Highlights

Latest research

    1. Neuroscience

    Canonical neurodevelopmental trajectories of structural and functional manifolds

    Alicja Monaghan, Richard AI Bethlehem ... Duncan E Astle
    Contrary to prior work, principal axes of structural and functional connectivity are established early in life, remaining stable and undergoing refinement throughout development.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

    Soenke Cordeiro, Robert Patejdl ... Marianne A Musinszki
    Identification of mangostins as potent BK channel activators links natural xanthones to vascular smooth muscle relaxation, providing a mechanistic basis for their reported antihypertensive effects.
    1. Cancer Biology
    2. Cell Biology

    HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content

    Sara M Frangos, Henver S Brunetta ... Graham P Holloway
    Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.
    1. Developmental Biology

    HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis

    Yuqian Shen, Ziyang Wang ... Dong Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Purified Zymogens Reveal Mechanisms of Snake Venom Metalloproteinase Auto-Activation

    Sophie Hall, Iara Aimê Cardoso ... Christiane Schaffitzel
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Neuroscience

    Development of Auditory and Spontaneous Movement Responses to Music over the First Postnatal Year

    Trinh Nguyen, Félix Bigand ... Giacomo Novembre
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
    1. Developmental Biology

    Functional definition of the Drosophila airway progenitor field through overlapping compensatory regulators

    Ryo Matsuda, Chie Hosono ... Christos Samakovlis
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    A single-cell transcriptomic atlas of inner ear morphogenesis in zebrafish

    Akankshi Munjal, Kalki Kukreja ... Ian A Swinburne
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Cell Biology

    An ancient transcription factor functions as the master regulator of primary cilia formation

    Weihua Wang, Xiqi Zhang ... Zhangfeng Hu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology

    A stress-responsive morphogenetic program of the uterine epithelium safeguards the establishment of early pregnancy

    Chihiro Ishizawa, Shizu Aikawa ... Yasushi Hirota
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid