Analysis of the effectiveness of pressure-reducing seat cushions. Literature review. Investigatio... more Analysis of the effectiveness of pressure-reducing seat cushions. Literature review. Investigation of the literature yielded 8 relevant studies. These studies encompassed three clinical trials with a total of 296 patients, and five laboratory experiments with a total of 107 subjects, including patients. The publications were written at level A (RCT and meta-analysis) and level B (other study forms) according to the principles of evidence-based medicine. Both the pressure parameters of the pressure-reducing seat cushion and the development of pressure ulcers were used as measures for outcome. A 7.6 cm foam cushion was used as reference; it was not considered as one of the pressure-reducing systems. Two studies compared different types of air seat cushions with a foam/gel seat cushion. The best distribution of pressure was found for the air compartment seat cushion. This type of seat cushion provided the smallest contact surface with high pressures. Three studies compared the pressure...
The Journal of International Medical Research, Jun 1, 1992
In recent publications much attention has focused on skin changes as a consequence of ageing. Dur... more In recent publications much attention has focused on skin changes as a consequence of ageing. During life many internal and external factors have an influence on the condition of the skin but ultraviolet radiation seems to be a major factor in both benign and malignant alterations. To retard the deterioration process, more than cosmetic concern is necessary. In a pilot study, a fish protein product is shown to have the capacity to ameliorate, both objectively and subjectively, the symptoms of photo-aged skin. Recommendations are made for further evaluation.
The user has requested enhancement of the downloaded file. All in-text references underlined in b... more The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately. haematologica/journal of hematology vol. 88(06):june 2003 659
The first wound an wound treatments were described five millennia ago. Since then, various princi... more The first wound an wound treatments were described five millennia ago. Since then, various principles of wound care have been passed on from generation to generation. In contrast to large numbers of general technological inventions over the last 100 years, progress beyond ancient wound care practices is a recent phenomenon. It is essential to know the historical aspects of wound treatment (both successes and failures) in order to continue this progress and provide future direction. A survey of the literature shows that concepts such as "laudable pus" persisted for hundreds of years and that lasting discoveries and meaningful progress did not occur until grand-scale manufacturing and marketing started. Landmarks such as understanding the principles of asepsis/antisepsis, fundamental cellular research findings, knowledge about antibiotics/antimicrobials, moist wound healing, and the chemical and physical processes of wound healing have provided the foundation to guide major ...
Foam mattress quality affects pressure ulcer risk but no reliable method to assess mattress fatig... more Foam mattress quality affects pressure ulcer risk but no reliable method to assess mattress fatigue and indentation is available. To ascertain Indentation Quality values of standard 14-cm (5-inch) foam mattresses after 15 years of use, a convenience sample of 50 visco-elastic foam mattresses from a total of 1,000 same-brand mattresses used in a Dutch University hospital was tested using a durometer. Indentation Quality values were obtained on the mattress cover at a relatively unloaded zone (corner), at the head and heel zones, the knee and shoulder areas, and in the middle (buttocks area). Indentation Quality values ranged from a mean of -11.91 mm (+/-2.58) in the unloaded zone to a mean of -26.96 mm (+/-4.31) in the middle zone (buttocks area, P <0.001 compared to all other mattress areas). The value at the relatively unloaded zone was significantly and positively related to the values at the head and the heel zones (r = .70, P <.01) and the knee and the shoulder zones (r = ...
BACKGROUND: Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is a low-grade B-cell lymphom... more BACKGROUND: Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is a low-grade B-cell lymphoma that originates in the skin, with no evidence of extracutaneous disease. Studies focusing on the optimal treatment of PCMZL have not been published thus far. We describe 50 patients with PCMZL to further characterize clinical characteristics and outcome and, in particular, to evaluate our current therapeutic approach.
