Papers by santosh Kumar Vaidya
European Journal of Medicinal Plants, 2020
Aims: Antioxidant and anti-arthritic potential of Casuarina equisetifolia fruit methanolic extrac... more Aims: Antioxidant and anti-arthritic potential of Casuarina equisetifolia fruit methanolic extract. Place: C.U. Shah College of Pharmacy and Research, Wadhwan, Surendranagar, Gujarat, India. Methodology: Extract was subjected to qualitative and quantitative investigation then antioxidant properties of extract was determine by two method namely Nitric Oxide free radical scavenging activity and Reducing power by FeCl3 method. Based on Phytochemical and antioxidant result anti-arthritic activity was performed on wistar rats using Complete Freund’s Adjuvant (CFA) and evaluated different parameter like paw volume, arthritic index, biochemical parameter and hematological parameter. Results: In this study found that the methanolic extract of Casuarina equisetifolia fruit (MLCEF) contain significant percentage of secondary metabolite like poly phenol that properties was proved antioxidant activity. Antioxidant properties was determined by two methods the MLCEF IC50 Value 30.27±2.43 and 158....
Indo American Journal of Pharmaceutical Research, 2015
The present study was carried out to evaluate the antioxidant and antitumor activity of methanoli... more The present study was carried out to evaluate the antioxidant and antitumor activity of methanolic and aqueous extract of leaves of Ipomoea reniformis has (IPR) against Ehrlich ascites carcinoma (EAC) in mice. The antioxidant activity of Alcoholic and Aqueous extract of leaf of Ipomoea reniformis were carried out by DPPH and lipid per oxidation anti-oxidant assay. It is comparatively studied on the basis of EC 50 value with reference to EC 50 value of ascorbic acid. The EC 50 value of standard, Alcoholic and Aqueous extract of Ipomoea reniformis were found 2.278, 2.392, 2.951 and 66.45, 68.11, 100 by DPPH and lipid per oxidation anti-oxidant assay respectively. For the anticancer potential of Ipomoea reniformis chois. (Convolvulaceae) leaves evaluated against Ehrlich Ascites Carcinoma induced cancer in mice. The EAC cells were maintained in Swiss albino mice, by intraperitoneal (i.p.) transplantation in every 9 days. The ascetic fluid was collected by syringe and the tumour cell count was performed in a neubauer chamber (haemocytometer) and 2 x 10 6 cells/per ml was obtained by dilution with normal saline. EAC cells of 9 days old were used for the screening study.72 Swiss albino mice were divided into six groups (n = 12) mentioned food and water ad libitum. All the animals in each groups except Group-I, received EAC cells (2×10 6 cells/mouse i.p.). This was taken as day '0'. Group-I served as normal saline control (5 ml/kg i.p.), Group-II served as EAC control. 24-h after EAC transplantation, Group-III received reference drug 5-FU (20 mg/kg i.p) for nine consecutive days and Group-IV to Group VI received plant extract by oral rout for nine consecutive days respectively. Twenty-four hours of last dose and 18 h of fasting, 6 animals of each group were sacrificed by cervical dislocation to measure antitumor, hematological and biochemical parameters, the rest were kept with food and water adlbitum to check mean survival time and percentage increase in life span of the tumor host and results of hematological, biochemical and antitumor were studied respectively. All the studied parameter reveals the Alcoholic and Aqueous extract of Ipomoea reniformis having potent antioxidant and anticancer potentials.
Current Issues in Pharmacy and Medical Sciences, 2020
Many diseases are associated with oxidative stress are caused by free radicals. Current research ... more Many diseases are associated with oxidative stress are caused by free radicals. Current research has been directed towards finding naturally occurring antioxidants of plant origin. The aim of the present study was to evaluate the in vitro antioxidant activities of methanolic extract of Lawsonia inermis L. bark (MELIB). The present study was carried out for determination of qualitative, quantitative phytochemical and in vitro antioxidant activity for scavenging of free radical DPPH, superoxide radical scavenging and lipid peroxidation. The bark extract is a rich source of secondary metabolites like flavonoids at a rutin equivalent 73.43±0.26%, polyphenol at a gallic acid equivalent 84.70±0.43%, tannins at a tannic acid equivalent 88.75±0.14% and terpenoids at a linalool equivalent 68.13±0.31. MELIB showed free radicals scavenging capacity by way of the DPPH method (6.93±0.51 to 62.63±0.10% inhibition), the superoxide radical scavenging method (1.82±0.41 to 57.11±0.18% inhibition) and...
