Objecti6e: The purpose was to find out whether there is a relationship between the central nervou... more Objecti6e: The purpose was to find out whether there is a relationship between the central nervous system involvement and retinopathy in diabetes mellitus. Study Design: In a multidisciplinary clinical study, diabetic patients with and without retinopathy were examined utilising auditory brainstem response (ABR) testing, and the results were interpreted from clinical and pathophysiological point of view. Patients and Methods: Thirty-three diabetic patients with retinopathy (study group) and 20 diabetic patients without retinopathy (control group) were included. Audiometry and ABR testing were made. The results of both groups were compared for ABR parameters. Results: Audimetric results of the study and control groups were similar. In the study group, ABR testing revealed prolonged absolute and interpeak latency of the waves. The difference was significant for I-III interval (PB0.01). The amplitudes of the waves were similar in both groups and wave V amplitude was significantly diminished in the study group. Abnormal waveforms were recorded by 40 and 12.5% in the study and control groups, respectively. Conclusion: Retinopathy is accompanied with lower brainstem disintegration. Microangiopathy is the possible mechanism that is involved in the occurrence of retinopathy and brainstem neuropathy. ABR can help diagnose retinopathy. Better understanding the role of ABR in diagnosis and early detection of retinopathy in diabetic patients needs further study.
To report the ocular manifestations associated with brucellosis in an endemic area. We prospectiv... more To report the ocular manifestations associated with brucellosis in an endemic area. We prospectively evaluated 147 patients with the diagnosis of brucellosis between May 1996 to May 2000 and recorded the ocular and systemic findings. The diagnosis was based on clinical findings, positive serological and bacteriological tests (Brucella agglutination test: over 1/160 titer, blood culture). Thirty-eight patients (26.0%) with brucellosis had ocular complications: conjunctivitis in 26 (17.7%), anterior uveitis in six (4.1%), posterior uveitis in one (0.7%), dacryoadenitis in two (1.4%), episcleritis in three (2.1%). Three of the seven patients with uveitis had spondylitis associated with brucellosis. Osteoarticular complications in brucellosis were more frequent in the patients with ocular involvement though the difference was not statistically significant compared with patients without ocular involvement. Ocular manifestations are frequent in brucellosis so an ophthalmologic examination...
The aim of this study was to investigate whether an association exists between the angiotensin co... more The aim of this study was to investigate whether an association exists between the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and microvascular complications of type 2 diabetes mellitus in Turkish patients. A total of 239 type 2 diabetic patients and 138 sex and age matched control subjects were included into the study. The I/D polymorphism was determined by polymerase chain reaction (PCR). Nephropathy status was determined according to urinary albumin/creatinine ratio (microg/mg) (<30 normoalbuminuria, 30-300 microalbuminuria, >300 macroalbuminuria) and retinopathy was evaluated by fundoscopic examination and by flourescein fundus angiography. The distribution of ACE I/D polymorphism and allele frequencies in diabetic patients were not significantly different from controls, DD genotype 32.2 versus 37.2%; ID genotype 50.6 versus 47.1%; and II 17.2 versus 15.2%; D allele 57.5 versus 61.2%; I allele 42.5 versus 38.8%. Genotype distribution between ...
Effects of mutations in the β2-adrenergic receptor (β2AR) gene on intraocular pressure (IOP), in ... more Effects of mutations in the β2-adrenergic receptor (β2AR) gene on intraocular pressure (IOP), in response to acute dynamic exercise, were investigated in 19 healthy males (age 22.6 ± 2.8 years). Intraocular pressures were measured pre- and post-exercise. Weight, height, body mass index, and maximal oxygen (VO2max) uptake were recorded and subjects were genotyped for Arg16Gly, Gln27Glu and Thr164Ile mutations of the β2AR gene. Post-exercise, reductions in mean IOP values were found in 16 subjects with the Gly16Gly and Arg16Gly genotypes, but these values remained low in the eight patients with the Gly16Gly genotype 3 h post-exercise, whereas they returned to baseline within 1 h in the eight subjects with the Arg16Gly genotype. β2AR stimulation during exercise could be an important regulator of IOP response and determining β2AR polymorphisms may improve understanding of pathogenesis and treatment selection in ophthalmic diseases, e.g. glaucoma.
