Welcome to the Laboratory for Musculoskeletal Crosstalk

Our goal is to identify systemic mediators that can treat, manage, or prevent a myriad of devastating interrelated diseases that co-occur with aging and obesity.

We leverage interdisciplinary approaches in bioengineering, endocrinology, and systems physiology to determine molecular mechanisms of tissue crosstalk in musculoskeletal diseases. Our work aims to delineate fat signals that contribute to disease susceptibility, particularly in osteoarthritis and pain, to generate a new class of regenerative medicine-based therapies. We use in vitro and in vivo approaches, induced pluripotent stem cells, CRISPR-Cas9 genome engineering, mouse models, human tissues, and state-of-the-art multi-omic spatial approaches. As pathological fat signaling may play a role in many disease processes, we work to define the mechanisms and create therapies that have implications to aging, obesity, diabetes and other chronic diseases. Our mission is to improve patient outcomes through exciting, collaborative and innovative approaches in Musculoskeletal Research.

Join us!