Summary Hepatoprotective activity of the ethanolic and aqueous extracts of Terminalia belerica Ro... more Summary Hepatoprotective activity of the ethanolic and aqueous extracts of Terminalia belerica Roxb. of the family Combretaceae was studied in Wistar rats using the ethanol-induced liver hepatotoxicty. Ethanol administration resulted in significant elevation of physical parameters (Viz. rat liver weight and liver volume), biochemical parameters like (Viz. serum aspirate transaminase (AST); alanine transminase (ALT); alkaline phasphatase (ALP); direct bilirubin and total bilirubin levels, while albumin and total protein were found to be decreased compared to normal group). Pretreatment with silymarin, ethanolic extract of Terminalia belerica (ALTB) and aqueous extract of Terminalia belerica (AQTB) significantly prevented the physical and biochemical changes induced by these hepatotoxins. Histopathology of liver confirmed our finding as the treatment with the extracts resulted in minor liver cell damage compared to toxic control group. The hepatoprotective effect offered by ALTB (400 ...
Fluoroquinolones is major antibacterial group comprising antimicrobial agent with wide antibacter... more Fluoroquinolones is major antibacterial group comprising antimicrobial agent with wide antibacterial spectrum though differences exist between compounds in their potency against Gram positive and Gram Negative bacteria. Present study was carried out in order to find out current status regarding resistance to seven fluoroquinolones by E.coli, Klebsiella spp. Pseudomonas aeruginosa and Proteus spp. ,recovered from hospitalized patients. The overall result showed resistance to Levofloxacin(75.29%),Gatifloxacin(48.23%),Lomefloxacin(80%),Sparfloxacin(92.94%), Ciprofloxacin (72.94%), Norfloxacin(72.94%), and Ofloxacin(76.47%).
Oromucosal delivery of drugs promotes rapid absorption and high bioavailability, with faster onse... more Oromucosal delivery of drugs promotes rapid absorption and high bioavailability, with faster onset of pharmacological effect. However, many oromucosal delivery systems are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The present work introduces a new tablet system for sublingual administration in which the tablet is based on interactive mixtures of components, consisting of carrier particles partially covered by fine dry particles of the drug, in this case rabeprazole sodium. In the interests of increasing retention of the drug at the site of absorption in the oral cavity, a bioadhesive component was also added to the carrier particles. With this approach, it is possible to obtain rapid dissolution in combination with bioadhesive retention of the drug in the oral cavity. Rabeprazole sodium is an anti-ulcer drug having oral bioavailability 52% due to hepatic first pass metabolism. This work aims to avoid degradation of drug in acidic environment of stomach. In this study, rabeprazole sodium sublingual tablets were prepared by direct compression method using different bioadhesive polymers such as HPMC K4M and chitosan and sodium starch glycolate as a superdisintegrant. The effect of different concentration of polymers and super-disintegrating agents was measured by applying Box-Behnken design. The prepared tablets were evaluated for thickness, weight variation, hardness, friability, disintegration time, wetting time, bioadhesive strength, surface pH, drug content and in vitro drug release. FT-IR spectroscopy study revealed that there was no possible interaction between drug and polymers. Our results show that optimized formulation showed bioadhesive strength 12.34 ± 0.695 gm along with disintegration time 48.45 ± 0.230 seconds and in vitro drug release 95.98% in 10 min.
