Papers by Panagiotis Zoumpoulakis
Journal of Pharmaceutical and Biomedical Analysis, Apr 1, 2002
A novel approach to treat hypertension is to interfere with the Renin-Angiotensin system (RAS) by... more A novel approach to treat hypertension is to interfere with the Renin-Angiotensin system (RAS) by blocking the binding of vasoconstrictive hormone Angiotensin II to the AT 1 receptor site. This approach led to the beneficial drug losartan (COZAAR) and other similar in structure to the antihypertensive drugs (sartans). In an effort to compare the stereoelectronic features of pharmacophoric segments of the different sartans, a research activity was initiated in our laboratory related to the conformational properties of these drugs. In a previous study, the structural features which determine the pharmacophoric segments of losartan were examined. In this study, the conformational properties of eprosartan (TEVETEN), a drug with fewer side effects, were examined. In addition, the superimposition ability of losartan and eprosartan with the peptide antagonist sarmesin was studied.
Metabolites
This study aimed to characterize dietary protein patterns (DPPs) in a sample pool of 298 well-nou... more This study aimed to characterize dietary protein patterns (DPPs) in a sample pool of 298 well-nourished pregnant women and explore potential associations between DPPs and neonatal anthropometrics. Maternal dietary data were collected using a validated food frequency questionnaire. Neonatal anthropometrics were abstracted from health booklets. A hierarchical cluster analysis identified three DPPs: “Dairy-focused”, “Med-fusion”, and “Traditional-inspired”. The “Dairy-focused” DPP exhibited the highest protein intake (p < 0.001), predominantly animal protein (p < 0.001), while the “Traditional-inspired” DPP presented higher plant protein (p < 0.001) and fiber intakes (p < 0.001), and, therefore, a reduced carbohydrate-to-fiber quotient (p < 0.001). The “Med-fusion” DPP had the lowest protein-to-fat ratio (p < 0.001). Infants of women following the “Dairy-focused” DPP had the highest birth height centiles (p = 0.007) and the lowest ponderal index (p = 0.003). The NMR-m...
Life
Banana ranks as the fifth most cultivated agricultural crop globally, highlighting its crucial so... more Banana ranks as the fifth most cultivated agricultural crop globally, highlighting its crucial socio-economic role. The banana’s health-promoting benefits are correlated with its composition in bioactive compounds, such as phenolic compounds. Thus, the present study attempts to evaluate the potential health benefits of banana phenolic content by combing analytical and in silico techniques. Particularly, the total phenolic content and antioxidant/antiradical activity of banana samples during ripening were determined spectrophotometrically. In parallel, liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was implemented to unravel the variations in the phenolic profile of banana samples during ripening. Chlorogenic acid emerged as a ripening marker of banana, while apigenin and naringenin were abundant in the unripe fruit. In a further step, the binding potential of the elucidated phytochemicals was examined by utilizing molecular target prediction tools. Human carbonic...
Antioxidants
Coffee is one of the most widely consumed beverages worldwide due to its sensory and potential he... more Coffee is one of the most widely consumed beverages worldwide due to its sensory and potential health-related properties. In the present comparative study, a preparation known as Greek or Turkish coffee, made with different types/varieties of coffee, has been investigated for its physicochemical attributes (i.e., color), antioxidant/antiradical properties, phytochemical profile, and potential biological activities by combining high-throughput analytical techniques, such as infrared spectroscopy (ATR-FTIR), liquid chromatography-tandem mass spectrometry (LC-MS/MS), and in silico methodologies. The results of the current study revealed that roasting degree emerged as the most critical factor affecting these parameters. In particular, the L* color parameter and total phenolic content were higher in light-roasted coffees, while decaffeinated coffees contained more phenolics. The ATR-FTIR pinpointed caffeine, chlorogenic acid, diterpenes, and quinic esters as characteristic compounds in ...
Applied Sciences
Currently, the evaluation of fruit ripening progress in relation to physicochemical and texture-q... more Currently, the evaluation of fruit ripening progress in relation to physicochemical and texture-quality parameters has become an increasingly important issue, particularly when considering consumer acceptance. Therefore, the purpose of the present study was the application of rapid, nondestructive, and conventional methods to assess the quality of banana peels and flesh in terms of ripening and during storage in controlled temperatures and humidity. For this purpose, we implemented various analytical techniques, such as attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy for texture, colorimetrics, and physicochemical features, along with image-analysis methods and discriminant as well as statistical analysis. Image-analysis outcomes showed that storage provoked significant degradation of banana peels based on the increased image-texture dissimilarity and the loss of the structural order of the texture. In addition, the computed features were sufficient to...
Applied Sciences
In the current market, there is a growing interest in traditional herbal nutraceuticals. Therefor... more In the current market, there is a growing interest in traditional herbal nutraceuticals. Therefore, herbal formulations have re-emerged as products with sought-after nutraceutical and disease-preventing properties. The health-promoting effects of herbal bioactives are attributed to the active phytoconstituents of these plants. Thus, the aim of the present study was to evaluate the putative nutraceutical effectiveness of the preparations of ten herbs (chamomile, purple coneflower, lemon verbena, pennyroyal, spearmint, oregano, marjoram, headed savory, sea buckthorn, and St. John’s wort) by combining in silico techniques and LC-MS/MS analysis. The binding potential of the selected phenolic compounds, according to literature and web databases, was investigated by using molecular target prediction tools. Aldose reductase (AR), an enzyme of polyol pathway which is related to hyperglycemic-induced pathologies, emerged as the most promising molecular target. The molecular docking results s...
