... The Authors. Fikret Okutucu, Solar Energy Institute, EGE University, Bornova, Turkey.Ahmet Ko... more ... The Authors. Fikret Okutucu, Solar Energy Institute, EGE University, Bornova, Turkey.Ahmet Kochan, Faculty of Architecture and Engineering, Çukurova University, Adana, Turkey. ... Turan, M., Ecevit, A., Gürdil, FI, Mutaf, G. (1981), Güneş Evi. ...
Primary leiomyosarcoma of bone is a rare aggressive tumor that occurs mainly in older people. It ... more Primary leiomyosarcoma of bone is a rare aggressive tumor that occurs mainly in older people. It resembles other malignancies clinically and radiologically, and differential diagnosis is based on histopathology, including immunohistochemistry. If leiomyosarcoma is found in bone, the possibility that it is a metastasis from a distant tumor should be investigated. The treatment is surgical excision with wide margins. Here we present three patients who had primary leiomyosarcoma of radius, ilium, and femur, respectively, and who were treated surgically.
The case describes successful distal tibial resection, fibular autograft, and ankle arthrodesis i... more The case describes successful distal tibial resection, fibular autograft, and ankle arthrodesis in two patients who had giant cell tumor in the distal tibia. At long-term followup, the patients had no pain and no limitation in daily or low-impact recreational activities. In conclusion, due to the large resection that is often necessary for aggressive tumors, fibular autograft and ankle arthrodesis may be a useful method in the distal tibia.
Primary malignant lymphoma of bone (PLB) is an uncommon tumour. A survey of 278 primary malignant... more Primary malignant lymphoma of bone (PLB) is an uncommon tumour. A survey of 278 primary malignant cases in our clinic showed that 20 cases of PLB were registered between 1986 and 1997. Fourteen of the 20 cases underwent surgical excision. The mean follow-up time was 36.3 months. The rate of response to treatment was 65% with a rate of complete recovery of 55%. The clinical stage of tumours correlated well with the prognosis. Our results seem worse than most of the series in the literature. A high proportion of stage IV disease and pathological fractures at presentation may be a factor. Le lymphosarcome primaire de l'os est une tumeur rare. Parmi 278 cas de tumeurs malignes primitives traitées entre 1986 et 1997 nous avons 20 cas de lymphosarcome. Quatorze des 20 sujets ont été operés. La durée mediane de suivi était 36.3 mois. Le pourcentage de réponse était 65% avec un pourcentage de réponse complete de 55%. Le stade clinique des tumeurs était bien corrélé avec le pronostic. Nos résultats sont inférieurs à ceux de la littérature, peut-être à cause de la haute incidence des fractures pathologiques et des stades IV de la maladie.
A retrospective assessment was performed on 196 tumors of the foot and ankle [out of 1786 bone an... more A retrospective assessment was performed on 196 tumors of the foot and ankle [out of 1786 bone and soft tissue tumor cases, (10.9%)] between March 1986 and March 1996 in the Ankara University Department of Orthopedics and Traumatology Tumor Section. Mean age was 28 years (range 3 to 75 years). Of the 196 foot and ankle tumor cases, 171 (87.2%) were benign, and 25 (12.8%) were malignant. One hundred ninety-four (98.9%) were primary tumors and 2 (1.1%) were metastatic tumors. One hundred thirty-six (69.4%) originated from bone, whereas 60 (30.6%) originated from soft tissue. The most frequent foot and ankle tumors were osteosarcoma among malignant osseous tumors, squamous cell carcinoma among malignant soft tissue lesions, solitary exostosis among benign osseous tumors, and xanthoma and giant cell tumor among benign soft tissue tumors. Mean follow-up time was 21.3 months (12 to 90 months). One hundred forty (71.4%) of the patients underwent various operations while the remaining 56 (28.6%) were treated conservatively. Of the 140 surgical cases, 13 (9.3%) had a recurrence, 3 (2.1%) died, and 124 (88.6%) had a clinical cure. For most of the patients who required surgery, nonaggressive procedures were sufficient while amputations were required for 14 patients.
We report on a 9-year-old boy who has type II autosomal dominant osteopetrosis associated with a ... more We report on a 9-year-old boy who has type II autosomal dominant osteopetrosis associated with a chronic grade II slipped capital femoral epiphysis. He was treated with a single cannulated screw. This rare association has been reported only once.
