... 137 La famiglia come focus dell'intervento, di Noburto Ban » 144 Empowerment familiare n... more ... 137 La famiglia come focus dell'intervento, di Noburto Ban » 144 Empowerment familiare nel campo della salute e dell'alimenta-zione, di SR Widjojo, Ridwan Malik » 148 Progressor: uno strumento psicodiagnostico e terapeutico per il medico di famiglia, di J0rn H. Beckmann ...
Le terapie sistemiche funzionano con individui, coppie, famiglie e gruppi utilizzando molti diver... more Le terapie sistemiche funzionano con individui, coppie, famiglie e gruppi utilizzando molti diversi tipi di interventi. Tuttavia, molti di que-sti interventi possono sembrare troppo poco basati su un rigoroso ap-proccio scientifico. In questo documento presentiamo le sfide emerse riguardo alla manualizzazione degli approcci che il settore ha prodot-to. Le terapie più riduzionistiche sono state riconosciute come il gold standard proprio per la loro manualizzazione, mentre la terapia fami-liare sistemica ha perso opportunità di influenza politica e approva-zione a causa della riluttanza ad affrontare le sfide della manualizza-zione. Sosteniamo che affinché le terapie sistemiche sopravvivano, dobbiamo trovare il modo di articolare ciò che facciamo in terapia, formazione e ricerca in modi che promuovano sia la creatività che il rigore necessari per essere efficaci. Presentiamo il programma EFTIFS e il progetto DAN, che mostrano come, attraverso l'uso di processi piuttosto che di procedure, si pos-sono produrre manuali che consentono ai terapeuti di essere comples-si e artistici quanto desiderano, ma mantengano comunque l'attenzione sul metodo scientifico che consentirà di essere riconosciuti come erogatori di psicoterapie basate sull'evidenza.
Il presente lavoro illustra le fasi salienti del lavoro di ricerca relativo alla formulazione di ... more Il presente lavoro illustra le fasi salienti del lavoro di ricerca relativo alla formulazione di una manualizzazione che, basandosi sui principi cardine del modello sistemico, coniugasse la processualita tipica del modello con la proceduralizzazione tipica del determinismo. La manualizzazione prevede interventi digitali analogici e narrativi, utilizzando come strumento rapido di verifica lo Score. Questa ricerca e inoltre stata di stimolo agli studenti della Scuola ISCRA che hanno fattivamente contribuito nella costruzione del percorso.
Background: Down's syndrome (DS) is characterized by several immunological defects, especially re... more Background: Down's syndrome (DS) is characterized by several immunological defects, especially regarding T cell compartment. DS is considered the best example of accelerated ageing in humans. Direct observations of the thymus have shown that in DS this organ undergoes severe histological and morphological changes. However, no data on its capacity to generate T cells are present in the literature. Here, using a new technology based upon real time PCR, we have investigated the capacity of the thymus to produce and release newly generated T lymphocytes (the so called "recent thymic emigrants", RTE) in children with DS. Methods: We studied 8 children affected by DS, aged 2-7 years, compared with 8 age-and sex-matched healthy controls. Flow cytometry was used to determine different lymphocytes subsets. Real time PCR with the Taqman system was used to quantify the amount of RTE, i.e. peripheral blood lymphocytes that express the T cell receptor rearrangement excision circles (TREC). Results: In comparison with control children, those with DS had a significant lower number of TREC+ peripheral blood cells. Moreover, in DS children but not in controls, a strong negative correlation between age and the levels of TREC+ cells was found. Conclusions: The direct measure of thymic output indicates that the impairment of the organ results in a reduced production of newly generated T cells. This observation could suggest that cytokines able to modulate thymic function, such as interleukins, could be useful to improve the functionality of the organ and to treat the immunodeficiency present in DS subjects.
Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility t... more Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility to cell death. We have studied apoptosis and mitochondrial (mt) membrane potential (DW m) in peripheral blood mononuclear cells (PBMC) from DS children and age-matched healthy donors after in vitro treatment with apoptogenic molecules, along with mtDNA content. We found that PBMC from DS and healthy controls had a similar tendency to undergo apoptosis and a similar amount of mtDNA. However, in cells from DS subjects, mitochondria showed a higher loss of DW m , underlying the presence of an increasing susceptibility of these organelles to damaging agents.
