Papers by Najmosama Nikrui
Obstetrical & Gynecological Survey, 1982
The present study analyzes the anatomical, pathological, and clinical elements in 62 cases of low... more The present study analyzes the anatomical, pathological, and clinical elements in 62 cases of low potential malignancy of the ovary (25 mutinous, 36 serous, and 1 endometrioid) from the Massachusetts General Hospital record room files from 1962 to 1979. Twentytwo serous tumors were stage I, six were stage 11, four were stage III, and four were recurrent. Among mutinous tumors twenty-one were stage I, one was stage III, one was stage IV, and two were recurrent. Four patients had ascites; one patient's tumor was ruptured at surgery. The majority of cases were in stage I. The average age was 54.5 years. Thirty-seven percent of the cases were nulligravida. An abdominal mass was the most frequent finding and increased abdominal girth was the most frequent symptom. All of the patients were treated by excision of the tumor with or without hysterectomy. Chemotherapy followed surgery in 16 patients and radiation was used in 10 cases following surgery. Only 1 patient with early disease died of tumor. Five-year survival was 91.4% among serous and 80.7% among mutinous. Ten-year survival was 83.2% for serous and 73.4% mutinous.
Zeitschrift für mikroskopisch-anatomische Forschung, 1969
Obstetrical & Gynecological Survey, 1974
Gynecologic Oncology, 1997
Critical Care Medicine, 2019
Learning Objectives: Burnout syndrome (BOS) is a substantial barrier to the maintenance of well-b... more Learning Objectives: Burnout syndrome (BOS) is a substantial barrier to the maintenance of well-being among critical care clinicians and can impair the provision of high-quality patient care. Limited data exist evaluating: 1) the incidence of BOS within North Carolina, South Carolina, Virginia, and West Virginia, 2) the significance of BOS in critical care clinicians, and 3) supportive infrastructure to prevent and/or help manage BOS. This study aims to assess the incidence, associations, and resources available to support clinicians experiencing BOS. Methods: All chapter members were invited to complete an anonymous, cross-sectional survey. The survey had 3 sections: demographics, the Mini Z burnout survey, and supportive infrastructure. Results: The survey was completed by 100 respondents, representing 35% of the chapter’s members. Physicians (39%), advanced practice providers ((APP) 25%), and pharmacists (21%) accounted for 85% responses, with 57% of respondents practicing in non...
JNCI: Journal of the National Cancer Institute, 1984
By means of a radioimmunoassay, which utilized [125I]-epiglycanin and anti-epiglycanin antiserum ... more By means of a radioimmunoassay, which utilized [125I]-epiglycanin and anti-epiglycanin antiserum induced in rabbits by injections of viable TA3-Ha ascites cells with Freund's complete adjuvant, picogram quantities of epiglycanin could be detected. Anti-epiglycanin antiserum was similarly produced in allogeneic mice. Unlabeled epiglycanin lost the capacity to compete with [125I]epiglycanin in the radioimmunoassay as a result of periodate oxidation or incubation with endo-alpha-N-acetyl-D-galactosaminidase (Diplococcus pneumoniae), an enzyme found to cleave only the disaccharide beta-D-galactopyranosyl-(1----3)-2-acetamido-2-deoxy-D-galactose chain from serine or threonine residues in epiglycanin. Glycosylhydrolases known to cleave alpha-D-mannose, beta-D-galactose (1,4-linked), beta-N-acetyl-D-glucosamine, and alpha-N-acetyl-D-galactosamine did not reduce the activity of epiglycanin. Neuraminidase enhanced the activity twofold to fivefold. The finding that little or no activity was demonstrated by the disaccharide, the reduced disaccharide, or other glycoproteins containing the same disaccharide chain suggested that the antigenic determinant probably involved the disaccharide and a unique amino acid sequence at the site of its attachment. By means of the radioimmunoassay epiglycanin cross-reactive antigens were detected in the peritoneal or pleural fluid and in the sera of patients with metastatic cancer. Lower concentrations of epiglycanin-like antigen(s) were found in the peritoneal fluid of patients with hepatitis or liver cirrhosis but not in normal serum.
