Papers by Renato Nogueira
International Archives of Medicine, 2016
Fibrous dysplasia is a benign and pseudoneoplasic osteopathy with slow progression, characterized... more Fibrous dysplasia is a benign and pseudoneoplasic osteopathy with slow progression, characterized by the replacement of normal bone by an excessive proliferation of fibrous connective tissue cell, interspersed with irregular bone trabeculae. In general, it affects 1 between 4,000 to 10,000 individuals living births. This is a not familiar, congenital disorder, which produces around 2.5% of all bone tumors and more than 7% of all non-malignant bone tumors. This article aims to report a clinical case of monostotic fibrous dysplasia in jaw, proceeding with its surgical correction and to make a review of literature, describing the most important features and the major controversies.
de Freitas 5 1. Residente (R3) da Residência em Cirurgia e Traumatologia Buco-Maxilo-Facial do Ho... more de Freitas 5 1. Residente (R3) da Residência em Cirurgia e Traumatologia Buco-Maxilo-Facial do Hospital Batista Memorial. 2. Professor de CTBMF da FFOE-UFC, Coordenador da Residência em CTBMF do HBM e Doutorando em Cirurgia pela UFC.
Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology, Sep 1, 2020
Revista Eletrônica Acervo Saúde, Oct 23, 2019
Analisar o perfil epidemiológico do câncer infantil na Paraíba. Métodos: A investigação foi reali... more Analisar o perfil epidemiológico do câncer infantil na Paraíba. Métodos: A investigação foi realizada mediante estudo documental, descritivo, transversal, com abordagem quantitativa. A coleta dos dados foi feita a partir das informações disponíveis na internet, no sitio do Instituto Nacional do Câncer. O instrumento utilizado para coleta de dados foi uma ficha contendo tipo de neoplasia, sexo e faixa etária mais acometida. Tais dados foram compilados no Microsoft Excel e sua análise foi efetivada mediante estatística descritiva. Resultados: Os achados indicaram que o tipo de câncer mais incidente nas crianças paraibanas, independente do sexo e com idade acima de um ano, corresponde às leucemias que são classificadas como grupo I; os do sistema nervoso central, grupo III e os linfomas, grupo II, respectivamente. Em relação ao grupo menor de um ano, observou-se que houve uma prevalência maior no sexo feminino nos grupos I, II, V, VI e IX, enquanto que no sexo masculino a maior prevalência foi encontrada no grupo III. Entretanto, é válido ressaltar que em relação ao grupo I, apesar de maior prevalência no sexo feminino, o grupo masculino também possui um valor considerável, com uma pequena diferença entre eles. Conclusão: A incidência dos mais variados tipos de tumores na população pediátrica é diferente em relação à faixa etária e ao sexo, tornando seu perfil epidemiológico bastante diversificado.
Oral Diseases, 2021
ObjectiveThis study aimed to evaluate the presence of human papillomavirus (HPV) and Epstein–Barr... more ObjectiveThis study aimed to evaluate the presence of human papillomavirus (HPV) and Epstein–Barr virus (EBV) and the expression of p53, p16, E‐cadherin, COX‐2, MLH1, and MYC in oral squamous cell carcinoma (OSCC).Materials and MethodsOne hundred OSCC specimens were submitted to in situ hybridization for HPV and EBV, and immunohistochemistry for detection of the human proteins.ResultsThirty‐one cases showed HPV in tumor tissue. EBV was not detected in any case investigated. The HPV(+) group demonstrated an increase of staining scores for nuclear p16 (p = .047), cytoplasmic MYC (p = .002), while a decrease for nuclear MLH1 (p = .048), suggesting that HPV may upregulate the expression of the first two proteins and down‐regulate the latter.ConclusionOur findings reinforce the hypothesis of the HPV‐related oral carcinogenesis involving the expression of p16 and MYC, and MLH1 suppression. Exclusively cytoplasmic stainings for p16, MLH1, and MYC were also associated with more advanced tum...