Foods
Nowadays, as the pandemic has reshaped snacking behaviors, and consumers have become more health-... more Nowadays, as the pandemic has reshaped snacking behaviors, and consumers have become more health-conscious, the need for the incorporation of “healthy snacking” in our diets has emerged. Although there is no agreed-upon definition of “healthy snacking”, dietary guidelines refer to snack foods with high nutritional and biological value. The aim of this study was to chemically characterize and determine the nutritional value of an innovative UVB-irradiated and baked snack from Pleurotus eryngii mushrooms. P. eryngii is an edible mushroom native to the Mediterranean basin. We applied proximate composition, amino acids, fatty acids, vitamins, and macro and trace elements analyses. Also, we computed indices to assess the nutritional quality of food, and we evaluated the sensory characteristics of the mushroom snack. We found high nutritional, consumer, and biological values for the snack. More specifically it was low in calories, high in fibre and protein, low in lipids, without added su...
Journal of Food Composition and Analysis
Πανεπιστημιακές Εκδόσεις Κρήτης, 2003
Πανεπιστημιακές Εκδόσεις Κρήτης, 2003
3th Hellenic Symposium of Medicinal Chemistry, 2008
Dalton Transactions, 2021
The silver(i) complexes of glycine, urea and salicylic acid were dispersed in poly-hydroxyethyl-m... more The silver(i) complexes of glycine, urea and salicylic acid were dispersed in poly-hydroxyethyl-methacrylate to form new biomaterials. Their bioactivity makes them efficient candidates for the development of antimicrobial contact lenses.
MedChemComm, 2017
21 novel N-(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides ... more 21 novel N-(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides have been synthesized and evaluated for their antimicrobial activity.
Materials Science and Engineering: C, 2020
The Metal Organic Framework (MOF) of formula {[Ag 6 (μ 3-HMNA) 4 (μ 3-MNA) 2 ] 2− •[(Et 3 NH) + ]... more The Metal Organic Framework (MOF) of formula {[Ag 6 (μ 3-HMNA) 4 (μ 3-MNA) 2 ] 2− •[(Et 3 NH) + ] 2 •(DMSO) 2 •(H 2 O)} (AGMNA), a known efficient antimicrobial compound which contains the anti-metabolite, 2-thio-nicotinic acid (H 2 MNA), was incorporated in polymer hydrogels using, hydroxyethyl-methacrylate (HEMA). The material pHEMA@AGMNA-1 was characterized by X-ray fluorescence (XRF) spectroscopy, X-ray powder diffraction analysis (XRPD), Scanning Electron Microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), Thermogravimetric Differential Thermal Analysis (TG-DTA), Differential Scanning Calorimetry (DTG/DSC), attenuated total reflection spectroscopy (FT-IR-ATR) and Ultrasonic Imaging. The antimicrobial capacity of pHEMA@AGMNA-1 was evaluated against the Gram negative bacterial strain Pseudomonas aeruginosa and the Gram positive ones of the genus of Staphylococcus epidermidis and Staphylococcus aureus, which are the etiology of the microbial keratitis. The % bacterial viability of P. aeruginosa, S. epidermidis and S. aureus upon their incubation with pHEMA@AGMNA-1 discs is significantly low (0.4 ± 0.1%, 1.5 ± 0.4% and 7.7 ± 0.5% respectively). The inhibition zones (IZ) caused
![Research paper thumbnail of An Efficient Disinfectant, Composite Material {SLS@[Zn3(CitH)2]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens](https://attachments.academia-assets.com/115292172/thumbnails/1.jpg)
Antibiotics, 2019
The [Zn3(CitH)2] (1) (CitH4= citric acid), was dispersed in sodium lauryl sulphate (SLS) to form ... more The [Zn3(CitH)2] (1) (CitH4= citric acid), was dispersed in sodium lauryl sulphate (SLS) to form the micelle of SLS@[Zn3(CitH)2] (2). This material 2 was incorporated in hydrogel made by hydroxyethyl-methacrylate (HEMA), an ingredient of contact lenses, toward the formation of pHEMA@(SLS@[Zn3(CitH)2]) (3). Samples of 1 and 2 were characterized by UV-Vis, 1H-NMR, FT-IR, FT-Raman, single crystal X-ray crystallography, X-ray fluorescence analysis, atomic absorption and TG/DTA/DSC. The antibacterial activity of 1–3 as well as of SLS against Gram-positive (Staphylococcus epidermidis (St. epidermidis) and Staphylococcus aureus (St. aureus)) and Gram-negative (Pseudomonas aeruginosa (PAO1), and Escherichia coli (E. coli)) bacteria was evaluated by the means of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and inhibitory zone (IZ). 2 showed 10 to 20-fold higher activity than 1 against the bacteria tested. Moreover the 3 decreases the abundance of Gram-posi...
Analytical Letters, 2019
Mushrooms are efficient accumulators of essential and toxic elements. Although oyster (Pleurotus ... more Mushrooms are efficient accumulators of essential and toxic elements. Although oyster (Pleurotus spp.) mushrooms are widely commercialized and consumed, few data exist regarding trace elements content and bioaccumulation in cultivated P. ostreatus and P. eryngii, while no data are available for P. nebrodensis. The contents of Al,
Animal Feed Science and Technology, 2018
Orange pulp improved egg yolk oxidative stability of both fresh and stored eggs. Performance an... more Orange pulp improved egg yolk oxidative stability of both fresh and stored eggs. Performance and egg quality traits were negatively affected by orange pulp.
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Papers by Panagiotis Zoumpoulakis