A cDNA for rhodopsin was isolated from a hbrary constructed from poly(A)'RNA of the squid (Tudaro... more A cDNA for rhodopsin was isolated from a hbrary constructed from poly(A)'RNA of the squid (Tudarodes pacifincs) retina. One positive clone with the longest insert of cDNA (3.1 kb) was selected by employing a PCR-amplified cDNA fragment as a probe. The nucleotide sequence of the cDNA revealed a single open reading frame of 1,344 bp encoding a polypeptide (M, 49.833). which covered a complete sequence for the squid opsin. This clone had a very long 3'-non-coding region (1.7 kb) including multiple polyadenylation signals, AATAAA. resembling the clones for Todarodes retinochrome and retinal-binding protein (RALBP). The analysis of hydropathicity demonstrated the presence of seven transmembrane spanning domains, and a possible retinal-binding site, Lys-305, was found in the 7th domain. Todurodes rhodopsin contained characteristic sequences of PPQGY repeated in the C-terminal region, as reported in Loligo and octopus rhodopsins. Structurai comparison of those ~phalopod rhodopsins is also discussed.
The Belle detector at the KEKB electron-positron collider has collected almost 1 billion Y(4S) ev... more The Belle detector at the KEKB electron-positron collider has collected almost 1 billion Y(4S) events in its decade of operation. Super-KEKB, an upgrade of KEKB is under construction, to increase the luminosity by two orders of magnitude during a three-year shutdown, with an ultimate goal of 8E35 /cm^2 /s luminosity. To exploit the increased luminosity, an upgrade of the Belle detector has been proposed. A new international collaboration Belle-II, is being formed. The Technical Design Report presents physics motivation, basic methods of the accelerator upgrade, as well as key improvements of the detector.
Protons with energies up to ~ 10 15 eV are the main component 1 of cosmic rays, but evidence for ... more Protons with energies up to ~ 10 15 eV are the main component 1 of cosmic rays, but evidence for the specific locations where they could have been accelerated to these energies has been lacking 2 . Electrons are known to be accelerated to cosmic-ray energies in supernova remnants 3, 4 , and the shock waves
We report the results of TeV gamma-ray observations of the shell type SNR RX J1713.7−3946 (G347.3... more We report the results of TeV gamma-ray observations of the shell type SNR RX J1713.7−3946 (G347.3−0.5). The discovery of strong non-thermal X-ray emission from the northwest part of the remnant strongly suggests the existence of electrons with energies up to ∼ 100 TeV in the remnant, making the SNR a good candidate TeV gamma-ray source. We observed RX J1713.7−3946 from May to August 1998 with the CANGAROO 3.8m atmospheric imagingČerenkov telescope and obtained evidence for TeV gamma-ray emission from the NW rim of the remnant with the significance of ∼ 5.6σ. The observed TeV gamma-ray flux from the NW rim region was estimated to be (5.3 ± 0.9[statistical] ± 1.6[systematic]) × 10 −12 photons cm −2 s −1 at energies ≥ 1.8 ± 0.9 TeV. The data indicate that the emitting region is much broader than the point spread function of our telescope. The extent of the emission is consistent with that of hard X-rays observed by ASCA. This TeV gamma-ray emission can be attributed to the Inverse Compton scattering of the Cosmic Microwave Background Radiation by shock accelerated ultra-relativistic electrons. Under this assumption, a rather low magnetic field of ∼ 11µG is deduced for the remnant from our observation.
Squid (~d#ro~espuc;~c~s~ retinochrome was reduced to N-retinyl protein with borane dimethylamine ... more Squid (~d#ro~espuc;~c~s~ retinochrome was reduced to N-retinyl protein with borane dimethylamine and cleaved by CNBr. The retinyl peptide was then isolated by chromatography while being monitored for absorbances at 215 and 330 nm, and the N-terminal amino acid sequence was determined to be Ser-Lys-Thr-Gly-X-Ala-Leu-Phe-Pro.