Brazilian Journal of Health Review, 2020
RESUMO Nos últimos anos diversos estudos têm demonstrado que o Mineral Trióxido Agregado (MTA) al... more RESUMO Nos últimos anos diversos estudos têm demonstrado que o Mineral Trióxido Agregado (MTA) além de ser um material biocompatível, o qual promove um selamento marginal adequado, prevenindo infiltrações, apresenta efeito antimicrobiano e favorece o reparo ósseo. Dessa maneira, tem sido utilizado em várias situações clínicas como no selamento de perfurações radiculares, retrobturações, proteção pulpar direta, pulpotomia, tampão apical em rizogênese incompleta, obturação de canais radiculares, tampão cervical em clareamentos dentários internos, reparo de fraturas radiculares, etc. O objetivo deste trabalho é relatar um caso clínico de paciente portador de dentes com lesões periapicais onde foi realizada apicectomia com utilização do MTA como material retrobturador. Palavra chave: Agregado de trióxido mineral; Endodontia; material endodôntico, cirurgia periapical.
Brazilian Journal of Health Review, 2020
O deslocamento de dentes ou raízes para o interior do seio maxilar é um acidente associado a forç... more O deslocamento de dentes ou raízes para o interior do seio maxilar é um acidente associado a forças excessivas durante movimentos de luxação para uma extração dentária, principalmente quando esta cavidade aérea se encontra em íntimo contato com o elemento dental e está pneumatizada. Complicações podem ocorrer no pós-operatório devido à presença de um corpo estranho no seio maxilar, sendo a sinusite maxilar a mais prevalente. O objetivo deste trabalho é reportar o caso de um terceiro molar superior deslocado para o interior do seio maxilar. Palavras-chave: Seio maxilar. Corpo estranho. Cirurgia.
Palavras-chave: Lesão central de células gigantes. Receptor de corticóide; Receptor de calcitonin... more Palavras-chave: Lesão central de células gigantes. Receptor de corticóide; Receptor de calcitonina. Cox-2. p16. Ciclina D1. Glicocorticóides. Tratamento.
Rev. cir. traumatol. buco-maxilo-fac, 2008
de Freitas 5 1. Residente (R3) da Residência em Cirurgia e Traumatologia Buco-Maxilo-Facial do Ho... more de Freitas 5 1. Residente (R3) da Residência em Cirurgia e Traumatologia Buco-Maxilo-Facial do Hospital Batista Memorial. 2. Professor de CTBMF da FFOE-UFC, Coordenador da Residência em CTBMF do HBM e Doutorando em Cirurgia pela UFC.
Brazilian Oral Research, 2017
The aim of this study was to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and... more The aim of this study was to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in keratocystic odontogenic tumors associated with Gorlin syndrome (SKOTs) and non-syndromic keratocystic odontogenic tumors (NSKOTs), and to establish correlations with the angiogenic index. Seventeen primary NSKOTs, seven recurrent NSKOTs, and 17 SKOTs were selected for the study. The percentage of immunopositive cells for GLUT-1 and GLUT-3 in the epithelial component of the tumors was assessed. The angiogenic index was determined by microvessel count. The results were analyzed statistically using the nonparametric Kruskal-Wallis test and Spearman's correlation test. High epithelial immunoexpression of GLUT-1 was observed in most tumors (p = 0.360). There was a higher frequency of negative cases for GLUT-3 in all groups. The few GLUT-3-positive tumors exhibited low expression of this protein in epithelial cells. No significant difference in the angiogenic index was observed between groups (p = 0.778). GLUT-1 expression did not correlate significantly with the angiogenic index (p > 0.05). The results suggest that the more aggressive biological behavior of SKOTs when compared to NSKOTs may not be related to GLUT-1 or GLUT-3 expression. GLUT-1 may play an important role in glucose uptake by epithelial cells of KOTs and this process is unlikely related to the angiogenic index. GLUT-1 could be a potential target for future development of therapeutic strategies for KOTs.
O queratocisto odontogênico (QO) é um cisto de desenvolvimento, que possui características clínic... more O queratocisto odontogênico (QO) é um cisto de desenvolvimento, que possui características clínico-patológicas peculiares. O seu crescimento, em geral, é lento e assintomático, sendo, portanto, diagnosticado quando provoca extensa osteólise. Geralmente, manifesta-se como uma lesão simples; entretanto, cistos múltiplos também podem ocorrer como parte da manifestação da síndrome do carcinoma nevóide basocelular (SCNB). Relatos freqüentes evidenciam que o comportamento desta lesão cística simula um neoplasma benigno. Este trabalho faz uma revisão literária relacionada ao comportamento biológico do QO, com o objetivo de esclarecer detalhes importantes e singulares que o diferenciam dos demais cistos e tumores odontogênicos tais como a alta ocorrência de recidiva, associação com a SCNB e seu potencial para transformação neoplásica. Descritores: Cistos odontogênicos. Síndrome do nevo basocelular.
International Journal of Oral and Maxillofacial Surgery, Dec 1, 2010
Central giant-cell granulomas are benign, but occasionally aggressive, lesions that traditionally... more Central giant-cell granulomas are benign, but occasionally aggressive, lesions that traditionally have been treated surgically. 21 cases of central giant-cell granuloma of the jaw were treated with intralesional injection of corticosteroids. The treatment protocol adopted was intralesional injection of 20 mg/ml triamcinolone hexacetonide diluted in an anaesthetic solution of 2% lidocaine/ epinephrine 1:200,000 in the proportion 1:1; 1.0 ml of the solution was infiltrated for every 1 cm 3 of radiolucid area of the lesion, totalling 6 biweekly applications. Ten patients had aggressive lesions and 11 nonaggressive. Two patients showed a negative response to the treatment and underwent surgical resection, 4 showed a moderate response and 15 a good response. 8 of the 19 who had a moderate-to-good response to the drug treatment underwent osteoplasty to reestablish facial aesthetics. In these cases, only mature or dysplastic bone was observed, with the presence or absence of rare giant multinucleated cells. The advantages of this therapy are its less-invasive nature, the probable lower cost to the patient, lower risk and the ability to treat the lesion surgically in the future, if necessary.
Archives of Oral Biology, Mar 1, 2012
Odontogenic keratocysts (OKCs), which have been recently reclassified by the World Health Organiz... more Odontogenic keratocysts (OKCs), which have been recently reclassified by the World Health Organization as benign neoplasms, 1 are distinguished from other odontogenic cysts by their aggressive biological behaviour, tendency towards recurrence, and association with nevoid basal cell carcinoma syndrome or Gorlin syndrome. 2,3 OKCs associated with Gorlin syndrome (SOKCs) have been suggested to present a greater growth and infiltration capacity and a higher tendency to recur than non-syndrome OKCs a r c h i v e s o f o r a l b i o l o g y 5 7 (2 0 1 2) 2 3 0-2 3 7 a r t i c l e i n f o Article history:
Journal of Craniofacial Surgery, Mar 1, 2016
Condylar resorption is understood as changes in shape and volume of the condylar bone, due to loc... more Condylar resorption is understood as changes in shape and volume of the condylar bone, due to local, systemic, and iatrogenic factors. The occurrence of condylar resorption after orthognathic surgery can occur when the condylar repositioning in mandibular fossa is performed improperly. In addition, systemic diseases such as osteoarthritis and rheumatoid arthritis seem to influence this process. The aim of this study was to report 3 cases of patients with severe condylar alterations, submitted to orthognathic surgery for treatment of dentofacial deformities. Considerations regarding the diagnosis, surgical planning (counterclockwise rotation), surgical techniques (bilateral sagittal split osteotomy, bimaxillary osteotomies, rigid fixation, maxillomandibular fixation period), and results (short terms) are discussed.
Journal of Craniofacial Surgery, Nov 1, 2017
The thyroglossal duct cyst is the neck congenital abnormality most common in the childhood. Clini... more The thyroglossal duct cyst is the neck congenital abnormality most common in the childhood. Clinically, it shows itself as a solitary neck mass in the region of hyoid bone, it is painless and can be dislocated during de physical examination and tongue protrusion. The most common treatment is its removal through the Sistrunk technique. Patient with diagnosis of thyroglossal duct cyst in neck region with extension to the mouth floor was treated by total surgical removal through intraoral access. The intraoral approach to the treatment of the thyroglossal duct cyst showed itself practicable and permitted the total removal of the lesion with no recurrence signs.
Journal of Craniofacial Surgery, Oct 1, 2015
Dentomaxillofacial Radiology, Sep 1, 2007
The aetiology of Proteus syndrome (PS) is yet unclear. This disease includes partial gigantism of... more The aetiology of Proteus syndrome (PS) is yet unclear. This disease includes partial gigantism of the hands and/or feet, nevi, hemihypertrophy due to overgrowth of long bones, subcutaneous tumours, macrocephaly, cranial hyperostosis, and pulmonary and renal abnormalities. This case report is about a 17-year-old boy with two uncommon findings associated with PS: apnoea-hypopnoea and mandibular retrusion. A multidisciplinary team was important to provide professional care for this patient. Dentists and physicians proposed an adjusted treatment plan. Maxillary disjunction was achieved with a combination of orthodontic treatment and surgical procedure. This represented the initial care for malocclusion treatment and also the preparation for orthognathic surgery. The oral maxillofacial surgeon and the otorhinolaryngologist proposed this approach in an attempt to improve pharynx airflow. The patient has been followed for almost 3 years.
