Karthikeyan K

Gujarat Institute of Desert Ecology, Environmental Monitoring and Assessment Division, Principal Scientist

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Phone: +91-8141276926
Address: Gujarat Institute of Desert Ecology
P.B. No. 83, Mundra Road
Bhuj, Dist: Kachchh, Gujarat - 370001, India.

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Bavi Krishnan

Bharathidasan University

vipin nagda

Sir Padampat Singhania University

V.Krishna Reddy

INTERNATIONAL JOURNAL OF PHARMACY AND BIOLOGICAL SCIENCES G J R Editor-In-Chief, IJPBS

Dr. Sharangouda J. Patil

Indian Council of Agricultural Research (ICAR)

Rani Durgawati University, Jabalpur, Madhya Pradesh, India

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Papers by Karthikeyan K

PRODUCTION, ISOLATION AND STRUCTURAL ELUCIDATION OF A NOVEL ANTIMICROBIAL METABOLITE FROM THE ENDOPHYTIC FUNGUS, PHOMOPSIS/DIAPORTHE THEAE

International Journal of Pharmaceutical Biological Science, 2018

The present study was aimed to isolate endophytic fungi from five different medicinal plants and ... more The present study was aimed to isolate endophytic fungi from five different medicinal plants and to structurally elucidate an antimicrobial compound from Phomopsis theae (asexual synonym of Phomopsis theae (syn. Diaporthe theae), an endophyte is the first and hitherto the only recorded Phomopsis/Diaporthe species isolated from Vitex negundo in Tamilnadu. A total of 77 coelomycetous endophytic fungi were isolated and identified based on spore morphology and the mechanism of spore production. Among 77 endophytic fungi, the isolate, Phomopsis/Diaporthe theae showed excellent antimicrobial activity against all the human pathogens tested. Further, its fermentation conditions were optimized to enhance the antimicrobial metabolites production. Bioassay guided fractionation of crude ethyl acetate extract of Phomopsis/Diaporthe theae led to the isolation of a novel antibacterial and anticandidal compound, which was later identified as pyrimidine imino methylfuran derivative (1). This compound showed pronounced antimicrobial activity against Staphylococcus aureus, Pseudomonas aeroginosa and Candida albicans even at very low concentration (5 µg/mL) and the MIC was found to be 1.25 µg/mL against all the pathogens. Thus, the obtained results convincingly suggest that Phomopsis/Diaporthe theae could be a promising candidate for the discovery of new antibiotics.

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Pervasiveness of endophytic fungal diversity in Anisomeles malabarica from Aliyar, Western Ghats, South India

Mycosphere, 2015

A total of 616 fungal isolates were obtained from 1600 segments of leaves and stems of the medici... more

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Antimicrobial and Antioxidant Potential of Selected Seaweeds from Kodinar, Southern Coast of Saurashtra, Gujarat, India

Journal of Applied Pharmaceutical Science, 2015

The antimicrobial and antioxidant activity was evaluated for the marine seaweeds viz., Enteromorp... more The antimicrobial and antioxidant activity was evaluated for the marine seaweeds viz., Enteromorpha sp. Cystoseria indica, Sargassum swartzii, Gracilaria corticata, Caulerpa taxifolia and Caulerpa racemosa from Kodinar coast, Gujarat. Different solvents viz., methanol, ethanol, chloroform and diethyl ether were used for seaweed extraction to envisage the antibacterial activity against both Gram positive and Gram negative bacteria viz., Escherichia coli, Proteus sp., Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus. Hydrogen peroxide scavenging assay and total antioxidant capacity were determined in ethanol extracted seaweeds. The maximum antibacterial activity was observed in the ethanol extract of all the seaweeds except C. racemosa. Among the seaweeds, the total antioxidant potential was found to be maximum in the ethanol extract of S. swartzii-19.84±0.14 (19.8 mg of Ascorbic acid/g of seaweed extract) and the greatest H2O2 scavenging activity was shown by the ethanol extract of S. swartzii (81.63±0.39 % inhibition) compared to the control (ascorbic acid) 95.24±0.22. Hence, from the present study it is evident that the seaweeds collected from Kodinar coast harbors excellent inhibitory activity against various human pathogens and has significant antioxidant potential as well. In particular, the antimicrobial and antioxidant activity of S. swartzii was found to be excellent and can be pointed out as the best candidate among the other seaweeds tested.

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Distribution of Heavy Metals and Associated Human Health Risk in Mine, Agricultural and Roadside Soil at the Largest Chromite Mine of India

Environmental Geochemistry and Health, 2018

Your article is protected by copyright and all rights are held exclusively by Springer Science+Bu... more Your article is protected by copyright and all rights are held exclusively by Springer Science+Business Media B.V., part of Springer Nature. This e-offprint is for personal use only and shall not be self-archived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com".

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Response of microbial community structure to seasonal fluctuation on soils of Rann of Kachchh, Gujarat, India: Representing microbial dynamics and functional potential.

Ecological Genetics and Genomics, 2018

Study of saline ecosystems often contributes to our perception of extreme environments and divers... more Study of saline ecosystems often contributes to our perception of extreme environments and diverse functional genes accountable for the biogeochemical cycle of the elements. In this study, metagenomic DNA was extracted from saline desert soil of Rann of Kachchh and analyzed to characterize the structural and functional dynamics of microbial community along with seasonal climatic alterations and changes in soil physicochemical properties. The samples differing in salinity gradient with seasonal fluctuation were collected and subjected to metagenome sequencing on Illumina Miseq platform. Transversely, bacteria were dominant as compare to archaea and three phyla of bacteria namely Proteobacteria, Firmicutes and Bacteroidetes accounted for the preponderance of taxa detected. Upon multivariate statistics, the resident microbial community was astonishingly diverse concealing wide diversity of taxa. The community from domain archaea was found to correlate with higher salt concentration and salinity along with electrical conductivity. The metabolic potential for all the seasons displayed a pathway profile representing carbon, nitrogen, methane and sulfur metabolism. Thus, the current study reveals metagenomic potential and possibility of novel microbial interactions for functioning of ecosystem in Rann of Kachchh.

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PRODUCTION, ISOLATION AND STRUCTURAL ELUCIDATION OF A NOVEL ANTIMICROBIAL METABOLITE FROM THE ENDOPHYTIC FUNGUS, PHOMOPSIS/DIAPORTHE THEAE

International Journal of Pharmaceutical Biological Science, 2018

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Pervasiveness of endophytic fungal diversity in Anisomeles malabarica from Aliyar, Western Ghats, South India

Mycosphere, 2015

A total of 616 fungal isolates were obtained from 1600 segments of leaves and stems of the medici... more

Download

Antimicrobial and Antioxidant Potential of Selected Seaweeds from Kodinar, Southern Coast of Saurashtra, Gujarat, India

Journal of Applied Pharmaceutical Science, 2015

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Distribution of Heavy Metals and Associated Human Health Risk in Mine, Agricultural and Roadside Soil at the Largest Chromite Mine of India