Papers by merve sibel güngören
Journal of Hepatology, 2014
≥F3 and 0.98, 0.79 and 0.78 for F4. For TE diagnostic performances were higher compared with thos... more ≥F3 and 0.98, 0.79 and 0.78 for F4. For TE diagnostic performances were higher compared with those of APRI (P = 0.006) and FIB-4 (P = 0.004) with optimal cutoff values at 7.5, 8.3 and 9 kPa for the diagnosis of F2, F3 and F4 respectively. Conclusions: In West-Africa, TE, APRI and FIB-4 are reliable for detection of fibrosis/cirrhosis in HBV-infected patients, TE having the best performances with slightly different cutoffs compared to Western studies.
Clinical Chemistry and Laboratory Medicine (CCLM)
Total testing process in a clinical laboratory is designed to produce useful information for pati... more Total testing process in a clinical laboratory is designed to produce useful information for patients and clinicians. The changing landscape of healthcare industry forces clinical laboratory leaders to meet the needs of their stakeholders, maximize operational efficiency and improve overall quality of patient care at the same time. The increasing number of data produced force healthcare services industry to digital transformation. Digital transformation is a process of change which includes finding solutions to novel and unmet requirements of an industry by integrating information, computing, communication and connectivity technologies to minimize the number of low-value tasks and focus on high-value tasks. As the process of digital transformation includes not only the modernization of IT infrastructure but also a paradigm shift in perception of value creation and delivery to improve the quality and cost-effectiveness of laboratory operations in the long run, financial, managerial, ...
Hacettepe Tıp Dergisi, 2007
Journal of Laboratory and Precision Medicine, 2018
Background: Although, liver biopsy is currently the gold standard tool for monitoring fibrosis pr... more Background: Although, liver biopsy is currently the gold standard tool for monitoring fibrosis progression, it is an invasive method and associate with some minor and major complications. Several non-invasive markers have been developed for assessment of liver fibrosis, but their validity has not been well studied in autoimmune hepatitis (AIH). The enhanced liver fibrosis (ELF) test is an alternative, non-invasive method for monitoring fibrosis progression. In this study, we evaluated performance of ELF test for predicting fibrosis stage in patients with AIH. Methods: Serum samples of 46 consecutive patients who were diagnosed with AIH were analyzed, and calculated for ELF scores. All patients underwent a liver biopsy. Patients with ≥F2 were considered to have a significant fibrosis according to the METAVIR scoring system. Diagnostic accuracy of ELF was evaluated with the receiver operator characteristic (ROC) curves analysis. Results: The mean ELF scores were significantly higher in patients with significant fibrosis that those with mild fibrosis (10.60±1.39 vs. 8.62±1.05, P<0.001). For significant fibrosis (≥F2), 8.84 cutoff point had 0.92 sensitivity, 0.78 specificity, 0.94 negative predictive values (NPV), 0.70 positive predictive values (PPV) and area under curve (AUC) was 0.89. Conclusions: The ELF test differentiates significant from non-significant liver fibrosis. Our results suggest that the ELF test can be a promising non-invasive method for monitoring fibrosis progression in AIH.
Turkish journal of medical sciences, 2021
BACKGROUND/AIM This study aimed to analyze the serum melatonin levels and changes in sleep patter... more BACKGROUND/AIM This study aimed to analyze the serum melatonin levels and changes in sleep patterns in pediatric patients with coronavirus disease 2019 (COVID-19). MATERIALS AND METHODS This study was designed as a descriptive, cross-sectional study. Serum melatonin levels and sleep parameters of children with the diagnosis of COVID-19 who had mild and moderate disease (i.e., COVID-19 group) were compared with those of children admitted with non-COVID-19 non-specific upper respiratory tract infection (i.e., control group). The Sleep Disturbance Scale for Children (SDSC) questionnaire was applied to the participants' primary caregivers to analyze their sleep patterns at present and six months before symptom onset and to investigate the impact of COVID-19 on sleep patterns. RESULTS The entire study cohort consisted of 106 patients. The COVID-19 group included 80 patients, while the control group consisted of 26 patients. The mean serum melatonin levels were 136.72 pg/mL and 172.63...
