Diabetes mellitus is a chronic disease that leads to complications including heart disease, strok... more Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes.
In this paper, a novel dual notch bands Ultra Wide-Band (UWB) antenna for WLAN and WiMAX applicat... more In this paper, a novel dual notch bands Ultra Wide-Band (UWB) antenna for WLAN and WiMAX applications is presented. The antenna contains a taper rectangular monopole antenna with new feed line which is designed and modified for 2-12 GHz. To achieve notch band at WLAN frequencies, different methods are compared such as L-shape slots for one notch or dual rings in notch designing. On the other hand, the novel F-shape feed line is designed to achieve dual notch band characteristic. The effects of stubs parameters at notch frequencies are presented. The benefit of this novel feed line is designing multi-band and reconfigurable antenna by changing stub line parameters. The simulated results of prototype antenna are obtained with HFSS and CST. Total size of the antenna is 60 mm × 60 mm × 1.6 mm. It is fabricated on FR-4 low cost substrate and fed by 50 Ω microstrip line.
Diabetes mellitus is a chronic disease that leads to complications including heart disease, strok... more Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes.
In this paper, a novel dual notch bands Ultra Wide-Band (UWB) antenna for WLAN and WiMAX applicat... more In this paper, a novel dual notch bands Ultra Wide-Band (UWB) antenna for WLAN and WiMAX applications is presented. The antenna contains a taper rectangular monopole antenna with new feed line which is designed and modified for 2-12 GHz. To achieve notch band at WLAN frequencies, different methods are compared such as L-shape slots for one notch or dual rings in notch designing. On the other hand, the novel F-shape feed line is designed to achieve dual notch band characteristic. The effects of stubs parameters at notch frequencies are presented. The benefit of this novel feed line is designing multi-band and reconfigurable antenna by changing stub line parameters. The simulated results of prototype antenna are obtained with HFSS and CST. Total size of the antenna is 60 mm × 60 mm × 1.6 mm. It is fabricated on FR-4 low cost substrate and fed by 50 Ω microstrip line.
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Papers by Dr R N Patel