In this study, we compared current data and data of the census made in the 1990s related to the v... more In this study, we compared current data and data of the census made in the 1990s related to the vascular flora of Capo Mortola (Ventimiglia, Italy), considering 270 taxa not dependent on crop management. The current status reported 198 alien species: 5 invasive, 65 naturalized 75 casual, 38 occurring as casual in human-dominated systems, but without direct intervention by humans and not close to parent plant, 15 occurring as casual alien, but still with some uncertainties for a definitive classification, and plus 3 cryptogenic and 1 eradicated (extinct) taxa, while in 1996 were 229 species: 87 naturalized and 142 adventitious (casual). Of these, 40 taxa show an increasing trend and 41 a decreasing or disappearing trend. If we consider the wild areas of Capo Mortola, 10 taxa are new to the Italian flora (7 casual and 3 naturalized) while 13 are new to the Ligurian flora only (all casual). If we also consider the neglected areas of the Botanical Gardens, 18 new casual species for the ...
The current chapter describes the DAN (Digital, Analogical, Narrative) manualized intervention de... more The current chapter describes the DAN (Digital, Analogical, Narrative) manualized intervention developed over the past two decades at the Iscra Institute in Modena, Italy. The name Iscra means spark, the title of a famous newspaper founded to free the Russian Empire divulgating socialdemocratic ideas. The intervention is aimed at promoting family wellbeing by applying systemic therapeutic methods through working with couples. Over the years, the DAN model has been perfected by including widely-used digital, analogical, and narrative tools, and a pilot study has been undertaken by having trainee family therapists carry out the intervention on young families. The tools developed by the Iscra research team, such as the tridimensional genogram, the Relational Style Profile couple interview (RSPc) and the Better Formed Tale, are briefly described in this chapter and the reader will find a case report in the following chapter "the Dan model in practice". It is argued that the manualised DAN intervention provides a simple way of applying important and established systemic techniques that will promote family wellbeing by helping young couples develop reflexivity and resilience. The Score had been adapted avoiding pathological terms and administered three times, having the best result at the end of the process.
... 137 La famiglia come focus dell'intervento, di Noburto Ban » 144 Empowerment familiare n... more ... 137 La famiglia come focus dell'intervento, di Noburto Ban » 144 Empowerment familiare nel campo della salute e dell'alimenta-zione, di SR Widjojo, Ridwan Malik » 148 Progressor: uno strumento psicodiagnostico e terapeutico per il medico di famiglia, di J0rn H. Beckmann ...
Le terapie sistemiche funzionano con individui, coppie, famiglie e gruppi utilizzando molti diver... more Le terapie sistemiche funzionano con individui, coppie, famiglie e gruppi utilizzando molti diversi tipi di interventi. Tuttavia, molti di que-sti interventi possono sembrare troppo poco basati su un rigoroso ap-proccio scientifico. In questo documento presentiamo le sfide emerse riguardo alla manualizzazione degli approcci che il settore ha prodot-to. Le terapie più riduzionistiche sono state riconosciute come il gold standard proprio per la loro manualizzazione, mentre la terapia fami-liare sistemica ha perso opportunità di influenza politica e approva-zione a causa della riluttanza ad affrontare le sfide della manualizza-zione. Sosteniamo che affinché le terapie sistemiche sopravvivano, dobbiamo trovare il modo di articolare ciò che facciamo in terapia, formazione e ricerca in modi che promuovano sia la creatività che il rigore necessari per essere efficaci. Presentiamo il programma EFTIFS e il progetto DAN, che mostrano come, attraverso l'uso di processi piuttosto che di procedure, si pos-sono produrre manuali che consentono ai terapeuti di essere comples-si e artistici quanto desiderano, ma mantengano comunque l'attenzione sul metodo scientifico che consentirà di essere riconosciuti come erogatori di psicoterapie basate sull'evidenza.
Il presente lavoro illustra le fasi salienti del lavoro di ricerca relativo alla formulazione di ... more Il presente lavoro illustra le fasi salienti del lavoro di ricerca relativo alla formulazione di una manualizzazione che, basandosi sui principi cardine del modello sistemico, coniugasse la processualita tipica del modello con la proceduralizzazione tipica del determinismo. La manualizzazione prevede interventi digitali analogici e narrativi, utilizzando come strumento rapido di verifica lo Score. Questa ricerca e inoltre stata di stimolo agli studenti della Scuola ISCRA che hanno fattivamente contribuito nella costruzione del percorso.
