• VS 2022 (Version 17.3.0 Preview 1.1)
• Sample OS project used to reproduce: https://github.com/tom-englert/TomsToolbox/tree/master/src/SampleApp.Mef1
• Updated Fody to 6.6.2
  => Debugging is no longer possible
  

Debug settings:

    <DebugType>embedded</DebugType>
    <DebugSymbols>true</DebugSymbols>