Helpful genomics tools & resources for the community.
ClinGen Member Resources
Group and Personnel Management System
The ClinGen Group and Personnel Management (GPM) System offers functionality to track information related to ClinGen Working Group and Expert Panel membership. This system is restricted to ClinGen personnel.
WebsiteGroup and Personnel Management System FAQ
Learn more about how to use the ClinGen Group and Personnel Management (GPM) by reviewing GPM Frequently Asked Questions.
WebsiteClinGen's Curation Interfaces
Gene-Disease Validity Tools
ClinGen's Gene-Disease Clinical Validity tools support evaluating the strength of evidence supporting or refuting a claim that variation in a particular gene causes a particular disease. The interface is currently restricted to Gene Curation curators.
Curations Interface
Variant Pathogenicity Tools
Variant Pathogenicity Tools utilized for sequence variant interpretation within a evidence-based framework. The interface is available for public use.
Curations Interface
Dosage Sensitivity Tools
The ClinGen Dosage Sensitivity tools aid the curation process that collects evidence supporting/refuting the haploinsufficiency and triplosensitivity of genes and genomic regions. The interface is currently restricted to Dosage Sensitivity curators.
Curations
Clinical Actionability Tools
Clinical Actionability tools support the curation process is to identify those human genes that, when significantly altered, confer a high risk of serious disease that could be prevented or mitigated if the risk were known. The interface is currently restricted to Clinical Actionability curators.
Curations InterfaceAdditional Curation Resources
ClinGen Data Sharing & Modeling Standards
The website is dedicated to providing updates on developments and documentation on the Data Exchange platform, data models and tools produced by the ClinGen Data Exchange Working Group.
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Criteria Specification Registry (CSpec)
The ClinGen Criteria Specification(CSpec) Registry is a centralized database designed for the management and maintenance of Criteria Specifications of ACMG evidence codes for variant pathogenicity classification defined by the ClinGen Variant Curation Expert Panels. The CSpec Registry supports the storage of the VCEP Criteria Specifications in a structured, machine-readable format.
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GenCC Database
The GenCC Database aggregates information pertaining to the validity of gene-disease relationships submitted by GenCC member organizations.
WebsiteGenomic Websites & OpenInfoButton Resources
A comprehensive list of genomics resources outside of ClinGen and information about how to utilize Open InfoButton.
About
Linked Data Hub
The ClinGen Linked Data Hub (LDH) facilitates efficient access to collated information such as links and select data from different data sources, which are made available using RESTful APIs. Currently, LDH focuses on linking information about human genes and variants to support ClinGen curation efforts.
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Training & Education
About ClinGen's Website
Learn about the features available on ClinGen's website, the external sources it utilizes, and how to cite ClinGen's work.
About
Biocurator Educational Materials
The Biocurator Educational Materials page provides links to videos of Biocurator Working Group calls on various topics, and links to additional useful websites and materials. We hope that you find these resources to be helpful.
About
ClinGen Curation Modules
These modules are intended to provide learners with educational credit for participating in ClinGen curation activities.
Clinical Genomics Careers Panel Series
Recordings from a multi-part, virtual panel series on various careers in genomics.
About
ClinGen Virtual Retreat 2021
Lectures and recordings from a two-day virtual workshop June 24 to June 25, 2021.
About
CNV Technical Standards Web Series
A multi-part web series to educate the community about the newly released ACMG/ClinGen technical standards for interpretation and reporting of constitutional copy number variants (CNVs).
About
H3Africa Rare Disease Working Group and ClinGen Workshop
Lectures and recordings from a three-day virtual workshop February 3 to February 5, 2021.
About
Hands-On Rare Disease Genomic Analysis Workshop
Lectures and recordings from a virtual workshop April 6 - April 8, 2022
AboutPart IV Practice Improvement
Learn about a module towards Part IV Practive Improvement for clinical laboratory geneticists.
AboutSidra Medicine Masterclass in Genomic Analysis
Materials from a two day masterclass December 1-2, 2024.
AboutFor Laboratories & Clinicians
CADRe (Consent & Disclosure Recommendations)
The CADRe model provides support for genetic testing consent and disclosure discussions with the aim of improving access to genetic information while meeting patients’ psychosocial and informational needs.
About
ClinGen Curation Modules
These modules are intended to provide learners with educational credit for participating in ClinGen curation activities.
ClinGen Volunteer Survey
Interested in volunteering for curation efforts, take our survey! Please tell us more about your interests, expertise, and desired level of involvement so we can pair you with an appropriate curation activity and/or Expert Panel.
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ClinGen Volunteer Expert Survey
Interested in contributing your expert knowledge and/or data to a ClinGen expert panel? Please consider volunteering as an expert. Expert members of VCEPs and GCEPs contribute diverse areas of expertise.
About
Clinical Laboratories Meeting Minimum Requirements for Data Sharing to Support Quality Assurance
View list of clinical labs who meet a minimum standard of data sharing
About
Genomic Analysis Software Platforms Meeting Minimum Requirements for Data Sharing to Support Quality Assurance
View list of genomic analysis software platforms that meet a minimum standard to support data sharing
About
Laboratory & Clinician Data Sharing Resources
How to share variant interpretations and supporting observations from your laboratory or clinic with ClinVar.
WebsitePatient Registries Data Sharing List
ClinGen considers the sharing of variant interpretations essential for supporting genomic medicine and a critical part of quality assurance for accurate genetic and genomic testing.
AboutClinGen Actionability Working Group Topic Nomination Form
To submit a gene-condition topic to the ClinGen Actionability WG for consideration, please complete this form. Provide as much detail as you have. Please submit a separate form for each gene-condition topic you would like to nominate.
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Clinical Genomics Laboratory Community
Get Involved! Visit this page if you're a clinical genomics laboratory, or a platform or database that supports these laboratories.
WebsiteFor Patients & Groups
CADRe (Consent & Disclosure Recommendations)
The CADRe model provides support for genetic testing consent and disclosure discussions with the aim of improving access to genetic information while meeting patients’ psychosocial and informational needs.
AboutPatient Registries Data Sharing List
ClinGen considers the sharing of variant interpretations essential for supporting genomic medicine and a critical part of quality assurance for accurate genetic and genomic testing.
About
Patient Data Sharing Program
Learn about the process for patients and patient groups to share data through GenomeConnect and other tools.
WebsiteNews & Media
ClinGen Twitter Feed
@ClinGenResource - Where you can stay up to date with what is going on at ClinGen and also track what we find interesting.
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ClinGen YouTube Channel
Where you can stay up to date with webinars, presentations, training videos, and other video resources developed or shared by ClinGen.
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