Jaya Sanyal
Supervisors: Prof. VADLAMUDI RAGHAVENDRA RAO, PROF. PRADIPTA KISHORE DAS, DR. LVKS BHASKAR, PROF. BIDHAN CHANDRA RAY, and PROF. KALLUR NAVA SARASWATHY
Phone: +91-9968859798
Phone: +91-9968859798
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150 PD patients were administered using Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr Scale (H&Y), Montgomery Asberg Depression Rating Score (MADRS) and Mini Mental State Examination (MMSE) in this cross-sectional evaluation study. CG burden was assessed by Caregiver's Burden Scale (CBS), Hospital Anxiety and Depression Scale (HADS), SF-36 and 20-itemBurden Assessment Schedule (BAS). Linear regression methods were used to evaluate factors contributing to burden and stress.Mean age of CG was 50.38±16.04 (range: 25-83 yrs).Marital status of CGs was noted to have significant relationship with CBS score (F=9.525, P b
0.0001). Siblings (brother/sister) reported the highest CBS score while the wives reported the least. Correlations were strong between CBS and HADS anxiety (r = 0.228, P = 0.0048) and HADS depression (r = 0.2172, P =0.0076). High correlations were found in caregiving duration, patients' stage of illness and motor disability among all the scales (CBS, HADS, SF36) determined. Step-wise regression analysis showed UPDRS (beta = 1.364–0.202 ranging among all scales) and H&Y stages (beta = 2.786–7.257) to have the strongest influence on CGs. CGs of patients with depression (MADRS: P=0.007 (SF36 mental) and dementia (MMSE: P=0.01) experienced greater stress. Social and financial status was disrupted in ~60% to 80% of the CGs. Motor imbalances with disability of PD patients and severity of disease are the main factors contributing to burden and stress in CGs.
intronic change, IVS8+48C4T was present in almost equally in PD patients and controls. Among the ethnically defined
Bengalee population of West Bengal, occurrence of Parkin mutation is 4% (6/150) of the PD patient pool supported with
decreased folds of expression of CSF PARKIN protein. Parkin polymorphisms, Ser167 and Val380 are risk factors for the
progression of the disease, and their frequency is greatly influenced by ethnic origin.
150 PD patients were administered using Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr Scale (H&Y), Montgomery Asberg Depression Rating Score (MADRS) and Mini Mental State Examination (MMSE) in this cross-sectional evaluation study. CG burden was assessed by Caregiver's Burden Scale (CBS), Hospital Anxiety and Depression Scale (HADS), SF-36 and 20-itemBurden Assessment Schedule (BAS). Linear regression methods were used to evaluate factors contributing to burden and stress.Mean age of CG was 50.38±16.04 (range: 25-83 yrs).Marital status of CGs was noted to have significant relationship with CBS score (F=9.525, P b
0.0001). Siblings (brother/sister) reported the highest CBS score while the wives reported the least. Correlations were strong between CBS and HADS anxiety (r = 0.228, P = 0.0048) and HADS depression (r = 0.2172, P =0.0076). High correlations were found in caregiving duration, patients' stage of illness and motor disability among all the scales (CBS, HADS, SF36) determined. Step-wise regression analysis showed UPDRS (beta = 1.364–0.202 ranging among all scales) and H&Y stages (beta = 2.786–7.257) to have the strongest influence on CGs. CGs of patients with depression (MADRS: P=0.007 (SF36 mental) and dementia (MMSE: P=0.01) experienced greater stress. Social and financial status was disrupted in ~60% to 80% of the CGs. Motor imbalances with disability of PD patients and severity of disease are the main factors contributing to burden and stress in CGs.
intronic change, IVS8+48C4T was present in almost equally in PD patients and controls. Among the ethnically defined
Bengalee population of West Bengal, occurrence of Parkin mutation is 4% (6/150) of the PD patient pool supported with
decreased folds of expression of CSF PARKIN protein. Parkin polymorphisms, Ser167 and Val380 are risk factors for the
progression of the disease, and their frequency is greatly influenced by ethnic origin.