Molecular clonality analysis of immunoglobulin (Ig) and T-cell receptor (TCR) genes is a widely u... more Molecular clonality analysis of immunoglobulin (Ig) and T-cell receptor (TCR) genes is a widely used diagnostic tool for discrimination between polyclonal, oligoclonal, and monoclonal lymphoproliferative skin lesions. We studied Ig/TCR clonality in a series of 60 patients with an initial suspicion of (primary) cutaneous B- or T-cell lymphoma (CBCL/CTCL). Clonality of Ig/TCR gene rearrangements was assessed by Southern blot (SB) and polymerase chain reaction (PCR) analysis using standardized PCR primers and protocols of the BIOMED-2 Concerted Action BMH4-CT98-3936. The obtained PCR products were subjected to heteroduplex (HD) and GeneScan (GS) analysis. We compared the data of 154 samples with the histopathologic diagnosis, based on the EORTC classification of skin lymphomas. Molecular results were largely concordant with histopathology. In 12 CBCL patients PCR analysis of Ig gene rearrangements detected clonality in 83% of cases whereas SB did so in 92%. Clonal TCR gene rearrangemen...
BACKGROUND: Topical negative pressure (TNP) therapy has become a useful adjunct in the management... more BACKGROUND: Topical negative pressure (TNP) therapy has become a useful adjunct in the management of various types of wounds. However, the TNP system still has characteristics of a "black box" with uncertain efficacy for many users. We extensively examined the effectiveness of TNP therapy reported in research studies.
LTCL were treated with radiotherapy or excision. All patients with skin-limited disease from grou... more LTCL were treated with radiotherapy or excision. All patients with skin-limited disease from groups 1 and 2 who were treated with multiagent chemotherapy had 1 or more skin relapses. The calcu- lated risk for systemic disease within 10 years of diagnosis was 4% for group 1, 16% for group 2, and 20% for group 3 (after initial therapy). Disease-related 5-year-survival rates were 100% (group 1), 96% (group 2), 91% (group 3), and 24% (group 4), respectively. The results con- firm the favorable prognoses of these primary cutaneous CD301 lymphoprolifer- ative disorders and underscore that LyP and primary cutaneous CD301 lympho- mas are closely related conditions. They also indicate that CD30 1 LTCL on the skin and in 1 draining lymph node station has a good prognosis similar to that for primary cutaneous CD301 LTCL without concurrent lymph node involvement. Mul- tiagent chemotherapy is only indicated for patients with full-blown or developing extracutaneous disease; it is never or rarely ...
Journal of the American Academy of Dermatology, 2004
Polyarthritis in the presence of a cutaneous T-cell lymphoma is a rare phenomenon. We describe a ... more Polyarthritis in the presence of a cutaneous T-cell lymphoma is a rare phenomenon. We describe a case of mycosis fungoides with development of a symmetric erosive polyarthritis of the small hand joints and feet, diagnosed as rheumatoid arthritis. An identical monoclonal T-cell population in the skin and in the synovium was detected by T-cell receptor gene rearrangement analysis, illustrating articular dissemination of lymphoma cells. Differentiating mycosis fungoides-associated arthritis from rheumatoid arthritis may have important implications for treatment. Based on this case, the relevant literature, and the newest disease concepts, pathogenic mechanisms and therapeutic options of mycosis fungoides-associated arthritis are discussed.
Journal of the American Academy of Dermatology, 1989
We report the case of a 30-year-old female patient with non-von Recklinghausen&#39;s neurofib... more We report the case of a 30-year-old female patient with non-von Recklinghausen&#39;s neurofibromatosis. In our opinion it does not fit within a system of classification recently described. Clinically, the abnormality resembled a giant pigmented nevus; however, light- and electron microscopy findings were consistent with those of a neurofibroma. No other symptoms of classic neurofibromatosis or other diseases were present. The family history showed no evidence of neurofibromatosis. To the best of our knowledge this manifestation of non-von Recklinghausen&#39;s neurofibromatosis has not been previously described. The cause and the inheritance pattern of this variant are not clear.