It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and ... more It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and threonine to isoleucine (Thr164Ile) exchanges in codons 16, 27 and 164, respectively, of the beta 2-adrenergic receptor (B2AR) gene significantly alter receptor function. As B2ARs are located on the afferent blood vessels supplying the ciliary body and trabecular meshwork cells, which control aqueous humour dynamics, polymorphisms of B2AR may be involved in the pathophysiology of certain eye diseases, such as glaucoma. Therefore, the aim of the present study was to investigate the distribution of B2AR polymorphisms in patients with primary congenital and primary open angle glaucoma. Methods: A group of 30 patients with primary congenital glaucoma, 105 with primary open angle glaucoma and 92 control patients were analysed for the Arg16Gly, Gln27Glu, and Thr164IIe polymorphisms of the B2AR by polymerase chain reaction-restriction fragment length polymorphism. Results: The allelic frequencies of Gly16, Glu27 and IIe164 variant alleles were 66.7, 38.3 and 3.3% in patients with congenital glaucoma, 59.5, 31.0 and 1.0% with glaucoma, and 54.9, 26.6 and 0.5% in controls, respectively. Although statistically non-significant, the frequencies of variant alleles were slightly higher in both groups of the glaucoma patients. Conclusions: These results suggest no evidence of an association between the Arg16Gly, Glu27Gln and Thr164Ile polymorphisms of the B2AR gene and risk of developing primary open angle glaucoma or primary congenital glaucoma. However, further studies are needed to understand the role of B2AR polymorphisms in patients with eye disease.
... 1Gaziantep Üniversitesi Tıp Fakültesi Göz Hastalıkları Anabilim Dalı Ümit Kaya1, Kıvanç Güngö... more ... 1Gaziantep Üniversitesi Tıp Fakültesi Göz Hastalıkları Anabilim Dalı Ümit Kaya1, Kıvanç Güngör1, İbrahim Erbağcı1, Necdet Bekir1 GİRİŞ ... Erken dönemlerde küçük, az sayıda olan papillaların merkezinde fibrovasküler bir yapı vardır ve sızıntı buradaki damarlardan olur. ...
... Dergisi Yıl: 1996 / Cilt: 5 / Sayı: 4. Glokom Cerrahisinde Topikat Mitomisin-c Uygulaması Nec... more ... Dergisi Yıl: 1996 / Cilt: 5 / Sayı: 4. Glokom Cerrahisinde Topikat Mitomisin-c Uygulaması Necdet A:BEKİR * , Kıvanç GÜNGÖR ** * Doç.Dr ... Mitomisin-C uygulanan olgularda göz içi basıncının uygulanmayan olgulara oranla erken dönemde anlamlı derecede ve uzun süreli daha ...
Inherited polymorphisms of codons 16, 27, and 164 of the b 2-adrenergic receptor (B2AR) gene may ... more Inherited polymorphisms of codons 16, 27, and 164 of the b 2-adrenergic receptor (B2AR) gene may result in significantly changed functions of this receptor. The aim of the present study was to investigate the frequencies of the main mutations of the B2AR gene in Turks. Methods A group of 104 unrelated Turkish subjects were analysed for the Arg16Gly, Gln27Glu, and Thr164Leu polymorphisms of B2AR by a newly designed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A 242-bp amplicon including the Arg16Gly and Gln27Glu polymorphisms was generated including an arbitrary restriction site, allowing the cleavage with Eco130I or Fnu4HI for analysis of the two polymorphic sites, respectively. For the amino acid polymorphism at codon 164 a 280-bp fragment was generated and digested by MnlI. Results The allelic frequencies of mutated Gly16, Glu27, and Ile164 alleles were found as 59.6%, 31.7%, and 0.5%, respectively. Although, the frequencies of the polymorphisms at codon 16 and 164 were found similar as in various Caucasian populations, the frequency of the Glu27 variant was found significantly lower than these populations. Conclusions Obviously there are interethnic differences in functionally relevant B2AR variants which may have implications for drug treatment and disease susceptibility.