Bulgular: HbA2>%3,5 olan 668, %3,5<HbA2<%4 olan 19 sonuç saptanmıştır.19 sonuçtan 10’u b... more Bulgular: HbA2>%3,5 olan 668, %3,5<HbA2<%4 olan 19 sonuç saptanmıştır.19 sonuçtan 10’u betatalasemi minör olarak kabul edilmiştir. HbA2 ≥%4 olan 649 sonuç vardır ve sonculara göre 602 hasta beta-talassemi minör olarak kabul edilmiştir. HbA2 düzeylerine göre, hastaların %25’i beta-talasemi minör olarak değerlendirilmiştir. HbF>%2 olan 391 hasta saptanmış ve HbA2<%3,5 olan 138 kayıt ayrıntılı incelemeye alınmıştır. Varyant analizi veri kümesi, 53 hasta içermektedir. HbA2≤%3,5 ve HbF≤%2 olan, varyant pikleri mevcut kayıtlar incelenmiş ve 28 vaka saptanmıştır. En sık görülen Hb varyantları sırasıyla HbH, HbS, HbD, HbC, HbE ve HbO-Arab’dır.
Our aim was to investigate whether Antimullerian Hormone (AMH), complete blood count (CBC), Homeo... more Our aim was to investigate whether Antimullerian Hormone (AMH), complete blood count (CBC), Homeostasis model assessment (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and weight gain have any diagnostic value for the prediction of cardiovascular disease (CVD) in obese and non-obese pregnant patients. A prospective, case-control study was carried out, including 187 patients (93 obese, and 94 non-obese). CVD risk for each patient was evaluated according to the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA). A multivariate logistic regression model was used to identify the independent risk factors of CVD in obese and non-obese patients. The obese patients had significantly lower levels of AMH when compared to the non-obese ones (p = .002). Insulin, HOMA-IR, HbA1c, and SBP were significantly higher in obese patients than non-obese ones (p < .001, p < .001 and p = .001, respectively). Age, SBP, and d...
Objective: A significant number of women presenting with physical symptoms have mental problems a... more Objective: A significant number of women presenting with physical symptoms have mental problems as the underlying cause of their symptoms. The study aimed to evaluate mental symptoms of women attending a primary health care center and to assess the relationship between mental symptoms and exposure to domestic violence. Method: The study population consisted of female out-patients who visited the selected primary health care center in one of the three consecutive working days with the selection criteria being above 18 years of age and having at least eight years of education. Data of the descriptive study were gathered through Symptom Check List (SCL)-90-R and a questionnaire comprised of questions on sociodemographics and domestic violence exposure. Chi-square, t test and ANOVA were used to analyse data by SPSS 15.0 statistical package programme. Results: The mean age of women (n=268) participating in the study was 33.7±9.9 years and 51.5% were exposed to domestic violence (psycholo...
Hepato-gastroenterology, 2015
The performance of non-invasive fibrosis markers has not been well studied in autoimmune hepatiti... more The performance of non-invasive fibrosis markers has not been well studied in autoimmune hepatitis (AIH). Acoustic radiation force impulse imaging (ARFI) is a non-invasive radiological method for assessment of liver fibrosis. The aim of this study was to evaluate the accuracy of ARFI for fibrosis staging in patients with AIH. AIH patients who undergone for control liver biopsy after at least two years of biochemical remission period were also assessed by ARFI. Liver fibrosis was staged according to the METAVIR scoring system. A total of 15 patients (13 women and 2 men) with mean age of 40.9 (18-59 years) were included in the study. Repeat liver biopsy was performed a mean of 4.9 (3-9 years) after AIH diagnosis. Nine patients had significant fibrosis scores (F ≥ 2) while, remain 6 patients had mild or no fibrosis. The mean (±SD) shear wave velocities for patients with fibrosis stage II-IV was significantly higher than those with fibrosis stage 0-I (2.28 ± 0.68 m/s and 1.20 ± 0.24, re...
Biochemia medica, Feb 15, 2020
IntroductionThis case report is about the importance of sleeping status for analysis of thyroid h... more IntroductionThis case report is about the importance of sleeping status for analysis of thyroid hormone stimulating hormone (TSH) and prolactin (PRL) which arose from discordant results of a patient who was referred for serum TSH and PRL testing within 12-hour period after an intercontinental flight.Case descriptionAn adult male patient was admitted to our laboratory for serum TSH and PRL tests and came back questioning the accuracy of his previous results.Further investigationsA new analysis with a new sample was offered. His new results were not consistent with his previous results.What happenedIt was revealed that the night before the first sampling, he travelled back to Turkey from The United States of America and came to testing within 12 hours after the arrival.DiscussionSleeping status is one of the factors that can affect laboratory results. Intercontinental flights causing jet-lag can alter the secretions of TSH and PRL which are predominantly modulated by thyrotropin-releasing hormone (TRH).Main lessonTravel history and sleeping status are important factors to be evaluated prior sampling for hormone analysis. Patients must be informed about the importance of sampling timing.
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Papers by merve sibel güngören