Analysis of the effectiveness of pressure-reducing seat cushions. Literature review. Investigatio... more Analysis of the effectiveness of pressure-reducing seat cushions. Literature review. Investigation of the literature yielded 8 relevant studies. These studies encompassed three clinical trials with a total of 296 patients, and five laboratory experiments with a total of 107 subjects, including patients. The publications were written at level A (RCT and meta-analysis) and level B (other study forms) according to the principles of evidence-based medicine. Both the pressure parameters of the pressure-reducing seat cushion and the development of pressure ulcers were used as measures for outcome. A 7.6 cm foam cushion was used as reference; it was not considered as one of the pressure-reducing systems. Two studies compared different types of air seat cushions with a foam/gel seat cushion. The best distribution of pressure was found for the air compartment seat cushion. This type of seat cushion provided the smallest contact surface with high pressures. Three studies compared the pressure...
The Journal of International Medical Research, Jun 1, 1992
In recent publications much attention has focused on skin changes as a consequence of ageing. Dur... more In recent publications much attention has focused on skin changes as a consequence of ageing. During life many internal and external factors have an influence on the condition of the skin but ultraviolet radiation seems to be a major factor in both benign and malignant alterations. To retard the deterioration process, more than cosmetic concern is necessary. In a pilot study, a fish protein product is shown to have the capacity to ameliorate, both objectively and subjectively, the symptoms of photo-aged skin. Recommendations are made for further evaluation.
The user has requested enhancement of the downloaded file. All in-text references underlined in b... more The user has requested enhancement of the downloaded file. All in-text references underlined in blue are added to the original document and are linked to publications on ResearchGate, letting you access and read them immediately. haematologica/journal of hematology vol. 88(06):june 2003 659
The first wound an wound treatments were described five millennia ago. Since then, various princi... more The first wound an wound treatments were described five millennia ago. Since then, various principles of wound care have been passed on from generation to generation. In contrast to large numbers of general technological inventions over the last 100 years, progress beyond ancient wound care practices is a recent phenomenon. It is essential to know the historical aspects of wound treatment (both successes and failures) in order to continue this progress and provide future direction. A survey of the literature shows that concepts such as "laudable pus" persisted for hundreds of years and that lasting discoveries and meaningful progress did not occur until grand-scale manufacturing and marketing started. Landmarks such as understanding the principles of asepsis/antisepsis, fundamental cellular research findings, knowledge about antibiotics/antimicrobials, moist wound healing, and the chemical and physical processes of wound healing have provided the foundation to guide major ...
Foam mattress quality affects pressure ulcer risk but no reliable method to assess mattress fatig... more Foam mattress quality affects pressure ulcer risk but no reliable method to assess mattress fatigue and indentation is available. To ascertain Indentation Quality values of standard 14-cm (5-inch) foam mattresses after 15 years of use, a convenience sample of 50 visco-elastic foam mattresses from a total of 1,000 same-brand mattresses used in a Dutch University hospital was tested using a durometer. Indentation Quality values were obtained on the mattress cover at a relatively unloaded zone (corner), at the head and heel zones, the knee and shoulder areas, and in the middle (buttocks area). Indentation Quality values ranged from a mean of -11.91 mm (+/-2.58) in the unloaded zone to a mean of -26.96 mm (+/-4.31) in the middle zone (buttocks area, P <0.001 compared to all other mattress areas). The value at the relatively unloaded zone was significantly and positively related to the values at the head and the heel zones (r = .70, P <.01) and the knee and the shoulder zones (r = ...
BACKGROUND: Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is a low-grade B-cell lymphom... more BACKGROUND: Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is a low-grade B-cell lymphoma that originates in the skin, with no evidence of extracutaneous disease. Studies focusing on the optimal treatment of PCMZL have not been published thus far. We describe 50 patients with PCMZL to further characterize clinical characteristics and outcome and, in particular, to evaluate our current therapeutic approach.
