{"id":716,"date":"2021-12-07T12:02:16","date_gmt":"2021-12-07T12:02:16","guid":{"rendered":"https:\/\/forcefieldtx.com\/?page_id=716"},"modified":"2025-03-05T11:31:38","modified_gmt":"2025-03-05T11:31:38","slug":"treatment","status":"publish","type":"page","link":"https:\/\/forcefieldtx.com\/treatment\/","title":{"rendered":"Treatment"},"content":{"rendered":"
[vc_row thb_full_width=”true” css=”.vc_custom_1701859544503{border-top-width: 15px !important;border-right-width: 15px !important;border-left-width: 15px !important;background-color: #002350 !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;}” bg_gradient1=”rgba(0,35,80,0.6)” bg_gradient2=”rgba(0,35,80,0.6)” thb_video_bg=”https:\/\/forcefieldtx.com\/wp-content\/uploads\/2023\/12\/Forcefield_Treatment_2023.mp4″ el_class=”align-center”][vc_column thb_color=”thb-light-column” css=”.vc_custom_1701896064285{padding-top: 15vh !important;padding-bottom: 15vh !important;}” el_class=”align-center” offset=”vc_col-lg-12″][vc_row_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”2\/3″ css=”.vc_custom_1701896179352{padding-left: 5vw !important;}”][vc_empty_space height=”2vh”][vc_column_text css=”.vc_custom_1639114819670{padding-top: 3vh !important;}” animation=”animation bottom-to-top”]\n

><\/span> Treatment
\n<\/span><\/h4>\n[\/vc_column_text][vc_column_text animation=”animation bottom-to-top”]\n

Revolutionising Treatment of Heart Attacks.<\/h1>\n[\/vc_column_text][vc_empty_space height=”3vh”][vc_column_text css=”.vc_custom_1701795879580{padding-right: 5vw !important;}” animation=”animation bottom-to-top”]Forcefield Therapeutics is pioneering proteins with the natural ability to retain heart function after a heart attack (myocardial infarction or MI) by preserving cardiomyocytes, sustaining cardiac function and preventing clinical changes in the heart.[\/vc_column_text][vc_empty_space height=”2vh”]\t\n\t\t\t\t\t<\/i><\/span>\t\t\tLearn More<\/span>\n\t\t\t<\/a>\n\t\t[vc_empty_space height=”1vh”][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”top” parallax=”content-moving” parallax_image=”234″ css=”.vc_custom_1638976853445{border-top-width: 15px !important;border-right-width: 15px !important;border-bottom-width: 15px !important;border-left-width: 15px !important;background-color: #f2f7f4 !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;border-bottom-color: #ffffff !important;border-bottom-style: solid !important;}” el_id=”Restorative” el_class=”Restorative” bg_gradient1=”rgba(255,255,255,0.9)” bg_gradient2=”rgba(255,255,255,0.9)”][vc_column][vc_row_inner content_placement=”top”][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”2\/3″][vc_empty_space height=”15vh”][vc_column_text]\n
Restorative Actions
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Responding to the urgent need to minimise the impact of myocardial infarction and prevent further cardiomyocyte death, we have identified three naturally occurring cardioprotectant proteins, with separate restorative actions.
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Revitalise
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Revitalise heart function preventing
\nprogression to heart failure
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Remove, Recycle & Restore
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Remove, recycle and restore damaged cardiomyocyte proteins<\/span><\/p>\n[\/vc_column_text][vc_icon icon_fontawesome=”fas fa-angle-down” color=”custom” size=”xs” align=”center” css_animation=”fadeInDown” custom_color=”#65f29b”][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_empty_space mobile_height=”6vh” height=””]\t

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Protect
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Protect damaged\/dying cardiomyocytes keeping them healthier for longer<\/span><\/p>\n[\/vc_column_text][vc_icon icon_fontawesome=”fas fa-angle-down” color=”custom” size=”xs” align=”center” css_animation=”fadeInDown” custom_color=”#65f29b”][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”text-center” css=”.vc_custom_1637938306132{margin-top: 5vh !important;}”][vc_column_inner]\t\n\t\t\t\t\t<\/i><\/span>\t\t\tLearn More<\/span>\n\t\t\t<\/a>\n\t\t[\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”10vh”][\/vc_column][\/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”top” css=”.vc_custom_1638958446855{background-color: #f9f9f9 !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” el_id=”Rejuvinating”][vc_column width=”2\/3″ css=”.vc_custom_1638883484350{border-top-width: 15px !important;border-right-width: 15px !important;border-left-width: 15px !important;background-color: #ebf9f5 !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;}”][vc_row_inner content_placement=”top” css=”.vc_custom_1638898387269{margin-top: 5vw !important;margin-right: 5vw !important;margin-bottom: 5vw !important;margin-left: 5vw !important;}”][vc_column_inner][vc_empty_space mobile_height=”6vh” height=””]\t

