cellular cytotoxicityとは 意味・読み方・使い方

To provide a test method of cytotoxicity capable of directly and precisely measuring the cellular activity of a cultivated cell used for a test independently one by one and quantitatively determining the toxicity of a chemical substance to be tested for cytotoxicity with high precision.例文帳に追加

試験に用いる培養細胞の細胞活性を、直接、１個１個個別に、正確に計測でき、被毒性試験化学物質の毒性を高い精度で定量化できる細胞毒性試験方法の提供。 - 特許庁

The PepT antibody has antibody-dependent cellular cytotoxicity activity (ADCC activity) and/or complement-dependent cytotoxicity activity (CDC activity) and specifically exhibits suppressing action to growth of pancreatic cancer cells.例文帳に追加

該ＰｅｐＴ抗体は、抗体依存性細胞性細胞傷害活性（ＡＤＣＣ活性）および／または補体依存性細胞傷害活性（ＣＤＣ活性）を有し、癌細胞、特に膵臓癌細胞の増殖を抑制する作用を示す。 - 特許庁

To provide an anti-glypican 3 antibody having higher ADCC (antibody-dependent cellular cytotoxicity) activity and CDC (complement-dependent cytotoxicity) activity compared with those of conventional antibody, and provide a cell growth inhibitor and an anticancer agent containing the antibody as an active component.例文帳に追加

従来の抗体と比較して高いＡＤＣＣ（抗体依存性細胞障害）活性およびＣＤＣ（補体依存性細胞障害）活性を有する抗グリピカン３抗体、ならびにかかる抗体を有効成分とする細胞増殖抑制剤及び抗癌剤の提供。 - 特許庁

This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and become internalized by mesothelin-positive cells and also induce immune effector activity such as antibody-dependent cellular cytotoxicity.例文帳に追加

メソテリン陽性細胞に特異的に結合し、当該細胞によって内在化し、また抗体依存性細胞障害活性等の免疫エフェクター活性を誘発する、モノクローナルおよびポリクローナル抗体。 - 特許庁

The molecule is particularly useful for treatment or prevention of a disease or disorder where an enhanced efficacy or effector cell function {e.g., antibody-dependent cellular cytotoxicity (ADCC)} mediated by FcγR is desired (e.g., cancer or infectious disease), and in enhancing the therapeutic efficacy of therapeutic antibodies (the effect of which is mediated by the ADCC).例文帳に追加

分子は、FcγRにより媒介されるエフェクター細胞機能（例えば、ADCC）の増大した効力が望まれる疾患または障害（例えば、癌、感染症）を治療または予防するのに、また、治療用抗体（その効果がADCCによって媒介される）の治療効力を高めるのに、特に有用である。 - 特許庁

The present invention is directed to method for the generation of modified glycoforms of glycoproteins, for example antibodies, including whole antibody molecules, antibody fragments, or fusion proteins that include a region equivalent to the Fc region of an immunoglobulin, having an enhanced Fc-mediated cellular cytotoxicity, and to glycoproteins so generated.例文帳に追加

また、糖タンパク質、例えば、抗体（抗体分子全体、抗体フラグメント、または免疫グロブリンのＦｃ領域に等価な領域を含む融合タンパク質を含み、増強されたＦｃ媒介細胞傷害性を有する）の改変された糖形態を生成するための方法、およびそのように生成された糖タンパク質。 - 特許庁

To provide a simple and highly reliable test substance immunomodulatory function evaluating method that uses physiological active substances suitable for measurement, more specifically, physiological active substances which can be collected from a culture supernatant, when peripheral blood mononuclear cells (PBMC) and a test substance are cultured in vitro, shows a high correlation with the cellular cytotoxicity of PBMC, and is less likely to show variations due to PBMC to be used.例文帳に追加

測定に適した生理活性物質、すなわち、インビトロで末梢血単核球（PBMC）と被検物質とを培養したときに、培養上清から採取することができ、且つPBMCの細胞傷害活性と高い相関関係を示す生理活性物質であって、用いるPBMCによってバラツキが出にくい生理活性物質を用いて、簡便かつ信頼性の高い、被検物質の免疫賦活能評価方法を提供する。 - 特許庁