enzymogenesisとは 意味・読み方・使い方

名詞

enzymogenesis (複数形 enzymogeneses)

1. (biochemistry) The evolutionary development of function of an enzyme, typically used for alcohol dehydrogenases.

   1992, Olle Danielsson; Hans Jörnvall, “"Enzymogenesis": classical liver alcohol dehydrogenase origin from the glutathione-dependent formaldehyde dehydrogenase line”, in Proc Natl Acad Sci U S A‎^[1], DOI:10.1073/pnas.89.19.9247, page 9250:

   Hence, the two cod enzyme structures define the earlier events and illustrate the "enzymogenesis," or emergence of a unique enzyme.

   • 2008, B. Persson; J. Hedlund; H. Jörnvall, “Medium- and short-chain dehydrogenase/reductase gene and protein families”, in Cellular and Molecular Life Sciences‎^[2], DOI:10.1007/s00018-008-8587-z:

     This multiple enzymogenesis of the same activity from different superfamilies is again analogous to the situation for ADHs and PDHs, where different forms belong to either of these two superfamilies.

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     2011, Aída Hernández-Tobías; Adriana Julián-Sánchez; Enrique Piña; Héctor Riveros-Rosas, “Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals?”, in Chem Biol Interact, DOI:10.1016/j.cbi.2011.02.008:

     On the supposition that these ADH families might have evolved in response to ethanol exposure, the possibility that ethanol triggered enzymogenesis within each ADH family will be discussed in the sections that follow.