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Pharma notes for general pharmacology.
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A eal: % Whar — body clea to dung
sou ef admintnahon to Blood yesre)
© Absorption - em
© Dichubstion - from blocd vertel do tay organ
° Bjobansfermedh wn (muck) “qu for exuution of dug
? from non- pelos to polo
( hyvobreoic te ind
&
Cuyopnit’e to dippholeit
© Exewtion (947: trough Kidney )
% PhovmodynemiCn * Whed doug deer do booty
© Mechanism of Action
(Prosser
—> Fo absorbs © Sam milion vaequired
°So Lipid soluble
+ Non- fonud fom
CAadic/adss) {
C Baye /Boue )
exuation 2 Diffeunt weltim i nequiud (Aadic{earre)
+ wake Soldbly
+ Yornud tom
ahon dunia: TV inhaler of cedaue lbicorboradt
eh dang th ermigng)
ho ochevre : TV infin of Aryivie Iyjdadhboude
foUowe) by Urmenium chlocde CNHyt)
(Co ubsedphon 0 exoution ) a ee : iw hum
v s :
{ 8 Bioton feunahon | by Feo .
uncon ony
* Pham L <4 Fundionllatabtan 7 expose af on Hex,
with pelor endo gino.)
Pho 1 Conjugahin 3 jouplivy
Seal
[ U Guyunonele 1 @
2. Corin Q
3. GQtalhion tonjrguhion — G)
4 Suljords S
S ohn Mi
Ge Aakyakon s
f cat shoo iy 2 Cuips- ABC
Gownshors quukhs dab me
sh iodo fondo
oy Achon :
Lo omym © Tne Inbibtivon é 2
3 [subinari? soxtetly . but do Frsy
enrymt — Induction
ubibid, dry converted to pole D exonted
Ib atone 9 7
Trirrien dang
Drobo, dat eee
exouhon 3 a 7 ‘ }
Cae -_
e cumune (EL) Velime of plowma cenpletily clan
ohh za rag Tr @ on unit time.
ik g_ dake oh aintreun
Plame dong concunkaahun
eno Crd kveh4 > dong ps
Fiuk ade irchis
dn Sigs WA A TT,
Power
6 i] ah Phungkotny
Aicoldl gS
Liv speakre
asleever es
oh Recektors
Ani iby
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ality of Anny sro advae fee Mubhe.
i From -\ to +1)
Heseymdlig arivahor
bal Pvt ieee lq olatinn (<1)
re > notnngy > Bat block site
portte — xbheok - Case Rertonre Cusve —> (we Come and Thee aay sa
Yen Fee ee 84 bt dy
a napdebel
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Gpaeh
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So
conan
Rasponst © Sigmoid shale
eg Sie
% Prometins cicrmid dom DRE?
+ Poleney > kt on Gap 9 met polenk > dig fielity Suge a
eetaet f dee ok mou pluck
Cas")
EPG > mucwatleon gravis 9 MO halyft ak hah wwbek comay—3 met tea,
: mony | trot
3 Fed Slopes goed sous
ec
~
Gof Ws Pelnteer Thrropelve aft
Con] monmam — Aceh hay
adver shheot Grenexal Phormacolog
wen t
GOGbbbEEE
dy of a Populcition
quand 4 .
