ACTG2

ACTG2
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Nomenclatura	Outros nomes ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM, actina gamma 2; actina, gamma 2; actina gamma 2, entérica, músculo liso; VSCM1, MMIHS5 ;
Símbolos	ACTG2 (HGNC: 145) ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM, VSCM1, MMIHS5
Identificadores; externos	OMIM: 102545 ; MGI: 104589 ; HomoloGene: 123845 ; EBI: ACTG2 ; GeneCards: Xene ACTG2 ; UniProt: ACTG2 ;
Locus	Cr. 2 p13.1
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Ortólogos
Especies
Humano	Rato
Entrez
72	11468
Ensembl
Véxase HS	Véxase MM
UniProt
P63267	P63268
RefSeq; (ARNm)
NM_001615	NM_009610
RefSeq; (proteína) NCBI
NP_001186822	NP_033740
Localización (UCSC)
Cr. 2:; 73.89 – 73.92 Mb	Cr. 6:; 83.49 – 83.51 Mb
PubMed (Busca)
72 ;	11468

A actina gamma do músculo liso entérico ou actina gamma 2 é unha proteína que nos humanos está codificada no xene ACTG2 do cromosoma 2 humano.^[1]^[2]^[3]

As actinas son proteínas conservadas que interveñen en varios tipos de motilidade celular e no mantemento do citoesqueleto. Nos vertebrados identificáronse tres grupos principais de isoformas da actina: alfa, beta e gamma. As actinas alfa atópanse no tecido muscular e son o principal constituínte do aparato contráctil. As actinas beta e gamma coexisten na maioría dos tipos celulares como compoñentes do citoesqueleto, e como mediadores da motilidade cellar interna. A actina gamma 2, codificada por este xene é unha actina do músculo liso atopado en tecidos entéricos.^[3]

Interaccións

A actina gamma 2 (ACTG2) presenta interaccións coa emerina.^[4]

Notas

↑ Miwa T, Manabe Y, Kurokawa K, Kamada S, Kanda N, Bruns G, Ueyama H, Kakunaga T (xullo de 1991). "Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes". Mol Cell Biol 11 (6): 3296–306. PMC 360182. PMID 1710027. doi:10.1128/mcb.11.6.3296.
↑ Ueyama H (maio de 1991). "A HindIII DNA polymorphism in the human enteric type smooth muscle actin gene (ACTSG)". Nucleic Acids Res 19 (2): 411. PMC 333620. PMID 1673027. doi:10.1093/nar/19.2.411.
1 2 "Entrez Gene: ACTG2 actin, gamma 2, smooth muscle, enteric".
↑ Lattanzi, Giovanna; Cenni Vittoria; Marmiroli Sandra; Capanni Cristina; Mattioli Elisabetta; Merlini Luciano; Squarzoni Stefano; Maraldi Nadir Mario (abril de 2003). "Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts". Biochem. Biophys. Res. Commun. (Estados Unidos) 303 (3): 764–70. ISSN 0006-291X. PMID 12670476. doi:10.1016/S0006-291X(03)00415-7.

Véxase tamén

Ligazóns externas

Localización no xenoma humano de ACTG2 e páxina con detalles sobre o xene ACTG2 no UCSC Genome Browser.

