Right now, as far as I can tell, there is only one guide in Gutenberg. However, when using the NUX package with multiple guides, it'd be more helpful if clicking the close button only dismissed that guide instead of completely disabling tips.

Each guide can be associated with completely different parts of an application and the user saying "I know this, don't bother me" about one component of the application shouldn't be treated as, "I'm an expert on everything in this app, no need to tell me about it ever". This would particularly hold true when adding new features to an application that you want to show guides for.