Osteochondromas represent the most common primary bone tumours ; they reportedly represent 20-50%... more Osteochondromas represent the most common primary bone tumours ; they reportedly represent 20-50% of all benign bone tumours and 10-15% of all bone tumours. Malignant transformation is their most severe complication. However, deformities and interference with major joint function are the most frequent complaints in patients with hereditary multiple osteochondroma. Treatment should therefore aim not only at surgical resection of the masses but also at prevention of deformities. This article reports observations made on 69 patients with hereditary multiple osteochondroma and 313 patients with solitary osteochondroma, with a mean follow-up of 13.4 years.
Squamous cell carcinoma (SCC) is a rare but well-documented complication of chronic osteomyelitis... more Squamous cell carcinoma (SCC) is a rare but well-documented complication of chronic osteomyelitis. Between February 1991 and March 1999, 13 cases (12 men and one woman) of SCC arising in chronic osteomyelitis were diagnosed and treated in our clinic. Mean age was 56.5 (38–70) years. Twelve patients underwent amputation and one underwent limb salvage. Average follow-up was 56 (24–121) months. Among the 13 patients two died of the disease. Treatment of choice for these tumours has been amputation. Carcinome cellulaire squameux est une complication d'ostéomyélite, peu fréquente, mais bien connue. Entre le février 91–mars 99, dans notre clinique, nous ont constate 13 malades (12 hommes et 1 femme) a qui nous ont vu la maladie développe a la base d'ostéomyélite chronique. L'age moyen était 56.5. (38–70) 12 malades ont subi une amputation et dans l'autre l'extrémité a été gardée. La surveillance a duré à peu près 56 (24–121) mois. Parmi ces 13 malades seulement deux sont morts. Pour ces tumeurs on peut dire que l'amputation est la méthode la plus efficace.
Background This study retrospectively reviewed 28 patients who presented with chondroblastoma in ... more Background This study retrospectively reviewed 28 patients who presented with chondroblastoma in our hospital during the period March 1986 to February 2006. We investigated factors associated with local recurrence of the tumors after surgery. Methods We recorded the patients’ sex and age, the location of the pathology, imaging studies (status of growth plate and activity of lesions), histological findings, and treatment outcomes. Results Pain was the presenting symptom in all patients. The tumors were generally located in the epiphyses or apophyses of long bones, especially in the proximal humerus (9 patients), proximal tibia (7 patients), and proximal femur (5 patients). Our preferred treatment method was generally aggressive curettage of the lesion followed by bone grafting. There was local recurrence in six patients. A secondary aneurysmal bone cyst was present in two patients. Conclusion Aggressive curettage and bone grafting resulted in local control in most patients. Tumor recurrence was not statistically associated with age, sex, growth plate status, tumor location, or tumor activity. The only parameter associated with increased local recurrence was previous surgery for chondroblastoma in the same location.
Background Secondary malignancies arising from benign bone tumors are rare. Their recognition and... more Background Secondary malignancies arising from benign bone tumors are rare. Their recognition and diagnosis are difficult, and their slow growth and late recurrence require long-term follow-up. In this study, malignant transformation rates of various histological types of benign cartilage-forming bone tumors in large series were evaluated. Methods Between 1986 and 2004, a retrospective analysis of 627 cartilage-forming benign bone tumors revealed that 32 patients had malignant transformation. Of the 32 patients, 14 had solitary osteochondromas, 10 had multiple osteochondromas, 6 had a solitary enchondroma, 1 had Ollier's disease, and 1 had Maffucci's syndrome. The patient with Ollier's disease had two chondrosarcomas, and one patient with multiple osteochondroma had three chondrosarcomas. The cases were included in the study only when complete clinical documentation, radiological records, and histological analyses were available. Results The rate of malignant transformation for cartilage-originating tumors was 5.1% (solitary osteochondromas 4.2%, multiple osteochondromas 9.2%, solitary enchondromas 4.2%). The average time between the initial diagnosis and malignant transformation was 9.8 years. The most common site of involvement was the proximal portion of the femur. The tumors generally were well differentiated. The mean follow-up period was 57.3 months. Five patients (15.6%) died of tumor recurrence or metastasis at an average of 20.6 months. One patient is alive with tumor at 104 months. Conclusions Cartilage-forming benign bone tumors are rather prone to undergo malignant transformation. Although malignant transformation of a benign bone tumor is a rarely encountered situation, orthopedic surgeons should be cautious while following patients with a benign bone neoplasm. Early recognition and appropriate surgical treatment are required to achieve successful outcomes. The rate of local recurrence in secondary chondrosarcomas depends not only on adequate surgical treatment but also on the localization and histological grade.
The clavicle is a rare site for bone tumors and little is known from the limited literature about... more The clavicle is a rare site for bone tumors and little is known from the limited literature about the prognostic factors and management techniques, including biopsy. The method of biopsy is controversial in the clavicle because of the risk of injury to the neighboring neurovascular structures. Twenty patients with clavicular lesions were retrospectively reviewed with clinical, radiological, and histopathological reports. A needle biopsy was planned in the presence of an osteolytic lesion providing nonforceful entry of the needle, detailed knowledge obtained about the local anatomy, and known availability of an oblique angle for the needle entry away from vascular structures. A needle or tru-cut biopsy was performed for preoperative histopathological diagnosis in 6 selected patients with no complications. Considering the histological diagnosis and prevalence of clavicular bone tumors, benign and malignant lesions had a similar prevalence rate; however, malignant tumors occurred in an older (>50 years) population (P=005). Statistical analysis revealed that the best cutoff point for age for discriminating malignant lesions was 50 years with high sensitivity. The main concern for these patients is primary lesion site treatment and symptom palliation. Every clavicular lesion in patients older than 50 years should be considered as malignant unless proven otherwise. This article demonstrates that needle biopsy can be performed safely in selected lesions with particular attention to cross-sectional local anatomy during needle insertion.
Introduction Osteochondromas are the most common benign tumour of the bone. They occur in two for... more Introduction Osteochondromas are the most common benign tumour of the bone. They occur in two forms as solitary and hereditary multiple form. Osteochondromas are generally located on the metaphysis of the long bones. From 1 to 4% of osteochondromas occur in the spine. Spinal osteochondromas can cause cord and root compression and also be asymptomatic. In the diagnosis of osteochondromas, radiological methods are very important. Purpose of study Because spinal osteochondroma is very rare, other benign and malign tumours should be kept in mind during differential diagnosis. In this paper, six patients with spinal osteochondral lesions were evaluated at our orthopaedic oncology department. Patients Between 1986 and 2009, six patients, four males, two females with an average age of 31.2 (9–65) were diagnosed with spinal osteochondroma at our clinic. Although one patient was diagnosed following another complaint, five patients were suffering from pain. In addition, four patients had swelling and one patient had neurological symptoms. Five patients were treated surgically, and the sixth one was followed conservatively. Discussion The patients with spinal osteochondral lesions applied with mostly pain and swelling at the dorsal of the vertebrae. Because neurological symptoms are rarely seen, radiological examination is of great importance in diagnosis. Conclusions Patients suffering from spinal osteochondroma, due to the risk of secondary chondrosarcoma, must be closely evaluated both clinically and radiologically. If necessary, the patient must be treated surgically following histopathological diagnosis.
Abstract: Objective: In this study, the role of GLUT1 expression in synovial sarcomas and its ass... more Abstract: Objective: In this study, the role of GLUT1 expression in synovial sarcomas and its association with disease pathogenesis were examined. Materials and Methods: Twenty two cases of synovial sarcoma were included in this study. The clinicopathological features of ...
Between 1987 and 1999 we diagnosed and treated 110 patients with osteoid osteoma. Sixty patients ... more Between 1987 and 1999 we diagnosed and treated 110 patients with osteoid osteoma. Sixty patients were younger than 20 years. One hundred and four patients had characteristic pain at night. The mean duration of symptoms before surgery was 16 months. One hundred and four symptomatic patients were treated operatively with either wide resection or curettage. Ninety-one patients had immediate and complete relief of pain. The average follow-up was 2.5 years. Entre 1987 et 1999 nous avons traités 110 malades souffrant d'un ostéome osteoide. 60 malades étaient âgés de moins de 20 ans. 104 malades avaient la douleur nocturne caractéristique. La durée moyenne de symptômes avant la chirurgie était de 16 mois. 104 malades symptomatiques ont été opérés avec résection large ou curetage. 91 malades ont eu un soulagement immédiat et complet des douleurs. La moyenne de suivi était de 2.5 années.
