 317–24. doi:10.1016/j.gde.2010.12.006. PMID: 21247752.

[pmid31604244-4] International Multiple Sclerosis Genetics Consortium (2019). “Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.”. Science 365 (6460). doi:10.1126/science.aav7188. PMID: 31604244.

[5] ttps://https://neurosciencenews.com/genetics-progressive-ms-23546/

[6] :10.1038/s41586-023-06250-x

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