Effects of mutations in the b 2-adrenergic receptor (b 2 AR) gene on intraocular pressure (IOP), ... more Effects of mutations in the b 2-adrenergic receptor (b 2 AR) gene on intraocular pressure (IOP), in response to acute dynamic exercise, were investigated in 19 healthy males (age 22.6 ± 2.8 years). Intraocular pressures were measured pre-and postexercise. Weight, height, body mass index, and maximal oxygen (VO 2max) uptake were recorded and subjects were genotyped for Arg16Gly, Gln27Glu and Thr164Ile mutations of the b 2 AR gene. Post-exercise, reductions in mean IOP values were found in 16 subjects with the Gly16Gly and Arg16Gly genotypes, but these values remained low in the eight patients with the Gly16Gly genotype 3 h post-exercise, whereas they returned to baseline within 1 h in the eight subjects with the Arg16Gly genotype. b 2 AR stimulation during exercise could be an important regulator of IOP response and determining b 2 AR polymorphisms may improve understanding of pathogenesis and treatment selection in ophthalmic diseases, e.g. glaucoma.
P seudotumor cerebri (PTC) is characterized by papilledema with increased intracranial pressure, ... more P seudotumor cerebri (PTC) is characterized by papilledema with increased intracranial pressure, normal cerebrospinal fluid (CSF) composition, and normal neuroimaging findings in the absence of space-occupying lesions or neurologic localizing signs. Although most of the cases are idiopathic, there are some associated factors. These include certain medical disorders, obesity, pregnancy, venous sinus thrombosis, trauma, surgery (radical neck surgery), immunologic conditions, infectious diseases, hypervitaminosis and hypovitaminosis A, iron deficiency anemia, some drugs (nalidixic acid, steroids, nitrofurantoin, tetracyclines, danazol, lithium carbonate, oral contraceptives, vitamin A, and cyclosporine). 1-4 The most frequent symptoms of PTC are headache, visual loss, transient visual obscuration, diplopia, and pulsatile tinnitus or "wooshing" noise in the ear. Visual obscurations are not correlated with the severity of intracranial hypertension and papilledema. The most serious condition in patients with PTC is visual loss. The severity of visual acuity loss cannot be predicted from the stage of papilledema. 1-3,5 Nonspecific infectious conditions, including bronchitis, sinusitis, gastroenteritis, and urinary tract infections, have been associated with PTC. 3 There are also several reports in the literature suggesting an association between specific infections and PTC (eg, Lyme disease, 6 Yersinia pseudotuberculosis, 7 typhoid fever, 8 and varicella 9). Brucellosis is a zoonosis, and virtually all infections derive directly or indirectly from animal exposure.
To document the clinical course and the treatment of episcleritis associated with brucellosis. Th... more To document the clinical course and the treatment of episcleritis associated with brucellosis. Three consecutive cases of patients with recurrent episcleritis associated with brucellosis were evaluated through clinical and laboratory data including serology (tube agglutination), blood culture, and synovial fluid culture. All the patients had ingested contaminated milk and/or fresh cheese. The diagnosis of brucellosis was confirmed by high antibody titer, positive blood culture, negative synovial fluid culture and unresponsive condition to the previous nonspecific therapy for episcleritis and reactive arthritis. The patients responded well to the therapy with doxycycline and rifampicin. We proposed that recurrent episcleritis had a co-occurence with reactive arthritis in the course of the brucellosis, and that it responded well to the antibrucellar antibiotics rather than to steroids. This also implies that brucellosis as a rule is an underlying triggering infection associated with reactive arthritis.
The aim of this presentation is to report a rare association between interatrial aneurysm and Axe... more The aim of this presentation is to report a rare association between interatrial aneurysm and Axenfeld-Rieger syndrome. We present a 20-year-old girl with Axenfeld-Rieger syndrome, in whom the diagnosis was confirmed by the facial dysmorphic appearance, slit-lamp examination, applanation tonometer, gonioscopy, and cardiovascular examination. The patient had prominent Schwalbe&#39;s line in all quadrants, iris atrophy, and secondary glaucoma in both eyes. The echocardiogram revealed an atrial septal defect with interatrial aneurysm. This is the first case report of coexisting Axenfeld-Rieger syndrome and interatrial aneurysm. We would like to stress that aneurysm can be a potential occult source of cerebral embolism.