Background: Down's syndrome (DS) is characterized by several immunological defects, especially re... more Background: Down's syndrome (DS) is characterized by several immunological defects, especially regarding T cell compartment. DS is considered the best example of accelerated ageing in humans. Direct observations of the thymus have shown that in DS this organ undergoes severe histological and morphological changes. However, no data on its capacity to generate T cells are present in the literature. Here, using a new technology based upon real time PCR, we have investigated the capacity of the thymus to produce and release newly generated T lymphocytes (the so called "recent thymic emigrants", RTE) in children with DS. Methods: We studied 8 children affected by DS, aged 2-7 years, compared with 8 age-and sex-matched healthy controls. Flow cytometry was used to determine different lymphocytes subsets. Real time PCR with the Taqman system was used to quantify the amount of RTE, i.e. peripheral blood lymphocytes that express the T cell receptor rearrangement excision circles (TREC). Results: In comparison with control children, those with DS had a significant lower number of TREC+ peripheral blood cells. Moreover, in DS children but not in controls, a strong negative correlation between age and the levels of TREC+ cells was found. Conclusions: The direct measure of thymic output indicates that the impairment of the organ results in a reduced production of newly generated T cells. This observation could suggest that cytokines able to modulate thymic function, such as interleukins, could be useful to improve the functionality of the organ and to treat the immunodeficiency present in DS subjects.
Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility t... more Different types of cells from subjects with Down syndrome (DS) have an increased susceptibility to cell death. We have studied apoptosis and mitochondrial (mt) membrane potential (DW m) in peripheral blood mononuclear cells (PBMC) from DS children and age-matched healthy donors after in vitro treatment with apoptogenic molecules, along with mtDNA content. We found that PBMC from DS and healthy controls had a similar tendency to undergo apoptosis and a similar amount of mtDNA. However, in cells from DS subjects, mitochondria showed a higher loss of DW m , underlying the presence of an increasing susceptibility of these organelles to damaging agents.
In this study, we compared current data and data of the census made in the 1990s related to the v... more In this study, we compared current data and data of the census made in the 1990s related to the vascular flora of Capo Mortola (Ventimiglia, Italy), considering 270 taxa not dependent on crop management. The current status reported 198 alien species: 5 invasive, 65 naturalized 75 casual, 38 occurring as casual in human-dominated systems, but without direct intervention by humans and not close to parent plant, 15 occurring as casual alien, but still with some uncertainties for a definitive classification, and plus 3 cryptogenic and 1 eradicated (extinct) taxa, while in 1996 were 229 species: 87 naturalized and 142 adventitious (casual). Of these, 40 taxa show an increasing trend and 41 a decreasing or disappearing trend. If we consider the wild areas of Capo Mortola, 10 taxa are new to the Italian flora (7 casual and 3 naturalized) while 13 are new to the Ligurian flora only (all casual). If we also consider the neglected areas of the Botanical Gardens, 18 new casual species for the ...
The current chapter describes the DAN (Digital, Analogical, Narrative) manualized intervention de... more The current chapter describes the DAN (Digital, Analogical, Narrative) manualized intervention developed over the past two decades at the Iscra Institute in Modena, Italy. The name Iscra means spark, the title of a famous newspaper founded to free the Russian Empire divulgating socialdemocratic ideas. The intervention is aimed at promoting family wellbeing by applying systemic therapeutic methods through working with couples. Over the years, the DAN model has been perfected by including widely-used digital, analogical, and narrative tools, and a pilot study has been undertaken by having trainee family therapists carry out the intervention on young families. The tools developed by the Iscra research team, such as the tridimensional genogram, the Relational Style Profile couple interview (RSPc) and the Better Formed Tale, are briefly described in this chapter and the reader will find a case report in the following chapter "the Dan model in practice". It is argued that the manualised DAN intervention provides a simple way of applying important and established systemic techniques that will promote family wellbeing by helping young couples develop reflexivity and resilience. The Score had been adapted avoiding pathological terms and administered three times, having the best result at the end of the process.
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