multichaperoneとは 意味・読み方・使い方

名詞

multichaperone ‎(複数形 multichaperones)

1. (biochemistry) A chaperone consisting of multiple proteins
   • 2015 September 29, “The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein”^[1], PLOS ONE, DOI:10.1371/journal.pone.0138936: 

     The complex containing Cdc37 and p23 is thought to be the primary stable form, and the HSP70- and HOP-associated complex is another proteasome-targeting form that induces ubiquitin-proteasome degradation [45 , 46 ]. 17-AAG is an ansamycin antibiotic that binds to HSP90 and inhibits the formation of the stabilized HSP90-client protein complex, resulting in the accumulation of the proteasome-targeting HSP90-based multichaperone.