camazepamとは 意味・読み方・使い方

Camazepam (marketed under the brand names Albego, Limpidon, and Paxor) is a benzodiazepine psychoactive drug which is the dimethyl carbamate ester of temazepam, a metabolite of diazepam. Whilst it possesses anxiolytic, anticonvulsant, skeletal muscle relaxant and hypnotic properties it differs from other benzodiazepines in that its anxiolytic properties are particularly marked but has only limited anticonvulsant, hypnotic and skeletal muscle relaxant properties. It is superior to other benzodiazepines due to its lack of typical benzodiazepine side effects such as impaired cognition, reaction times and coordination. Camazepam is best suited as an anxiolytic due to its reduced hypnotic effects and reduced cognitive and motor impairing effects. However, with higher doses such as 40 mg of camazepam, impairments similar to those which occur with other benzodiazepines appear such as disrupted sleep pattern and impaired cognitive performance. Animal studies have shown camazepam and its active metabolites have anticonvulsant properties. Skin disorders have been reported with use of camazepam however. Camazepam is believed to increase attention. Camazepam unlike other benzodiazepines does not disrupt normal sleep patterns. Camazepam has been shown in animal experiments to have a very low affinity for benzodiazepine receptors compared to other benzodiazepines. Camazepam is almost completely absorbed into the bloodstream after oral administration with 90 percent bioavailability achieved in humans. Camazepam is metabolised into an active metabolite temazepam. Compared to temazepam, camazepam has shown roughly equal anxiolytic properties, and less anticonvulsant, sedative and motor-impairing properties.