Somatic Cancer Variant Curation

The ClinGen somatic cancer curation process involves evaluating the strength of evidence supporting or refuting the clinical significance (i.e. therapeutic, prognostic and diagnostic effect) of somatic variants in different cancer types, using the AMP/ASCO/CAP guidelines, and the MVLD data representation of cancer variants.

The ClinGen Somatic Cancer Clinical Domain (CDWG) aims to collaborate with expert groups such as the Association of Molecular Pathologists (AMP), the College of American Pathologists (CAP) and the American Society of Clinical Oncology (ASCO), as well as expert curated and harmonized knowledgebases including CIViC, ClinVar, and the GA4GH VICC-metaKB, to develop processes that support

  • Accurate determination of the clinical significance of somatic changes in cancer for use by physicians, clinical laboratories, researchers, and guideline-developing groups

  • Enhance the usability, dissemination and implementation of somatic changes in cancer to improve patient care through genomic medicine.

The ClinGen Somatic Cancer CDWG uses an open source, web-based platform called CIViC (Clinical Interpretations of Variants in Cancer) to curate the clinical significance of somatic variants in cancer. 

To view when upcoming ClinGen Somatic + CIViC training sessions will occur, please check our training calendar. To inquire about training opportunities, please contact [email protected].
Training Materials
Training Materials

Training videos and SOP documents available for those interested in Somatic Variant Curation.

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Documents & Announcements
Documents & Announcements

Documents and announcements related to Somatic Variant Curation

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Somatic Variant Curation Interface
Somatic Variant Curation Interface

  • Click on the Sign In/ Sign Up button on the Top Right of the webpage
  • You can sign-in using your Google ID, ORCID or GitHub ID
  • Email CIViC [email protected] and request them to associate your account with the ClinGen Somatic Organization

Sign In/Sign Up
Somatic Cancer Clinical Domain Working Group
Somatic Cancer Clinical Domain Working Group

The Somatic Cancer Clinical Domain WG aims to collaborate with expert groups to develop processes that support accurate determination of the clinical significance of somatic changes, and guideline-developing groups to improve patient care through genomic medicine. 

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Cancer Variant Interpretation
Cancer Variant Interpretation

The CVI [Cancer Variant Interpretation] Working Group focuses on developing standards and guidelines for the interpretation of genetic variants in cancer.

Link to CVI page