Journal of Bone and Joint Surgery-british Volume, 2001
H ydatid disease of bone is rare. It probably represents between 0.5% and 4% of all human hydatid... more H ydatid disease of bone is rare. It probably represents between 0.5% and 4% of all human hydatid disease and, in about 60% of patients, affects the spine or pelvis. Between 1986 and 1998, we treated 15 cases of bone hydatidosis. Curettage, swabbing with povidone iodine and filling the defect with polymethylmethacrylate (PMMA) were carried out in ten patients. Three of these had a recurrence after five years, but seven had no signs of relapse during a mean follow-up of 52 months. We believe that the combination of antihelminthic therapy, wide resection and the use of PMMA gives the best outcome in the treatment of bone hydatidosis.
We assessed the results of surgical treatment of malignant sacral tumours and aimed to supply inf... more We assessed the results of surgical treatment of malignant sacral tumours and aimed to supply information on incidence and distribution of these lesions. Methods: Forty-six malignant cases out of 65 tumours of the sacrum were assessed retrospectively. Three of the patients did not accept treatment. Surgical treatment was applied to 23 (65.2%) of the remaining 43 patients. Surgical techniques used were resection and PMMA (polymethylmethacrylate) application through a posterior approach, sacral reconstruction, and resection through a combined posterior and anterior approach. Results: Twelve of the lesions were primary while 34 were secondary. Among the primary sacrum tumours, the most common was chordoma (six cases, forming 9.2% of all the sacral lesions). Of a secondary sacral lesions, nine cases of breast carcinoma were found, forming the most common group. The recurrence rate was 23.3%. Conclusions: Chordoma was the most common primary sacral tumour, but found no incidence of giant cell tumour which has been previously reported as the second most common primary sacral tumour. We believe the posterior approach for resection of the tumour is sufficient in most instances and lumbopelvic instability must be prevented by reconstructive procedures.
... The Authors. Fikret Okutucu, Solar Energy Institute, EGE University, Bornova, Turkey.Ahmet Ko... more ... The Authors. Fikret Okutucu, Solar Energy Institute, EGE University, Bornova, Turkey.Ahmet Kochan, Faculty of Architecture and Engineering, Çukurova University, Adana, Turkey. ... Turan, M., Ecevit, A., Gürdil, FI, Mutaf, G. (1981), Güneş Evi. ...
Primary leiomyosarcoma of bone is a rare aggressive tumor that occurs mainly in older people. It ... more Primary leiomyosarcoma of bone is a rare aggressive tumor that occurs mainly in older people. It resembles other malignancies clinically and radiologically, and differential diagnosis is based on histopathology, including immunohistochemistry. If leiomyosarcoma is found in bone, the possibility that it is a metastasis from a distant tumor should be investigated. The treatment is surgical excision with wide margins. Here we present three patients who had primary leiomyosarcoma of radius, ilium, and femur, respectively, and who were treated surgically.
The case describes successful distal tibial resection, fibular autograft, and ankle arthrodesis i... more The case describes successful distal tibial resection, fibular autograft, and ankle arthrodesis in two patients who had giant cell tumor in the distal tibia. At long-term followup, the patients had no pain and no limitation in daily or low-impact recreational activities. In conclusion, due to the large resection that is often necessary for aggressive tumors, fibular autograft and ankle arthrodesis may be a useful method in the distal tibia.
Primary malignant lymphoma of bone (PLB) is an uncommon tumour. A survey of 278 primary malignant... more Primary malignant lymphoma of bone (PLB) is an uncommon tumour. A survey of 278 primary malignant cases in our clinic showed that 20 cases of PLB were registered between 1986 and 1997. Fourteen of the 20 cases underwent surgical excision. The mean follow-up time was 36.3 months. The rate of response to treatment was 65% with a rate of complete recovery of 55%. The clinical stage of tumours correlated well with the prognosis. Our results seem worse than most of the series in the literature. A high proportion of stage IV disease and pathological fractures at presentation may be a factor. Le lymphosarcome primaire de l'os est une tumeur rare. Parmi 278 cas de tumeurs malignes primitives traitées entre 1986 et 1997 nous avons 20 cas de lymphosarcome. Quatorze des 20 sujets ont été operés. La durée mediane de suivi était 36.3 mois. Le pourcentage de réponse était 65% avec un pourcentage de réponse complete de 55%. Le stade clinique des tumeurs était bien corrélé avec le pronostic. Nos résultats sont inférieurs à ceux de la littérature, peut-être à cause de la haute incidence des fractures pathologiques et des stades IV de la maladie.