It is well known that orthogonal frequency-division multiplexing (OFDM) is robust to frequency-se... more It is well known that orthogonal frequency-division multiplexing (OFDM) is robust to frequency-selective fading in wireless channels due to the exploitation of a guard interval that is inserted at the beginning of each OFDM symbol. However, once delayed signals beyond the guard interval are introduced in a channel with a large delay spread, intersymbol interference causes a severe degradation in the transmission performance. In this paper, we propose a novel pre-fast Fourier transform (FFT) OFDM adaptive antenna array, which requires only one FFT processor at a receiver, for suppressing such delayed signals. We derive the optimum weight set for beamformers based on the maximum signal-to-noise-and-interference power ratio (Max-SNIR) and the minimum mean square error (mmse) criteria, respectively. In addition, we propose a novel mmse-criterion-based commutative optimization scheme, which is more robust to the estimation error of the channel state information. Furthermore, we show the equivalence between the Max-SNIR-criterion-based scheme and the proposed commutative optimization scheme. Computer simulation results show its good performance even in channels where directions of arrival of arriving waves are randomly determined.
Although an association between Chlamydia pneumoniae (Cpn) or Cytomegalovirus (CMV) infection and... more Although an association between Chlamydia pneumoniae (Cpn) or Cytomegalovirus (CMV) infection and coronary atherosclerosis has been reported, such an association is less clear for acute coronary syndromes (ACS). The purpose of this study was to investigate the pathogenic roles of Cpn and CMV infection of coronary plaques in ACS. We divided 38 coronary plaque specimens obtained from 38 patients who underwent directional coronary atherectomy or thrombectomy into an ACS group (n = 21) and a non-ACS group (n = 17). Cpn and CMV in specimens were stained using immunohistochemical techniques and analyzed quantitatively. The detection rate for either Cpn- or CMV-positive cells in ACS patients was slightly higher compared with non-ACS patients. Detection rates for both Cpn- and CMV-positive cells were significantly higher in ACS patients than in non-ACS patients (P = 0.010). Furthermore, the density of Cpn- and CMV-positive cells in plaques was significantly higher in ACS patients than in non-ACS patients (P < 0.003). The results indicate that the presence and severity of Cpn and CMV infection in coronary plaques are greater in patients with ACS compared with non-ACS patients. We conclude that infection with Cpn and CMV in coronary plaques may be involved in the pathogenesis of ACS.
A cDNA for rhodopsin was isolated from a hbrary constructed from poly(A)'RNA of the squid (Tudaro... more A cDNA for rhodopsin was isolated from a hbrary constructed from poly(A)'RNA of the squid (Tudarodes pacifincs) retina. One positive clone with the longest insert of cDNA (3.1 kb) was selected by employing a PCR-amplified cDNA fragment as a probe. The nucleotide sequence of the cDNA revealed a single open reading frame of 1,344 bp encoding a polypeptide (M, 49.833). which covered a complete sequence for the squid opsin. This clone had a very long 3'-non-coding region (1.7 kb) including multiple polyadenylation signals, AATAAA. resembling the clones for Todarodes retinochrome and retinal-binding protein (RALBP). The analysis of hydropathicity demonstrated the presence of seven transmembrane spanning domains, and a possible retinal-binding site, Lys-305, was found in the 7th domain. Todurodes rhodopsin contained characteristic sequences of PPQGY repeated in the C-terminal region, as reported in Loligo and octopus rhodopsins. Structurai comparison of those ~phalopod rhodopsins is also discussed.
The Belle detector at the KEKB electron-positron collider has collected almost 1 billion Y(4S) ev... more The Belle detector at the KEKB electron-positron collider has collected almost 1 billion Y(4S) events in its decade of operation. Super-KEKB, an upgrade of KEKB is under construction, to increase the luminosity by two orders of magnitude during a three-year shutdown, with an ultimate goal of 8E35 /cm^2 /s luminosity. To exploit the increased luminosity, an upgrade of the Belle detector has been proposed. A new international collaboration Belle-II, is being formed. The Technical Design Report presents physics motivation, basic methods of the accelerator upgrade, as well as key improvements of the detector.
