Papers by R. Wangteeraprasert
Phytotherapy Research, 2012
In our continuing efforts to find new antiherpetic agents from plants, an extract prepared from t... more In our continuing efforts to find new antiherpetic agents from plants, an extract prepared from the stems of Carissa spinarum L. was found to possess appreciable activity against herpes simplex viruses (HSV I and II). A chemical study of this plant was then initiated, and this led to the isolation of 12 compounds, including a coumarin, two cardiac glycosides and nine lignans. These isolated compounds were evaluated for several biological activities, including antiherpetic, cytotoxic, antioxidant and antibacterial effects. The cardiac glycoside evomonoside was found to be the only antiherpetic principle, showing moderate activity against herpes simplex virus types I and II in the inactivation method. The lignans (À)-carinol, (À)-carissanol and (À)-nortrachelogenin exhibited cytotoxicity against breast (MCF7) and lung (A549) cancer cells. Moderate anti-DPPH free radical activity was observed for all the lignans. None of the isolates showed antibacterial activity.
Helvetica Chimica Acta, 2009
Two new compounds, the sesquiterpene glucoside carandoside (1) and (6S,7R,8R)-7a-[(bglucopyranosy... more Two new compounds, the sesquiterpene glucoside carandoside (1) and (6S,7R,8R)-7a-[(bglucopyranosyl)oxy]lyoniresinol (2), were isolated from the stem of Carissa carandas, together with three known lignans. The structures of the isolated compounds were determined on the basis of spectroscopic evidence. Their DPPH free radical-scavenging activities were also evaluated.
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Papers by R. Wangteeraprasert