A retrospective assessment was performed on 196 tumors of the foot and ankle [out of 1786 bone an... more A retrospective assessment was performed on 196 tumors of the foot and ankle [out of 1786 bone and soft tissue tumor cases, (10.9%)] between March 1986 and March 1996 in the Ankara University Department of Orthopedics and Traumatology Tumor Section. Mean age was 28 years (range 3 to 75 years). Of the 196 foot and ankle tumor cases, 171 (87.2%) were benign, and 25 (12.8%) were malignant. One hundred ninety-four (98.9%) were primary tumors and 2 (1.1%) were metastatic tumors. One hundred thirty-six (69.4%) originated from bone, whereas 60 (30.6%) originated from soft tissue. The most frequent foot and ankle tumors were osteosarcoma among malignant osseous tumors, squamous cell carcinoma among malignant soft tissue lesions, solitary exostosis among benign osseous tumors, and xanthoma and giant cell tumor among benign soft tissue tumors. Mean follow-up time was 21.3 months (12 to 90 months). One hundred forty (71.4%) of the patients underwent various operations while the remaining 56 (28.6%) were treated conservatively. Of the 140 surgical cases, 13 (9.3%) had a recurrence, 3 (2.1%) died, and 124 (88.6%) had a clinical cure. For most of the patients who required surgery, nonaggressive procedures were sufficient while amputations were required for 14 patients.
We report on a 9-year-old boy who has type II autosomal dominant osteopetrosis associated with a ... more We report on a 9-year-old boy who has type II autosomal dominant osteopetrosis associated with a chronic grade II slipped capital femoral epiphysis. He was treated with a single cannulated screw. This rare association has been reported only once.
Osteochondromas represent the most common primary bone tumours ; they reportedly represent 20-50%... more Osteochondromas represent the most common primary bone tumours ; they reportedly represent 20-50% of all benign bone tumours and 10-15% of all bone tumours. Malignant transformation is their most severe complication. However, deformities and interference with major joint function are the most frequent complaints in patients with hereditary multiple osteochondroma. Treatment should therefore aim not only at surgical resection of the masses but also at prevention of deformities. This article reports observations made on 69 patients with hereditary multiple osteochondroma and 313 patients with solitary osteochondroma, with a mean follow-up of 13.4 years.
Squamous cell carcinoma (SCC) is a rare but well-documented complication of chronic osteomyelitis... more Squamous cell carcinoma (SCC) is a rare but well-documented complication of chronic osteomyelitis. Between February 1991 and March 1999, 13 cases (12 men and one woman) of SCC arising in chronic osteomyelitis were diagnosed and treated in our clinic. Mean age was 56.5 (38–70) years. Twelve patients underwent amputation and one underwent limb salvage. Average follow-up was 56 (24–121) months. Among the 13 patients two died of the disease. Treatment of choice for these tumours has been amputation. Carcinome cellulaire squameux est une complication d'ostéomyélite, peu fréquente, mais bien connue. Entre le février 91–mars 99, dans notre clinique, nous ont constate 13 malades (12 hommes et 1 femme) a qui nous ont vu la maladie développe a la base d'ostéomyélite chronique. L'age moyen était 56.5. (38–70) 12 malades ont subi une amputation et dans l'autre l'extrémité a été gardée. La surveillance a duré à peu près 56 (24–121) mois. Parmi ces 13 malades seulement deux sont morts. Pour ces tumeurs on peut dire que l'amputation est la méthode la plus efficace.