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Cardioprotective Biology<\/span>
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Forcefield\u2019s novel approach stimulates cardioprotective biology as shown in proof-of-principle studies.<\/span><\/h3>\n[\/vc_column_text][vc_empty_space height=”3vh”][vc_column_text animation=”animation bottom-to-top”]Our cardioprotectant proteins prevent cardiomyocytes dying and improve long-term outcomes. They do this via three key mechanisms, namely: promotion of cellular repair (autophagy), prevention of cell death (apoptosis), inhibition of scarring (fibrosis), ultimately leading to less heart failure.<\/p>\n

Other treatments tested in the clinic have failed to demonstrate these combination of effects (cyclosporine, cardiac ischaemic post-conditioning, sodium nitrite and MYDGF).[\/vc_column_text][vc_empty_space height=”3vh”][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”1\/3″ css=”.vc_custom_1640079523425{border-top-width: 15px !important;border-right-width: 15px !important;border-left-width: 15px !important;background-color: #4bc3af !important;background-position: 0 0 !important;background-repeat: no-repeat !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;}”][vc_row_inner css=”.vc_custom_1637923678716{margin-top: 5vw !important;margin-bottom: 5vw !important;}”][vc_column_inner thb_color=”thb-light-column”][vc_empty_space mobile_height=”6vh” height=””]\t

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In our gold-standard mouse studies, the proteins outperformed existing treatments.<\/h4>\n[\/vc_column_text][vc_empty_space height=”2vh”][vc_column_text css=”.vc_custom_1640080275240{padding-right: 3vw !important;}” animation=”animation bottom-to-top”]\n

These studies showed that the proteins successfully preserved left ventricular function compared to control treated animals at d15 post-MI, with significantly larger diastolic volume at d60 post-MI when heart failure occurs in controls.<\/h6>\n
There was no evidence of pathological remodelling in treated animals. As early as d2 post-MI the positive cellular effect of these proteins was observed to include prevention of cardiomyocyte apoptosis by TUNEL staining of heart tissue and removal of cellular damage by autophagy shown by LC3 positive autophagosomes and autophagic flux. Lastly, one of the proteins had a profound anti-fibrotic effect, preventing fibroblast activation and scarring through suppression of TGF-beta mediated pathology.<\/h6>\n[\/vc_column_text][vc_empty_space height=”5vh”]\t\n\t\t\t\t\tLearn More<\/span>\n\t\t\t<\/a>\n\t\t[vc_empty_space mobile_height=”6vh” height=””][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” full_height=”yes” content_placement=”top” css=”.vc_custom_1638964442991{border-top-width: 15px !important;border-right-width: 15px !important;border-left-width: 15px !important;background-color: #f4f4f4 !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;}” el_id=”OurApproach” el_class=”align-center” bg_gradient1=”rgba(255,255,255,0.9)” bg_gradient2=”rgba(255,255,255,0.9)”][vc_column el_class=”align-center” offset=”vc_col-lg-10″][vc_empty_space height=”10vh”][vc_row_inner content_placement=”top”][vc_column_inner width=”1\/4″]\t
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Our Approach<\/span>
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We intend to develop this therapy as an easily and acutely administered formulation enabling rapid treatment post-myocardial infarction before heart damage becomes irreversible.
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Short-term treatment provides both a short- and long-term solution, preserving cardiac function and preventing likely progression to heart failure. <\/span>This approach is designed to be used in combination with the existing Standard of Care (SOC) in the critical period immediately after MI.<\/span><\/p>\n

We will develop a biopharmaceutical with a safe and efficacious mode of action (MoA) and ease of manufacturing. <\/span>The proteins are known but have not previously been applied to treat MI<\/span>.[\/vc_column_text][vc_empty_space height=”5vh”][vc_column_text animation=”animation top-to-bottom”]\n

Our goal is to improve outcomes after heart attack by retaining cardiomyocyte function<\/span><\/h4>\n[\/vc_column_text][vc_empty_space height=”2vh”]\t
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Simplicity<\/span><\/h5>\n

