FBXO2
Jedini F-kutijski protein 2 jest protein koji je kod ljudi kodiran genom FBXO2 sa hromosoma 1.[2][3][4]
Amiokiselininska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 296 aminokiselina, a molekulska težina 33.328 Da.[5]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDGDGDPESV | GQPEEASPEE | QPEEASAEEE | RPEDQQEEEA | AAAAAYLDEL | ||||
| PEPLLLRVLA | ALPAAELVQA | CRLVCLRWKE | LVDGAPLWLL | KCQQEGLVPE | ||||
| GGVEEERDHW | QQFYFLSKRR | RNLLRNPCGE | EDLEGWCDVE | HGGDGWRVEE | ||||
| LPGDSGVEFT | HDESVKKYFA | SSFEWCRKAQ | VIDLQAEGYW | EELLDTTQPA | ||||
| IVVKDWYSGR | SDAGCLYELT | VKLLSEHENV | LAEFSSGQVA | VPQDSDGGGW | ||||
| MEISHTFTDY | GPGVRFVRFE | HGGQDSVYWK | GWFGARVTNS | SVWVEP |
Funkcija
[uredi | uredi izvor]Ovaj gen kodira člana porodice F-kutijskih proteina koji se odlikuje motivom od približno 40 aminokiselina, F-kutijom. Proteini F-kutije čine jednu od četiri podjedinice ubikvitinske proteinskog ligaznog kompleksa zvanog SCFs (SKP1-kulin-F-kutija), koji funkcioniše u fosforilaciono-zavisnoj ubikvitinaciji .
Proteini F-kutije podijeljeni su u tri klase: Fbws koji sadrže WD-40 domen, Fbls koji sadrže leucin bogata ponavljanja i Fbxs koji sadrže ili različite module interakcije protein-protein ili ne sadrže prepoznatljive motive. Protein kodiran ovim genom pripada klasi Fbxs. Ovaj protein je veoma sličan pacovskom proteinu NFB42 (neuralni F-kutijski sa 42 kDa) koji je obogaćen u nervnom sistemu i može imati ulogu u održavanju neurona u postmitotskom stanju.[4]
Reference
[uredi | uredi izvor]- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
- ↑ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
- 1 2 "Entrez Gene: FBXO2 F-box protein 2".
- ↑ "UniProt, Q9UK22" (jezik: eng.). Pristupljeno 26. 11. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura
[uredi | uredi izvor]- Erhardt JA, Hynicka W, DiBenedetto A, et al. (1999). "A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest". J. Biol. Chem. 273 (52): 35222–7. doi:10.1074/jbc.273.52.35222. PMID 9857061.
- Yoshida Y, Chiba T, Tokunaga F, et al. (2002). "E3 ubiquitin ligase that recognizes sugar chains". Nature. 418 (6896): 438–42. Bibcode:2002Natur.418..438Y. doi:10.1038/nature00890. PMID 12140560. S2CID 4424996.
- Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins". Gene. 296 (1–2): 11–20. doi:10.1016/S0378-1119(02)00867-3. PMID 12383498.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Eom CY, Lehman IR (2003). "Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9803–7. Bibcode:2003PNAS..100.9803E. doi:10.1073/pnas.1733876100. PMC 187846. PMID 12904574.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.