Papers by Hagera Dilnashin
Research Square (Research Square), Jan 25, 2021
Stress-induced dopaminergic (DAergic) neuronal death in the midbrain region is the primary cause ... more Stress-induced dopaminergic (DAergic) neuronal death in the midbrain region is the primary cause of Parkinson's disease (PD). From the discovery of L-dopa, multiple drugs were discovered to improve lifestyle of PD patients, but they failed due to their multiple side effects. Tinospora cordifolia (Tc), a medicinal herb has been used in traditional medicines to treat neurodegenerative diseases. In our previous study, the neuroprotective role of Tc against MPTP intoxicated Parkinsonian mice was reported. Here, we further explore the neuroprotective molecular mechanisms of Tc in Rotenone (ROT) intoxicated mouse model through proteomics approach. Mice were pretreated with Tc extract by oral administration, followed by ROT-intoxication. Behavioral tests were performed to check motor functions of mice. Protein was isolated, and label free quanti cation (LFQ) was carried out to identify differentially expressed protein (DEPs) in control vs. PD and PD vs. treatment group. In this study, we report 800 DEPs in control vs. PD and 133 in PD vs. Treatment group. In silico tools clearly demonstrate signi cant enrichment of biochemical and molecular pathways with DEPs which are known to be important for PD progression including mitochondrial gene expression, PD pathways, TGF-β signaling, Alzheimer's disease etc. This results were further validated by qRT-PCR and found that the expression of target gene were identical to the proteomics data. This study provides a novel insight for the disease progression as well new therapeutic tagets. More importantly, it demonstrates that Tc exerts the therapeutic effects through the regulation of multiple pathways to protect DAergic neurons.
Role of Withania somnifera (Ashwagandha) in Neuronal Health
BENTHAM SCIENCE PUBLISHERS eBooks, Dec 4, 2022
Globalizing Traditional Knowledge of Indian Medicine: Evidence-based Therapeutics
BENTHAM SCIENCE PUBLISHERS eBooks, Dec 4, 2022
Behavioral and Brain Functions, May 7, 2019
Background: Bisphenol A (BPA), a major endocrine disruptor and a xenobiotic compound is used abun... more Background: Bisphenol A (BPA), a major endocrine disruptor and a xenobiotic compound is used abundantly in the production of polycarbonate plastics and epoxy resins. Human exposure to this compound is primarily via its leaching from the protective internal epoxy resin coatings of containers into the food and beverages. In addition, the plastics used in dental prostheses and sealants also contain considerable amount of BPA and have a high risk of human exposure. Since it is a well-known endocrine disruptor and closely mimics the molecular structure of human estrogen thereby impairing learning and memory. Withania somnifera (Ws), commonly known as Ashwagandha is known for its varied therapeutic uses in Ayurvedic system of medicine. The present study was undertaken to demonstrate the impairment induced by BPA on the spatial learning, working memory and its alleviation by Ws in Swiss albino mice. The study was conducted on thirty Swiss albino mice, randomly distributed among three groups: control, BPA and BPA + Ws. The behavioral recovery after treatment with Ws was investigated using the Y-maize and Morris water maize test. Whereas, for the estimation of recovery of NMDA receptor which is related to learning and memory in hippocampus region by western blot and immunohistochemistry. Furthermore, the oxidative stress and antioxidant level was assessed by biochemical tests like MDA, SOD and catalase. Results: The study revealed that administration of Ws alleviated the behavioral deficits induced by BPA. Alongside, Ws treatment reinstated the number of NMDA receptors in hippocampus region and showed anti-oxidative property while ameliorating the endogenous anti-oxidant level in the brain. Conclusion: These findings suggest that Ws significantly ameliorates the level of BPA intoxicated oxidative stress thereby potentially treating cognitive dysfunction which acts as the primary symptom in a number of neurodegenerative diseases.
