Papers by Hoseyn A. Amiri
Case Studies in Thermal Engineering, Dec 31, 2023
Chemical Engineering Science
Journal of Chromatography A
Chemical Engineering Research and Design
Micromachines
Separation and isolation of suspended submicron particles is fundamental to a wide range of appli... more Separation and isolation of suspended submicron particles is fundamental to a wide range of applications, including desalination, chemical processing, and medical diagnostics. Ion concentration polarization (ICP), an electrokinetic phenomenon in micro-nano interfaces, has gained attention due to its unique ability to manipulate molecules or particles in suspension and solution. Less well understood, though, is the ability of this phenomenon to generate circulatory fluid flow, and how this enables and enhances continuous particle capture. Here, we perform a comprehensive study of a low-voltage ICP, demonstrating a new electrokinetic method for extracting submicron particles via flow-enhanced particle redirection. To do so, a 2D-FEM model solves the Poisson–Nernst–Planck equation coupled with the Navier–Stokes and continuity equations. Four distinct operational modes (Allowed, Blocked, Captured, and Dodged) were recognized as a function of the particle’s charges and sizes, resulting i...
Micromachines
Cryopreservation is the final step of stem cell production before the cryostorage of the product.... more Cryopreservation is the final step of stem cell production before the cryostorage of the product. Conventional methods of adding cryoprotecting agents (CPA) into the cells can be manual or automated with robotic arms. However, challenging issues with these methods at industrial-scale production are the insufficient mixing of cells and CPA, leading to damage of cells, discontinuous feeding, the batch-to-batch difference in products, and, occasionally, cross-contamination. Therefore, the current study proposes an alternative way to overcome the abovementioned challenges; a highly efficient micromixer for low-cost, continuous, labour-free, and automated mixing of stem cells with CPA solutions. Our results show that our micromixer provides a more homogenous mixing of cells and CPA compared to the manual mixing method, while the cell properties, including surface markers, differentiation potential, proliferation, morphology, and therapeutic potential, are well preserved.
Cornell University - arXiv, Aug 30, 2022
Size-based separation of bioparticles/cells is crucial to a variety of biomedical processing step... more Size-based separation of bioparticles/cells is crucial to a variety of biomedical processing steps for applications such as exosomes and DNA isolation. Design and improvement of such microfluidic devices is a challenge to best answer the demand for producing homogeneous end-result for study and use. Deterministic lateral displacement (DLD) exploits a similar principle that has drawn extensive attention over years. However, the lack of predictive understanding of the particle trajectory and its induced mode makes designing a DLD device an iterative procedure. Therefore, this paper investigates a fast versatile design automation platform to address this issue. To do so, convolutional and artificial neural networks were employed to learn velocity fields and critical diameters of a wide range of DLD configurations. Later, these networks were combined with a multi-objective evolutionary algorithm to construct the automation tool. After ensuring the accuracy of the neural networks, the developed tool was tested for 12 critical conditions. Reaching the imposed conditions, the automation components performed reliably with errors of less than 4%. Moreover, this tool is generalizable to other field-based problems and since the neural network is an integral part of this method, it enables transfer learning for similar physics. All the codes generated and used in this study alongside the pre-trained neural network models are available on https://github.com/HoseynAAmiri/DLDNN.
Lab on a Chip
Separation and enrichment of target cells prior to downstream analyses is an essential pre-treatm... more Separation and enrichment of target cells prior to downstream analyses is an essential pre-treatment step in many biomedical and clinical assays. Separation techniques utilizing simple, cost-effective, and user-friendly devices are...
Micromachines
Mixing at the microscale is of great importance for various applications ranging from biological ... more Mixing at the microscale is of great importance for various applications ranging from biological and chemical synthesis to drug delivery. Among the numerous types of micromixers that have been developed, planar passive spiral micromixers have gained considerable interest due to their ease of fabrication and integration into complex miniaturized systems. However, less attention has been paid to non-planar spiral micromixers with various cross-sections and the effects of these cross-sections on the total performance of the micromixer. Here, mixing performance in a spiral micromixer with different channel cross-sections is evaluated experimentally and numerically in the Re range of 0.001 to 50. The accuracy of the 3D-finite element model was first verified at different flow rates by tracking the mixing index across the loops, which were directly proportional to the spiral radius and were hence also proportional to the Dean flow. It is shown that higher flow rates induce stronger vortic...
Chemical Engineering and Processing - Process Intensification
Microfluidics and Nanofluidics
International Journal of Numerical Methods for Heat & Fluid Flow
Purpose The purpose of this paper is to design, investigate and optimize a horizontal axis tidal ... more Purpose The purpose of this paper is to design, investigate and optimize a horizontal axis tidal turbine (HATT) using computer-aided numerical simulation and computational fluid dynamics (CFD). This is the first step of research and development (R&D) for implementation in the Persian Gulf condition. To do so, suitable locations are reviewed. Then, the optimization is focused on determining the optimum fixed pitch angle (β) of a three-bladed HATT based on the widespread multiple reference frame (MRF) technique to calculate power and thrust coefficients at different operational rotating speeds. Design/methodology/approach To simplify the problem and reducing the computational costs due to cyclic symmetry only one blade, accordingly one-third of the whole computational domain is considered in the modeling. Due to flow’s nature involving rotating, separation and recirculation, a realizable κ-ε turbulence model with standard wall function is selected to capture flow characteristics influ...
Gauss-Jordan Elimination Method | C++ Code.
Mind the link (a simple reference) I shared if you h... more Gauss-Jordan Elimination Method | C++ Code.
Mind the link (a simple reference) I shared if you had a question.
Newton Interpolation Method C++ code.
Numerical Interpolation Function.
شبیهسازی اجزای محدود به داماندازی هیدرودینامیکی در سیستمی با آرایش تلهای
Finite element simula... more شبیهسازی اجزای محدود به داماندازی هیدرودینامیکی در سیستمی با آرایش تلهای
Finite element simulations of hydrodynamic trapping in microfluidic particle-trap array systems
Trimesh and Rectmesh Comparison, with Graphs and Figures to Monitor the Code..
This Finite Element MATLAB Code Has Been Written For Stress And Buckling Analysis Of A VAWT Base ... more This Finite Element MATLAB Code Has Been Written For Stress And Buckling Analysis Of A VAWT Base As A 8 Node And 12 Element 3D Truss. The Limit Analysis Is Also Considered By Varying Load And We Can See Deflections And Results While Program Calculates And They Will Be Stored In Program Path.
LU decomposition code by C++ programming..
Take a look at the links..
Uploads
Papers by Hoseyn A. Amiri
Mind the link (a simple reference) I shared if you had a question.
Finite element simulations of hydrodynamic trapping in microfluidic particle-trap array systems
Mind the link (a simple reference) I shared if you had a question.
Finite element simulations of hydrodynamic trapping in microfluidic particle-trap array systems