The present investigation on psychological distress among the residential area in Ahmedabad regar... more The present investigation on psychological distress among the residential area in Ahmedabad regard to taken age group. This research conducted on 200 subjects on the potential moderating role of urban and rural area and the age group in the relation between psychological distresses. Purposive sampling method was used to gather the sample of 200 urban and rural area. In this research, residential area and age taken as independent variables. "2x2 Factoral Design" was used to categorize to the sample in 2 equal parts of 2 independent variables. First independent variable has two levels; Urban and rural. Second variable is age i.e. 20-30 and 40-50 years. The result showed that a global look at the scores of residential area on Kessler Psychological Distress Scale (K10) shows that the significant difference at >0.05 level between the residential area with F-ratio of 48.247, and there is significant difference between the level of Psychological Distress and age with F-ratio of 32.4825 at >0.05 level. Rural societies having low distress feeling in each variables as compared to the urban society. They differ with respect with each other. These two type of area are significantly different on psychological distress scores. There is not significant interaction effect seen between residential area and age in the level of psychological distress therefore they do not differ when the group of age (20-30 and 40-50 years) and the residential area (urban and rural) interacts with each other.
. Aegaeum Journal ( 0776-3808) , 2020
Objectives: The aim of this work was to formulate and evaluate sublingual tablets of Asenapine ma... more Objectives: The aim of this work was to formulate and evaluate sublingual tablets of Asenapine maleate for the treatment of schizophrenia and the treatment of manic episodes associated with bipolar I disorder. Methods: In the present work, the bitter taste of Asenapine maleate was masked by using Kyron T-114 in 1:1.5 ratio. The Drug-Resin Complex was formulated as sublingual tablets using Cross Povidone (X 1) and Avicel PH102 (X 2) by direct compression method. The sublingual tablets were evaluated such as thickness, hardness, % Friability, Wetting time, disintegration time, Water absorption ratio and % CDR.Results: In this study, the fast release of tablets depends on the concentration of Cross Povidone (X 1) and Avicel PH102 (X 2). The selected formulation showed the fastest release of the tablets in 54 s. Stability study was performed by taking an optimized formulation and it was observed stable. The sublingual tablets showed acceptable results in all studies.Conclusion: The results indicate that the formulation can be used for the treatment of schizophrenia and the treatment of manic episodes associated with bipolar I disorder. Moreover, Asenapine maleate as sublingual tablets may overcome the first pass effect, gives better bioavailability, rapid onset of action and patient compliance.
Aegaeum Journal (776-3808) , 2020
The aim of this work was to formulate and evaluate sublingual tablets of Enalapril maleate for ra... more The aim of this work was to formulate and evaluate sublingual tablets of Enalapril maleate for rapid management of Hypertension. In the present work, the metallic taste of Enalapril maleate was masked by using Kyron T-114 in 1:2 ratio. The Drug-Resin Complex was formulated as sublingual tablets using Cross Povidone (X1) and Avicel PH102 (X2) by direct compression method. The sublingual tablets were evaluated such as thickness, hardness, % Friability, Wetting time, disintegration time, Water absorption ratio and % CDR. In this study, the fast release of tablets depends on the concentration of Cross Povidone (X1) and Avicel PH102 (X2). The selected formulation showed the fastest release of the tablets in 45 s. Stability study was performed by taking an optimized formulation and it was observed stable. The sublingual tablets showed acceptable results in all studies. The results indicate that the formulation can be used for rapid management of Hypertension. Also, Enalapril maleate’s bioavailability may be increased by selecting sublingual route of administration.
Aegaeum Journal (0776-3808) , 2020
Lawsonia inermis Linn., is commonly known as Henna, It is cultivated as a hedge plant throughout ... more Lawsonia inermis Linn., is commonly known as Henna, It is cultivated as a hedge plant throughout India and as a commercial crop in certain states of India. Bark is unarmed and grayish brown when young but branches of older trees are spine tipped. It has been used traditionally for treating renal lithiases, jaundice, wound healing; prevent skin inflammation, jaundice, renal calculus, leprosy, obstinate skin diseases and enlargement of the spleen. Present study emphasis on to perform of urolithiatic of activities in rat, at two different dose level 300 and 500 mg/kg, b.w. The result of urolithiatic activity of MELIB biochemical parameter revealed that the Calcium, Oxalate, Phosphate, concentration in urine significantly decreased as compare to the disease control.