The purpose was to find out whether there is a relationship between the central nervous system in... more The purpose was to find out whether there is a relationship between the central nervous system involvement and retinopathy in diabetes mellitus. Study Design: In a multidisciplinary clinical study, diabetic patients with and without retinopathy were examined utilising auditory brainstem response (ABR) testing, and the results were interpreted from clinical and pathophysiological point of view. Patients and Methods: Thirty-three diabetic patients with retinopathy (study group) and 20 diabetic patients without retinopathy (control group) were included. Audiometry and ABR testing were made. The results of both groups were compared for ABR parameters. Results: Audimetric results of the study and control groups were similar. In the study group, ABR testing revealed prolonged absolute and interpeak latency of the waves. The difference was significant for I-III interval (PB0.01). The amplitudes of the waves were similar in both groups and wave V amplitude was significantly diminished in the study group. Abnormal waveforms were recorded by 40 and 12.5% in the study and control groups, respectively. Conclusion: Retinopathy is accompanied with lower brainstem disintegration. Microangiopathy is the possible mechanism that is involved in the occurrence of retinopathy and brainstem neuropathy. ABR can help diagnose retinopathy. Better understanding the role of ABR in diagnosis and early detection of retinopathy in diabetic patients needs further study.
To present a case of brucellosis-related unilateral dacryoadenitis. A 16-year-old boy had unilate... more To present a case of brucellosis-related unilateral dacryoadenitis. A 16-year-old boy had unilateral lacrimal gland enlargement, shown by magnetic resonance imaging of the orbits. Clinical findings, tube agglutination, the culture of a lacrimal gland aspirate, and histopathological examination confirmed the diagnosis of brucellosis. Tube agglutination testing for brucellosis gave a titer of over 1/640. The aspirate from the lacrimal glands grew Brucella melitensis and histopathological findings were consistent with brucellosis. Dacryoadenitis may occur in the course of systemic brucellosis caused by Brucella melitensis.
The aim of this study was to delineate the precise relationship between the sphenoid sinus and in... more The aim of this study was to delineate the precise relationship between the sphenoid sinus and internal carotid artery and the optic nerve, as well as to assess incidence of the anatomic variations of these structures. A review of 92 paranasal sinus tomographic scans was made for anatomic variations of the sphenoid sinus and related bony and neurovascular structures. Coronal and axial tomographic sections were obtained with 2.5-mm section thickness. We assessed the protrusion of the internal carotid artery (ICA) and the optic nerve (ON) into the sphenoid sinus, bone dehiscence of these structures, and pneumatization of the anterior clinoid process (ACP) and pterygoid recess (PR), as well as the variations of the sphenoid sinus septum. The protrusion of the ICA into the sphenoid sinus was found in 24 (26.1%) patients. An ON protrusion was present in 29 (31.5%) patients. Pneumatization of the PR was encountered in 27 (29.3%) patients. There was not a statistically significant relationship between the pneumatization of the PR and ICA protrusion into the sphenoid sinus (chi2 = 0.258, p = 0.168). A significant relationship between the ACP pneumatization and protrusion of the ON into the sphenoid sinus was found (chi2= 0.481,p = 0.007). Preoperative recognition of the anatomic variations by the radiologist is beneficial for identification of the limits of dissection. This is particularly important in the sphenoid sinus area where extensive pneumatization of the skull base bones may distort the anatomic configuration. Therefore, axial and coronal CT sections should always be obtained prior to any surgery in the sphenoid sinus area.
The aim of this study was to investigate whether an association exists between the angiotensin co... more The aim of this study was to investigate whether an association exists between the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and microvascular complications of type 2 diabetes mellitus in Turkish patients. A total of 239 type 2 diabetic patients and 138 sex and age matched control subjects were included into the study. The I/D polymorphism was determined by polymerase chain reaction (PCR). Nephropathy status was determined according to urinary albumin/creatinine ratio (microg/mg) (<30 normoalbuminuria, 30-300 microalbuminuria, >300 macroalbuminuria) and retinopathy was evaluated by fundoscopic examination and by flourescein fundus angiography. The distribution of ACE I/D polymorphism and allele frequencies in diabetic patients were not significantly different from controls, DD genotype 32.2 versus 37.2%; ID genotype 50.6 versus 47.1%; and II 17.2 versus 15.2%; D allele 57.5 versus 61.2%; I allele 42.5 versus 38.8%. Genotype distribution between ...