should
binchio hn
athivad
wed countoies Angle : Advontage
Trtsa-venow
Tribe —- mado, doe
—— 9 Sah adm
Tntaa Dermal Almost Zero
-s AdLaqy testi
Cbleb formation Function ees
— > BCH vacua given tmough hss
Et
(Nen-iemad) Ctonnd )
Ho em + Otle
Non-Palax Soo
Day aby exist Tn tht fous
Non- loniud Ss TG)
Dang
Paton
4
id Sebublo Waker Coluble
duu cand mudium — feral Lit ootn
cl mumbr on:
Arerdic/ midiven —¥ ed
Bosre
25° ecnea aa ae volume ~ Steile
Fast, infected , Tebation Pucauhon
Water exist in. beth foun + ionad 2 non- fonied-
SWlo- aut cuow 45° Sod a
am a eeRReBABSAGARaaganeanneagannngngggg SS * PKa Wake a ponameber a
= La pH ot = whch dung oy Sof. fond = SOY
Ss Non-Toniud
No pKa of andre dang Wn be rrat Fond Viaveua
a i Relic
a Dd; Ka = 6:0 thin,
3 ie e PKa Gidhed
= pH Toniud (WS) Non Lonind (LL)
<3
. Handwuon Havielloach — Equahon
- tr uy how a Substond behave {nr
ditfeund — madiuin
Cromudy
[Non tent]
pH = pka + log
— Alc to Hendstro, Hate! badn equation
Audie drys = OL absorbedl FeOM = Chomnadn
and Bic duuy ov abserbed — dyvern
Inkesttne-
> Youy name anding lth Vines ore bac
> Buk paatkicaly ASL drug oat ody sovbed
ow fe Flom iWeAH Ks Hho stomach wana
auder @ howl
SSSSCSCSECCSESESHSSSSSIIIIS Aa Thi = contnadyubon
dike gate Umptying and mow Hime ih
Intestin
= Now how = dutd'c drug — CH0sse4 Tn Pinte.
ws ‘ ‘
witty ore = maclium *
became of otha Cackon
sik bie ga"/, i].
coo — Tonived Non- Toned
Cus) Ces)
Absevoed
Se
ts again splity
Ih 9421 natto
4
Se tan again V]-
CLS) GA abserbed ond
ww again spl ein
492) Ache
b
This you on and on MART
tho drag & On intottine
Breavailabi ly Pesantays / Faxthion of, deug. that
PD DA"
MoUs — Sytenuc — ietuakatton
Joo meluby given
10 “rer absmbed
Go absrbed ~omd
gow in Vupakic avalab'on
b Ao mtteetnad Yany Liver (FIM pats mebstoie\
BOM systene
TOW Bebb nnhdd dd
KA
o
SSSSSSSSHSEEOS
4
VBUUUGESEC ES
* Factou thot ofed — bioavailability — aN
© Absebtion
E® Fut Pay Metulolim, # — jus Bjoowuslability
Bq. High FRM drugs
+ Lignecann
+ P nopranctoe
: Guyot Toul tok
> Bioavarlabiliby >
¥
Iv vows 2 00"
SC ey IM ak 7 FS- 00}.
Mal = 5-l0o4e
AVC omy \oo 1 (ve
Rreavel (edb lliy, aad
AVL,
— > Absoiphion very goed
tuk FRM ato very
hgh so vey
Broavadebily -
So given Hracugn dt taunt
nous —* Sublingured
{ue
No FRM
vag
oo
@® Selly Adem
@ Com, beamuinahs
Crow our ingat)
When action 42K. > Bioequivalenc, ond oh, Same agg —e Acceptable
+ 20%.
As pistin (1s0 mg ) Brag vetlab’ lity
a“
Los pain
fama
nun whey
So Broaywiabily of this
ay mond Shoril b¢
blw $O- (20 4y/dbL +o
be Bio equivalent
© moet drug differ vary at in bioeqys valu
nurgg
ot =e Fa eg. Anh -ebi Wp tt
— a> Prangoin Cnn 7
ilantin FE tRele
Goong)
Bioequvabnt
Mox™ Tolnattooly
Conunrintron, COCSSSSEE SEE SESE SSSTSIS SIA HOK HHH hh Ise
L
AUC tells extent of dung abserphion
Tre —? telb Ant of doy cubsmphion
Grow —? tel wy abouk true close Ange
‘nos @ should be used - Provera a :
t Y es
piuutio >" dry, Wah coun. g Wet po lag of NO
} omd Joly Unity :
(swt) =D Rehowe vom Ordama( Surtling
pean yt We cue acjudte
j duwahy
vo *
Truride- ike (v)
4 ~ 4
“4 Carbonic Anhydiit
Whit
fc
4 |
a
Potosi. OY (0) Osrreric
eee iw
Diwwhy, L
ae Stee. AA at 4
me
L
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weil ae ( (ore fe
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- aml}
< ar
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oc e (beh
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‘annie
Nema troupe Uae Aut]
bem Heel fo wut
Aca cy browfodey
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Over
Vart aud
Si clemece
erwrutatnate,
Fonsi etka
lool pinmthy) blocky ay Not/k+/2u- Anatylniey
fo Nar ramet I te Astoay HO),
Wlockay a sido apecs chong with
VUMTT
= 3 Be Tron ator
Sha. Bled
Toxin
Faligning
Pegpeicame
vyo fohyshon & 5 EEE
P53 we Oe eee
&
i Vu eect
teapert acorn’ Provicarm a
aM Vuyperli|pdorta \. 4
eee
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u :
ee = iabinihiec
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ee Ge flood dU he er day \
iG 3
| Wy nin 4 blood
L
erlucae plusmn cones
lov
agp gacarinrsen
no spose
png aca ea caieled
Rn es a Bee
pont Fed peur hwy
syne in DU.