Background This study retrospectively reviewed 28 patients who presented with chondroblastoma in ... more Background This study retrospectively reviewed 28 patients who presented with chondroblastoma in our hospital during the period March 1986 to February 2006. We investigated factors associated with local recurrence of the tumors after surgery. Methods We recorded the patients’ sex and age, the location of the pathology, imaging studies (status of growth plate and activity of lesions), histological findings, and treatment outcomes. Results Pain was the presenting symptom in all patients. The tumors were generally located in the epiphyses or apophyses of long bones, especially in the proximal humerus (9 patients), proximal tibia (7 patients), and proximal femur (5 patients). Our preferred treatment method was generally aggressive curettage of the lesion followed by bone grafting. There was local recurrence in six patients. A secondary aneurysmal bone cyst was present in two patients. Conclusion Aggressive curettage and bone grafting resulted in local control in most patients. Tumor recurrence was not statistically associated with age, sex, growth plate status, tumor location, or tumor activity. The only parameter associated with increased local recurrence was previous surgery for chondroblastoma in the same location.
Background Secondary malignancies arising from benign bone tumors are rare. Their recognition and... more Background Secondary malignancies arising from benign bone tumors are rare. Their recognition and diagnosis are difficult, and their slow growth and late recurrence require long-term follow-up. In this study, malignant transformation rates of various histological types of benign cartilage-forming bone tumors in large series were evaluated. Methods Between 1986 and 2004, a retrospective analysis of 627 cartilage-forming benign bone tumors revealed that 32 patients had malignant transformation. Of the 32 patients, 14 had solitary osteochondromas, 10 had multiple osteochondromas, 6 had a solitary enchondroma, 1 had Ollier's disease, and 1 had Maffucci's syndrome. The patient with Ollier's disease had two chondrosarcomas, and one patient with multiple osteochondroma had three chondrosarcomas. The cases were included in the study only when complete clinical documentation, radiological records, and histological analyses were available. Results The rate of malignant transformation for cartilage-originating tumors was 5.1% (solitary osteochondromas 4.2%, multiple osteochondromas 9.2%, solitary enchondromas 4.2%). The average time between the initial diagnosis and malignant transformation was 9.8 years. The most common site of involvement was the proximal portion of the femur. The tumors generally were well differentiated. The mean follow-up period was 57.3 months. Five patients (15.6%) died of tumor recurrence or metastasis at an average of 20.6 months. One patient is alive with tumor at 104 months. Conclusions Cartilage-forming benign bone tumors are rather prone to undergo malignant transformation. Although malignant transformation of a benign bone tumor is a rarely encountered situation, orthopedic surgeons should be cautious while following patients with a benign bone neoplasm. Early recognition and appropriate surgical treatment are required to achieve successful outcomes. The rate of local recurrence in secondary chondrosarcomas depends not only on adequate surgical treatment but also on the localization and histological grade.
The clavicle is a rare site for bone tumors and little is known from the limited literature about... more The clavicle is a rare site for bone tumors and little is known from the limited literature about the prognostic factors and management techniques, including biopsy. The method of biopsy is controversial in the clavicle because of the risk of injury to the neighboring neurovascular structures. Twenty patients with clavicular lesions were retrospectively reviewed with clinical, radiological, and histopathological reports. A needle biopsy was planned in the presence of an osteolytic lesion providing nonforceful entry of the needle, detailed knowledge obtained about the local anatomy, and known availability of an oblique angle for the needle entry away from vascular structures. A needle or tru-cut biopsy was performed for preoperative histopathological diagnosis in 6 selected patients with no complications. Considering the histological diagnosis and prevalence of clavicular bone tumors, benign and malignant lesions had a similar prevalence rate; however, malignant tumors occurred in an older (>50 years) population (P=005). Statistical analysis revealed that the best cutoff point for age for discriminating malignant lesions was 50 years with high sensitivity. The main concern for these patients is primary lesion site treatment and symptom palliation. Every clavicular lesion in patients older than 50 years should be considered as malignant unless proven otherwise. This article demonstrates that needle biopsy can be performed safely in selected lesions with particular attention to cross-sectional local anatomy during needle insertion.