Aegaeum Journal (0776-3808) , 2020
The objective of this study was to investigate Antiurolithiatic activity of alcoholic leaf extrac... more The objective of this study was to investigate Antiurolithiatic activity of alcoholic leaf extract of Mallotus philippinensis Lam. against ethylene glycol-induced urolithiasis in Wistar rats. The rats were randomly divided in to five groups of six animals each. Group I served as a normal control and maintained on regular rat food and drinking water ad libitum and received distilled water. All remaining group received calculi inducing treatment for 28 days which comprised of 0.75% v/v ethylene glycol in drinking water ad libitum. Group II which received ethylene glycol only, served as diseases control for 28 days. Group III and IV served as AEMP treatment group and received AEMP at doses of 250 and 500 mg/kg b.w. respectively from 28th day. Group V served as standard, received Cystone 750 mg/kg for 28 days. Various biochemical parameters such as phosphorus, calcium, in urine were observed. Treatment with both doses of AEMP (250 & 500 mg/kg) and Cystone (750 mg/kg) significantly reduced calcium, oxalate and phosphate concentration in urine as compared to disease control animals. The alcoholic leaf extract of Mallotus philippinensis Lam. reduces and inhibits the growth of urinary stones showing its effect as an antiurolithiatic agent.
Antioxidant and antimutagenic Potential of Ipomoea reniformis Roxb. Leaf, Cyclophosphamide induced bone marrow micronucleuses test in mice., 2020
Ipomoea reniformis Roxb. (convolvulaceae) has been used traditionally for treating neuralgia, rhe... more Ipomoea reniformis Roxb. (convolvulaceae) has been used traditionally for treating neuralgia, rheumatism, inflammation, enlargement of liver , kidney diseases, rheumatism, cancerous wounds, migraine, ulcer, abscesses and glandular swelling. Present study determines Antioxidant and antimutagenic potential of the methanolic extracts of Ipomoea reniformis Roxb. leaf. Antioxidant properties of Methanolic extract of Ipomoea reniformis Roxb. Leaf (MLPIR) was performed by two methods DDPH and ferric chloride induced lipid peroxidation method. Antimutagenic was determined by Cyclophosphamide induced bone marrow micronucleuses test in mice, at two different dose level 200 and 400 mg/kg, b.w.The result of antioxidant properties of MLPIR was nearer to the standard (Ascorbic acid), based on antioxidant result antimutagenic activity was performed the when the MLIPR treated animal were compared to the diseases control found significant reduction in MNPCE and MNNCE an P/N ratio.
Key words: Ipomoea reniformis Roxb., Cyclophosphamide, Antimutagenic, Antioxidant, Reactive Oxygen Species
Casuarina equisetifolia Lin. (Casuarinaceae) has been used traditionally for treating inflammatio... more Casuarina equisetifolia Lin. (Casuarinaceae) has been used traditionally for treating inflammation, cancer and other diseases, but its efficacy has not been scientifically examined in treating arthritis. Present study determines antiarthritic potential of the methanolic extracts of Casuarina equisetifolia Lin. bark (MALCE). Antiarthritic activity of Casuarina equisetifolia Lin. bark (MALCE) extracts in Complete Freund's Adjuvant (FCA) Induced arthritis in rat model was appraised at 200 and 400 mg/kg, b.w. doses for 21 days, respectively; Body Weight, Paw Edema, Arthritic Index, Hematological Parameters and Biochemical profile were evaluated Plant extract 200 and 400 mg/kg, b.w. significantly increased Body Weight and significantly decreased in paw Odema and Arthritic Index as compared to the disease control. In Hematological Hb, RBC, WBC and ESR were evaluated extract treated animal result exhibited significantly increasement in Hb, RBC and significantly decresment in WBC and ESR. In evaluation of Biochemical Parameters significant decresment found in evaluation of Urea, AST, ALT and ALP. When Total Protein and Albumin were evaluated not significant change observed. The shade dried Casuarina equisetifolia Lin. bark was powdered to get a course granule. About 300 g of dried powder were extracted with 90% methanol by continuous hot percolation, using soxhlet apparatus. The resulted dark brown extract was concentrated up to 100 ml on Rota vapour under reduced pressure. The concentrated crude extracts were lyophilized in to powder and used for the study [23, 24].
