FBXO2

Fbxo2
Identifiers
Aliases	FBG1FBX2Fbs1Fbs2NFB42Prpl4F-box protein 2
External IDs	GeneCards:
Gene location (Human) Chr. Chromosome 4 (human) Band 4 E2|4 78.68 cM Start 148,245,078 bp End 148,250,881 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vestibular membrane of cochlear duct utricle vestibular sensory epithelium facial motor nucleus anterior horn of spinal cord optic nerve stria vascularis pontine nuclei medial vestibular nucleus cochlea n/a More reference expression data BioGPS n/a
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 230904 n/a Ensembl ENSMUSG00000041556 n/a UniProt n a Q80UW2 RefSeq (mRNA) NM_176848 n/a RefSeq (protein) n/a NP_789818 Location (UCSC) Chr 4: 148.25 – 148.25 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.

Further reading

• Erhardt JA, Hynicka W, DiBenedetto A, et al. (1999). "A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest". J. Biol. Chem. 273 (52): 35222–7. doi:10.1074/jbc.273.52.35222. PMID 9857061.
• Yoshida Y, Chiba T, Tokunaga F, et al. (2002). "E3 ubiquitin ligase that recognizes sugar chains". Nature. 418 (6896): 438–42. Bibcode:2002Natur.418..438Y. doi:10.1038/nature00890. PMID 12140560. S2CID 4424996.
• Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins". Gene. 296 (1–2): 11–20. doi:10.1016/S0378-1119(02)00867-3. PMID 12383498.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Eom CY, Lehman IR (2003). "Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9803–7. Bibcode:2003PNAS..100.9803E. doi:10.1073/pnas.1733876100. PMC 187846. PMID 12904574.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.