Papers by Munazza Shareef
Matrix Science Pharma
Hyperlipidemia is the major risk factor of arteriosclerosis, coronary heart diseases and death. P... more Hyperlipidemia is the major risk factor of arteriosclerosis, coronary heart diseases and death. Phenolic compounds have been shown to offer the protection against cardiovascular complications. In the present study, we studied the effect of semisynthetic phenolic compounds on the hyperlipidemic mice fed with high fat diet (cholesterol, cholic acid and peanut oil). Phenolic compounds were mixed with HFD and the dose of the test compounds were 1 0mg/kg for 6 weeks. After 6 weeks, the average body weight of lab diet, HFD, standard and test compounds were evaluated. Average body weight of test compound 1, test compound 2 and test compound 3 showed insignificant results (P>1) as compared to the standard drug (Atorvastatin in this study). The liver weight of mice increased (P>1) in all treatment groups relative to standard drug fed group. The plasma lipids such as triglyceride and LDL-cholesterol were found to be increased (P>1) in Test compound 1, test compound 2 , test compound 3 and HFD fed mice when compared to that of standard drug (Atorvastatin) fed mice. But high-density lipoprotein (HDL) cholesterol increased in standard when compared to that of lab diet fed mice, HFD and test compounds. In conclusion, the supplementation of semi synthetic phenolic compounds may have a weak potential of hypolipidemic effect on mice fed high-fat diet.
Matrix Science Medica
It is seen that most of the deaths are occurring due to diseases of cardiovascular system. There ... more It is seen that most of the deaths are occurring due to diseases of cardiovascular system. There is a significant impact of lifestyle changes on the quality of health. Utilization of food highly rich with saturated fat and having low fiber content is one of the factors of disarray in energy balance. It is now evinced that hyperlipidemia is depicted as a major risk factor for the premature development of atherosclerosis and its cardiovascular complications. The prevalence of obesity has doubled in the past 25 years; today, two-thirds of adults are overweight in the United State [1].
Matrix Science Pharma
Nigella sativa (N. sativa) is an important herb with multiple pharmacological activities. Therape... more Nigella sativa (N. sativa) is an important herb with multiple pharmacological activities. Therapeutic properties of N. sativa based on the availability of thymoquinone (TQ) which is an essential oil and an active chemical component. This review concerns about the anti-bacterial activity of N. sativa in the gut of broiler chicks. The addition of N. sativa powder appeared to have a positive impact on growth performance of broiler chicks as it improved body weight gain and feed conversion ratio (FCR) of broilers at finisher phase and it could be considered as a substitute of antibiotic growth promoter (lincomycin) for broiler chicks. It also affect the immune titer of Infectious Bursal Disease and New Castle Disease in the broiler chicks.
Matrix Science Pharma
Nigella sativa (N. sativa) is an important herb with multiple pharmacological activities. Therape... more Nigella sativa (N. sativa) is an important herb with multiple pharmacological activities. Therapeutic properties of N. sativa based on the availability of thymoquinone (TQ) which is an essential oil and an active chemical component. Current study was designed to investigate the antibacterial effect of N.sativa in comparison with lincomycin, as growth promoter in the gut of broiler chicks. Activity of N. sativa powder on feed conversion ratio in broiler chicks was also recorded. Day old birds were taken and divided into three groups and having three biological replicates in each treatment group (6 chicks). First group was control group that received normal diet; second group received the normal diet with growth promoter and third group fed with routine diet and powder of N. sativa. Birds were slaughtered at the end of study period (day 36 th). Blood and tissue samples were collected on 28 th and 36 th day of trial. The results of this study showed that addition of 1% N. sativa powder appeared to have a positive impact on growth performance of broiler chicks as it improved body weight gain and feed conversion ratio (FCR) of broilers at finisher phase (P<0.05) and it could be considered as a substitute of antibiotic growth promoter (lincomycin) for broiler chicks.
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Papers by Munazza Shareef