HEPATITIS
VIRALES
Santiago Del Castillo Álvarez
Monitor-Docente
Microbiología y Parasitología
XI Semestre
Medicina UPB
VIRUS DE LA HEPATITIS A (VHA)
TAXONOMIA RNA Monocatenario
● Familia: Picornaviridae. Sentido positivo
● Género: Hepatovirus.
Baltimore IV
MORFOLOGIA
Esférica, capside
icosaédrica, desnudo,
Tamaño de aprox
27-28nm
VIRUS DE LA HEPATITIS A (VHA)
REPLICACIÓN
● Producción de un
Único polipéptido que
contiene Proteínas
estructurales (VP 1-3) y
otras replicativas.
● VP1, VP2 y VP3
Mecanismos de Transmisión
01. Interpersonal
Fecal-oral
02. Alimentos y Agua
contaminada.
● Contacto Estrecho
● Sexual (HSH)
03. Hemoderivados
04. Vertical
Patogenia
Incubación
15-50 Días, promedio de
28-30 días
PTE infeccioso
Desde 2da semana de
infx hasta 1 post ictericia
Viremia
Desde el pródromo y
persiste mientras estén
las Transaminasas
elevadas
MANIFESTACIONES CLÍNICAS No genera infección
crónica
PIEL Y MUCOSAS
GENERALES
Gastro y
genitourinario
Cuadro Pseudogripal
ICTERICIA
Prodromo: Astenia,
Coluria, heces color
Fiebre, mialgias,
arcilla o acólicas. Dolor
artralgias, cefalea.
abdominal
Epidemiología
Diagnóstico
IgM anti VHA RT-PCR
Ampliamente disponible, Más costosa, muestra de
muestra de sangre. materia fecal.
Virus de la hepatitis E (VHE)
TAXONOMIA RNA Monocatenario
● Familia: Sentido positivo
Hepeviridae
● Género: Baltimore IV
Hepevirus
MORFOLOGIA
Esférica, capside
icosaédrica, desnudo,
Tamaño de aprox 32nm
VIRUS DE LA HEPATITIS E (VHE)
REPLICACIÓN
● Producción de
Proteínas como ORF3
que parece tener papel
regulador en la
infección y ORF2
principal de la cápside
● ORF2 antígeno
de las vacunas
en desarrollo.
Mecanismos de Transmisión
Patogenia
Incubación
28-40 Días, promedio de
35 días
PTE infeccioso
No hay claridad en los
tiempos.
Viremia
Desaparece
rápidamente y dificulta
el diagnóstico.
MANIFESTACIONES CLÍNICAS Puede evolucionar a
infección crónica en
inmunocomprometidos
PIEL Y MUCOSAS
GENERALES
Gastro y
genitourinario
Cuadro Pseudogripal
ICTERICIA
Prodromo: Astenia,
Coluria, heces color
50% Fiebre, mialgias,
arcilla o acólicas. Dolor
artralgias, cefalea.
abdominal
Epidemiología
Diagnóstico
IgM anti VHE RT-PCR
Ampliamente disponible, Más costosa, muestra de
muestra de sangre. materia fecal.
VHA VS VHE
Virus de la
Hepatitis C
(VHC)
VIRUS DE LA HEPATITIS C (VHC)
TAXONOMIA RNA Monocatenario
● Familia: Flaviviridae. Sentido positivo
● Género: Hepacivirus.
Baltimore IV
MORFOLOGIA
Esférica, capside
icosaédrica, ENVUELTO,
Tamaño de aprox 55nm
VIRUS DE LA HEPATITIS C (VHC)
REPLICACIÓN
● Proteínas estructurales:
Core © E1, E2 y
viroporina
● Proteínas no
estructurales: NS2,NS3,
NS4A NS4B, NS5A
NS5B (RNA POL)
● POLIPROTEÍNA ÚNICA.
Mecanismos de Transmisión
01. PARENTERAL
02. SEXUAL.
● Drogas IV
● Transplante de
Organos.
● Transfusiones*
04. Vertical
Patogenia
Incubación
15-160 Días, promedio de
50 días
PTE infeccioso
No hay claridad en los
tiempos.
Viremia
Puede durar muchos
años.
Epidemiología
Diagnóstico
Anticuerpos
totales anti RT-PCR
VHC VHC
ELISA
Diagnóstico
Tratamiento
INH RNA
INH Proteasa INH NS5A POLIMERASA
PREVIR ASVIR BUVIR
VIRUS DE LA HEPATITIS B (VHB)
TAXONOMIA DNA DOBLE CADENA
● Familia: PARCIAL
Hepadnaviridae.
Baltimore VII
● Género:
Orthohepadnavirus.
MORFOLOGIA
Esférica, capside
icosaédrica, ENVUELTO,
Tamaño de aprox 42nm
VIRUS DE LA HEPATITIS B (VHB)
REPLICACIÓN
● 4 genes:
● S: antígeno de
superficie.