Revolutionising Treatment<\/span><\/h3>\n[\/vc_column_text][vc_empty_space mobile_height=”3vh” height=”5vh”][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/3″][vc_empty_space mobile_height=”0vh” height=””]\t
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Long-term benefit
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Safe and Efficacious<\/span><\/h5>\n
\u00a0<\/span><\/h5>\n[\/vc_column_text][vc_icon icon_fontawesome=”fas fa-angle-down” color=”custom” size=”xs” align=”center” css_animation=”fadeInDown” custom_color=”#65f29b”][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_empty_space mobile_height=”6vh” height=””]\t
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Single i.v. dose
\n<\/span><\/h3>\n[\/vc_column_text][vc_column_text animation=”animation bottom-to-top”]\n
Naturally occurring protein<\/span>
\nadded to SOC
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Manufacturing
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Standard manufacturing process<\/span><\/h5>\n[\/vc_column_text][vc_icon icon_fontawesome=”fas fa-angle-down” color=”custom” size=”xs” align=”center” css_animation=”fadeInDown” custom_color=”#65f29b”][\/vc_column_inner][\/vc_row_inner][vc_row_inner el_class=”text-center” css=”.vc_custom_1637938306132{margin-top: 5vh !important;}”][vc_column_inner]\t\n\t\t\t\t\t<\/i><\/span>\t\t\tLearn More<\/span>\n\t\t\t<\/a>\n\t\t[\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”10vh”][\/vc_column][\/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”middle” disable_element=”yes” bg_gradient_direction=”-90″ css=”.vc_custom_1701787816783{border-top-width: 15px !important;border-right-width: 15px !important;border-bottom-width: 15px !important;border-left-width: 15px !important;background-color: #65f29b !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;border-bottom-color: #ffffff !important;border-bottom-style: solid !important;}” bg_gradient1=”rgba(75,195,175,0.9)” bg_gradient2=”rgba(101,242,155,0.85)” el_class=”align-center” el_id=”FunSel” thb_video_bg=”https:\/\/forcefieldtx.com\/wp-content\/uploads\/2021\/12\/Forcefield_Treatment_2.mp4″][vc_column thb_color=”thb-light-column” offset=”vc_col-lg-10″][vc_empty_space height=”15vh”][vc_row_inner][vc_column_inner width=”1\/4″][\/vc_column_inner][vc_column_inner width=”3\/4″]\t
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A transformational search engine that has enabled us to discover a totally new way to protect the heart after MI.<\/h4>\n

FunSel is a completely new way of discovering drugs \u2013 Functional selection, removing the bias built into previous drug discovery which is always disease or target focused. FunSel is gene and mechanism of action agnostic, based instead on the physiology of the organ and disease in question.<\/h4>\n[\/vc_column_text]\t\n\t\t\t\t\t<\/i><\/span>\t\t\tPlatform<\/span>\n\t\t\t<\/a>\n\t\t[\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”15vh”][\/vc_column][\/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”middle” css=”.vc_custom_1701863884344{border-top-width: 15px !important;border-right-width: 15px !important;border-bottom-width: 15px !important;border-left-width: 15px !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;border-bottom-color: #ffffff !important;border-bottom-style: solid !important;}” thb_video_bg=”https:\/\/forcefieldtx.com\/wp-content\/uploads\/2021\/12\/Forcefield_Treatment_2.mp4″ bg_gradient1=”rgba(0,35,80,0.6)” bg_gradient2=”rgba(0,35,80,0.6)” el_id=”Quote”][vc_column thb_color=”thb-light-column”][vc_empty_space height=”15vh”][vc_row_inner][vc_column_inner width=”1\/4″][\/vc_column_inner][vc_column_inner width=”3\/4″ css=”.vc_custom_1701780301031{padding-right: 10% !important;}”][vc_column_text animation=”animation bottom-to-top”]\n

\u201c<\/span> This is a particularly exciting therapy to develop as it acts directly on the heart unlike most other drugs we currently use after MI, which target neurohumoral pathways or platelet function.<\/h3>\n

It therefore has the potential to effect major improvements in patient outcome. Moreover, it would involve a very focused and time-limited treatment over just 1-2 days.\u201d<\/span><\/h3>\n[\/vc_column_text][vc_column_text css=”.vc_custom_1637630993063{padding-right: 5vw !important;}” animation=”animation bottom-to-top”]\n
Prof. Ajay Shah
\n<\/span>Clinical Advisor
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