Bibliografía

Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha) 42 (5): 227–30. PMID 8997639. doi:10.1007/BF02818986.
Adams LD, Tomasselli AG, Robbins P, et al. (1992). "HIV-1 protease cleaves actin during acute infection of human T-lymphocytes". AIDS Res. Hum. Retroviruses 8 (2): 291–5. PMID 1540415. doi:10.1089/aid.1992.8.291.
Tomasselli AG, Hui JO, Adams L, et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus". J. Biol. Chem. 266 (22): 14548–53. PMID 1907279. doi:10.1016/S0021-9258(18)98721-1.
Shoeman RL, Kesselmier C, Mothes E, et al. (1991). "Non-viral cellular substrates for human immunodeficiency virus type 1 protease". FEBS Lett. 278 (2): 199–203. Bibcode:1991FEBSL.278..199S. PMID 1991513. doi:10.1016/0014-5793(91)80116-K.
Miwa T, Kamada S (1990). "The nucleotide sequence of a human smooth muscle (enteric type) gamma-actin cDNA". Nucleic Acids Res. 18 (14): 4263. PMC 331204. PMID 2377475. doi:10.1093/nar/18.14.4263.
Ueyama H, Inazawa J, Nishino H, et al. (1995). "Chromosomal mapping of the human smooth muscle actin gene (enteric type, ACTA3) to 2p13.1 and molecular nature of the hindIII polymorphism". Genomics 25 (3): 720–3. PMID 7759108. doi:10.1016/0888-7543(95)80016-F.
Szucsik JC, Lessard JL (1996). "Cloning and sequence analysis of the mouse smooth muscle gamma-enteric actin gene". Genomics 28 (2): 154–62. PMID 8530021. doi:10.1006/geno.1995.1126.
Bukrinskaya A, Brichacek B, Mann A, Stevenson M (1999). "Establishment of a Functional Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcription Complex Involves the Cytoskeleton". J. Exp. Med. 188 (11): 2113–25. PMC 2212381. PMID 9841925. doi:10.1084/jem.188.11.2113.
Zhang H, Wang L, Kao S, et al. (1999). "Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF". Curr. Biol. 9 (21): 1271–4. Bibcode:1999CBio....9.1271Z. PMC 4513661. PMID 10556093. doi:10.1016/S0960-9822(99)80511-9.
Kohnen G, Campbell S, Jeffers MD, Cameron IT (2000). "Spatially regulated differentiation of endometrial vascular smooth muscle cells". Hum. Reprod. 15 (2): 284–92. PMID 10655297. doi:10.1093/humrep/15.2.284.
Filmore RA, Dean DA, Zimmer WE (2003). "The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia". Gene Expr. 10 (5–6): 201–11. PMC 5977519. PMID 12450213. doi:10.3727/000000002783992424 (inactivo 11 de xullo de 2025).
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Cheng C, Sharp PA (2003). "RNA Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes". Mol. Cell. Biol. 23 (6): 1961–7. PMC 149466. PMID 12612070. doi:10.1128/MCB.23.6.1961-1967.2003.
Wu RF, Gu Y, Xu YC, et al. (2004). "Human Immunodeficiency Virus Type 1 Tat Regulates Endothelial Cell Actin Cytoskeletal Dynamics through PAK1 Activation and Oxidant Production". J. Virol. 78 (2): 779–89. PMC 368750. PMID 14694110. doi:10.1128/JVI.78.2.779-789.2004.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. Bibcode:2005Natur.434..724H. PMID 15815621. doi:10.1038/nature03466.

Este artigo é, polo de agora, só un bosquexo. Traballa nel para axudar a contribuír a que a Galipedia mellore e medre.

[pmid1710027-1] Miwa T, Manabe Y, Kurokawa K, Kamada S, Kanda N, Bruns G, Ueyama H, Kakunaga T (xullo de 1991). "Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes". Mol Cell Biol 11 (6): 3296–306. PMC 360182. PMID 1710027. doi:10.1128/mcb.11.6.3296.

[pmid1673027-2] Ueyama H (maio de 1991). "A HindIII DNA polymorphism in the human enteric type smooth muscle actin gene (ACTSG)". Nucleic Acids Res 19 (2): 411. PMC 333620. PMID 1673027. doi:10.1093/nar/19.2.411.

[entrez-3] 1 2 "Entrez Gene: ACTG2 actin, gamma 2, smooth muscle, enteric".

[pmid12670476-4] Lattanzi, Giovanna; Cenni Vittoria; Marmiroli Sandra; Capanni Cristina; Mattioli Elisabetta; Merlini Luciano; Squarzoni Stefano; Maraldi Nadir Mario (abril de 2003). "Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts". Biochem. Biophys. Res. Commun. (Estados Unidos) 303 (3): 764–70. ISSN 0006-291X. PMID 12670476. doi:10.1016/S0006-291X(03)00415-7.

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