Objecti6e: The purpose was to find out whether there is a relationship between the central nervou... more Objecti6e: The purpose was to find out whether there is a relationship between the central nervous system involvement and retinopathy in diabetes mellitus. Study Design: In a multidisciplinary clinical study, diabetic patients with and without retinopathy were examined utilising auditory brainstem response (ABR) testing, and the results were interpreted from clinical and pathophysiological point of view. Patients and Methods: Thirty-three diabetic patients with retinopathy (study group) and 20 diabetic patients without retinopathy (control group) were included. Audiometry and ABR testing were made. The results of both groups were compared for ABR parameters. Results: Audimetric results of the study and control groups were similar. In the study group, ABR testing revealed prolonged absolute and interpeak latency of the waves. The difference was significant for I-III interval (PB0.01). The amplitudes of the waves were similar in both groups and wave V amplitude was significantly diminished in the study group. Abnormal waveforms were recorded by 40 and 12.5% in the study and control groups, respectively. Conclusion: Retinopathy is accompanied with lower brainstem disintegration. Microangiopathy is the possible mechanism that is involved in the occurrence of retinopathy and brainstem neuropathy. ABR can help diagnose retinopathy. Better understanding the role of ABR in diagnosis and early detection of retinopathy in diabetic patients needs further study.
To report the ocular manifestations associated with brucellosis in an endemic area. We prospectiv... more To report the ocular manifestations associated with brucellosis in an endemic area. We prospectively evaluated 147 patients with the diagnosis of brucellosis between May 1996 to May 2000 and recorded the ocular and systemic findings. The diagnosis was based on clinical findings, positive serological and bacteriological tests (Brucella agglutination test: over 1/160 titer, blood culture). Thirty-eight patients (26.0%) with brucellosis had ocular complications: conjunctivitis in 26 (17.7%), anterior uveitis in six (4.1%), posterior uveitis in one (0.7%), dacryoadenitis in two (1.4%), episcleritis in three (2.1%). Three of the seven patients with uveitis had spondylitis associated with brucellosis. Osteoarticular complications in brucellosis were more frequent in the patients with ocular involvement though the difference was not statistically significant compared with patients without ocular involvement. Ocular manifestations are frequent in brucellosis so an ophthalmologic examination...
The aim of this study was to investigate whether an association exists between the angiotensin co... more The aim of this study was to investigate whether an association exists between the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and microvascular complications of type 2 diabetes mellitus in Turkish patients. A total of 239 type 2 diabetic patients and 138 sex and age matched control subjects were included into the study. The I/D polymorphism was determined by polymerase chain reaction (PCR). Nephropathy status was determined according to urinary albumin/creatinine ratio (microg/mg) (<30 normoalbuminuria, 30-300 microalbuminuria, >300 macroalbuminuria) and retinopathy was evaluated by fundoscopic examination and by flourescein fundus angiography. The distribution of ACE I/D polymorphism and allele frequencies in diabetic patients were not significantly different from controls, DD genotype 32.2 versus 37.2%; ID genotype 50.6 versus 47.1%; and II 17.2 versus 15.2%; D allele 57.5 versus 61.2%; I allele 42.5 versus 38.8%. Genotype distribution between ...
Effects of mutations in the β2-adrenergic receptor (β2AR) gene on intraocular pressure (IOP), in ... more Effects of mutations in the β2-adrenergic receptor (β2AR) gene on intraocular pressure (IOP), in response to acute dynamic exercise, were investigated in 19 healthy males (age 22.6 ± 2.8 years). Intraocular pressures were measured pre- and post-exercise. Weight, height, body mass index, and maximal oxygen (VO2max) uptake were recorded and subjects were genotyped for Arg16Gly, Gln27Glu and Thr164Ile mutations of the β2AR gene. Post-exercise, reductions in mean IOP values were found in 16 subjects with the Gly16Gly and Arg16Gly genotypes, but these values remained low in the eight patients with the Gly16Gly genotype 3 h post-exercise, whereas they returned to baseline within 1 h in the eight subjects with the Arg16Gly genotype. β2AR stimulation during exercise could be an important regulator of IOP response and determining β2AR polymorphisms may improve understanding of pathogenesis and treatment selection in ophthalmic diseases, e.g. glaucoma.