Natural Herbs Polishing Memory: Neuroprotection against Alzheimer's Disease
BENTHAM SCIENCE PUBLISHERS eBooks, Mar 8, 2023
Curcumin Modulates p62–Keap1–Nrf2-Mediated Autophagy in Rotenone-Induced Parkinson’s Disease Mouse Models
ACS Chemical Neuroscience
Protective Effect of Potent Protein-like Drug Isolated from Indian Medicinal Plants over Diabetic Neuropathy
BENTHAM SCIENCE PUBLISHERS eBooks, Mar 8, 2023
Role of Animal Models in Parkinson's Disease (PD): What role they play in preclinical translational research
CNS & Neurological Disorders - Drug Targets
Background: Animal models for drug discovery and development in Parkinson ’s disease have played ... more Background: Animal models for drug discovery and development in Parkinson ’s disease have played an important role in the characterization of the pathophysiology of diseases and associated mechanisms of injury, drug target identification, and evaluation of novel therapeutic agents for toxicity/safety, pharmacokinetics, pharmacodynamics, and efficacy. Objective: The review is intended to reform the scope, advantages, and limitations of various Parkinson’s Disease models and their scope in translational research. The lack of a gold standard for PD animal models presents a major challenge in devising a validation system. This review is an attempt to provide a way to adopt the validation approach for PD animal model for research. Methods: Because underlying disease mechanisms are so similar across species, it is possible to extrapolate results from Parkinson's disease studies using animal models. Furthermore, behavioural tests used to access the neurobehavioral test with its limitat...
Scientific Reports
Major pathological features of Parkinson’s disease (PD) include increase in oxidative stress lead... more Major pathological features of Parkinson’s disease (PD) include increase in oxidative stress leading to the aggregation of α-synuclein, mitochondrial dysfunction and apoptosis of dopaminergic neurons. In addition, downregulation of the expression of neurotrophic factors like-Brain Derived Neurotrophic Factor (BDNF) is also involved in PD progression. There has been a lot of interest in trophic factor-based neuroprotective medicines over the past few decades to treat PD symptoms. Rotenone, an insecticide, inhibits the mitochondrial complex I causing overproduction of ROS, oxidative stress, and aggregation of α-synuclein. It has been shown that BDNF and Tropomyosin receptor kinase B (TrkB) interaction initiates the regulation of neuronal cell development and differentiation by the serine/threonine protein kinases like Akt and GSK-3β. Additionally, Transcription factor CREB (cAMP Response Element-binding protein) also determines the gene expression of BDNF. The homeostasis of these sig...
Anti-Parkinsonian effect of Mucuna pruriens and Ursolic acid on GSK3β/Calcium signaling in neuroprotection against Rotenone-induced Parkinsonism
Phytomedicine Plus
Medicinal Plants and Natural Compounds as Antiparkinsonian Agents
Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition)
Medicinal plants have been used since ages for the treatment of human diseases in the Indian medi... more Medicinal plants have been used since ages for the treatment of human diseases in the Indian medicinal system of Ayurveda. Parkinson's diseases (PD) on the other hand is a kind of neurodegenerative disorder that shows debilitating symptoms; and the treatment of the disease rely on the symptomatic management. The drugs available for the treatment of the disease show severe side effects on prolonged usage. Thus, many medicinal plants and their derivative natural compounds have been tested for their anti-Parkinsonian activity with minimal side effects. Mucuna pruriens, Withania somnifera, Tinospora cordifolia are the example of medicinal plants that have shown anti-Parkinsonian activity while the natural compounds found in medicinal plants like Baicalein, curcumin, Ginseng, Resveratol have also maintained the nerve cell function and prevented the neuronal death. Thus, the polyphenols and other bioactive constituent of medicinal plants should be further studied for their therapeutic...
Journal of Educational Technology Systems, 1979
The information explosion in science and the shift in our economy from the production of industri... more The information explosion in science and the shift in our economy from the production of industrial goods to a greater emphasis on science and knowledge-based industries has created a discontinuity in the nature of jobs and our educational needs. Ironically, wide-spread dissatisfaction with our schools has lead to a nationwide, back-to-basics movement. Computers which have become indispensible to the operation of science, business, and government are not a major part of American education. While many schools have introduced computers into their curriculum, these local efforts only partially satisfy the country's needs at costs which are prohibitive and unnecessary when viewed nationally. In an information society, a computer literate populace is as important as energy is to an industrial society. Other nations have begun the task of restructuring their systems to include computers and unless we begin soon, the next crisis in American education will be the computer literacy crisis.
The Global Economic Impact of Neurodegenerative Diseases: Opportunities and Challenges
Bioeconomy for Sustainable Development
The main challenge in today’s world to the healthcare system is the elevated occurrence of the ne... more The main challenge in today’s world to the healthcare system is the elevated occurrence of the neurodegenerative disorders. Progress in the field of bioinformatics and biomedical research has allowed us to understand the pathobiology of the neurodegenerative disorders in a detailed manner. The threat of these diseases increases with aging, and Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are the major ones affecting the public health and posing the higher economic burden. The research centers, pharmaceutical companies, and academic institutions are conducting research work in collaborations these days to enhance the development of new therapeutic strategies and develop novel drugs in a sustainable way. This can help in the development of safer therapies with reduced risk and can help in developing the authentic and evident biomarkers so that the disease can be diagnosed at early stages and treated accordingly. The advancement can therefore help in improving the quality of life of patients suffering from these debilitating neurodegenerative disorders and can also help in providing the job opportunities to the students interested in drug development program.
Neuroprotection by Mucuna pruriens in Neurodegenerative Diseases
Neurochemical Research
The medicinal plant Mucuna pruriens (Fabaceae) is widely known for its anti-oxidative and anti-in... more The medicinal plant Mucuna pruriens (Fabaceae) is widely known for its anti-oxidative and anti-inflammatory properties. It is a well-established drug in Ayurveda and has been widely used for the treatment of neurological disorders and male infertility for ages. The seeds of the plant have potent medicinal value and its extract has been tested in different models of neurodegenerative diseases, especially Parkinson's disease (PD). Apart from PD, Mucuna pruriens is now being studied in models of other nervous systems disorders such as Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS) and stroke because of its neuroprotective importance. This review briefly discusses the pathogenesis of PD, AD, ALS and stroke. It aims to summarize the medicinal importance of Mucuna pruriens in treatment of these diseases, and put forward the potential targets where Mucuna pruriens can act for therapeutic interventions. In this review, the effect of Mucuna pruriens on ameliorating the neurodegeneration evident in PD, AD, ALS and stroke is briefly discussed. The potential targets for neuroprotection by the plant are delineated, which can be studied further to validate the hypothesis regarding the use of Mucuna pruriens for the treatment of these diseases.
Pathophysiology of the Disease Causing Physical Disability
Biomedical Engineering and its Applications in Healthcare, 2019
An “individual with a disability” has a physical impairment or record of such an impairment that ... more An “individual with a disability” has a physical impairment or record of such an impairment that substantially limits a “major life activity.” Today, “person with a disability” is a more widely used term than “handicapped” as this phrasing reflects a positive approach by putting people first, not the disability. The disability term is used to refer an individual functioning including motor, sensory, cognitive, intellectual impairment, mental illness, and various types of chronic diseases (Oliver 1995; Crow 2008).
Application of Biomedical Engineering in Neuroscience, 2019
Ключевые слова: Министерство социального развития, труда и занятости Республики Калмыкия, соцподд... more Ключевые слова: Министерство социального развития, труда и занятости Республики Калмыкия, соцподдержка, соцгарантии. Статья посвящена анализу эффективности функционирования Министерства социального развития, труда и занятости Республики Калмыкия. Региональные модели управления соцработой имеют особенности. Модель оказывает социальную поддержку определенным категориям граждан, исходя из российского законодательства, где количественные свойства управленческой системы управления обеспечиваются нуждами и потенциалом социальной защиты. Лимитирующей формой, методами и технологиями соцработы являются резервы, которые задействованы и требуют разрешения задач. Региональная модель имеет систему условий-эколого-экономических, политико-организационных, социально-демографических, национальных, социально-психологических, которые принимают в расчет «на входе» управленческой системы, при функционировании и развитии. Субъект соцобслуживания выступают госорганы регионов России. В Республике Калмыкия таким госорганом выступает Министерство социального развития, труда и занятости, и подведомственные ему организации, предоставляющие соцуслуги. Правительство РК способствует развитию новейших способов соцработы, которые улучшают соцобслуживание и поддерживает слабо защищенных категорий населения. Трудность в развитии организаций соцобслуживания в РК-это недостаточность мест в этих организациях из-за низкого обеспечения регионом стационарных организаций. Для этого Министерство ликвидирует очередность в организации соцобслуживания, строят новые корпуса соцобслуживания. В перечне поставщиков соцуслуг РК включены негосударственные учреждения соцобслуживания.
Impact of the alkaloid colletotrichumine A on the pathogenicity of Colletotrichum capsici in Capsicum annum L
Rhizosphere, 2020
Abstract Herein we report a study examining the effects of colletotrichumine A, an indole-pyrazin... more Abstract Herein we report a study examining the effects of colletotrichumine A, an indole-pyrazine alkaloid isolated from the anthracnose pathogen Colletotrichum capsici, on chilli plants. A colletotrichumine A-pathogen combination was more toxic to the host than individual inoculations of colletotrichumine A or the pathogen. The colletotrichumine A-pathogen combination led to an increased activity of defense related enzymes viz. PPO and SOD, while levels of the lignification enzymes PAL and PO decreased. Higher levels of phenols including catechin and ferulic acid were also observed with the colletotrichumine A-pathogen combination compared to individual treatment. The likely role of colletotrichumine A during chilli anthracnose infection is supported by histochemical analysis of infected plants that showed increased cell death after infection.
Economic Importance of Medicinal Plants in Asian Countries
Bioeconomy for Sustainable Development, 2019
Due to their characteristic benefits and medicinal value, medicinal plants are gaining importance... more Due to their characteristic benefits and medicinal value, medicinal plants are gaining importance worldwide. It is becoming famous, and people are using herbal therapy as an alternative medicinal therapy. Because of their increased traditional use and cultural acceptability, these medicinal plants are greatly admired and also have minimal side effects and thus are gaining global importance. Herbal drugs which are cost-effective than synthetic drugs in many cases are being promoted by most of the developing countries, and they have started discovering and filing patents on the medicinal plants and their derivatives. Many drugs still have not undergone the process of drug approval and are not yet validated for their safety and efficacy. These medicinal plant-derived drugs can be formulated by medicine-based industries. The international trade of medicinal plants and their products was estimated to be USD 60 billion in 2010, and by 2050, it is expected to reach USD 5 trillion. Asian countries are very rich in medicinal plant species and are the major exporters of these plants and their products. These medicinal plants can be popularized and used to improve the economy of low-income countries of Asia and create livelihoods for its people. Moreover, overexploitation of these medicinal plants should be limited, the valuable species of high marketing value should be conserved, and their cultivation should be promoted for future use.
Obstacles in the Adaptation of Biopesticides in India
Circular Economy and Sustainability, 2021
The COVID-19 pandemic had a devastating impact on the human health and global economy. The food a... more The COVID-19 pandemic had a devastating impact on the human health and global economy. The food and agriculture sectors have also felt these effects. In many countries, the measures taken to curb the spread of the virus were initiated to hinder the supply of agricultural products to markets and consumers inside and outside the borders. How this impacts the food safety, nutrition, and the livelihoods of farmers, fishermen, and others working in the food supply chain depends mainly on short-, medium-, and long-term policy responses. Epidemics pose severe challenges to the food system in the short term, but they also offer an opportunity to face challenges and accelerate the transformation of the food and agricultural sectors to increase resilience. The aim of the review was to highlight the valuable insight on the impact of COVID-19 on the Indian agricultural system and rural economy, as well as potential strategies for post-pandemic recovery.
Uploads
Papers by Hagera Dilnashin