Journal of Urology, 1985
We report on a 56-year-old woman with extensive condyloma acuminatum of the external genitalia an... more We report on a 56-year-old woman with extensive condyloma acuminatum of the external genitalia and vagina, with spread to and diffuse involvement of the urethra, bladder and distal ureters. A chronic course, failure to respond to conservative measures and evidence of malignant transformation led to radical surgical treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research, 1999
A Phase I study of paclitaxel and doxorubicin administered as concurrent 96-h continuous i.v. inf... more A Phase I study of paclitaxel and doxorubicin administered as concurrent 96-h continuous i.v. infusion was performed to determine the maximum tolerated dose (MTD), principal toxicities, and pharmacokinetics of this combination in women with relapsed epithelial ovarian cancer. The paclitaxel dose was fixed at 100 mg/m2 (25 mg/m2/day for 4 days). The dose of doxorubicin was escalated from 30 mg/m2 (7.5 mg/m2/day for 4 days) in increments of 10 mg/m2 until dose-limiting toxicity was observed. All patients received granulocyte colony-stimulating factor 5 microg/kg/day prophylactically. Apparent steady-state plasma levels of both drugs were determined in the final cohort of patients treated at the MTD. A total of 17 patients received 52 cycles of therapy. The median age was 58 years, and all patients had previously received one to five different regimens (median, 2) of chemotherapy, including both platinum and paclitaxel. The treatment was tolerated well, with grade 1-2 nausea being the ...
Acta cytologica
Endometrial papillary serous carcinoma (EPSC) is an uncommon variant of endometrial carcinoma tha... more Endometrial papillary serous carcinoma (EPSC) is an uncommon variant of endometrial carcinoma that histologically resembles ovarian serous carcinoma and has an aggressive clinical course. The cytomorphologic features of 17 patients with histologically confirmed EPSC of the endometrium were reviewed and compared with those of 20 patients with histologically typical endometrial adenocarcinoma (TEC). Preoperative cervicovaginal Papanicolaou smear results were available from 14 of the 17 patients with EPSC; 10 (71%) were positive, 1 (7%) was suspicious and 3 (21%) were negative for malignancy. Initial cervicovaginal smear results were available from all 20 patients with TEC; 7 (35%) were positive, 4 (20%) were atypical or suspicious and 9 (45%) were negative for malignancy. Twelve patients with EPSC had peritoneal washings or fluids examined; seven were positive and five negative. Twelve patients with TEC had peritoneal washings or fluids examined; two (17%) were positive and ten (83%) ...
Radiotherapy and Oncology, 1984
New England Journal of Medicine, 1985
Medical Progress from The New England Journal of Medicine Common Epithelial Cancer of the Ovary.
The Journal of Immunology, 2000
Journal of Clinical Ultrasound, 1979
A retrospective comparison between ultrasound and subsequent laparoscopy was made in 70 female pa... more A retrospective comparison between ultrasound and subsequent laparoscopy was made in 70 female patients to evaluate the sonographic features of minimal pelvic disease (in particular, adnexal thickening). The overall accuracy of sonography as compared with laparoscopy was 75 percent (53 of 70), with a true positive rate of 72 percent (40 of 51) and a true negative rate of 68 percent (13 of 19). In this study the concept of clinical or sonographic adnexal thickening did not correlate with observations at laparoscopy. Of the 7 patients diagnosed by ultrasound as having adnexal thickening, only 1 had pelvic inflammatory disease, whereas the other 6 showed no abnormalities at laparoscopy.
International Journal of Gynecology & Obstetrics, 1995
Gynecologic Oncology, 1986
Gynecologic Oncology, 1981
The present study analyzes the anatomical, pathological, and clinical elements in 62 cases of low... more The present study analyzes the anatomical, pathological, and clinical elements in 62 cases of low potential malignancy of the ovary (25 mutinous, 36 serous, and 1 endometrioid) from the Massachusetts General Hospital record room files from 1962 to 1979. Twentytwo serous tumors were stage I, six were stage 11, four were stage III, and four were recurrent. Among mutinous tumors twenty-one were stage I, one was stage III, one was stage IV, and two were recurrent. Four patients had ascites; one patient's tumor was ruptured at surgery. The majority of cases were in stage I. The average age was 54.5 years. Thirty-seven percent of the cases were nulligravida. An abdominal mass was the most frequent finding and increased abdominal girth was the most frequent symptom. All of the patients were treated by excision of the tumor with or without hysterectomy. Chemotherapy followed surgery in 16 patients and radiation was used in 10 cases following surgery. Only 1 patient with early disease died of tumor. Five-year survival was 91.4% among serous and 80.7% among mutinous. Ten-year survival was 83.2% for serous and 73.4% mutinous.