It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and ... more It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and threonine to isoleucine (Thr164Ile) exchanges in codons 16, 27 and 164, respectively, of the beta 2-adrenergic receptor (B2AR) gene significantly alter receptor function. As B2ARs are located on the afferent blood vessels supplying the ciliary body and trabecular meshwork cells, which control aqueous humour dynamics, polymorphisms of B2AR may be involved in the pathophysiology of certain eye diseases, such as glaucoma. Therefore, the aim of the present study was to investigate the distribution of B2AR polymorphisms in patients with primary congenital and primary open angle glaucoma. Methods: A group of 30 patients with primary congenital glaucoma, 105 with primary open angle glaucoma and 92 control patients were analysed for the Arg16Gly, Gln27Glu, and Thr164IIe polymorphisms of the B2AR by polymerase chain reaction-restriction fragment length polymorphism. Results: The allelic frequencies of Gly16, Glu27 and IIe164 variant alleles were 66.7, 38.3 and 3.3% in patients with congenital glaucoma, 59.5, 31.0 and 1.0% with glaucoma, and 54.9, 26.6 and 0.5% in controls, respectively. Although statistically non-significant, the frequencies of variant alleles were slightly higher in both groups of the glaucoma patients. Conclusions: These results suggest no evidence of an association between the Arg16Gly, Glu27Gln and Thr164Ile polymorphisms of the B2AR gene and risk of developing primary open angle glaucoma or primary congenital glaucoma. However, further studies are needed to understand the role of B2AR polymorphisms in patients with eye disease.
... 1Gaziantep Üniversitesi Tıp Fakültesi Göz Hastalıkları Anabilim Dalı Ümit Kaya1, Kıvanç Güngö... more ... 1Gaziantep Üniversitesi Tıp Fakültesi Göz Hastalıkları Anabilim Dalı Ümit Kaya1, Kıvanç Güngör1, İbrahim Erbağcı1, Necdet Bekir1 GİRİŞ ... Erken dönemlerde küçük, az sayıda olan papillaların merkezinde fibrovasküler bir yapı vardır ve sızıntı buradaki damarlardan olur. ...
... Dergisi Yıl: 1996 / Cilt: 5 / Sayı: 4. Glokom Cerrahisinde Topikat Mitomisin-c Uygulaması Nec... more ... Dergisi Yıl: 1996 / Cilt: 5 / Sayı: 4. Glokom Cerrahisinde Topikat Mitomisin-c Uygulaması Necdet A:BEKİR * , Kıvanç GÜNGÖR ** * Doç.Dr ... Mitomisin-C uygulanan olgularda göz içi basıncının uygulanmayan olgulara oranla erken dönemde anlamlı derecede ve uzun süreli daha ...
Inherited polymorphisms of codons 16, 27, and 164 of the b 2-adrenergic receptor (B2AR) gene may ... more Inherited polymorphisms of codons 16, 27, and 164 of the b 2-adrenergic receptor (B2AR) gene may result in significantly changed functions of this receptor. The aim of the present study was to investigate the frequencies of the main mutations of the B2AR gene in Turks. Methods A group of 104 unrelated Turkish subjects were analysed for the Arg16Gly, Gln27Glu, and Thr164Leu polymorphisms of B2AR by a newly designed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A 242-bp amplicon including the Arg16Gly and Gln27Glu polymorphisms was generated including an arbitrary restriction site, allowing the cleavage with Eco130I or Fnu4HI for analysis of the two polymorphic sites, respectively. For the amino acid polymorphism at codon 164 a 280-bp fragment was generated and digested by MnlI. Results The allelic frequencies of mutated Gly16, Glu27, and Ile164 alleles were found as 59.6%, 31.7%, and 0.5%, respectively. Although, the frequencies of the polymorphisms at codon 16 and 164 were found similar as in various Caucasian populations, the frequency of the Glu27 variant was found significantly lower than these populations. Conclusions Obviously there are interethnic differences in functionally relevant B2AR variants which may have implications for drug treatment and disease susceptibility.
