STYXL2

STYXL2
Identifiers
Aliases	STYXL2, dual specificity phosphatase 27 (putative), dual specificity phosphatase 27, atypical, serine/threonine/tyrosine interacting like 2, DUSP27
External IDs	MGI: 2685055; GeneCards: STYXL2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	167,129,165 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,955,491 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; tibialis anterior muscle; ; Skeletal muscle tissue of rectus abdominis; ; deltoid muscle; ; apex of heart; ; right ventricle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; biceps brachii;
	Top expressed in
	interventricular septum; ; knee joint; ; medial head of gastrocnemius muscle; ; soleus muscle; ; muscle of thigh; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; tibialis anterior muscle; ; temporal muscle; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine/serine/threonine phosphatase activity; phosphatase activity;
Cellular component	cytoplasm; sarcomere;
Biological process	protein dephosphorylation; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	92235
	240892
	ENSG00000198842
	ENSMUSG00000026564
	Q5VZP5
	Q148W8
	NM_001080426
	NM_001033344; NM_001160049
	NP_001073895
	NP_001028516; NP_001153521
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine/tyrosine-interacting-like 2 is a protein that in humans is encoded by the STYXL2 gene (previously DUSP27).^[5] Though it is homologous to certain dual-specificity phosphatases, a conserved cysteine in the putative active site has been replaced by a serine, suggesting that it may no longer function as a phosphatase.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198842 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026564 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Dual specificity phosphatase 27, atypical". Retrieved 2018-10-20.
↑ "Q5VZP5 · STYL2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-14.

Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A (December 2009). "Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study". Eur. J. Hum. Genet. 17 (12): 1650–7. doi:10.1038/ejhg.2009.94. PMC 2783544. PMID 19536175.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198842 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026564 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Dual specificity phosphatase 27, atypical". Retrieved 2018-10-20.

[6] "Q5VZP5 · STYL2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-14.

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References

Further reading