● C: nucleocapside core y
antigeno E
● X: Proteina X
● P: DNA Polimerasa
● HBsAg target
de las vacunas
Patogenia
Incubación
30-180 Días, promedio
de 60-90 días
HBsAg
Detectable después de
la semana 3-4 y durante
toda la infección
Anti HBs
Indican curación o
vacunación.
Patogenia
IgM anti HBc (core)
Marcador de infección
aguda más sensible.
Anti HBc TOTAL
(core)
Prevalecen en el tiempo.
Epidemiología
Mecanismos de Transmisión
01. PARENTERAL
02. SEXUAL.
● Drogas IV
● Transplante de
Organos.
● Transfusiones*
03. Horizontal. 04. Vertical
Diagnóstico HBsAg IgM anti HBc Anti core total Anti HBs
+ + + -
HBsAg IgM anti HBc Anti core total Anti HBs
- - + +
HBsAg IgM anti HBc Anti core total Anti HBs
- - - +
HBsAg IgM anti HBc Anti core total Anti HBs
+ - + -
Tratamiento
AGUDO= SOPORTE
VIRUS DE LA HEPATITIS D (VHD)
TAXONOMIA RNA circular
● Familia: No asignada Cadena simple
● Género: Deltavirus.
MORFOLOGIA
Esférica, capside
icosaédrica, ENVUELTO,
Tamaño de aprox
35-37nm
Patogenia
Incubación
30-180 Días, promedio
de 60-90 días
VHB
Requiere de la infx por
HB
Antigeno delta HDAg
Uníca proteina
producida por el virus.
Coinfección y sobreinfección
Vacunación
Muchas
gracias.
This slide is only for Premium users
A PICTURE IS WORTH A
THOUSAND WORDS
This slide is only for Premium users
THIS IS A MAP
VENUS
Venus is the second
planet from the Sun
MARS
Despite being red, Mars
is actually a cold place
EARTH
The Earth is the only
planet that harbors life
This slide is only for Premium users
OUR CENTER
Do you know what helps you make your
point clear?
Lists like this one:
1. They’re simple
2. You can organize your ideas clearly
3. You’ll never forget to buy milk!
And the most important thing: the
audience will definitely not miss the
point of your presentation
This slide is only for Premium users
MISSION VISION
Mercury is the smallest Neptune is the farthest
planet and the closest one planet from the Sun. It's
to the Sun also the fourth-largest
This slide is only for Premium users
MILESTONES REACHED
EARTH VENUS
It’s the third planet It has a beautiful
from the Sun name
2003-2005 2005-2007 2007-2009 2009-2011 2011-2012
PLUTO MERCURY MARS
It’s now considered It’s the closest It’s actually a cold
a dwarf planet planet to the Sun place
This slide is only for Premium users
This slide is only for Premium users
This slide is only for Premium users
KEY NUMBERS
120,000
Pluto is now considered a dwarf planet
30,000
Mars is actually a cold place
5,000
Mercury is the smallest of them all
This slide is only for Premium users
OUR GRAPHS
MERCURY
Mercury is the closest
planet to the Sun and
the smallest one
VENUS
Venus has a beautiful
name and is the
second planet
MARS
* To modify this graph, click on it, follow the link, change the Despite being red,
data and paste the new graph here, replacing this one. Mars is actually a cold
You can see how to modify the graph here place full of iron oxide
This slide is only for Premium users
This slide is only for Premium users
SERVICES
MERCURY MARS
Mercury is the closest Despite being red, Mars
planet to the Sun and is actually a cold place.
the smallest one It's full of iron oxide dust
VENUS NEPTUNE
Venus has a beautiful Neptune is the farthest
name and is the second planet from the Sun. It's
planet from the Sun also the fourth-largest
This slide is only for Premium users
This slide is only for Premium users
QUALITY IMPROVEMENT MEASURES
MERCURY MARS
Mercury is the smallest planet Jupiter is made of gas and it’s
JUPITER in the Solar System the biggest planet of them all
Venus is the second planet Saturn is a gas giant and has
SATURN from the Sun several rings
Despite being red, Mars is Neptune is the farthest planet
VENUS actually a cold place from the Sun
This slide is only for Premium users
A BRIEF STORY
Saturn is a gas giant and has several
rings. It's composed mostly of
hydrogen and helium. It was named
after the Roman god of wealth
This slide is only for Premium users
OUR PROCESS
JUPITER MERCURY
Jupiter is a gas giant Mercury is the closest
and the biggest planet planet to the Sun
NEPTUNE PLUTO
Neptune is the farthest Pluto is considered a
planet from the Sun dwarf planet
This slide is only for Premium users
AWARDS
MERCURY VENUS MARS
Mercury is the closest Venus has a beautiful Despite being red, Mars
planet to the Sun and name and extremely is actually a cold place.