European Journal of Medicinal Plants (2231-0894) , 2020
Aims: Antioxidant and Antimutagenic (Anticlastogenic) activity of alcoholic extract of Bauhinia v... more Aims: Antioxidant and Antimutagenic (Anticlastogenic) activity of alcoholic extract of Bauhinia variegata (Linn.) root. Methodology: Shade dried Bauhinia variegata (Linn.) root, extraction was carryout by isolation extract were subjected to primary and secondary Phytochemical investigation. Then In-vitro antioxidant properties were estimated by reducing power and nitric oxide free radical scavenging method. Based on Phytochemical constituent and antioxidant properties In-vivo Antimutagenic (Anticlastogenic) activity was performed. Results: Preliminary phytochemical investigation revealed the presence of carbohydrates, free Original Research Article Golwala et al.; EJMP, 31(2): 32-39, 2020; Article no.EJMP.55150 33 amino acids, and secondary metabolites like tannins, phenolic compounds and flavonoids, then polyphenol estimation found ALBV contains 86.38% phenolic compounds. In antioxidant properties determination IC50 respectively found 55.27±2.57 µg/ml, 125.52±8.15 µg/ml against of Ascorbic acid and Curcumin. Then In-vivo Antimutagenic (Anticlastogenic) activity ALBV shows significant reeducation in % MNPCE, % MNNCE and P/N ratio at 24 h, 48 h and 72 h against the cyclophosphamide-induced mutagenicity. Conclusion: Therefore, from the present study, it is concluded that alcoholic extract of Bauhinia variegata root (ALBV) can prove to be a very good antioxidant and effective chemopreventive against cyclophosphamide-induced mutagenesis.
Aims: Antioxidant and anti-arthritic potential of Casuarina equisetifolia fruit methanolic extrac... more Aims: Antioxidant and anti-arthritic potential of Casuarina equisetifolia fruit methanolic extract. Methodology: Extract was subjected to qualitative and quantitative investigation then antioxidant properties of extract was determine by two method namely Nitric Oxide free radical scavenging activity and Reducing power by FeCl 3 method. Based on Phytochemical and antioxidant result antiarthritic activity was performed on wistar rats using Complete Freund's Adjuvant (CFA) and evaluated different parameter like paw volume, arthritic index, biochemical parameter and hematological parameter. Results: In this study found that the methanolic extract of Casuarina equisetifolia fruit (MLCEF) contain significant percentage of secondary metabolite like poly phenol that properties was proved antioxidant activity. Antioxidant properties was determined by two methods the MLCEF IC50 Value 30.27±2.43 and 158.45±7.15 was found IC50 value reveled that MLCEF is a potent free radical
Aim: Evaluation of Antioxidant and Anti-Parkinson activity of Portulaca oleracea seed methanolic ... more Aim: Evaluation of Antioxidant and Anti-Parkinson activity of Portulaca oleracea seed methanolic extract. Methodology: Collect plant materials were extracted with methanol. Extract was subjected to qualitative and quantitative investigation and antioxidant properties of extract was determine by Nitric oxide free radical scavenging activity and Reducing power by FeCl 3 method. Anti-Parkinson activity evaluated by two behavioral models namely, haloperidol induced catalepsy, and orofacial dyskinesia both models various behavioral activity/ parameter (catalepsy, vacuous chewing movement and tongue protrusion) were evaluated. Results: Preliminary qualitative phytochemical screening was to reveal presence of polyphenols, flavanoids, glycoside, alkaloids, carbohydrates and reducing sugar etc. Based preliminary Original Research Article stress may be one of the possible mechanisms for the anti-Parkinson effects of Portulaca oleracea seed (MLPO).