Introduction Osteochondromas are the most common benign tumour of the bone. They occur in two for... more Introduction Osteochondromas are the most common benign tumour of the bone. They occur in two forms as solitary and hereditary multiple form. Osteochondromas are generally located on the metaphysis of the long bones. From 1 to 4% of osteochondromas occur in the spine. Spinal osteochondromas can cause cord and root compression and also be asymptomatic. In the diagnosis of osteochondromas, radiological methods are very important. Purpose of study Because spinal osteochondroma is very rare, other benign and malign tumours should be kept in mind during differential diagnosis. In this paper, six patients with spinal osteochondral lesions were evaluated at our orthopaedic oncology department. Patients Between 1986 and 2009, six patients, four males, two females with an average age of 31.2 (9–65) were diagnosed with spinal osteochondroma at our clinic. Although one patient was diagnosed following another complaint, five patients were suffering from pain. In addition, four patients had swelling and one patient had neurological symptoms. Five patients were treated surgically, and the sixth one was followed conservatively. Discussion The patients with spinal osteochondral lesions applied with mostly pain and swelling at the dorsal of the vertebrae. Because neurological symptoms are rarely seen, radiological examination is of great importance in diagnosis. Conclusions Patients suffering from spinal osteochondroma, due to the risk of secondary chondrosarcoma, must be closely evaluated both clinically and radiologically. If necessary, the patient must be treated surgically following histopathological diagnosis.
Abstract: Objective: In this study, the role of GLUT1 expression in synovial sarcomas and its ass... more Abstract: Objective: In this study, the role of GLUT1 expression in synovial sarcomas and its association with disease pathogenesis were examined. Materials and Methods: Twenty two cases of synovial sarcoma were included in this study. The clinicopathological features of ...
Between 1987 and 1999 we diagnosed and treated 110 patients with osteoid osteoma. Sixty patients ... more Between 1987 and 1999 we diagnosed and treated 110 patients with osteoid osteoma. Sixty patients were younger than 20 years. One hundred and four patients had characteristic pain at night. The mean duration of symptoms before surgery was 16 months. One hundred and four symptomatic patients were treated operatively with either wide resection or curettage. Ninety-one patients had immediate and complete relief of pain. The average follow-up was 2.5 years. Entre 1987 et 1999 nous avons traités 110 malades souffrant d'un ostéome osteoide. 60 malades étaient âgés de moins de 20 ans. 104 malades avaient la douleur nocturne caractéristique. La durée moyenne de symptômes avant la chirurgie était de 16 mois. 104 malades symptomatiques ont été opérés avec résection large ou curetage. 91 malades ont eu un soulagement immédiat et complet des douleurs. La moyenne de suivi était de 2.5 années.
Journal of Bone and Joint Surgery-british Volume, 2001
H ydatid disease of bone is rare. It probably represents between 0.5% and 4% of all human hydatid... more H ydatid disease of bone is rare. It probably represents between 0.5% and 4% of all human hydatid disease and, in about 60% of patients, affects the spine or pelvis. Between 1986 and 1998, we treated 15 cases of bone hydatidosis. Curettage, swabbing with povidone iodine and filling the defect with polymethylmethacrylate (PMMA) were carried out in ten patients. Three of these had a recurrence after five years, but seven had no signs of relapse during a mean follow-up of 52 months. We believe that the combination of antihelminthic therapy, wide resection and the use of PMMA gives the best outcome in the treatment of bone hydatidosis.
We assessed the results of surgical treatment of malignant sacral tumours and aimed to supply inf... more We assessed the results of surgical treatment of malignant sacral tumours and aimed to supply information on incidence and distribution of these lesions. Methods: Forty-six malignant cases out of 65 tumours of the sacrum were assessed retrospectively. Three of the patients did not accept treatment. Surgical treatment was applied to 23 (65.2%) of the remaining 43 patients. Surgical techniques used were resection and PMMA (polymethylmethacrylate) application through a posterior approach, sacral reconstruction, and resection through a combined posterior and anterior approach. Results: Twelve of the lesions were primary while 34 were secondary. Among the primary sacrum tumours, the most common was chordoma (six cases, forming 9.2% of all the sacral lesions). Of a secondary sacral lesions, nine cases of breast carcinoma were found, forming the most common group. The recurrence rate was 23.3%. Conclusions: Chordoma was the most common primary sacral tumour, but found no incidence of giant cell tumour which has been previously reported as the second most common primary sacral tumour. We believe the posterior approach for resection of the tumour is sufficient in most instances and lumbopelvic instability must be prevented by reconstructive procedures.
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Papers by Yusuf Yildiz