Protons with energies up to ~ 10 15 eV are the main component 1 of cosmic rays, but evidence for ... more Protons with energies up to ~ 10 15 eV are the main component 1 of cosmic rays, but evidence for the specific locations where they could have been accelerated to these energies has been lacking 2 . Electrons are known to be accelerated to cosmic-ray energies in supernova remnants 3, 4 , and the shock waves
We report the results of TeV gamma-ray observations of the shell type SNR RX J1713.7−3946 (G347.3... more We report the results of TeV gamma-ray observations of the shell type SNR RX J1713.7−3946 (G347.3−0.5). The discovery of strong non-thermal X-ray emission from the northwest part of the remnant strongly suggests the existence of electrons with energies up to ∼ 100 TeV in the remnant, making the SNR a good candidate TeV gamma-ray source. We observed RX J1713.7−3946 from May to August 1998 with the CANGAROO 3.8m atmospheric imagingČerenkov telescope and obtained evidence for TeV gamma-ray emission from the NW rim of the remnant with the significance of ∼ 5.6σ. The observed TeV gamma-ray flux from the NW rim region was estimated to be (5.3 ± 0.9[statistical] ± 1.6[systematic]) × 10 −12 photons cm −2 s −1 at energies ≥ 1.8 ± 0.9 TeV. The data indicate that the emitting region is much broader than the point spread function of our telescope. The extent of the emission is consistent with that of hard X-rays observed by ASCA. This TeV gamma-ray emission can be attributed to the Inverse Compton scattering of the Cosmic Microwave Background Radiation by shock accelerated ultra-relativistic electrons. Under this assumption, a rather low magnetic field of ∼ 11µG is deduced for the remnant from our observation.
Squid (~d#ro~espuc;~c~s~ retinochrome was reduced to N-retinyl protein with borane dimethylamine ... more Squid (~d#ro~espuc;~c~s~ retinochrome was reduced to N-retinyl protein with borane dimethylamine and cleaved by CNBr. The retinyl peptide was then isolated by chromatography while being monitored for absorbances at 215 and 330 nm, and the N-terminal amino acid sequence was determined to be Ser-Lys-Thr-Gly-X-Ala-Leu-Phe-Pro.
It is well known that orthogonal frequency-division multiplexing (OFDM) is robust to frequency-se... more It is well known that orthogonal frequency-division multiplexing (OFDM) is robust to frequency-selective fading in wireless channels due to the exploitation of a guard interval that is inserted at the beginning of each OFDM symbol. However, once delayed signals beyond the guard interval are introduced in a channel with a large delay spread, intersymbol interference causes a severe degradation in the transmission performance. In this paper, we propose a novel pre-fast Fourier transform (FFT) OFDM adaptive antenna array, which requires only one FFT processor at a receiver, for suppressing such delayed signals. We derive the optimum weight set for beamformers based on the maximum signal-to-noise-and-interference power ratio (Max-SNIR) and the minimum mean square error (mmse) criteria, respectively. In addition, we propose a novel mmse-criterion-based commutative optimization scheme, which is more robust to the estimation error of the channel state information. Furthermore, we show the equivalence between the Max-SNIR-criterion-based scheme and the proposed commutative optimization scheme. Computer simulation results show its good performance even in channels where directions of arrival of arriving waves are randomly determined.
Although an association between Chlamydia pneumoniae (Cpn) or Cytomegalovirus (CMV) infection and... more Although an association between Chlamydia pneumoniae (Cpn) or Cytomegalovirus (CMV) infection and coronary atherosclerosis has been reported, such an association is less clear for acute coronary syndromes (ACS). The purpose of this study was to investigate the pathogenic roles of Cpn and CMV infection of coronary plaques in ACS. We divided 38 coronary plaque specimens obtained from 38 patients who underwent directional coronary atherectomy or thrombectomy into an ACS group (n = 21) and a non-ACS group (n = 17). Cpn and CMV in specimens were stained using immunohistochemical techniques and analyzed quantitatively. The detection rate for either Cpn- or CMV-positive cells in ACS patients was slightly higher compared with non-ACS patients. Detection rates for both Cpn- and CMV-positive cells were significantly higher in ACS patients than in non-ACS patients (P = 0.010). Furthermore, the density of Cpn- and CMV-positive cells in plaques was significantly higher in ACS patients than in non-ACS patients (P < 0.003). The results indicate that the presence and severity of Cpn and CMV infection in coronary plaques are greater in patients with ACS compared with non-ACS patients. We conclude that infection with Cpn and CMV in coronary plaques may be involved in the pathogenesis of ACS.
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Papers by Hara Hara