Aims: Antioxidant and anti-arthritic potential of Casuarina equisetifolia fruit methanolic extrac... more Aims: Antioxidant and anti-arthritic potential of Casuarina equisetifolia fruit methanolic extract. Methodology: Extract was subjected to qualitative and quantitative investigation then antioxidant properties of extract was determine by two method namely Nitric Oxide free radical scavenging activity and Reducing power by FeCl 3 method. Based on Phytochemical and antioxidant result antiarthritic activity was performed on wistar rats using Complete Freund's Adjuvant (CFA) and evaluated different parameter like paw volume, arthritic index, biochemical parameter and hematological parameter. Results: In this study found that the methanolic extract of Casuarina equisetifolia fruit (MLCEF) contain significant percentage of secondary metabolite like poly phenol that properties was proved antioxidant activity. Antioxidant properties was determined by two methods the MLCEF IC50 Value 30.27±2.43 and 158.45±7.15 was found IC50 value reveled that MLCEF is a potent free radical
Casuarina equisetifolia Lin. (Casuarinaceae) has been used traditionally for treating inflammatio... more Casuarina equisetifolia Lin. (Casuarinaceae) has been used traditionally for treating inflammation, cancer and other diseases, but its efficacy has not been scientifically examined in treating arthritis. Present study determines antiarthritic potential of the methanolic extracts of Casuarina equisetifolia Lin. bark (MALCE). Antiarthritic activity of Casuarina equisetifolia Lin. bark (MALCE) extracts in Complete Freund's Adjuvant (FCA) Induced arthritis in rat model was appraised at 200 and 400 mg/kg, b.w. doses for 21 days, respectively; Body Weight, Paw Edema, Arthritic Index, Hematological Parameters and Biochemical profile were evaluated Plant extract 200 and 400 mg/kg, b.w. significantly increased Body Weight and significantly decreased in paw Odema and Arthritic Index as compared to the disease control. In Hematological Hb, RBC, WBC and ESR were evaluated extract treated animal result exhibited significantly increasement in Hb, RBC and significantly decresment in WBC and ESR. In evaluation of Biochemical Parameters significant decresment found in evaluation of Urea, AST, ALT and ALP. When Total Protein and Albumin were evaluated not significant change observed. The shade dried Casuarina equisetifolia Lin. bark was powdered to get a course granule. About 300 g of dried powder were extracted with 90% methanol by continuous hot percolation, using soxhlet apparatus. The resulted dark brown extract was concentrated up to 100 ml on Rota vapour under reduced pressure. The concentrated crude extracts were lyophilized in to powder and used for the study [23, 24].
Aim: Evaluation of Antioxidant and Anti-Parkinson activity of Portulaca oleracea seed methanolic ... more Aim: Evaluation of Antioxidant and Anti-Parkinson activity of Portulaca oleracea seed methanolic extract. Methodology: Collect plant materials were extracted with methanol. Extract was subjected to qualitative and quantitative investigation and antioxidant properties of extract was determine by Nitric oxide free radical scavenging activity and Reducing power by FeCl 3 method. Anti-Parkinson activity evaluated by two behavioral models namely, haloperidol induced catalepsy, and orofacial dyskinesia both models various behavioral activity/ parameter (catalepsy, vacuous chewing movement and tongue protrusion) were evaluated. Results: Preliminary qualitative phytochemical screening was to reveal presence of polyphenols, flavanoids, glycoside, alkaloids, carbohydrates and reducing sugar etc. Based preliminary Original Research Article stress may be one of the possible mechanisms for the anti-Parkinson effects of Portulaca oleracea seed (MLPO).