Journal of Oral and Maxillofacial Surgery, Sep 1, 2015
Ameloblastoma treatment can lead to significant bone defects; consequently, oral rehabilitation c... more Ameloblastoma treatment can lead to significant bone defects; consequently, oral rehabilitation can be challenging. We present the case of a 14-year-old girl diagnosed with a conventional ameloblastoma in the mandible who was treated using en bloc resection and rehabilitated with autotransplantation of the immature third molars and orthodontic treatment. The lesion was in the region of the lower left canine and premolars, and en bloc resection resulted in a significant alveolar bone defect. Autotransplantation of the lower third molars to the site of the lower left premolars was performed. After 2 years, the upper left third molar was transplanted to the site of the lower left canine. During the orthodontic treatment period, considerable alveolar bone formation was observed in the region of the transplanted teeth, and roots developed. To the best of our knowledge, this is the first reported case of alveolar bone formation induction caused by tooth transplantation after ameloblastoma treatment.
Revista Brasileira de Cancerologia, Sep 30, 2008
Artigo Original Saúde Bucal em Pacientes Oncológicos Artigo submetido em 5/7/07; aceito para publ... more Artigo Original Saúde Bucal em Pacientes Oncológicos Artigo submetido em 5/7/07; aceito para publicação em 27/12/07 Resumo O câncer configura-se como um grande problema de saúde pública tanto nos países desenvolvidos como nos países em desenvolvimento, e, no Brasil, é a segunda maior causa de morte por doença. A assistência nesta área é uma das mais onerosas, incluindo custos com a prevenção, testes diagnósticos e tratamento. Este trabalho teve como objetivo principal realizar um levantamento clínico-epidemiológico dos pacientes portadores de neoplasias malignas atendidos no Núcleo de Estudos em Pacientes Especiais (NEPE)-Fortaleza/Ceará/Brasil, bem como analisar as principais necessidades de tratamento odontológico desses pacientes no ato do exame clínico inicial. Foram avaliados 412 pacientes, que representaram 20% dos pacientes atendidos pelo NEPE no período avaliado. Quanto ao sexo, 63% dos pacientes eram do sexo masculino e 37% do sexo feminino. A faixa etária de maior prevalência com 162 pacientes (40%) foi a de 41 a 60 anos, sendo os tumores mais comuns as neoplasias de cavidade oral (19%), seguido das neoplasias em região de cabeça e pescoço não-cavidade oral (18%), dos tumores de origem linfóide (12%) e das leucemias (9%). A maioria desses pacientes (78%), ao primeiro exame bucal, necessitava de algum procedimento odontológico, sendo que 44% dos pacientes receberam indicação de procedimentos cirúrgicos, 43% de procedimentos restauradores e 65% de procedimentos periodontais. Concluiu-se, assim, que um número significativo de pacientes, no ato do exame clínico inicial, necessitava de algum tipo de tratamento odontológico de adequação do meio bucal para que pudessem se submeter ao tratamento oncológico indicado.
International Journal of Oral and Maxillofacial Surgery, Mar 1, 2017
Multiple myeloma is a rare bone malignancy. It occurs exclusively at medullary sites, and rarely ... more Multiple myeloma is a rare bone malignancy. It occurs exclusively at medullary sites, and rarely at extramedullary locations. Scientific literature search revealed few case reports describing occurrence of multiple myeloma in the head and neck region as primary manifestation of the disease. However, the occurrence of relapse of multiple myeloma in these sites is exceedingly rare. This poster describes a case of a-56-year old female with past history of multiple myeloma that was treated by chemotherapy and bone marrow transplant and was in remission state. Her chief complaint was numbness of the lower lip of sudden onset. Clinical and radiographic examination was suspicious of possible relapse of multiple myeloma which was subsequently confirmed by bone marrow aspirate and histopathological investigations. This unique case highlights the important role of dental surgeons encountering patients with malignancies. A thorough knowledge of various clinical and radiographic manifestations of these diseases is paramount to help in detecting any occurrence of the disease or its relapse.
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Papers by Renato Nogueira