Gynecologic Oncology, 1996
Postsurgical therapy for advanced endometrial carcinoma The records of 86 pathologic stage III en... more Postsurgical therapy for advanced endometrial carcinoma The records of 86 pathologic stage III endometrial carcinoma has evolved over the past several decades. In the 1960s and patients treated at Massachusetts General Hospital between 1974 1970s, preoperative radiation therapy with 40-50 Gy was and 1992 were retrospectively reviewed to identify predictors of believed to reduce tumor cell implantation [3]. This approach poor outcome and to determine the effect of postsurgical therapy overtreated some patients with minimal disease and interon recurrence and survival. Patients underwent TAH/BSO with fered with interpretation of the extent of myometrial invasion selective lymphadenectomy and peritoneal washings. Cases prior [4, 5]. In the 1970s and 1980s, low-dose (10-20 Gy) preopto 1988 were retrospectively restaged using the FIGO surgical erative radiotherapy with individualized postoperative therstaging criteria. Postoperatively, patients received individualized apy was also reconsidered because surgical-pathologic studregimens of EBRT (external beam radiotherapy), brachytherapy, ies demonstrated a more complete understanding of disease and cytotoxic or hormonal chemotherapy. The 5-year survival and progression. These investigations identified high-risk prog-5-year disease-free survival (DFS) for all patients were 54 and 44%, respectively. Forty-two percent of stage IIIA/B patients recurred in nostic factors that could more reliably predict disease proa median time of 14 months. Fifty-four percent of stage IIIC gression and direct postsurgical therapy [6-9]. In 1988, the patients recurred in a median time of 16 months. Of patients who clinical staging system was abandoned in favor of the FIGO recurred, 90% stage IIIA/B and 71% stage IIIC patients recurred surgical staging system [10]. at extrapelvic sites. Age greater than 70, high-grade lesions, and
Gynecologic Oncology, 1993
Gynecologic Oncology, 1996
Between 1982 and 1992, 24 women with Stage III clear cell ovarian cancer were identified from the... more Between 1982 and 1992, 24 women with Stage III clear cell ovarian cancer were identified from the tumor registry. Thirty-four women with Stage III papillary serous tumors treated between 1987 and 1989 were used as a comparison. All patients underwent cytoreductive surgery followed by conventional platinum-based chemotherapy. In the women with clear cell histology, nine (37.5%) had endometriosis in the surgical specimen compared with one (3%) in the papillary serous group (P = 0.002). Ten women (42%) with clear cell histology experienced a thromboembolic event during the course of treatment, compared to six (18%) in the papillary serous group (P = 0.05). In the group with clear cell histology, overall, 70% of women had progressive disease. Fifty-two percent experienced clinical progression while receiving platinum-based chemotherapy. In addition, four patients were found to have progressive disease at second-look laparotomy. Only two patients had a pathologic complete response. In the group with papillary serous histology, 29% overall had progressive disease while on chemotherapy (P = 0.005). The median survival for the women with clear cell histology was 12 months compared to 22 months for those with papillary serous (P = 0.02). For women with clear cell histology, univariate analysis was used to evaluate prognostic factors. Age less than 50 was a poor prognostic factor (P = 0.045). The presence of endometriosis, thromboembolic event, or optimal cytoreduction were not prognostic factors (P = 0.67, P = 0.34, P = 0.39). Patients with advanced clear cell ovarian cancer have a poor response to conventional platinum-based chemotherapy and overall prognosis is poor.
Uploads
Papers by Najmosama Nikrui