Ms Aaguinbul asedsevphon
aie — contamt Leob divans
Kypo = NW PMY
Te
a Hgpeandn vg, tnvolvey
Motor/ECfernt owes
SON ETAT — indachi gongtion bio peed and gun
Hype. Bee wulnxed
Coronet — CSarbatralvn)
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Nas Maosts t eX) Hajdatiits )
| te ai
fa an Yuet a ; Trvwmn hwo ach,
fh i
Combis tnondl Dial bropdvay moe
onng
2aeee TN ebalinnitd 4
a indy oe eae 1
Condaia, Debusn » z
ies ot Nog PRelesen GB'Dekraty maids
acai — @ Urey Wieder |
Qntcion i Stmlot, Qgedn of
ganitole Gq of inom 4
women
eile ins cAeoihuial) 2
Antiadruanyte day (Mask me)
: ¥ Not alt
chotwayle AH (Moi con)
yh
UL Sexe
ago :
Conbeabtnny Achve Most, > Chelthuge. Shug,
Ralerehtas Pay ivr Muy dav y 9 ‘i
Contatchiont Adive Mydueud 9 Adrnnuyze da
Relsahtn — Peusive Mosiy —) Ankiadwruey ed
* Blood yene
s Male i856 oer, uses oh pn ue 6 Conkrnindicorloiany
‘ Lol comkpahen diate a
sen Alten chide Le Bron drcal athnaoy
male 7 gine Pua 6 Inotehe spon
Peet Masts emd deta TOT
Aa
BE eeostoricn Ls Vephe VEOH
Pe oe cea 2. Cononng Irangfiency
Mayealrne gna
“8 a As Obstruckve OAL cd
oparahve deowran alten Seen cr
Senaunshot ==
——
Pite centegorel Tubal. a tua contin
BAH mula)
1 M2)M3 acaba
fading af Add
aye
_Conmatndircedtion
\. Neve Coney Je qPhancome
Prostaly< Paypedmoplay ;
Liki funtion con oct, Ws Ne ako do dept NA. Wi
eo} Ada :
mpi dake lay
oh oarepreet 5, © Avonal pple — cor ve betel by
@) Verteten able Com Se blak
eaunlptng
Vero dvareso 1
Me te & cobediility
Perens 2
ee Rehormmhon
Behorech sy,
Uven Day —
ryan DY
clanieeabioh — Seneensheat
—— CHOLINERGIC DRUGS
Anticholinesterases
are tie) eee ely
Muscarine
Pilocarpine
Arecoline
1c
Carbachol
Cc ‘arba ryl
Bethanechol Physostigmine | Tacrine
(Eserine) (Sevin) Echothiophate
Neostigmine Propoxur* Malathion*
Pyridostigmine (Bayyon) Diazinon*
* Insecticides Edrophonium (TIK-20)
© Nerve gases Rivastigmine Tabun ©
for chemical Donepezil Sarin £ .
warfare Galantamine Soman Liles.