the smallest one high temperatures It's full of iron oxide
This slide is only for Premium users
PATIENT CARE
Neptune is the farthest planet
from the Sun. It's also the
fourth-largest object by
diameter in the Solar System
This slide is only for Premium users
AREAS WE COVER
MERCURY VENUS MARS
Mercury is the closest Venus is the second Mars is actually a very
planet to the Sun planet from the Sun cold place
JUPITER SATURN NEPTUNE
Jupiter is the biggest Saturn is composed of Neptune is the farthest
planet of them all hydrogen and helium planet from the Sun
This slide is only for Premium users
This slide is only for Premium users
This slide is only for Premium users
20,000,000
Big numbers catch your audience’s attention
This slide is only for Premium users
PATIENT SATISFACTION
JUPITER
20% 30% Jupiter is a gas giant
and the biggest planet
MERCURY
Mercury is the closest
planet to the Sun
NEPTUNE
50% Neptune is the farthest
planet from the Sun
This slide is only for Premium users
This slide is only for Premium users
INNOVATIONS
MARS
Despite being red, Mars is
actually a cold place. It's full of
iron oxide dust
VENUS
Venus has a beautiful name
and is the second planet from
the Sun. It’s terribly hot
MERCURY
Mercury is the closest planet
to the Sun and the smallest
one in the Solar System
This slide is only for Premium users
This slide is only for Premium users
OUR TEAM
JENNA DOE TIMMY JIMMY
You can talk a bit about You can talk a bit about
this person here this person here
This slide is only for Premium users
TESTIMONIALS
“Mercury is the closest “Despite being red, Mars
planet to the Sun” is actually a cold place”
JENNA DOE, 25 JOHN JAMES, 36
“Venus is the second “Neptune is the farthest
planet from the Sun” planet from the Sun”
FRED BLOGGS, 31 HELENA SMITH, 58
This slide is only for Premium users
VISIT OUR WEBSITE!
You can replace the image on
the screen with your own
work. Just right-click on it and
select “Replace image”
This slide is only for Premium users
THANKS!
Do you have any questions?
youremail@[Link]
+91 620 421 838
[Link]
CREDITS: This presentation template was created by
Slidesgo, including icons by Flaticon, and infographics &
images by Freepik and illustrations
Please keep this slide for attribution
This slide is only for Premium users
ALTERNATIVE RESOURCES
This slide is only for Premium users
RESOURCES
Did you like the resources on this template? Get them for free at our other websites:
VECTORS
● Organic motion graphics landing page template
● Hand drawn national nurses day illustration
● Nature cosmetics landing page template
● Illustrated medical stickers set
● Medical feast illustration with thermometer and stethoscope
● Health clinic poster template
● Young doctors health professional team
● Self care health concept
● World health day flat design
PHOTOS
● Close-up patient talking to doctor online
● Medium shot health worker helping patient
● Cheerful medics team in lab
● Female doctor taking notes on a clipboard
This slide is only for Premium users
Instructions for use
In order to use this template, you must credit Slidesgo by keeping the Thanks slide.
You are allowed to:
- Modify this template.
- Use it for both personal and commercial projects.
You are not allowed to:
- Sublicense, sell or rent any of Slidesgo Content (or a modified version of Slidesgo Content).
- Distribute Slidesgo Content unless it has been expressly authorized by Slidesgo.
- Include Slidesgo Content in an online or offline database or file.
- Offer Slidesgo templates (or modified versions of Slidesgo templates) for download.
- Acquire the copyright of Slidesgo Content.
For more information about editing slides, please read our FAQs or visit Slidesgo School:
[Link] and [Link]
Fonts & colors used
This presentation has been made using the following fonts:
Alata
([Link]
Montserrat
([Link]
#2f4a8a #ffffff #666666 #4869b1 #7eacec
#f8dbc4 #ffb172 #c3d9fb #90d1cb #afdcdd
Storyset
Create your Story with our illustrated concepts. Choose the style you like the most, edit its colors, pick the
background and layers you want to show and bring them to life with the animator panel! It will boost your
presentation. Check out how it works.
Pana Amico Bro Rafiki Cuate
Use our editable graphic resources...
You can easily resize these resources without losing quality. To change the color, just ungroup the resource
and click on the object you want to change. Then, click on the paint bucket and select the color you want.
Group the resource again when you’re done. You can also look for more infographics on Slidesgo.
JANUARY FEBRUARY MARCH APRIL MAY JUNE
PHASE 1
Task 1
Task 2
PHASE 2
Task 1
Task 2
JANUARY FEBRUARY MARCH APRIL
PHASE 1
Task 1
Task 2
...and our sets of editable icons
You can resize these icons without losing quality.
You can change the stroke and fill color; just select the icon and click on the paint bucket/pen.
In Google Slides, you can also use Flaticon’s extension, allowing you to customize and add even more icons.
Educational Icons Medical Icons
Business Icons Teamwork Icons
Help & Support Icons Avatar Icons
Creative Process Icons Performing Arts Icons
Nature Icons
SEO & Marketing Icons
Medical Infographics
