Clinical Domain Working Groups

The TP53 gene provides instructions for tumor protein p53 (or p53). This protein acts as a tumor suppressor, regulating cell division by preventing cells from proliferating in an uncontrolled way.

The TP53 Variant Expert Panel will curate clinically relevant variants using the specified classification rules developed by the group. After interpreting variants using these specified guidelines, the group will make their final interpretations publicly available through ClinVar.