(Scopolamine)
(Muscarinic antagonists, Atropintc drugs, Parasympatholytics)
ST CeCe eet Synthetic compounds
Atropine methonitrate
Horiabropied: . Mydriatics Vasicoselective | Antiparkinsonian
Hyoscine butyl bromide
Ipratropium bromide Cydopentolate Oxybutynin Trihexyphenidyl
Tiotropium bromide Tropicamide Flavoxate (Benzhexol)
Tolterodine Procydidine
Antisecretory-antispasmodics Biperiden
Quaternary comps. | Tertiary amines
Propantheline Dicyclomine
Oxyphenonium Valethamate
Clidinium Pirenzepine
Pipenzolate methyl
bromide
Isopropamide
Glycopyrrolate
o ADRENERGIC DRUGS
{Sympathomimetics)
Pressor agents Bronchodilators CNS stimulants Uterine relaxants
Noradrenaline tsoprenaline Amphetamine Ritodrine
(Norepinephrine) Salbutamol Dexamphetamine Isoxsuprine
Ephedrine (Albuterol) Methamphetamine Salbutamol
Dopamine Terbutaline Methylphenidate Terbutaline
Phenylephrine Salmeterol
Methoxamine Formaterol
Mephentermine Bambuterol
Cardiac stimulants Nasal decongestants Anorectics
Adrenaline Xylometazoline Amphetamine
lsoprenaline Oxymetazoline fenfluramine
Dobutamine Naphazoline Oexfenfluramine
Phenylephrine Sibutramine
Phenylpropanolamine
Pseudoephedrine Ae tie Quen on
ganesh by neater “bona,
Bs Seegimonwit: — (eC
Verte uy thle *
tohtin 3 Trwohsa Baronet
Fivloy 3 AULrgn, (Deak, pollan , ote’)
ho AsPamn
(dithedhy in heettvrns)
(As mos ot wlan (Br)
9 Csomel) (Hemiph nenrne Saarinen)
Tq - Mott atl conlptc co
3 0
Spsele cent
Leucobuent
[Link]
Lautobwene 4
o Genot Cirint . eet i
re fe, Asthma Auk > Vor b
e paonthe drab ateq
Chunittceon (exanp tu) D> Sorrenshat
EE DRUGS FOR BRONCHIAL ASTHMA
Ets ye) des Leelee (eeng Clee] tc)
Sod, cromoglycate
Ketotifen
eT) Sol eat
Fale) fee
Montelukast
Zafirlukast
PS ht eole hy
Omalizumab
inhalational
Bronchodilators
Systemic
Hydrocortisone Beclomethasone
Prednisolone dipropionate
Other glucocorticoids | Budesonide
Fluticasone
», By Sympathomimetics | Methylxanthines | Anticholinergics propionate
Flunisolide
Salbutamol Theophylline Ipratropium Br. :
Terbutaline Aminophylline Tiotropium Br, Cictesonide
Bambuterol Choline
Salmeterol theophyllinate
Formoterol Hydroxyethyt
theophylline
Doxophylline ie Chisrrornonk + oo
Trtocho)| chteosidy
Nom-daebaty
Cott
. 4
A ~ Tbowunannt
+
uleas 4 Wuskorht
govt
aa
> fh nwolshe Poly nest
Syd
~ HIF Hepakotorre > Cuntum * Coroniion
L _ Uy
Lex Wika No Histemiva
Conde WH
Lo as
x Dern canrorueer
Css a3
PARAL Pipecuroninn
re Ve Wao
Rocrwntun '
Rabuicunortien
Qu made Arluxcat, ef, Uhetey — in pebtent
liven 4 Remol direarr -
N
Betoun Hoberman s Euiminahbh
ANY Histewns
AMID [maikalli2 wn nay
YoStymenn ohn wed ty
Apis (oe eh om \
Sisco Aleka i
ey
Uistaminn arrabter
— Semin tah
Dotarruhy yn,
recy & Conbuthyy,
Pvetely : Verodicluhiy, ; :
Thoure pemnvillly, CHa phuntraing,
+ Newotoumitten, ° Prom aay -
© Ranthidan.
* Fomohdting
8 Tipro liso
Ry 4 Norcolupiy Ankita
oe
EE Sen Att ithe DA Can Arntthileoning
Caviiolluyt | Anh muh \
Annverhip ) Con pecacst
Nob woster 85K
No tedehon
Ne Antoholawiylt. adh' a
Coknirtue
Lmatidty
Fexo enact,
AStami 20g
Leve etnies
Use
AULAg'C
a Aug
» Rowanity
uu. Mohon S(Ue vert
ca Partyyrson's
g- Naw + Vo
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