Effects of mutations in the b 2-adrenergic receptor (b 2 AR) gene on intraocular pressure (IOP), ... more Effects of mutations in the b 2-adrenergic receptor (b 2 AR) gene on intraocular pressure (IOP), in response to acute dynamic exercise, were investigated in 19 healthy males (age 22.6 ± 2.8 years). Intraocular pressures were measured pre-and postexercise. Weight, height, body mass index, and maximal oxygen (VO 2max) uptake were recorded and subjects were genotyped for Arg16Gly, Gln27Glu and Thr164Ile mutations of the b 2 AR gene. Post-exercise, reductions in mean IOP values were found in 16 subjects with the Gly16Gly and Arg16Gly genotypes, but these values remained low in the eight patients with the Gly16Gly genotype 3 h post-exercise, whereas they returned to baseline within 1 h in the eight subjects with the Arg16Gly genotype. b 2 AR stimulation during exercise could be an important regulator of IOP response and determining b 2 AR polymorphisms may improve understanding of pathogenesis and treatment selection in ophthalmic diseases, e.g. glaucoma.
P seudotumor cerebri (PTC) is characterized by papilledema with increased intracranial pressure, ... more P seudotumor cerebri (PTC) is characterized by papilledema with increased intracranial pressure, normal cerebrospinal fluid (CSF) composition, and normal neuroimaging findings in the absence of space-occupying lesions or neurologic localizing signs. Although most of the cases are idiopathic, there are some associated factors. These include certain medical disorders, obesity, pregnancy, venous sinus thrombosis, trauma, surgery (radical neck surgery), immunologic conditions, infectious diseases, hypervitaminosis and hypovitaminosis A, iron deficiency anemia, some drugs (nalidixic acid, steroids, nitrofurantoin, tetracyclines, danazol, lithium carbonate, oral contraceptives, vitamin A, and cyclosporine). 1-4 The most frequent symptoms of PTC are headache, visual loss, transient visual obscuration, diplopia, and pulsatile tinnitus or "wooshing" noise in the ear. Visual obscurations are not correlated with the severity of intracranial hypertension and papilledema. The most serious condition in patients with PTC is visual loss. The severity of visual acuity loss cannot be predicted from the stage of papilledema. 1-3,5 Nonspecific infectious conditions, including bronchitis, sinusitis, gastroenteritis, and urinary tract infections, have been associated with PTC. 3 There are also several reports in the literature suggesting an association between specific infections and PTC (eg, Lyme disease, 6 Yersinia pseudotuberculosis, 7 typhoid fever, 8 and varicella 9). Brucellosis is a zoonosis, and virtually all infections derive directly or indirectly from animal exposure.
To document the clinical course and the treatment of episcleritis associated with brucellosis. Th... more To document the clinical course and the treatment of episcleritis associated with brucellosis. Three consecutive cases of patients with recurrent episcleritis associated with brucellosis were evaluated through clinical and laboratory data including serology (tube agglutination), blood culture, and synovial fluid culture. All the patients had ingested contaminated milk and/or fresh cheese. The diagnosis of brucellosis was confirmed by high antibody titer, positive blood culture, negative synovial fluid culture and unresponsive condition to the previous nonspecific therapy for episcleritis and reactive arthritis. The patients responded well to the therapy with doxycycline and rifampicin. We proposed that recurrent episcleritis had a co-occurence with reactive arthritis in the course of the brucellosis, and that it responded well to the antibrucellar antibiotics rather than to steroids. This also implies that brucellosis as a rule is an underlying triggering infection associated with reactive arthritis.
The aim of this presentation is to report a rare association between interatrial aneurysm and Axe... more The aim of this presentation is to report a rare association between interatrial aneurysm and Axenfeld-Rieger syndrome. We present a 20-year-old girl with Axenfeld-Rieger syndrome, in whom the diagnosis was confirmed by the facial dysmorphic appearance, slit-lamp examination, applanation tonometer, gonioscopy, and cardiovascular examination. The patient had prominent Schwalbe&#39;s line in all quadrants, iris atrophy, and secondary glaucoma in both eyes. The echocardiogram revealed an atrial septal defect with interatrial aneurysm. This is the first case report of coexisting Axenfeld-Rieger syndrome and interatrial aneurysm. We would like to stress that aneurysm can be a potential occult source of cerebral embolism.