AEGAEUM JOURNAL, 2020
Casuarina equisetifolia Lin. (Casuarinaceae) has been used traditionally for treating
inflammatio... more Casuarina equisetifolia Lin. (Casuarinaceae) has been used traditionally for treating
inflammation, cancer and other diseases, but its efficacy has not been scientifically examined in treating
arthritis. Present study determines antiarthritic potential of the methanolic extracts of Casuarina
equisetifolia Lin. bark (MALCE).
Antiarthritic activity of Casuarina equisetifolia Lin. bark (MALCE) extracts in Complete
Freund’s Adjuvant (FCA) Induced arthritis in rat model was appraised at 200 and 400 mg/kg, b.w. doses
for 21 days, respectively; Body Weight, Paw Edema, Arthritic Index, Hematological Parameters and
Biochemical profile were evaluated
Plant extract 200 and 400 mg/kg, b.w. significantly increased Body Weight and significantly
decreased in paw Odema and Arthritic Index as compared to the disease control. In Hematological Hb,
RBC, WBC and ESR were evaluated extract treated animal result exhibited significantly increasement in
Hb, RBC and significantly decresment in WBC and ESR. In evaluation of Biochemical Parameters
significant decresment found in evaluation of Urea, AST, ALT and ALP. When Total Protein and Albumin
were evaluated not significant change observed.
Key words: Complete Freund’s adjuvant, Odema, autoimmune, proinflammatory, TNFα
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Papers by santosh Kumar Vaidya
Key words: Ipomoea reniformis Roxb., Cyclophosphamide, Antimutagenic, Antioxidant, Reactive Oxygen Species
inflammation, cancer and other diseases, but its efficacy has not been scientifically examined in treating
arthritis. Present study determines antiarthritic potential of the methanolic extracts of Casuarina
equisetifolia Lin. bark (MALCE).
Antiarthritic activity of Casuarina equisetifolia Lin. bark (MALCE) extracts in Complete
Freund’s Adjuvant (FCA) Induced arthritis in rat model was appraised at 200 and 400 mg/kg, b.w. doses
for 21 days, respectively; Body Weight, Paw Edema, Arthritic Index, Hematological Parameters and
Biochemical profile were evaluated
Plant extract 200 and 400 mg/kg, b.w. significantly increased Body Weight and significantly
decreased in paw Odema and Arthritic Index as compared to the disease control. In Hematological Hb,
RBC, WBC and ESR were evaluated extract treated animal result exhibited significantly increasement in
Hb, RBC and significantly decresment in WBC and ESR. In evaluation of Biochemical Parameters
significant decresment found in evaluation of Urea, AST, ALT and ALP. When Total Protein and Albumin
were evaluated not significant change observed.
Key words: Complete Freund’s adjuvant, Odema, autoimmune, proinflammatory, TNFα
Key words: Ipomoea reniformis Roxb., Cyclophosphamide, Antimutagenic, Antioxidant, Reactive Oxygen Species
inflammation, cancer and other diseases, but its efficacy has not been scientifically examined in treating
arthritis. Present study determines antiarthritic potential of the methanolic extracts of Casuarina
equisetifolia Lin. bark (MALCE).
Antiarthritic activity of Casuarina equisetifolia Lin. bark (MALCE) extracts in Complete
Freund’s Adjuvant (FCA) Induced arthritis in rat model was appraised at 200 and 400 mg/kg, b.w. doses
for 21 days, respectively; Body Weight, Paw Edema, Arthritic Index, Hematological Parameters and
Biochemical profile were evaluated
Plant extract 200 and 400 mg/kg, b.w. significantly increased Body Weight and significantly
decreased in paw Odema and Arthritic Index as compared to the disease control. In Hematological Hb,
RBC, WBC and ESR were evaluated extract treated animal result exhibited significantly increasement in
Hb, RBC and significantly decresment in WBC and ESR. In evaluation of Biochemical Parameters
significant decresment found in evaluation of Urea, AST, ALT and ALP. When Total Protein and Albumin
were evaluated not significant change observed.
Key words: Complete Freund’s adjuvant, Odema, autoimmune, proinflammatory, TNFα