Molecular clonality analysis of immunoglobulin (Ig) and T-cell receptor (TCR) genes is a widely u... more Molecular clonality analysis of immunoglobulin (Ig) and T-cell receptor (TCR) genes is a widely used diagnostic tool for discrimination between polyclonal, oligoclonal, and monoclonal lymphoproliferative skin lesions. We studied Ig/TCR clonality in a series of 60 patients with an initial suspicion of (primary) cutaneous B- or T-cell lymphoma (CBCL/CTCL). Clonality of Ig/TCR gene rearrangements was assessed by Southern blot (SB) and polymerase chain reaction (PCR) analysis using standardized PCR primers and protocols of the BIOMED-2 Concerted Action BMH4-CT98-3936. The obtained PCR products were subjected to heteroduplex (HD) and GeneScan (GS) analysis. We compared the data of 154 samples with the histopathologic diagnosis, based on the EORTC classification of skin lymphomas. Molecular results were largely concordant with histopathology. In 12 CBCL patients PCR analysis of Ig gene rearrangements detected clonality in 83% of cases whereas SB did so in 92%. Clonal TCR gene rearrangemen...
BACKGROUND: Topical negative pressure (TNP) therapy has become a useful adjunct in the management... more BACKGROUND: Topical negative pressure (TNP) therapy has become a useful adjunct in the management of various types of wounds. However, the TNP system still has characteristics of a "black box" with uncertain efficacy for many users. We extensively examined the effectiveness of TNP therapy reported in research studies.
LTCL were treated with radiotherapy or excision. All patients with skin-limited disease from grou... more LTCL were treated with radiotherapy or excision. All patients with skin-limited disease from groups 1 and 2 who were treated with multiagent chemotherapy had 1 or more skin relapses. The calcu- lated risk for systemic disease within 10 years of diagnosis was 4% for group 1, 16% for group 2, and 20% for group 3 (after initial therapy). Disease-related 5-year-survival rates were 100% (group 1), 96% (group 2), 91% (group 3), and 24% (group 4), respectively. The results con- firm the favorable prognoses of these primary cutaneous CD301 lymphoprolifer- ative disorders and underscore that LyP and primary cutaneous CD301 lympho- mas are closely related conditions. They also indicate that CD30 1 LTCL on the skin and in 1 draining lymph node station has a good prognosis similar to that for primary cutaneous CD301 LTCL without concurrent lymph node involvement. Mul- tiagent chemotherapy is only indicated for patients with full-blown or developing extracutaneous disease; it is never or rarely ...
Journal of the American Academy of Dermatology, 2004
Polyarthritis in the presence of a cutaneous T-cell lymphoma is a rare phenomenon. We describe a ... more Polyarthritis in the presence of a cutaneous T-cell lymphoma is a rare phenomenon. We describe a case of mycosis fungoides with development of a symmetric erosive polyarthritis of the small hand joints and feet, diagnosed as rheumatoid arthritis. An identical monoclonal T-cell population in the skin and in the synovium was detected by T-cell receptor gene rearrangement analysis, illustrating articular dissemination of lymphoma cells. Differentiating mycosis fungoides-associated arthritis from rheumatoid arthritis may have important implications for treatment. Based on this case, the relevant literature, and the newest disease concepts, pathogenic mechanisms and therapeutic options of mycosis fungoides-associated arthritis are discussed.
Journal of the American Academy of Dermatology, 1989
We report the case of a 30-year-old female patient with non-von Recklinghausen&#39;s neurofib... more We report the case of a 30-year-old female patient with non-von Recklinghausen&#39;s neurofibromatosis. In our opinion it does not fit within a system of classification recently described. Clinically, the abnormality resembled a giant pigmented nevus; however, light- and electron microscopy findings were consistent with those of a neurofibroma. No other symptoms of classic neurofibromatosis or other diseases were present. The family history showed no evidence of neurofibromatosis. To the best of our knowledge this manifestation of non-von Recklinghausen&#39;s neurofibromatosis has not been previously described. The cause and the inheritance pattern of this variant are not clear.
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