The purpose was to find out whether there is a relationship between the central nervous system in... more The purpose was to find out whether there is a relationship between the central nervous system involvement and retinopathy in diabetes mellitus. Study Design: In a multidisciplinary clinical study, diabetic patients with and without retinopathy were examined utilising auditory brainstem response (ABR) testing, and the results were interpreted from clinical and pathophysiological point of view. Patients and Methods: Thirty-three diabetic patients with retinopathy (study group) and 20 diabetic patients without retinopathy (control group) were included. Audiometry and ABR testing were made. The results of both groups were compared for ABR parameters. Results: Audimetric results of the study and control groups were similar. In the study group, ABR testing revealed prolonged absolute and interpeak latency of the waves. The difference was significant for I-III interval (PB0.01). The amplitudes of the waves were similar in both groups and wave V amplitude was significantly diminished in the study group. Abnormal waveforms were recorded by 40 and 12.5% in the study and control groups, respectively. Conclusion: Retinopathy is accompanied with lower brainstem disintegration. Microangiopathy is the possible mechanism that is involved in the occurrence of retinopathy and brainstem neuropathy. ABR can help diagnose retinopathy. Better understanding the role of ABR in diagnosis and early detection of retinopathy in diabetic patients needs further study.
To present a case of brucellosis-related unilateral dacryoadenitis. A 16-year-old boy had unilate... more To present a case of brucellosis-related unilateral dacryoadenitis. A 16-year-old boy had unilateral lacrimal gland enlargement, shown by magnetic resonance imaging of the orbits. Clinical findings, tube agglutination, the culture of a lacrimal gland aspirate, and histopathological examination confirmed the diagnosis of brucellosis. Tube agglutination testing for brucellosis gave a titer of over 1/640. The aspirate from the lacrimal glands grew Brucella melitensis and histopathological findings were consistent with brucellosis. Dacryoadenitis may occur in the course of systemic brucellosis caused by Brucella melitensis.
The aim of this study was to delineate the precise relationship between the sphenoid sinus and in... more The aim of this study was to delineate the precise relationship between the sphenoid sinus and internal carotid artery and the optic nerve, as well as to assess incidence of the anatomic variations of these structures. A review of 92 paranasal sinus tomographic scans was made for anatomic variations of the sphenoid sinus and related bony and neurovascular structures. Coronal and axial tomographic sections were obtained with 2.5-mm section thickness. We assessed the protrusion of the internal carotid artery (ICA) and the optic nerve (ON) into the sphenoid sinus, bone dehiscence of these structures, and pneumatization of the anterior clinoid process (ACP) and pterygoid recess (PR), as well as the variations of the sphenoid sinus septum. The protrusion of the ICA into the sphenoid sinus was found in 24 (26.1%) patients. An ON protrusion was present in 29 (31.5%) patients. Pneumatization of the PR was encountered in 27 (29.3%) patients. There was not a statistically significant relationship between the pneumatization of the PR and ICA protrusion into the sphenoid sinus (chi2 = 0.258, p = 0.168). A significant relationship between the ACP pneumatization and protrusion of the ON into the sphenoid sinus was found (chi2= 0.481,p = 0.007). Preoperative recognition of the anatomic variations by the radiologist is beneficial for identification of the limits of dissection. This is particularly important in the sphenoid sinus area where extensive pneumatization of the skull base bones may distort the anatomic configuration. Therefore, axial and coronal CT sections should always be obtained prior to any surgery in the sphenoid sinus area.
The aim of this study was to investigate whether an association exists between the angiotensin co... more The aim of this study was to investigate whether an association exists between the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and microvascular complications of type 2 diabetes mellitus in Turkish patients. A total of 239 type 2 diabetic patients and 138 sex and age matched control subjects were included into the study. The I/D polymorphism was determined by polymerase chain reaction (PCR). Nephropathy status was determined according to urinary albumin/creatinine ratio (microg/mg) (<30 normoalbuminuria, 30-300 microalbuminuria, >300 macroalbuminuria) and retinopathy was evaluated by fundoscopic examination and by flourescein fundus angiography. The distribution of ACE I/D polymorphism and allele frequencies in diabetic patients were not significantly different from controls, DD genotype 32.2 versus 37.2%; ID genotype 50.6 versus 47.1%; and II 17.2 versus 15.2%; D allele 57.5 versus 61.2%; I allele 42.5 versus 38.8%. Genotype distribution between ...
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Papers by K. Güngör