I loaded the "DEER_2017.osm" that ships with OpenStudio 2.4.3 into OS app and then went to Apply Measures Now. My measure directory is "nrel_published" from develop branch of measure repo.

The dialog came up in about 10 seconds and listed all of the measure, but when I select a measure (even if it is a measure without any arguments) it took 130 seconds before I could click run. My guess is this is measure manager working through all the measures. Once I have waited for this if I leave the dialog and come back it is very quick. None of the measure.XML files were updated during this time.

If I quit the app and the launch and re-load the model, it takes 120 seconds again when I first use apply measures now.