NDFIP2

NDFIP2
Identifiers
Aliases	NDFIP2, N4WBP5A, Nedd4 family interacting protein 2
External IDs	OMIM: 610041; MGI: 1923523; GeneCards: NDFIP2
Gene location (Human)
Chr.	Chromosome 13 (human)
End	79,556,077 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	105,546,732 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; skin of arm; ; sperm; ; pancreatic epithelial cell; ; Brodmann area 46; ; mucosa of ileum; ; skin of thigh; ; palpebral conjunctiva; ; jejunal mucosa; ; pons;
	Top expressed in
	habenula; ; deep cerebellar nuclei; ; medial vestibular nucleus; ; olfactory tubercle; ; submandibular gland; ; ventral tegmental area; ; pontine nuclei; ; lateral geniculate nucleus; ; left colon; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; protein binding; WW domain binding;
Cellular component	cytoplasm; integral component of membrane; endosome; Golgi apparatus; multivesicular body membrane; intracellular membrane-bounded organelle; membrane; Golgi membrane; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; endosome membrane;
Biological process	negative regulation of gene expression; negative regulation of protein transport; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein ubiquitination; negative regulation of transporter activity; signal transduction; vacuolar transport; metal ion transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54602
	76273
	ENSG00000102471
	ENSMUSG00000053253
	Q9NV92
	Q91ZP6
	NM_001161407; NM_019080; NM_001394685
	NM_001190989; NM_029561
	NP_001154879; NP_061953
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene.^[5]^[6]^[7]

Interactions

NDFIP2 has been shown to interact with NEDD4.^[8]

Conversely, it has also been shown that NDFIP2 does not interact with the NEDD4-2 variant in neurons of the dorsal root ganglia, but it does participate in the regulation of TRKA, TRKB, and TRKC. This could indicate a direct relationship between NDFIP2 and the cellular mechanisms of nociception.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102471 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053253 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (January 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research. 6 (5): 329–336. doi:10.1093/dnares/6.5.329. PMID 10574461.
↑ Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, et al. (August 2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". The Journal of Biological Chemistry. 277 (33): 29406–29416. doi:10.1074/jbc.M203018200. PMID 12050153.
↑ "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2".
↑ Cristillo AD, Nie L, Macri MJ, Bierer BE (September 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". The Journal of Biological Chemistry. 278 (36): 34587–34597. doi:10.1074/jbc.M304723200. PMID 12796489.
↑ Cañada-García D, Hernández-García A, Vicente-García C, Valero J, Ayon-Olivas M, Kumar S, et al. (March 2026). "Ndfip2 in TrkA-expressing sensory neurons regulates noxious mechanosensation through control of TrkA signaling and protein levels". Cell Death & Disease. 17 (1) 437. doi:10.1038/s41419-026-08670-9. hdl:10366/171519. PMC 13158297. PMID 41912490.

Interactions

References

Further reading